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New Frontiers in Cellular Reprogramming: Exploiting Cellular Plasticity

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Publications

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Author(s): Timothy P. Cash, Sonia Alcalá, María del Rosario Rico-Ferreira, Elena Hernández-Encinas, Jennifer García, María Isabel Albarrán, Sandra Valle, Javier Muñoz, Sonia Martínez-González, Carmen Blanco-Aparicio, Joaquín Pastor, Manuel Serrano, Bruno Sainz
Published in: Cancers, 12/7, 2020, Page(s) 1790, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12071790

Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation

Author(s): Jorge Blázquez-Prieto, Covadonga Huidobro, Inés López-Alonso, Laura Amado-Rodriguez, Paula Martín-Vicente, Cecilia López-Martínez, Irene Crespo, Cristina Pantoja, Pablo J Fernandez-Marcos, Manuel Serrano, Jacob I Sznajder, Guillermo M Albaiceta
Published in: Translational Research, 233, 2021, Page(s) 104-116, ISSN 1931-5244
Publisher: Elsevier BV
DOI: 10.1016/j.trsl.2021.01.008

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

Author(s): M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare, K. M. Sakamoto
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17100-z

MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation

Author(s): Cristina Batlle, Isabel Calvo, Valentin Iglesias, Cian J. Lynch, Marcos Gil-Garcia, Manuel Serrano, Salvador Ventura
Published in: Communications Biology, 4/1, 2021, ISSN 2399-3642
Publisher: Springer Nature Limited
DOI: 10.1038/s42003-021-01930-8

Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19

Author(s): Raquel Bernad, Cian J. Lynch, Rocio G. Urdinguio, Camille Stephan-Otto Attolini, Mario F. Fraga, Manuel Serrano
Published in: Cells, 10/4, 2021, Page(s) 876, ISSN 2073-4409
Publisher: MPDI
DOI: 10.3390/cells10040876

A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence

Author(s): Beatriz Lozano-Torres, Juan F Blandez, Irene Galiana, José A Lopez-Dominguez, Miguel Rovira, Marta Paez-Ribes, Estela González-Gualda, Daniel Muñoz-Espín, Manuel Serrano, Félix Sancenón, Ramón Martínez-Máñez
Published in: Analytical Chemistry, 93/5, 2021, Page(s) 3052-3060, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c05447

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Author(s): A. Roichman, S. Elhanati, M. A. Aon, I. Abramovich, A. Di Francesco, Y. Shahar, M. Y. Avivi, M. Shurgi, A. Rubinstein, Y. Wiesner, A. Shuchami, Z. Petrover, I. Lebenthal-Loinger, O. Yaron, A. Lyashkov, C. Ubaida-Mohien, Y. Kanfi, B. Lerrer, P. J. Fernández-Marcos, M. Serrano, E. Gottlieb, R. de Cabo, H. Y. Cohen
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23545-7

A versatile drug delivery system targeting senescent cells

Author(s): Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Published in: EMBO Molecular Medicine, 2018, Page(s) e9355, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809355

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Author(s): Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano
Published in: Cell Reports, 22/2, 2018, Page(s) 396-410, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.12.062

AAV vector-mediated in vivo reprogramming into pluripotency

Author(s): Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano, Dirk Grimm
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05059-x

Senescence promotes in vivo reprogramming through p16 INK 4a and IL-6

Author(s): Lluc Mosteiro, Cristina Pantoja, Alba de Martino, Manuel Serrano
Published in: Aging Cell, 17/2, 2018, Page(s) e12711, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12711

An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

Author(s): Beatriz Lozano-Torres, Irene Galiana, Miguel Rovira, Eva Garrido, Selim Chaib, Andrea Bernardos, Daniel Muñoz-Espín, Manuel Serrano, Ramón Martínez-Máñez, Félix Sancenón
Published in: Journal of the American Chemical Society, 139/26, 2017, Page(s) 8808-8811, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b04985

Analysis of the advantages of cis reporters in optimized FACS-Gal

Author(s): Miguel Ángel Sánchez-Luengo, Miguel Rovira, Manuel Serrano, Pablo Jose Fernandez-Marcos, Lola Martinez
Published in: Cytometry Part A, 91/7, 2017, Page(s) 721-729, ISSN 1552-4922
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23086

