Characterising protein oligomers and their role in neurodegenerative disease in humans

Publications

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme

Auteurs: Rachel Cliffe, Jason C. Sang, Franziska Kundel, Daniel Finley, David Klenerman, Yu Ye
Publié dans: Cell Reports, Numéro 26/8, 2019, Page(s) 2140-2149.e3, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.01.096

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

Auteurs: Suman De, David Klenerman
Publié dans: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Numéro 1867/10, 2019, Page(s) 870-878, ISSN 1570-9639
Éditeur: Elsevier BV
DOI: 10.1016/j.bbapap.2018.12.010

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

Auteurs: Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Publié dans: Communications Biology, Numéro 4/1, 2021, ISSN 2399-3642
Éditeur: Communication Biology
DOI: 10.1038/s42003-021-02126-w

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

Auteurs: Georg Meisl , Eric Hidari , Kieren Allinson , Timothy Rittman , Sarah L DeVos , Justin S Sanchez , Catherine K Xu , Karen E Duff , Keith A Johnson , James B Rowe , Bradley T Hyman, Tuomas P J Knowles , David Klenerman
Publié dans: Science Advances, 2021, ISSN 2375-2548
Éditeur: AAAS
DOI: 10.1126/sciadv.abh1448

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease

Auteurs: Dimitrios I Sideris, John S H Danial, Derya Emin, Francesco S Ruggeri, Zengjie Xia, Yu P Zhang, Evgeniia Lobanova, Helen Dakin, Suman De, Alyssa Miller, Jason C Sang, Tuomas P J Knowles, Michele Vendruscolo, Graham Fraser, Damian Crowther, David Klenerman
Publié dans: Brain Communications, Numéro 3/3, 2021, ISSN 2632-1297
Éditeur: Oxford University Press
DOI: 10.1093/braincomms/fcab147

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

Auteurs: John B Sanderson, Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini, Aurelia Hays Watson, Laura De Boni, Valentina N Lagomarsino, Tracy L Young-Pearse, Xinyue Liu, Thomas C Pochapsky, Bradley T Hyman, Dennis W Dickson, David Klenerman, Dennis J Selkoe, Tim Bartels
Publié dans: Brain Communications, Numéro 2/1, 2020, ISSN 2632-1297
Éditeur: Oxford University Press
DOI: 10.1093/braincomms/fcaa010

Optical structural analysis of individual α-synuclein oligomers

Auteurs: Juan Alberto Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M. Dobson, David Klenerman, Steven Lee
Publié dans: Angewandte Chemie International Edition, Numéro 12, 2018, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201710779

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Auteurs: Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H. Horrocks, Magnus Kjaergaard, Sarah L. Shammas, Sophie E. Jackson, Christopher M. Dobson, David Klenerman
Publié dans: ACS Chemical Biology, Numéro 12, 2018, ISSN 1554-8929
Éditeur: American Chemical Society
DOI: 10.1021/acschembio.7b01039

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Auteurs: Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, Craig D. Hughes, Francesco S. Ruggeri, Tim Guilliams, Alexander K. Buell, Ji-Eun Lee, Sonia Gandhi, Steven F. Lee, Clare E. Bryant, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
Publié dans: BMC Biology, Numéro 15/1, 2017, ISSN 1741-7007
Éditeur: BioMed Central
DOI: 10.1186/s12915-017-0390-6

Ultrasensitive Measurement of Ca 2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Auteurs: Patrick Flagmeier, Suman De, David C. Wirthensohn, Steven F. Lee, Cécile Vincke, Serge Muyldermans, Tuomas P. J. Knowles, Sonia Gandhi, Christopher M. Dobson, David Klenerman
Publié dans: Angewandte Chemie International Edition, Numéro 56/27, 2017, Page(s) 7750-7754, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201700966

Inhibiting the Ca 2+ Influx Induced by Human CSF

Auteurs: Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Publié dans: Cell Reports, Numéro 21/11, 2017, Page(s) 3310-3316, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.11.057

