Presynaptic Regulatory Principles in Synaptic Plasticity, Neuronal Network Function, and Behaviour

Project Information

SYNPRIME

Grant agreement ID: 670283

DOI 10.3030/670283

Project closed

EC signature date 14 August 2015

Start date 1 September 2015

End date 31 August 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 495 593,75

EU contribution € 2 495 593,75

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (11)

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

Author(s): Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeff A. Stogsdill, Lisa Traunmüller, Jiex
Published in: Neuron, Issue 106/1, 2020, Page(s) 37-65.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.01.008

Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

Author(s): Yuji Okamoto, Noa Lipstein, Yunfeng Hua, Kun-Han Lin, Nils Brose, Takeshi Sakaba, Mitsuharu Midorikawa
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.14643

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

Author(s): Noa Lipstein, Nanda M. Verhoeven-Duif, Francesco E. Michelassi, Nathaniel Calloway, Peter M. van Hasselt, Katarzyna Pienkowska, Gijs van Haaften, Mieke M. van Haelst, Ron van Empelen, Inge Cuppen, Heleen C. van Teeseling, Annemieke M.V. Evelein, Jacob A. Vorstman, Sven Thoms, Olaf Jahn, Karen J. Duran, Glen R. Monroe, Timothy A. Ryan, Holger Taschenberger, Jeremy S. Dittman, Jeong-Seop Rhee, Gepke
Published in: Journal of Clinical Investigation, Issue 127/3, 2017, Page(s) 1005-1018, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI90259

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

Author(s): Albrecht Sigler, Won Chan Oh, Cordelia Imig, Bekir Altas, Hiroshi Kawabe, Benjamin H. Cooper, Hyung-Bae Kwon, Jeong-Seop Rhee, Nils Brose
Published in: Neuron, Issue 94/2, 2017, Page(s) 304-311.e4, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.03.029

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones

Author(s): Hiroshi Kawabe, Miso Mitkovski, Pascal S. Kaeser, Johannes Hirrlinger, Felipe Opazo, Dennis Nestvogel, Stefan Kalla, Anna Fejtova, Sophie E. Verrier, Simon R. Bungers, Benjamin H. Cooper, Frederique Varoqueaux, Yun Wang, Ralf B. Nehring, Eckart D. Gundelfinger, Christian Rosenmund, Silvio O. Rizzoli, Thomas C. Südhof, Jeong-Seop Rhee, Nils Brose
Published in: The Journal of Cell Biology, Issue 216/4, 2017, Page(s) 1143-1161, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201606086

Dynamically Primed Synaptic Vesicle States: Key to Understand Synaptic Short-Term Plasticity

Author(s): Erwin Neher, Nils Brose
Published in: Neuron, Issue 100/6, 2018, Page(s) 1283-1291, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.11.024

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release

Author(s): Francisco José López-Murcia, Kerstin Reim, Olaf Jahn, Holger Taschenberger, Nils Brose
Published in: Cell Reports, Issue 26/10, 2019, Page(s) 2521-2530.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.030

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses

Author(s): Lydia Maus, ChoongKu Lee, Bekir Altas, Sinem M. Sertel, Kirsten Weyand, Silvio O. Rizzoli, JeongSeop Rhee, Nils Brose, Cordelia Imig, Benjamin H. Cooper
Published in: Cell Reports, Issue 30/11, 2020, Page(s) 3632-3643.e8, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.02.083

The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

Author(s): Dennis B. Nestvogel, Ricardo Martins Merino, Carolina Leon-Pinzon, Manuel Schottdorf, ChoongKu Lee, Cordelia Imig, Nils Brose, Jeong-Seop Rhee
Published in: Cell Reports, Issue 30/10, 2020, Page(s) 3261-3269.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.02.045

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Author(s): Frank Koopmans, Pim van Nierop, Maria Andres-Alonso, Andrea Byrnes, Tony Cijsouw, Marcelo P. Coba, L. Niels Cornelisse, Ryan J. Farrell, Hana L. Goldschmidt, Daniel P. Howrigan, Natasha K. Hussain, Cordelia Imig, Arthur P.H. de Jong, Hwajin Jung, Mahdokht Kohansalnodehi, Barbara Kramarz, Noa Lipstein, Ruth C. Lovering, Harold MacGillavry, Vittoria Mariano, Huaiyu Mi, Momchil Ninov, David Osumi-Sut
Published in: Neuron, Issue 103/2, 2019, Page(s) 217-234.e4, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.05.002

Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices

Author(s): Cordelia Imig, Francisco José López-Murcia, Lydia Maus, Inés Hojas García-Plaza, Lena Sünke Mortensen, Manuela Schwark, Valentin Schwarze, Julie Angibaud, U. Valentin Nägerl, Holger Taschenberger, Nils Brose, Benjamin H. Cooper
Published in: Neuron, 2020, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.09.004