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New Frontiers in Cellular Reprogramming: Exploiting Cellular Plasticity

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Publications

A versatile drug delivery system targeting senescent cells

Author(s): Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Published in: EMBO Molecular Medicine, 2018, Page(s) e9355, ISSN 1757-4676
DOI: 10.15252/emmm.201809355

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Author(s): Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano
Published in: Cell Reports, Issue 22/2, 2018, Page(s) 396-410, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.12.062

AAV vector-mediated in vivo reprogramming into pluripotency

Author(s): Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano, Dirk Grimm
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-05059-x

Senescence promotes in vivo reprogramming through p16 INK 4a and IL-6

Author(s): Lluc Mosteiro, Cristina Pantoja, Alba de Martino, Manuel Serrano
Published in: Aging Cell, Issue 17/2, 2018, Page(s) e12711, ISSN 1474-9718
DOI: 10.1111/acel.12711

An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

Author(s): Beatriz Lozano-Torres, Irene Galiana, Miguel Rovira, Eva Garrido, Selim Chaib, Andrea Bernardos, Daniel Muñoz-Espín, Manuel Serrano, Ramón Martínez-Máñez, Félix Sancenón
Published in: Journal of the American Chemical Society, Issue 139/26, 2017, Page(s) 8808-8811, ISSN 0002-7863
DOI: 10.1021/jacs.7b04985

Analysis of the advantages of cis reporters in optimized FACS-Gal

Author(s): Miguel Ángel Sánchez-Luengo, Miguel Rovira, Manuel Serrano, Pablo Jose Fernandez-Marcos, Lola Martinez
Published in: Cytometry Part A, Issue 91/7, 2017, Page(s) 721-729, ISSN 1552-4922
DOI: 10.1002/cyto.a.23086

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Author(s): Elena Lopez-Guadamillas, Pablo J. Fernandez-Marcos, Cristina Pantoja, Maribel Muñoz-Martin, Dolores Martínez, Gonzalo Gómez-López, Ramón Campos-Olivas, Angela M. Valverde, Manuel Serrano
Published in: Scientific Reports, Issue 6, 2016, Page(s) 34542, ISSN 2045-2322
DOI: 10.1038/srep34542

PI3Kα inhibition reduces obesity in mice

Author(s): Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Sonia Martinez, Joaquin Pastor, Pablo J. Fernandez-Marcos, Manuel Serrano
Published in: Aging, 2016, ISSN 1945-4589
DOI: 10.18632/aging.101075

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Author(s): Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar, Rosa M. Marión, Dafni Chondronasiou, Miguel Rovira, Pablo J. Fernandez-Marcos, Maribel Muñoz-Martin, Carmen Blanco-Aparicio, Joaquin Pastor, Gonzalo Gómez-López, Alba De Martino, Maria A. Blasco, María Abad, Manuel Serrano
Published in: Science, Issue 354/6315, 2016, Page(s) aaf4445, ISSN 0036-8075
DOI: 10.1126/science.aaf4445

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

Author(s): Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo, Manuel Serrano
Published in: Nature Communications, Issue 7, 2016, Page(s) 10438, ISSN 2041-1723
DOI: 10.1038/ncomms10438

G6PD protects from oxidative damage and improves healthspan in mice

Author(s): Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano
Published in: Nature Communications, Issue 7, 2016, Page(s) 10894, ISSN 2041-1723
DOI: 10.1038/ncomms10894

Lysosomal trapping of palbociclib and its functional implications

Author(s): Susana Llanos, Diego Megias, Carmen Blanco-Aparicio, Elena Hernández-Encinas, Miguel Rovira, Federico Pietrocola, Manuel Serrano
Published in: Oncogene, Issue 38/20, 2019, Page(s) 3886-3902, ISSN 0950-9232
DOI: 10.1038/s41388-019-0695-8

Cellular Senescence: Defining a Path Forward

Author(s): Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daoho
Published in: Cell, Issue 179/4, 2019, Page(s) 813-827, ISSN 0092-8674
DOI: 10.1016/j.cell.2019.10.005

Identification and characterization of Cardiac Glycosides as senolytic compounds

Author(s): Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-12888-x

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Author(s): Estela González‐Gualda, Marta Pàez‐Ribes, Beatriz Lozano‐Torres, David Macias, Joseph R. Wilson, Cristina González‐López, Hui‐Ling Ou, Sofía Mirón‐Barroso, Zhenguang Zhang, Araceli Lérida‐Viso, Juan F. Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P. Martins, Manuel Serrano, Gary J. Doherty, Ramón Martínez‐Máñez, Daniel Muñoz‐Espín
Published in: Aging Cell, Issue 19/4, 2020, ISSN 1474-9718
DOI: 10.1111/acel.13142