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

Auteurs: Daniel R. Whiten, Dezerae Cox, Mathew H. Horrocks, Christopher G. Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R. Kumita, Heath Ecroyd, Christopher M. Dobson, David Klenerman, Mark R. Wilson
Publié dans: Cell Reports, Numéro 23/12, 2018, Page(s) 3492-3500, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.05.074

Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells

Auteurs: Mathew Horrocks, Daniel R Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C Wirthensohn, Franziska Kundel, Steven F Lee, Christopher Dobson, Sonia Gandhi, Maria Spillantini, David Klenerman, Rohan T Ranasinghe, Santiago E Sanchez, Dilan Athauda
Publié dans: ChemBioChem, 2018, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800209

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Auteurs: Kundel, F.; Hong, L.; Falcon, B.; McEwan, W. A.; Michaels, T. C. T.; Meisl, G.; Esteras, N.; Abramov, A. Y.; Knowles, T. J. P.; Goedert, M.; Klenerman, D.
Publié dans: ACS Chemical Neuroscience (2018), 2018, Page(s) 1276–1282, ISSN 1948-7193
Éditeur: American Chemical Society
DOI: 10.17863/CAM.25419

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

Auteurs: Christopher G. Taylor, Georg Meisl, Mathew H. Horrocks, Henrik Zetterberg, Tuomas P. J. Knowles, David Klenerman
Publié dans: Analytical Chemistry, Numéro 90/17, 2018, Page(s) 10385-10393, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.8b02226

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells

Auteurs: Anna Drews, Jennie Flint, Nadia Shivji, Peter Jönsson, David Wirthensohn, Erwin De Genst, Cécile Vincke, Serge Muyldermans, Chris Dobson, David Klenerman
Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep31910

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Auteurs: Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-09477-3

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

Auteurs: Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Publié dans: Acta Neuropathologica Communications, Numéro 7/1, 2019, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-019-0777-4

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

Auteurs: Ji-Eun Lee, Jason C. Sang, Margarida Rodrigues, Alexander R. Carr, Mathew H. Horrocks, Suman De, Marie N. Bongiovanni, Patrick Flagmeier, Christopher M. Dobson, David J. Wales, Steven F. Lee, David Klenerman
Publié dans: Nano Letters, Numéro 18/12, 2018, Page(s) 7494-7501, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.8b02916

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Auteurs: Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, Juan A. Botía, Maria Iljina, Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Publié dans: Acta Neuropathologica, Numéro 137/1, 2019, Page(s) 103-120, ISSN 0001-6322
Éditeur: Springer Verlag
DOI: 10.1007/s00401-018-1907-y

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Auteurs: Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Publié dans: Communications Biology, Numéro 3/1, 2020, ISSN 2399-3642
Éditeur: Nature research
DOI: 10.1038/s42003-020-0792-9

Quantifying Co-Oligomer Formation by α-Synuclein

Auteurs: Marija Iljina, Alexander J. Dear, Gonzalo A. Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R. Whiten, Thomas C. T. Michaels, Daan Frenkel, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Publié dans: ACS Nano, Numéro 12/11, 2018, Page(s) 10855-10866, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.8b03575

Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers

Auteurs: Santiago Enrique Sanchez, Daniel R. Whiten, Georg Meisl, Francesco Simone Ruggeri, Eric Hidari, David Klenerman
Publié dans: ChemBioChem, 2021, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100285

Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease

Auteurs: Evgeniia Lobanova, Daniel Whiten, Francesco S Ruggeri, Chris Taylor, Antonina Kouli, Zengjie Xia, Derya Emin, Yu P Zhang, Jeff Y L Lam, Caroline H Williams-Gray, David Klenerman
Publié dans: Brain, 2021, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awab306

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

Auteurs: Daniel R Whiten, Philip W Brownjohn, Steven Moore, Suman De, Alessio Strano, Yukun Zuo, Moritz Haneklaus, David Klenerman, Frederick J Livesey
Publié dans: Brain Communications, Numéro 2/2, 2020, ISSN 2632-1297
Éditeur: Oxford University Press
DOI: 10.1093/braincomms/fcaa146

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