N-Myc and Aurora A: From Protein Stability to Chromosome Topology N-Myc and Aurora A: From Protein Stability to Chromosome Topology Myc and Aurora A: From Protein Stability to Chromosome Topology

Project Information

AUROMYC

Grant agreement ID: 669771

DOI 10.3030/669771

Project closed

EC signature date 24 July 2015

Start date 1 August 2015

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 455 180,00

EU contribution € 2 455 180,00

Coordinated by

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany

Publications

Peer reviewed articles (14)

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

Author(s): Theresa Endres, Daniel Solvie, Jan B. Heidelberger, Valentina Andrioletti, Apoorva Baluapuri, Carsten P. Ade, Matthias Muhar, Ursula Eilers, Seychelle M. Vos, Patrick Cramer, Johannes Zuber, Petra Beli, Nikita Popov, Elmar Wolf, Peter Gallant, Martin Eilers
Published in: Molecular Cell, Issue 81/4, 2021, Page(s) 830-844.e13, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.035

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma

Author(s): Isabelle Roeschert, Evon Poon, Anton G. Henssen, Heathcliff Dorado Garcia, Marco Gatti, Celeste Giansanti, Yann Jamin, Carsten P. Ade, Peter Gallant, Christina Schülein-Völk, Petra Beli, Mark Richards, Mathias Rosenfeldt, Matthias Altmeyer, John Anderson, Angelika Eggert, Matthias Dobbelstein, Richard Bayliss, Louis Chesler, Gabriele Büchel, Martin Eilers
Published in: Nature Cancer, 2021, ISSN 2662-1347
Publisher: Springer Nature
DOI: 10.1038/s43018-020-00171-8

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Author(s): Daniel Dauch, Ramona Rudalska, Giacomo Cossa, Jean-Charles Nault, Tae-Won Kang, Torsten Wuestefeld, Anja Hohmeyer, Sandrine Imbeaud, Tetyana Yevsa, Lisa Hoenicke, Tatu Pantsar, Przemyslaw Bozko, Nisar P Malek, Thomas Longerich, Stefan Laufer, Antti Poso, Jessica Zucman-Rossi, Martin Eilers, Lars Zender
Published in: Nature Medicine, Issue 22/7, 2016, Page(s) 744-753, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4107

Targeting MYC Proteins for Tumor Therapy

Author(s): Elmar Wolf, Martin Eilers
Published in: Annual Review of Cancer Biology, Issue 4/1, 2020, Page(s) 61-75, ISSN 2472-3428
Publisher: Annual reviews
DOI: 10.1146/annurev-cancerbio-030518-055826

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription

Author(s): Giacomo Cossa, Isabelle Roeschert, Florian Prinz, Apoorva Baluapuri, Raphael Silveira Vidal, Christina Schülein-Völk, Yun-Chien Chang, Carsten Patrick Ade, Guido Mastrobuoni, Cyrille Girard, Amit Kumar, Lars Wortmann, Susanne Walz, Reinhard Lührmann, Stefan Kempa, Bernhard Kuster, Elmar Wolf, Dominik Mumberg, Martin Eilers
Published in: Molecular Cell, Issue 81/11, 2021, Page(s) 2495, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.05.013

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Author(s): Mark W. Richards, Selena G. Burgess, Evon Poon, Anne Carstensen, Martin Eilers, Louis Chesler, Richard Bayliss
Published in: Proceedings of the National Academy of Sciences, Issue 113/48, 2016, Page(s) 13726-13731, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1610626113

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

Author(s): Gabriele Büchel, Anne Carstensen, Ka-Yan Mak, Isabelle Roeschert, Eoin Leen, Olga Sumara, Julia Hofstetter, Steffi Herold, Jacqueline Kalb, Apoorva Baluapuri, Evon Poon, Colin Kwok, Louis Chesler, Hans Michael Maric, David S. Rickman, Elmar Wolf, Richard Bayliss, Susanne Walz, Martin Eilers
Published in: Cell Reports, Issue 21/12, 2017, Page(s) 3483-3497, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.11.090

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Author(s): Giacomo Cossa, Isabelle Roeschert, Florian Prinz, Apoorva Baluapuri, Raphael Silveira Vidal, Christina Schülein-Völk, Yun-Chien Chang, Carsten Patrick Ade, Guido Mastrobuoni, Cyrille Girard, Lars Wortmann, Susanne Walz, Reinhard Lührmann, Stefan Kempa, Bernhard Kuster, Elmar Wolf, Dominik Mumberg, Martin Eilers
Published in: Molecular Cell, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.01.008

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

Author(s): Apoorva Baluapuri, Julia Hofstetter, Nevenka Dudvarski Stankovic, Theresa Endres, Pranjali Bhandare, Seychelle Monique Vos, Bikash Adhikari, Jessica Denise Schwarz, Ashwin Narain, Markus Vogt, Shuang-Yan Wang, Robert Düster, Lisa Anna Jung, Jens Thorsten Vanselow, Armin Wiegering, Matthias Geyer, Hans Michael Maric, Peter Gallant, Susanne Walz, Andreas Schlosser, Patrick Cramer, Martin Eilers, El
Published in: Molecular Cell, Issue 74/4, 2019, Page(s) 674-687.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.02.031

A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Author(s): Stefanie Schmidt, David Gay, Friedrich Wilhelm Uthe, Sarah Denk, Madelon Paauwe, Niels Matthes, Markus Elmar Diefenbacher, Sheila Bryson, Fiona Clare Warrander, Florian Erhard, Carsten Patrick Ade, Apoorva Baluapuri, Susanne Walz, Rene Jackstadt, Catriona Ford, Georgios Vlachogiannis, Nicola Valeri, Christoph Otto, Christina Schülein-Völk, Katja Maurus, Werner Schmitz, John Raymond Philip Knight
Published in: Nature Cell Biology, Issue 21/11, 2019, Page(s) 1413-1424, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0408-0

Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

Author(s): Steffi Herold, Jacqueline Kalb, Gabriele Büchel, Carsten P. Ade, Apoorva Baluapuri, Jiajia Xu, Jan Koster, Daniel Solvie, Anne Carstensen, Christina Klotz, Sabrina Rodewald, Christina Schülein-Völk, Matthias Dobbelstein, Elmar Wolf, Jan Molenaar, Rogier Versteeg, Susanne Walz, Martin Eilers
Published in: Nature, Issue 567/7749, 2019, Page(s) 545-549, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1030-9

Target gene-independent functions of MYC oncoproteins

Author(s): Apoorva Baluapuri, Elmar Wolf, Martin Eilers
Published in: Nature Reviews Molecular Cell Biology, 2020, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-0215-2

MYC- and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

Author(s): Bastian Krenz, Anneli Gebhardt-Wolf, Carsten P Ade, Abdallah Gaballa, Florian Roehrig, Emilia Vendelova, Apoorva Baluapuri, Ursula Eilers, Peter Gallant, Luana D' Artista, Armin Wiegering, Georg Gasteiger, Mathias T. Rosenfeldt, Stefan Bauer, Lars Zender, Elmar Wolf, Martin Eilers
Published in: Cancer Research, 2021, Page(s) canres.CAN-21-1677-E.2021, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-1677

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

Author(s): Ashwin Narain, Pranjali Bhandare, Bikash Adhikari, Simone Backes, Martin Eilers, Lars Dölken, Andreas Schlosser, Florian Erhard, Apoorva Baluapuri, Elmar Wolf
Published in: Molecular Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.06.016