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DE NOVO GENERATION OF SOMATIC STEM CELLS: REGULATION AND MECHANISMS OF CELL PLASTICITY

Publications

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Author(s): Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
Published in: Cell Stem Cell, Issue 22/1, 2018, Page(s) 35-49.e7, ISSN 1934-5909
DOI: 10.1016/j.stem.2017.11.001

Comparison of computational methods for Hi-C data analysis

Author(s): Mattia Forcato, Chiara Nicoletti, Koustav Pal, Carmen Maria Livi, Francesco Ferrari, Silvio Bicciato
Published in: Nature Methods, Issue 14/7, 2017, Page(s) 679-685, ISSN 1548-7091
DOI: 10.1038/nmeth.4325

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Author(s): Antonio Totaro, Martina Castellan, Giusy Battilana, Francesca Zanconato, Luca Azzolin, Stefano Giulitti, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Communications, Issue 8, 2017, Page(s) 15206, ISSN 2041-1723
DOI: 10.1038/ncomms15206

A TIAM Double Hit to Oppose YAP/TAZ

Author(s): Luca Azzolin, Stefano Piccolo
Published in: Cancer Cell, Issue 31/5, 2017, Page(s) 607-608, ISSN 1535-6108
DOI: 10.1016/j.ccell.2017.04.009

Eradicating tumor drug resistance at its YAP-biomechanical roots

Author(s): F. Zanconato, S. Piccolo
Published in: The EMBO Journal, Issue 35/5, 2016, Page(s) 459-461, ISSN 0261-4189
DOI: 10.15252/embj.201593584

Mechanobiology of YAP and TAZ in physiology and disease

Author(s): Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Reviews Molecular Cell Biology, Issue 18/12, 2017, Page(s) 758-770, ISSN 1471-0072
DOI: 10.1038/nrm.2017.87

YAP/TAZ at the Roots of Cancer

Author(s): Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Cancer Cell, Issue 29/6, 2016, Page(s) 783-803, ISSN 1535-6108
DOI: 10.1016/j.ccell.2016.05.005

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Author(s): Craig S. Nowell, Pascal D. Odermatt, Luca Azzolin, Sylke Hohnel, Erwin F. Wagner, Georg E. Fantner, Matthias P. Lutolf, Yann Barrandon, Stefano Piccolo, Freddy Radtke
Published in: Nature Cell Biology, Issue 18/2, 2016, Page(s) 168-180, ISSN 1465-7392
DOI: 10.1038/ncb3290

Regeneration of the entire human epidermis using transgenic stem cells

Author(s): Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Johann W. Bauer, Graziella Pellegrini, Laura De Rosa, Davide Scaglione, Julia Reichelt, Alfred Klausegger, Daniela Kneisz, Oriana Romano, Alessia Secone Seconetti, Roberta Contin, Elena Enzo, Irena Jurman, Sonia Carulli, Frank Jacobsen, Thomas Luecke, Marcus Lehnhardt, Meike Fischer, Maximilian Kueckelhaus, Daniela Quaglino, Michele Morgante, Silvio Bi
Published in: Nature, Issue 551/7680, 2017, Page(s) 327-332, ISSN 0028-0836
DOI: 10.1038/nature24487

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

Author(s): Eleonora Ingallina, Giovanni Sorrentino, Rebecca Bertolio, Kamil Lisek, Alessandro Zannini, Luca Azzolin, Luisa Ulloa Severino, Denis Scaini, Miguel Mano, Fiamma Mantovani, Antonio Rosato, Silvio Bicciato, Stefano Piccolo, Giannino Del Sal
Published in: Nature Cell Biology, Issue 20/1, 2018, Page(s) 28-35, ISSN 1465-7392
DOI: 10.1038/s41556-017-0009-8

GDA, a web-based tool for Genomics and Drugs integrated analysis

Author(s): Jimmy Caroli, Giovanni Sorrentino, Mattia Forcato, Giannino Del Sal, Silvio Bicciato
Published in: Nucleic Acids Research, Issue 46/W1, 2018, Page(s) W148-W156, ISSN 0305-1048
DOI: 10.1093/nar/gky434

