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R-loops as a major modulator of transcription-associated recombination and chromatin dynamics

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Publications

Detection of DNA-RNA Hybrids In Vivo

Author(s): María García-Rubio, Sonia I. Barroso, Andrés Aguilera
Published in: Methods in Molecular Biology, 2018, Page(s) 347-361
DOI: 10.1007/978-1-4939-7306-4_24

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

Author(s): Francisco García-Benítez, Hélène Gaillard, Andrés Aguilera
Published in: Proceedings of the National Academy of Sciences, Issue 114/41, 2017, Page(s) 10942-10947, ISSN 0027-8424
DOI: 10.1073/pnas.1707845114

Human THO–Sin3A interaction reveals new mechanisms to prevent R‐loops that cause genome instability

Author(s): Irene Salas‐Armenteros, Carmen Pérez‐Calero, Aleix Bayona‐Feliu, Emanuela Tumini, Rosa Luna, Andrés Aguilera
Published in: The EMBO Journal, Issue 36/23, 2017, Page(s) 3532-3547, ISSN 0261-4189
DOI: 10.15252/embj.201797208

The Role of Replication-Associated Repair Factors on R-Loops

Author(s): Vaibhav Bhatia, Emilia Herrera-Moyano, Andres Aguilera, Belen Gomez-Gonzalez
Published in: Genes, Issue 8/7, 2017, Page(s) 171, ISSN 2073-4425
DOI: 10.3390/genes8070171

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Author(s): Alba Duch, Berta Canal, Sonia I. Barroso, María García-Rubio, Gerhard Seisenbacher, Andrés Aguilera, Eulàlia de Nadal, Francesc Posas
Published in: Nature Communications, Issue 9/1, 2018, Page(s) 379, ISSN 2041-1723
DOI: 10.1038/s41467-017-02756-x

Gene gating at nuclear pores prevents the formation of R loops


Published in: ISSN 2372-3556
DOI: 10.1080/23723556.2017.1405140

Epigenetic features of human telomeres

Author(s): María D Cubiles, Sonia Barroso, María I Vaquero-Sedas, Alicia Enguix, Andrés Aguilera, Miguel A Vega-Palas
Published in: Nucleic Acids Research, Issue 46/5, 2018, Page(s) 2347-2355, ISSN 0305-1048
DOI: 10.1093/nar/gky006

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

Author(s): Juan Lafuente-Barquero, Sarah Luke-Glaser, Marco Graf, Sonia Silva, Belén Gómez-González, Arianna Lockhart, Michael Lisby, Andrés Aguilera, Brian Luke
Published in: PLOS Genetics, Issue 13/12, 2017, Page(s) e1007136, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1007136

The need to regulate replication fork speed

Author(s): Belén Gómez-González, Andrés Aguilera
Published in: Science, Issue 358/6364, 2017, Page(s) 722-723, ISSN 0036-8075
DOI: 10.1126/science.aaq0678

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability

Author(s): Sonia Silva, Lola P. Camino, Andrés Aguilera
Published in: Proceedings of the National Academy of Sciences, Issue 115/43, 2018, Page(s) 11024-11029, ISSN 0027-8424
DOI: 10.1073/pnas.1807258115

The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability

Author(s): Emanuela Tumini, Emilia Herrera-Moyano, Marta San Martín-Alonso, Sonia Barroso, Carlos M. Galmarini, Andrés Aguilera
Published in: Molecular Cancer Research, Issue 17/3, 2019, Page(s) 773-782, ISSN 1541-7786
DOI: 10.1158/1541-7786.mcr-18-0575

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Author(s): Tatiana Garcia-Muse, U. Galindo-Diaz, M. Garcia-Rubio, J.S. Martin, J. Polanowska, N. O’Reilly, A. Aguilera, Simon J. Boulton
Published in: Cell Reports, Issue 26/3, 2019, Page(s) 775-787.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.12.074

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Author(s): Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxi
Published in: Microbial Cell, Issue 6/1, 2019, Page(s) 1-64, ISSN 2311-2638
DOI: 10.15698/mic2019.01.664

The Nup84 complex coordinates the DNA damage response to warrant genome integrity

Author(s): Hélène Gaillard, José M Santos-Pereira, Andrés Aguilera
Published in: Nucleic Acids Research, Issue 47/8, 2019, Page(s) 4054-4067, ISSN 0305-1048
DOI: 10.1093/nar/gkz066

The DNA damage response acts as a safeguard against harmful DNA–RNA hybrids of different origins

Author(s): Sonia Barroso, Emilia Herrera‐Moyano, Sergio Muñoz, María García‐Rubio, Belén Gómez‐González, Andrés Aguilera
Published in: EMBO reports, Issue 20/9, 2019, Page(s) e47250, ISSN 1469-221X
DOI: 10.15252/embr.201847250

What causes an RNA-DNA hybrid to compromise genome integrity?

