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Mechanisms of alternative pre-mRNA splicing regulation in cancer and pluripotent cells

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Publications

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

Author(s): Panagiotis Papasaikas, Juan Valcárcel
Published in: Trends in Biochemical Sciences, Issue 41/1, 2016, Page(s) 33-45, ISSN 0968-0004
DOI: 10.1016/j.tibs.2015.11.003

The complete local genotype-phenotype landscape for the alternative splicing of a human exon

Author(s): Julien, P., Miñana, B., Valcárcel, J.* and Lehner, B* * Co-corresponding authors
Published in: Nature Communications, Issue 7, 2016, Page(s) 11558, ISSN 2041-1723

Structural basis for the recognition of proline-rich motifs in spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in alternative splicing regulation

Author(s): Mourao, A., Bonnal, S., Warner, L., Soni, K., Bordonné, R., Valcárcel, J. * and Sattler, M. * * Co-corresponding authors
Published in: elife, Issue 5, 2016, ISSN 2050-084X

Tumor suppressor properties of the splicing regulatory factor RBM10

Author(s): Jordi Hernández, Elias Bechara, Doerte Schlesinger, Javier Delgado, Luis Serrano, Juan Valcárcel
Published in: RNA Biology, Issue 13/4, 2015, Page(s) 466-472, ISSN 1547-6286
DOI: 10.1080/15476286.2016.1144004

A synthetic anti-tumor splicing inhibitor variant with improved activity and versatile chemistry

Author(s): Makowski, K., Vigevani, L., Albericio, F., Valcárcel, J.* and Álvarez, M*: Sudemycin K * Co-corresponding authors
Published in: ACS Chemical Biology, Issue 12/1, 2016, Page(s) 163-173, ISSN 1554-8929

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Author(s): Metehan Cifdaloz, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, Tonantzin G. Calvo, Panagiotis Karras, David Olmeda, Belén Miñana, Gonzalo Gómez-López, Estela Cañon, Eduardo Eyras, Haihong Guo, Ferdinand Kappes, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, Diego Megías, Juan Valcárcel, María S. Soengas
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02353-y

Impaired spermatogenesis, muscle and erythrocyte function in U12 intron-splicing defective Zrsr1 mutant mice

Author(s): Horiuchi, K., Perez-Cerezales, S., Papasaikas, P., López-Cardona, A.P., Ramos-Ibeas, P., Laguna-Barraza, R., Fonseca Balvis, N., Perocuesta, E., Fernández-González, R., Planells, B., Ross, P.J., Alén, F., Orio, L., Rodriguez de Fonseca, F., Pintado, B., Valcárcel, J*. and Gutiérrez-Adán, A* * Co-corresponding authors
Published in: Cell Reports, Issue 23/1, 2018, Page(s) 143-155, ISSN 2211-1247

Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Author(s): Luisa Vigevani, André Gohr, Thomas Webb, Manuel Irimia, Juan Valcárcel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02007-z

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

Author(s): Endre Sebestyén, Babita Singh, Belén Miñana, Amadís Pagès, Francesca Mateo, Miguel Angel Pujana, Juan Valcárcel, Eduardo Eyras
Published in: Genome Research, Issue 26/6, 2016, Page(s) 732-744, ISSN 1088-9051
DOI: 10.1101/gr.199935.115

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry

Author(s): Kamil Makowski, Luisa Vigevani, Fernando Albericio, Juan Valcárcel, Mercedes Álvarez
Published in: ACS Chemical Biology, Issue 12/1, 2016, Page(s) 163-173, ISSN 1554-8929
DOI: 10.1021/acschembio.6b00562

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

Author(s): Sandra Keiper, Panagiotis Papasaikas, Cindy L. Will, Juan Valcárcel, Cyrille Girard, Reinhard Lührmann
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-11293-8

Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors

Author(s): Cesar S. Huertas, Sophie Bonnal, Maria Soler, Alfonso M. Escuela, Juan Valcárcel, Laura M. Lechuga
Published in: Analytical Chemistry, Issue 91/23, 2019, Page(s) 15138-15146, ISSN 0003-2700
DOI: 10.1021/acs.analchem.9b03898