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Author(s): Francesca Zanconato, Mattia Forcato, Giusy Battilana, Luca Azzolin, Erika Quaranta, Beatrice Bodega, Antonio Rosato, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Cell Biology, Issue 17/9, 2015, Page(s) 1218-1227, ISSN 1465-7392
DOI: 10.1038/ncb3216

<em>De Novo</em> Generation of Somatic Stem Cells by YAP/TAZ

Author(s): Tito Panciera, Luca Azzolin, Daniele Di Biagio, Antonio Totaro, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Journal of Visualized Experiments, Issue 135, 2018, ISSN 1940-087X
DOI: 10.3791/57462

YAP/TAZ upstream signals and downstream responses

Author(s): Antonio Totaro, Tito Panciera, Stefano Piccolo
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 888-899, ISSN 1465-7392
DOI: 10.1038/s41556-018-0142-z

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Author(s): Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Medicine, Issue 24/10, 2018, Page(s) 1599-1610, ISSN 1078-8956
DOI: 10.1038/s41591-018-0158-8

Glucocorticoid receptor signalling activates YAP in breast cancer

Author(s): Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato, Giannino Del Sal
Published in: Nature Communications, Issue 8, 2017, Page(s) 14073, ISSN 2041-1723
DOI: 10.1038/ncomms14073

Crosstalk between YAP/TAZ and Notch Signaling

Author(s): Antonio Totaro, Martina Castellan, Daniele Di Biagio, Stefano Piccolo
Published in: Trends in Cell Biology, Issue 28/7, 2018, Page(s) 560-573, ISSN 0962-8924
DOI: 10.1016/j.tcb.2018.03.001

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

Author(s): Tito Panciera, Luca Azzolin, Atsushi Fujimura, Daniele Di Biagio, Chiara Frasson, Silvia Bresolin, Sandra Soligo, Giuseppe Basso, Silvio Bicciato, Antonio Rosato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Cell Stem Cell, Issue 19/6, 2016, Page(s) 725-737, ISSN 1934-5909
DOI: 10.1016/j.stem.2016.08.009

YAP/TAZ as therapeutic targets in cancer

Author(s): Francesca Zanconato, Giusy Battilana, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Current Opinion in Pharmacology, Issue 29, 2016, Page(s) 26-33, ISSN 1471-4892
DOI: 10.1016/j.coph.2016.05.002

YAP and TAZ: a signalling hub of the tumour microenvironment

Author(s): Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Reviews Cancer, Issue 19/8, 2019, Page(s) 454-464, ISSN 1474-175X
DOI: 10.1038/s41568-019-0168-y

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

Author(s): Tito Panciera, Anna Citron, Daniele Di Biagio, Giusy Battilana, Alessandro Gandin, Stefano Giulitti, Mattia Forcato, Silvio Bicciato, Valeria Panzetta, Sabato Fusco, Luca Azzolin, Antonio Totaro, Angelo Paolo Dei Tos, Matteo Fassan, Vincenzo Vindigni, Franco Bassetto, Antonio Rosato, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature Materials, 2020, ISSN 1476-1122
DOI: 10.1038/s41563-020-0615-x

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

Author(s): Antonio Totaro, Qiuyu Zhuang, Tito Panciera, Giusy Battilana, Luca Azzolin, Giulia Brumana, Alessandro Gandin, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Proceedings of the National Academy of Sciences, Issue 116/36, 2019, Page(s) 17848-17857, ISSN 0027-8424
DOI: 10.1073/pnas.1908228116

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

Author(s): Lei Chang, Luca Azzolin, Daniele Di Biagio, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Mariaceleste Aragona, Stefano Giulitti, Tito Panciera, Alessandro Gandin, Gianluca Sigismondo, Jeroen Krijgsveld, Matteo Fassan, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Published in: Nature, Issue 563/7730, 2018, Page(s) 265-269, ISSN 0028-0836
DOI: 10.1038/s41586-018-0658-1

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Author(s): Giovanna Brusatin, Tito Panciera, Alessandro Gandin, Anna Citron, Stefano Piccolo
Published in: Nature Materials, Issue 17/12, 2018, Page(s) 1063-1075, ISSN 1476-1122
DOI: 10.1038/s41563-018-0180-8