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Mechanisms of alternative pre-mRNA splicing regulation in cancer and pluripotent cells

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Splicing Calls Back

Author(s): Tobias Hoffmann, Juan Valcárcel
Published in: Cell, Issue 179/7, 2019, Page(s) 1446-1447, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.11.028

Empowering MYC carcinogenesis via RNA loops

Author(s): Suzanne G. Mays, Juan Valcárcel
Published in: Molecular Cell, Issue 81/7, 2021, Page(s) 1365-1367, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.03.011

Mutations primarily alter the inclusion of alternatively spliced exons

Author(s): Pablo Baeza-Centurion, Belén Miñana, Juan Valcárcel, Ben Lehner
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59959

RNA-binding proteins in human genetic disease

Author(s): Fátima Gebauer, Thomas Schwarzl, Juan Valcárcel, Matthias W. Hentze
Published in: Nature Reviews Genetics, Issue 22/3, 2021, Page(s) 185-198, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-020-00302-y

Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cell proliferation

Author(s): Elena Martin, Claudia Vivori, Malgorzata Rogalska, Jorge Herrero, Juan Valcarcel
Published in: RNA, 2021, Page(s) rna.078935.121, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1261/rna.078935.121

Roles and mechanisms of alternative splicing in cancer — implications for care

Author(s): Sophie C. Bonnal, Irene López-Oreja, Juan Valcárcel
Published in: Nature Reviews Clinical Oncology, Issue 17/8, 2020, Page(s) 457-474, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-020-0350-x

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

Author(s): Panagiotis Papasaikas, Juan Valcárcel
Published in: Trends in Biochemical Sciences, Issue 41/1, 2016, Page(s) 33-45, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2015.11.003

The complete local genotype–phenotype landscape for the alternative splicing of a human exon

Author(s): Philippe Julien, Belén Miñana, Pablo Baeza-Centurion, Juan Valcárcel, Ben Lehner
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms11558

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

Author(s): André Mourão, Sophie Bonnal, Komal Soni, Lisa Warner, Rémy Bordonné, Juan Valcárcel, Michael Sattler
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.14707

Tumor suppressor properties of the splicing regulatory factor RBM10

Author(s): Jordi Hernández, Elias Bechara, Doerte Schlesinger, Javier Delgado, Luis Serrano, Juan Valcárcel
Published in: RNA Biology, Issue 13/4, 2015, Page(s) 466-472, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2016.1144004

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Author(s): Metehan Cifdaloz, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, Tonantzin G. Calvo, Panagiotis Karras, David Olmeda, Belén Miñana, Gonzalo Gómez-López, Estela Cañon, Eduardo Eyras, Haihong Guo, Ferdinand Kappes, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, Diego Megías, Juan Valcárcel, María S. Soengas
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02353-y

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Author(s): Keiko Horiuchi, Serafín Perez-Cerezales, Panagiotis Papasaikas, Priscila Ramos-Ibeas, Angela Patricia López-Cardona, Ricardo Laguna-Barraza, Noelia Fonseca Balvís, Eva Pericuesta, Raul Fernández-González, Benjamín Planells, Alberto Viera, Jose Angel Suja, Pablo Juan Ross, Francisco Alén, Laura Orio, Fernando Rodriguez de Fonseca, Belén Pintado, Juan Valcárcel, Alfonso Gutiérrez-Adán
Published in: Cell Reports, Issue 23/1, 2018, Page(s) 143-155, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.03.028

Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Author(s): Luisa Vigevani, André Gohr, Thomas Webb, Manuel Irimia, Juan Valcárcel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02007-z

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

Author(s): Endre Sebestyén, Babita Singh, Belén Miñana, Amadís Pagès, Francesca Mateo, Miguel Angel Pujana, Juan Valcárcel, Eduardo Eyras
Published in: Genome Research, Issue 26/6, 2016, Page(s) 732-744, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.199935.115

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry

Author(s): Kamil Makowski, Luisa Vigevani, Fernando Albericio, Juan Valcárcel, Mercedes Álvarez
Published in: ACS Chemical Biology, Issue 12/1, 2016, Page(s) 163-173, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.6b00562

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

Author(s): Sandra Keiper, Panagiotis Papasaikas, Cindy L. Will, Juan Valcárcel, Cyrille Girard, Reinhard Lührmann
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11293-8

Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors

Author(s): Cesar S. Huertas, Sophie Bonnal, Maria Soler, Alfonso M. Escuela, Juan Valcárcel, Laura M. Lechuga
Published in: Analytical Chemistry, Issue 91/23, 2019, Page(s) 15138-15146, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b03898

Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing

Author(s): Pablo Baeza-Centurion, Belén Miñana, Jörn M. Schmiedel, Juan Valcárcel, Ben Lehner
Published in: Cell, Issue 176/3, 2019, Page(s) 549-563.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.010

Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

Author(s): Claudia Vivori, Panagiotis Papasaikas, Ralph Stadhouders, Bruno Di Stefano, Anna Ribó Rubio, Clara Berenguer Balaguer, Serena Generoso, Anna Mallol, José Luis Sardina, Bernhard Payer, Thomas Graf, Juan Valcárcel
Published in: Genome Biology, Issue 22/1, 2021, Page(s) 171, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/s13059-021-02372-5

A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons

Author(s): Antonio Torres-Méndez, Sophie Bonnal, Yamile Marquez, Jonathan Roth, Marta Iglesias, Jon Permanyer, Isabel Almudí, Dave O’Hanlon, Tanit Guitart, Matthias Soller, Anne-Claude Gingras, Fátima Gebauer, Fabian Rentzsch, Benjamin J. Blencowe, Juan Valcárcel, Manuel Irimia
Published in: Nature Ecology & Evolution, Issue 3/4, 2019, Page(s) 691-701, ISSN 2397-334X
Publisher: Nature Publishers
DOI: 10.1038/s41559-019-0813-6

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

Author(s): Caterina Carbonell, Arnau Ulsamer, Claudia Vivori, Panagiotis Papasaikas, René Böttcher, Manel Joaquin, Belén Miñana, Juan Ramón Tejedor, Eulàlia de Nadal, Juan Valcárcel, Francesc Posas
Published in: Cell Reports, Issue 27/3, 2019, Page(s) 847-859.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.03.060

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