Dissecting microbiome and immune interactions in human intestinal (cancer) organoids

Project Information

Organoid

Grant agreement ID: 670133

DOI

10.3030/670133

Project closed

EC signature date 30 October 2015

Start date 1 November 2015

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 3 062 438,00

EU contribution

€ 3 062 438,00

Coordinated by

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Author(s): Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber, Arne van Hoeck, Henry M. Wood, Jason Nomburg, Carino Gurjao, Freek Manders, Guillaume Dalmasso, Paul B. Stege, Fernanda L. Paganelli, Maarten H. Geurts, Joep Beumer, Tomohiro Mizutani, Yi Miao, Reinier van der Linden, Stefan van der Elst, K. Christopher Garcia, Janetta Top, Rob J. L. Willems, Marios Giannakis, Richard Bonnet, Phil
Published in: Nature, Issue 580/7802, 2020, Page(s) 269-273, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2080-8

Organoids and organs-on-chips: Insights into human gut-microbe interactions

Author(s): Jens Puschhof, Cayetano Pleguezuelos-Manzano, Hans Clevers
Published in: Cell Host & Microbe, Issue 29/6, 2021, Page(s) 867-878, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.04.002

SARS-CoV-2 productively infects human gut enterocytes

Author(s): Mart M. Lamers, Joep Beumer, Jelte van der Vaart, Kèvin Knoops, Jens Puschhof, Tim I. Breugem, Raimond B. G. Ravelli, J. Paul van Schayck, Anna Z. Mykytyn, Hans Q. Duimel, Elly van Donselaar, Samra Riesebosch, Helma J. H. Kuijpers, Debby Schipper, Willine J. van de Wetering, Miranda de Graaf, Marion Koopmans, Edwin Cuppen, Peter J. Peters, Bart L. Haagmans, Hans Clevers
Published in: Science, Issue 369/6499, 2020, Page(s) 50-54, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abc1669

Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids

Author(s): Kim Elisabeth Boonekamp, Inha Heo, Benedetta Artegiani, Priyanca Asra, Gijs van Son, Joep de Ligt, Hans Clevers
Published in: Developmental Biology, Issue 474, 2021, Page(s) 37-47, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2021.01.009

COVID-19: organoids go viral

Author(s): Hans Clevers
Published in: Nature Reviews Molecular Cell Biology, Issue 21/7, 2020, Page(s) 355-356, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-0258-4

Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions

Author(s): Kim E Boonekamp, Talya L Dayton, Hans Clevers
Published in: Journal of Molecular Cell Biology, Issue 12/8, 2020, Page(s) 562-568, ISSN 1759-4685
Publisher: Oxford Academic
DOI: 10.1093/jmcb/mjaa034

Modelling Cryptosporidium infection in human small intestinal and lung organoids

Author(s): Inha Heo, Devanjali Dutta, Deborah A. Schaefer, Nino Iakobachvili, Benedetta Artegiani, Norman Sachs, Kim E. Boonekamp, Gregory Bowden, Antoni P. A. Hendrickx, Robert J. L. Willems, Peter J. Peters, Michael W. Riggs, Roberta O’Connor, Hans Clevers
Published in: Nature Microbiology, Issue 3/7, 2018, Page(s) 814-823, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-018-0177-8

Cancer modeling meets human organoid technology

Author(s): David Tuveson, Hans Clevers
Published in: Science, Issue 364/6444, 2019, Page(s) 952-955, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw6985

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Author(s): Laura C. Demmers, Kai Kretzschmar, Arne Van Hoeck, Yotam E. Bar-Epraïm, Henk W. P. van den Toorn, Mandy Koomen, Gijs van Son, Joost van Gorp, Apollo Pronk, Niels Smakman, Edwin Cuppen, Hans Clevers, Albert J. R. Heck, Wei Wu
Published in: Nature Communications, Issue 11/1, 2020, Page(s) 1-11, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19142-9

Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells

Author(s): Cayetano Pleguezuelos‐Manzano, Jens Puschhof, Stieneke den Brink, Veerle Geurts, Joep Beumer, Hans Clevers
Published in: Current Protocols in Immunology, Issue 130/1, 2020, Page(s) 1-30, ISSN 1934-3671
Publisher: Greene Pub. Associates
DOI: 10.1002/cpim.106

Other (1)

Modelling cancer immunomodulation using epithelial organoid cultures

Author(s): Yotam E. Bar-Ephraim, Kai Kretzschmar, Priyanca Asra, Evelien de Jongh, Kim E. Boonekamp, Jarno Drost, Joost van Gorp, Apollo Pronk, Niels Smakman, Inez J. Gan, Zsolt Sebestyén, Jürgen Kuball, Robert G.J. Vries, Hans Clevers
Published in: bioRxiv, Issue oct 2018, 2018, Page(s) 1-13
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/377655