Reactions That Translate mRNA into Drug-like Molecules

Project Information

TRIGGDRUG

Grant agreement ID: 669628

DOI 10.3030/669628

Project closed

EC signature date 24 July 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 470 400,00

EU contribution € 2 470 400,00

Coordinated by

HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany

Publications

Peer reviewed articles (10)

Expanding the scope of native chemical ligation - templated small molecule drug synthesis via benzanilide formation

Author(s): Richard Houska, Marvin Björn Stutz, Oliver Seitz
Published in: Chemical Science, 2021, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc00513h

Toward conditional control of Smac mimetic activity by RNA‐templated reduction of azidopeptides on PNA or 2′‐ OMe‐RNA

Author(s): Yannic Altrichter, Justus Schöller, Oliver Seitz
Published in: Biopolymers, 2021, ISSN 0006-3525
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bip.23466

RNA-templated chemical synthesis of proapoptotic L- and d-peptides

Author(s): Li-Hao Chang, Oliver Seitz
Published in: Bioorganic & Medicinal Chemistry, Issue 09680896, 2022, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2022.116786

DNA-Templated Reactions with High Catalytic Efficiency Achieved by a Loss-of-Affinity Principle

Author(s): Dino Gluhacevic von Krüchten, Magdalena Roth, Oliver Seitz
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c03188

Templated chemistry for bioorganic synthesis and chemical biology

Author(s): Oliver Seitz
Published in: Journal of Peptide Science, Issue 25/7, 2019, ISSN 1075-2617
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/psc.3198

Nucleic acid constructs for the interrogation of multivalent protein interactions

Author(s): Sean B. Yeldell, Oliver Seitz
Published in: Chemical Society Reviews, 2020, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00518e

Comparing Agent‐Based Delivery of DNA and PNA Forced Intercalation (FIT) Probes for Multicolor mRNA Imaging

Author(s): Jasmine Chamiolo, Ge‐min Fang, Felix Hövelmann, Dhana Friedrich, Andrea Knoll, Alexander Loewer, Oliver Seitz
Published in: ChemBioChem, 2018, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800526

Nucleic Acid Templated Reactions for Chemical Biology

Author(s): Margherita Di Pisa, Oliver Seitz
Published in: ChemMedChem, Issue 12/12, 2017, Page(s) 872-882, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201700266

Simultaneous Targeting of Two Master Regulators of Apoptosis with Dual-Action PNA– and DNA–Peptide Conjugates

Author(s): Yannic Altrichter, Oliver Seitz
Published in: Bioconjugate Chemistry, Issue 31/8, 2020, Page(s) 1928-1937, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00284

A Self‐immolative Molecular Beacon for Amplified Nucleic Acid Detection**

Author(s): Magdalena Roth, Oliver Seitz
Published in: Chemistry – A European Journal, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202102600