DE NOVO GENERATION OF SOMATIC STEM CELLS: REGULATION AND MECHANISMS OF CELL PLASTICITY

Project Information

DENOVOSTEM

Grant agreement ID: 670126

DOI 10.3030/670126

Project closed

EC signature date 24 July 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 498 934,00

EU contribution € 2 498 934,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

Author(s): Giulia Della Chiara, Federica Gervasoni, Michaela Fakiola, Chiara Godano, Claudia D’Oria, Luca Azzolin, Raoul Jean Pierre Bonnal, Giulia Moreni, Lorenzo Drufuca, Grazisa Rossetti, Valeria Ranzani, Ramona Bason, Marco De Simone, Francesco Panariello, Ivan Ferrari, Tanya Fabbris, Francesca Zanconato, Mattia Forcato, Oriana Romano, Jimmy Caroli, Paola Gruarin, Maria Lucia Sarnicola, Michelangelo Co
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22544-y

Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma

Author(s): Martina Castellan, Alberto Guarnieri, Atsushi Fujimura, Francesca Zanconato, Giusy Battilana, Tito Panciera, Hanna Lucie Sladitschek, Paolo Contessotto, Anna Citron, Andrea Grilli, Oriana Romano, Silvio Bicciato, Matteo Fassan, Elena Porcù, Antonio Rosato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Cancer, Issue 2/2, 2021, Page(s) 174-188, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-020-00150-z

Broadly Applicable Hydrogel Fabrication Procedures Guided by YAP/TAZ-Activity Reveal Stiffness, Adhesiveness, and Nuclear Projected Area as Checkpoints for Mechanosensing

Author(s): Alessandro Gandin, Veronica Torresan, Lorenzo Ulliana, Tito Panciera, Paolo Contessotto, Anna Citron, Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo, Giovanna Brusatin
Published in: Adv. Healthcare Mater., Issue 3/2022, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202102276

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

Author(s): Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Am
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18580-9

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Author(s): Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
Published in: Cell Stem Cell, Issue 22/1, 2018, Page(s) 35-49.e7, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2017.11.001

Comparison of computational methods for Hi-C data analysis

Author(s): Mattia Forcato, Chiara Nicoletti, Koustav Pal, Carmen Maria Livi, Francesco Ferrari, Silvio Bicciato
Published in: Nature Methods, Issue 14/7, 2017, Page(s) 679-685, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4325

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Author(s): Antonio Totaro, Martina Castellan, Giusy Battilana, Francesca Zanconato, Luca Azzolin, Stefano Giulitti, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Communications, Issue 8, 2017, Page(s) 15206, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15206

A TIAM Double Hit to Oppose YAP/TAZ

Author(s): Luca Azzolin, Stefano Piccolo
Published in: Cancer Cell, Issue 31/5, 2017, Page(s) 607-608, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2017.04.009

Eradicating tumor drug resistance at its YAP-biomechanical roots

Author(s): F. Zanconato, S. Piccolo
Published in: The EMBO Journal, Issue 35/5, 2016, Page(s) 459-461, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201593584

Mechanobiology of YAP and TAZ in physiology and disease

Author(s): Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Reviews Molecular Cell Biology, Issue 18/12, 2017, Page(s) 758-770, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/nrm.2017.87

YAP/TAZ at the Roots of Cancer

Author(s): Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Cancer Cell, Issue 29/6, 2016, Page(s) 783-803, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2016.05.005

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Author(s): Craig S. Nowell, Pascal D. Odermatt, Luca Azzolin, Sylke Hohnel, Erwin F. Wagner, Georg E. Fantner, Matthias P. Lutolf, Yann Barrandon, Stefano Piccolo, Freddy Radtke
Published in: Nature Cell Biology, Issue 18/2, 2016, Page(s) 168-180, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3290

Regeneration of the entire human epidermis using transgenic stem cells

Author(s): Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Johann W. Bauer, Graziella Pellegrini, Laura De Rosa, Davide Scaglione, Julia Reichelt, Alfred Klausegger, Daniela Kneisz, Oriana Romano, Alessia Secone Seconetti, Roberta Contin, Elena Enzo, Irena Jurman, Sonia Carulli, Frank Jacobsen, Thomas Luecke, Marcus Lehnhardt, Meike Fischer, Maximilian Kueckelhaus, Daniela Quaglino, Michele Morgante, Silvio Bi
Published in: Nature, Issue 551/7680, 2017, Page(s) 327-332, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24487

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

Author(s): Eleonora Ingallina, Giovanni Sorrentino, Rebecca Bertolio, Kamil Lisek, Alessandro Zannini, Luca Azzolin, Luisa Ulloa Severino, Denis Scaini, Miguel Mano, Fiamma Mantovani, Antonio Rosato, Silvio Bicciato, Stefano Piccolo, Giannino Del Sal
Published in: Nature Cell Biology, Issue 20/1, 2018, Page(s) 28-35, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-017-0009-8

