Mechanisms of alternative pre-mRNA splicing regulation in cancer and pluripotent cells

Project Information

MASCP

Grant agreement ID: 670146

DOI 10.3030/670146

Project closed

EC signature date 11 September 2015

Start date 1 October 2015

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 159 574,00

EU contribution € 2 159 574,00

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

Publications

Non-peer reviewed articles (2)

Splicing Calls Back

Author(s): Tobias Hoffmann, Juan Valcárcel
Published in: Cell, Issue 179/7, 2019, Page(s) 1446-1447, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.11.028

Empowering MYC carcinogenesis via RNA loops

Author(s): Suzanne G. Mays, Juan Valcárcel
Published in: Molecular Cell, Issue 81/7, 2021, Page(s) 1365-1367, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.03.011

Peer reviewed articles (19)

Mutations primarily alter the inclusion of alternatively spliced exons

Author(s): Pablo Baeza-Centurion, Belén Miñana, Juan Valcárcel, Ben Lehner
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59959

RNA-binding proteins in human genetic disease

Author(s): Fátima Gebauer, Thomas Schwarzl, Juan Valcárcel, Matthias W. Hentze
Published in: Nature Reviews Genetics, Issue 22/3, 2021, Page(s) 185-198, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-020-00302-y

Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cell proliferation

Author(s): Elena Martin, Claudia Vivori, Malgorzata Rogalska, Jorge Herrero, Juan Valcarcel
Published in: RNA, 2021, Page(s) rna.078935.121, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1261/rna.078935.121

Roles and mechanisms of alternative splicing in cancer — implications for care

Author(s): Sophie C. Bonnal, Irene López-Oreja, Juan Valcárcel
Published in: Nature Reviews Clinical Oncology, Issue 17/8, 2020, Page(s) 457-474, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-020-0350-x

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

Author(s): Panagiotis Papasaikas, Juan Valcárcel
Published in: Trends in Biochemical Sciences, Issue 41/1, 2016, Page(s) 33-45, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2015.11.003

The complete local genotype–phenotype landscape for the alternative splicing of a human exon

Author(s): Philippe Julien, Belén Miñana, Pablo Baeza-Centurion, Juan Valcárcel, Ben Lehner
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms11558

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

Author(s): André Mourão, Sophie Bonnal, Komal Soni, Lisa Warner, Rémy Bordonné, Juan Valcárcel, Michael Sattler
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.14707

Tumor suppressor properties of the splicing regulatory factor RBM10

Author(s): Jordi Hernández, Elias Bechara, Doerte Schlesinger, Javier Delgado, Luis Serrano, Juan Valcárcel
Published in: RNA Biology, Issue 13/4, 2015, Page(s) 466-472, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2016.1144004

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Author(s): Metehan Cifdaloz, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, Tonantzin G. Calvo, Panagiotis Karras, David Olmeda, Belén Miñana, Gonzalo Gómez-López, Estela Cañon, Eduardo Eyras, Haihong Guo, Ferdinand Kappes, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, Diego Megías, Juan Valcárcel, María S. Soengas
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02353-y

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Author(s): Keiko Horiuchi, Serafín Perez-Cerezales, Panagiotis Papasaikas, Priscila Ramos-Ibeas, Angela Patricia López-Cardona, Ricardo Laguna-Barraza, Noelia Fonseca Balvís, Eva Pericuesta, Raul Fernández-González, Benjamín Planells, Alberto Viera, Jose Angel Suja, Pablo Juan Ross, Francisco Alén, Laura Orio, Fernando Rodriguez de Fonseca, Belén Pintado, Juan Valcárcel, Alfonso Gutiérrez-Adán
Published in: Cell Reports, Issue 23/1, 2018, Page(s) 143-155, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.03.028

Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Author(s): Luisa Vigevani, André Gohr, Thomas Webb, Manuel Irimia, Juan Valcárcel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02007-z

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

Author(s): Endre Sebestyén, Babita Singh, Belén Miñana, Amadís Pagès, Francesca Mateo, Miguel Angel Pujana, Juan Valcárcel, Eduardo Eyras
Published in: Genome Research, Issue 26/6, 2016, Page(s) 732-744, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.199935.115

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry

Author(s): Kamil Makowski, Luisa Vigevani, Fernando Albericio, Juan Valcárcel, Mercedes Álvarez
Published in: ACS Chemical Biology, Issue 12/1, 2016, Page(s) 163-173, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.6b00562

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

Author(s): Sandra Keiper, Panagiotis Papasaikas, Cindy L. Will, Juan Valcárcel, Cyrille Girard, Reinhard Lührmann
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11293-8

Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors

Author(s): Cesar S. Huertas, Sophie Bonnal, Maria Soler, Alfonso M. Escuela, Juan Valcárcel, Laura M. Lechuga
Published in: Analytical Chemistry, Issue 91/23, 2019, Page(s) 15138-15146, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b03898

Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing

Author(s): Pablo Baeza-Centurion, Belén Miñana, Jörn M. Schmiedel, Juan Valcárcel, Ben Lehner
Published in: Cell, Issue 176/3, 2019, Page(s) 549-563.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.010

Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

Author(s): Claudia Vivori, Panagiotis Papasaikas, Ralph Stadhouders, Bruno Di Stefano, Anna Ribó Rubio, Clara Berenguer Balaguer, Serena Generoso, Anna Mallol, José Luis Sardina, Bernhard Payer, Thomas Graf, Juan Valcárcel
Published in: Genome Biology, Issue 22/1, 2021, Page(s) 171, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/s13059-021-02372-5

A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons

Author(s): Antonio Torres-Méndez, Sophie Bonnal, Yamile Marquez, Jonathan Roth, Marta Iglesias, Jon Permanyer, Isabel Almudí, Dave O’Hanlon, Tanit Guitart, Matthias Soller, Anne-Claude Gingras, Fátima Gebauer, Fabian Rentzsch, Benjamin J. Blencowe, Juan Valcárcel, Manuel Irimia
Published in: Nature Ecology & Evolution, Issue 3/4, 2019, Page(s) 691-701, ISSN 2397-334X
Publisher: Nature Publishers
DOI: 10.1038/s41559-019-0813-6

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

Author(s): Caterina Carbonell, Arnau Ulsamer, Claudia Vivori, Panagiotis Papasaikas, René Böttcher, Manel Joaquin, Belén Miñana, Juan Ramón Tejedor, Eulàlia de Nadal, Juan Valcárcel, Francesc Posas
Published in: Cell Reports, Issue 27/3, 2019, Page(s) 847-859.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.03.060