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Author(s): Elena Lopez-Guadamillas, Pablo J. Fernandez-Marcos, Cristina Pantoja, Maribel Muñoz-Martin, Dolores Martínez, Gonzalo Gómez-López, Ramón Campos-Olivas, Angela M. Valverde, Manuel Serrano
Published in: Scientific Reports, 6, 2016, Page(s) 34542, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep34542

PI3Kα inhibition reduces obesity in mice

Author(s): Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Sonia Martinez, Joaquin Pastor, Pablo J. Fernandez-Marcos, Manuel Serrano
Published in: Aging, 2016, ISSN 1945-4589
Publisher: Aging (Albany NY)
DOI: 10.18632/aging.101075

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Author(s): Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar, Rosa M. Marión, Dafni Chondronasiou, Miguel Rovira, Pablo J. Fernandez-Marcos, Maribel Muñoz-Martin, Carmen Blanco-Aparicio, Joaquin Pastor, Gonzalo Gómez-López, Alba De Martino, Maria A. Blasco, María Abad, Manuel Serrano
Published in: Science, 354/6315, 2016, Page(s) aaf4445, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf4445

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

Author(s): Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo, Manuel Serrano
Published in: Nature Communications, 7, 2016, Page(s) 10438, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10438

G6PD protects from oxidative damage and improves healthspan in mice

Author(s): Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano
Published in: Nature Communications, 7, 2016, Page(s) 10894, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10894

Lysosomal trapping of palbociclib and its functional implications

Author(s): Susana Llanos, Diego Megias, Carmen Blanco-Aparicio, Elena Hernández-Encinas, Miguel Rovira, Federico Pietrocola, Manuel Serrano
Published in: Oncogene, 38/20, 2019, Page(s) 3886-3902, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-0695-8

Cellular Senescence: Defining a Path Forward

Author(s): Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daoho
Published in: Cell, 179/4, 2019, Page(s) 813-827, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.10.005

Identification and characterization of Cardiac Glycosides as senolytic compounds

Author(s): Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12888-x

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Author(s): Estela González‐Gualda, Marta Pàez‐Ribes, Beatriz Lozano‐Torres, David Macias, Joseph R. Wilson, Cristina González‐López, Hui‐Ling Ou, Sofía Mirón‐Barroso, Zhenguang Zhang, Araceli Lérida‐Viso, Juan F. Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P. Martins, Manuel Serrano, Gary J. Doherty, Ramón Martínez‐Máñez, Daniel Muñoz‐Espín
Published in: Aging Cell, 19/4, 2020, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13142

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

Author(s): Alberto Rodríguez-Matellán, Noelia Alcazar, Félix Hernández, Manuel Serrano, Jesús Ávila
Published in: Stem Cell Reports, 15/5, 2020, Page(s) 1056-1066, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.09.010

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Author(s): Jose M. Bermúdez-Muñoz, Adelaida M. Celaya, Ángela García-Mato, Daniel Muñoz-Espín, Lourdes Rodríguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Published in: Antioxidants, 10/9, 2021, Page(s) 1351, ISSN 2076-3921
Publisher: MPDI
DOI: 10.3390/antiox10091351

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Author(s): Cian J. Lynch, Raquel Bernad, Ana Martínez-Val, Marta N. Shahbazi, Sandrina Nóbrega-Pereira, Isabel Calvo, Carmen Blanco-Aparicio, Carolina Tarantino, Elena Garreta, Laia Richart-Ginés, Noelia Alcazar, Osvaldo Graña-Castro, Gonzalo Gómez-Lopez, Irene Aksoy, Maribel Muñoz-Martín, Sonia Martinez, Sagrario Ortega, Susana Prieto, Elisabeth Simboeck, Alain Camasses, Camille Stephan-Otto Attolini
Published in: Nature Cell Biology, 22/10, 2020, Page(s) 1223-1238, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0573-1

Dissection of two routes to naïve pluripotency using different kinase inhibitors

Author(s): Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano, Javier Munoz
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22181-5

Manipulating the Mediator complex to induce naïve pluripotency

Author(s): Cian J. Lynch, Raquel Bernad, Isabel Calvo, Manuel Serrano
Published in: Experimental Cell Research, 395/2, 2020, Page(s) 112215, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2020.112215

A novel redox cycle diverts cells from oncogene-induced senescence into cancer

Author(s): Mate Maus and Manuel Serrano
Published in: Molecular Cell, 2021, ISSN 1097-4164
Publisher: Elsevier Inc.
DOI: 10.1016/j.molcel.2021.08.023