GDA, a web-based tool for Genomics and Drugs integrated analysis

Author(s): Jimmy Caroli, Giovanni Sorrentino, Mattia Forcato, Giannino Del Sal, Silvio Bicciato
Published in: Nucleic Acids Research, Issue 46/W1, 2018, Page(s) W148-W156, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky434

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Author(s): Francesca Zanconato, Mattia Forcato, Giusy Battilana, Luca Azzolin, Erika Quaranta, Beatrice Bodega, Antonio Rosato, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Cell Biology, Issue 17/9, 2015, Page(s) 1218-1227, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3216

<em>De Novo</em> Generation of Somatic Stem Cells by YAP/TAZ

Author(s): Tito Panciera, Luca Azzolin, Daniele Di Biagio, Antonio Totaro, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Journal of Visualized Experiments, Issue 135, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/57462

YAP/TAZ upstream signals and downstream responses

Author(s): Antonio Totaro, Tito Panciera, Stefano Piccolo
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 888-899, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0142-z

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Author(s): Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Medicine, Issue 24/10, 2018, Page(s) 1599-1610, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0158-8

Glucocorticoid receptor signalling activates YAP in breast cancer

Author(s): Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato, Giannino Del Sal
Published in: Nature Communications, Issue 8, 2017, Page(s) 14073, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14073

Crosstalk between YAP/TAZ and Notch Signaling

Author(s): Antonio Totaro, Martina Castellan, Daniele Di Biagio, Stefano Piccolo
Published in: Trends in Cell Biology, Issue 28/7, 2018, Page(s) 560-573, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2018.03.001

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

Author(s): Tito Panciera, Luca Azzolin, Atsushi Fujimura, Daniele Di Biagio, Chiara Frasson, Silvia Bresolin, Sandra Soligo, Giuseppe Basso, Silvio Bicciato, Antonio Rosato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Cell Stem Cell, Issue 19/6, 2016, Page(s) 725-737, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2016.08.009

YAP/TAZ as therapeutic targets in cancer

Author(s): Francesca Zanconato, Giusy Battilana, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Current Opinion in Pharmacology, Issue 29, 2016, Page(s) 26-33, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2016.05.002

YAP and TAZ: a signalling hub of the tumour microenvironment

Author(s): Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Reviews Cancer, Issue 19/8, 2019, Page(s) 454-464, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-019-0168-y

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

Author(s): Tito Panciera, Anna Citron, Daniele Di Biagio, Giusy Battilana, Alessandro Gandin, Stefano Giulitti, Mattia Forcato, Silvio Bicciato, Valeria Panzetta, Sabato Fusco, Luca Azzolin, Antonio Totaro, Angelo Paolo Dei Tos, Matteo Fassan, Vincenzo Vindigni, Franco Bassetto, Antonio Rosato, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Materials, 2020, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-0615-x

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

Author(s): Antonio Totaro, Qiuyu Zhuang, Tito Panciera, Giusy Battilana, Luca Azzolin, Giulia Brumana, Alessandro Gandin, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Proceedings of the National Academy of Sciences, Issue 116/36, 2019, Page(s) 17848-17857, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1908228116

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

Author(s): Lei Chang, Luca Azzolin, Daniele Di Biagio, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Mariaceleste Aragona, Stefano Giulitti, Tito Panciera, Alessandro Gandin, Gianluca Sigismondo, Jeroen Krijgsveld, Matteo Fassan, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature, Issue 563/7730, 2018, Page(s) 265-269, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0658-1

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Author(s): Giovanna Brusatin, Tito Panciera, Alessandro Gandin, Anna Citron, Stefano Piccolo
Published in: Nature Materials, Issue 17/12, 2018, Page(s) 1063-1075, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-018-0180-8

GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

Author(s): Lauren V. Albrecht, Nydia Tejeda-Muñoz, Maggie H. Bui, Andrew C. Cicchetto, Daniele Di Biagio, Gabriele Colozza, Ernst Schmid, Stefano Piccolo, Heather R. Christofk, Edward M. De Robertis
Published in: Cell Reports, Issue 32/4, 2020, Page(s) 107973, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107973

Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages

Author(s): Ilaria Marigo, Rosalinda Trovato, Francesca Hofer, Vincenzo Ingangi, Giacomo Desantis, Kevin Leone, Francesco De Sanctis, Stefano Ugel, Stefania Canè, Anna Simonelli, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Massimo Rugge, Federico Boschi, Giulia Borile, Thomas Eisenhaure, Siranush Sarkizova, David Lieb, Nir Hacohen, Luca Azzolin, Stefano Piccolo, Rita Lawlor, Aldo Scarpa, Luisa Carbogni
Published in: Cancer Discovery, Issue 10/11, 2020, Page(s) 1758-1773, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0036

Non-peer reviewed articles (1)

Linking cancer transcriptional addictions by CDK7 to YAP/TAZ

Author(s): Stefano Piccolo
Published in: Genes & Development, Issue 34/1-2, 2020, Page(s) 4-6, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.335562.119