Author(s): Ana G. Rondón, Andrés Aguilera
Published in: DNA Repair, Issue 81, 2019, Page(s) 102660, ISSN 1568-7864
DOI: 10.1016/j.dnarep.2019.102660

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

Author(s): Irene Salas-Armenteros, Sonia I. Barroso, Ana G. Rondón, Mónica Pérez, Eloisa Andújar, Rosa Luna, Andrés Aguilera
Published in: Cell Reports, Issue 28/6, 2019, Page(s) 1551-1563.e7, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.07.010

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Author(s): Diana Zatreanu, Zhong Han, Richard Mitter, Emanuela Tumini, Hannah Williams, Lea Gregersen, A. Barbara Dirac-Svejstrup, Stefania Roma, Aengus Stewart, Andres Aguilera, Jesper Q. Svejstrup
Published in: Molecular Cell, Issue 76/1, 2019, Page(s) 57-69.e9, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.07.037

R Loops: From Physiological to Pathological Roles

Author(s): Tatiana García-Muse, Andrés Aguilera
Published in: Cell, Issue 179/3, 2019, Page(s) 604-618, ISSN 0092-8674
DOI: 10.1016/j.cell.2019.08.055

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

Author(s): Pedro Ortega, Belén Gómez-González, Andrés Aguilera
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-13210-5

Histone deacetylases facilitate the accurate repair of broken forks


Published in: ISSN 2372-3556
DOI: 10.1080/23723556.2019.1705731

Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle

Author(s): Belén Gómez-González, Sonia Barroso, Emilia Herrera-Moyano, Andrés Aguilera
Published in: Cell Cycle, Issue 19/5, 2020, Page(s) 525-531, ISSN 1538-4101
DOI: 10.1080/15384101.2020.1728015

The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops

Author(s): Rosa Luna, Ana G. Rondón, Carmen Pérez-Calero, Irene Salas-Armenteros, Andrés Aguilera
Published in: Cold Spring Harbor Symposia on Quantitative Biology, 2020, Page(s) 039594, ISSN 0091-7451
DOI: 10.1101/sqb.2019.84.039594

Histone Mutants Separate R Loop Formation from Genome Instability Induction

Author(s): Desiré García-Pichardo, Juan C. Cañas, María L. García-Rubio, Belén Gómez-González, Ana G. Rondón, Andrés Aguilera
Published in: Molecular Cell, Issue 66/5, 2017, Page(s) 597-609.e5, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.05.014

Roles of human POLD1 and POLD3 in genome stability

Author(s): Emanuela Tumini, Sonia Barroso, Carmen Pérez -Calero, Andrés Aguilera
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep38873

FANCD2 Facilitates Replication through Common Fragile Sites

Author(s): Advaitha Madireddy, Settapong T. Kosiyatrakul, Rebecca A. Boisvert, Emilia Herrera-Moyano, María L. García-Rubio, Jeannine Gerhardt, Elizabeth A. Vuono, Nichole Owen, Zi Yan, Susan Olson, Andrés Aguilera, Niall G. Howlett, Carl L. Schildkraut
Published in: Molecular Cell, Issue 64/2, 2016, Page(s) 388-404, ISSN 1097-2765
DOI: 10.1016/j.molcel.2016.09.017

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

Author(s): Sandra Muñoz-Galván, María García-Rubio, Pedro Ortega, Jose F. Ruiz, Sonia Jimeno, Benjamin Pardo, Belén Gómez-González, Andrés Aguilera
Published in: PLOS Genetics, Issue 13/5, 2017, Page(s) e1006781, ISSN 1553-7390
DOI: 10.1371/journal.pgen.1006781

Transcription as a Threat to Genome Integrity

Author(s): Hélène Gaillard, Andrés Aguilera
Published in: Annual Review of Biochemistry, Issue 85/1, 2016, Page(s) 291-317, ISSN 0066-4154
DOI: 10.1146/annurev-biochem-060815-014908

Transcription–replication conflicts: how they occur and how they are resolved

Author(s): Tatiana García-Muse, Andrés Aguilera
Published in: Nature Reviews Molecular Cell Biology, Issue 17/9, 2016, Page(s) 553-563, ISSN 1471-0072
DOI: 10.1038/nrm.2016.88

DNA–RNA hybrids: the risks of DNA breakage during transcription


Published in: ISSN 1545-9993
DOI: 10.1038/nsmb.3395