Establishment of Sister Chromatid Cohesion

Project Information

ChromatidCohesion

Grant agreement ID: 670412

DOI 10.3030/670412

Project closed

EC signature date 7 August 2015

Start date 1 October 2015

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 120 099,99

EU contribution € 2 120 099,99

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Publications

Peer reviewed articles (18)

Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.

Author(s): Yasutaka Kakui; Adam Rabinowitz; David J. Barry; Frank Uhlmann
Published in: Nature genetics, Issue 1, 2017, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3938

Bridging-induced phase separation induced by cohesin SMC protein complexes.

Author(s): Je-Kyung Ryu; Céline Bouchoux; Hon Wing Liu; Eugene Kim; Masashi Minamino; Ralph de Groot; Allard J. Katan; Andrea Bonato; Davide Marenduzzo; Davide Michieletto; Frank Uhlmann; Cees Dekker
Published in: Science Advances, Issue 1, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abe5905

Topological in vitro loading of the budding yeast cohesin ring onto DNA.

Author(s): Minamino, Masashi; Higashi, Torahiko L; Bouchoux, Céline; Uhlmann, Frank
Published in: Life Science Alliance, Issue 1, 2018, ISSN 2575-1077
Publisher: EMBO Press
DOI: 10.26508/lsa.201800143

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

Author(s): Torahiko L Higashi; Patrik Eickhoff; Joana S. Simoes; Julia Locke; Andrea Nans; Helen R. Flynn; Ambrosius P. Snijders; George Papageorgiou; Nicola O’Reilly; Zhuo A. Chen; Francis J. O’Reilly; Juri Rappsilber; Juri Rappsilber; Alessandro Costa; Frank Uhlmann
Published in: Molecular Cell, Issue 1, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.07.013

Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast

Author(s): Tereza Gerguri; Xiao Fu; Yasutaka Kakui; Yasutaka Kakui; Bhavin S Khatri; Bhavin S Khatri; Christopher Barrington; Paul A. Bates; Frank Uhlmann
Published in: Nucleic Acids Research, Issue 1, 2021, ISSN 1362-4962
Publisher: Oxford Academic
DOI: 10.1093/nar/gkaa1270

Establishment of DNA-DNA Interactions by the Cohesin Ring

Author(s): Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann
Published in: Cell, Issue 172/3, 2018, Page(s) 465-477.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.12.021

Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast

Author(s): Yasutaka Kakui, Adam Rabinowitz, David J Barry, Frank Uhlmann
Published in: Nature Genetics, Issue 49/10, 2017, Page(s) 1553-1557, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3938

SMC complexes orchestrate the mitotic chromatin interaction landscape

Author(s): Yasutaka Kakui, Frank Uhlmann
Published in: Current Genetics, Issue 64/2, 2018, Page(s) 335-339, ISSN 0172-8083
Publisher: Springer Verlag
DOI: 10.1007/s00294-017-0755-y

Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex

Author(s): Rahul Thadani, Julia Kamenz, Sebastian Heeger, Sofía Muñoz, Frank Uhlmann
Published in: Cell Reports, Issue 23/8, 2018, Page(s) 2308-2317, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.04.082

SMC complexes: from DNA to chromosomes

Author(s): Frank Uhlmann
Published in: Nature Reviews Molecular Cell Biology, Issue 17/7, 2016, Page(s) 399-412, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/nrm.2016.30

Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome

Author(s): Catarina P. Samora, Julie Saksouk, Panchali Goswami, Ben O. Wade, Martin R. Singleton, Paul A. Bates, Armelle Lengronne, Alessandro Costa, Frank Uhlmann
Published in: Molecular Cell, Issue 63/3, 2016, Page(s) 371-384, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2016.05.036

Evidence for cohesin sliding along budding yeast chromosomes

Author(s): Maria Ocampo-Hafalla, Sofía Muñoz, Catarina P. Samora, Frank Uhlmann
Published in: Open Biology, Issue 6/6, 2016, Page(s) 150178, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.150178

DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism

Author(s): Yasuto Murayama, Frank Uhlmann
Published in: Cell, Issue 163/7, 2015, Page(s) 1628-1640, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2015.11.030

Conserved roles of chromatin remodellers in cohesin loading onto chromatin

Author(s): Sofía Muñoz, Francesca Passarelli, Frank Uhlmann
Published in: Current Genetics, 2020, ISSN 0172-8083
Publisher: Springer Verlag
DOI: 10.1007/s00294-020-01075-x

Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment

Author(s): Hon Wing Liu, Céline Bouchoux, Mélanie Panarotto, Yasutaka Kakui, Harshil Patel, Frank Uhlmann
Published in: Molecular Cell, Issue 78/4, 2020, Page(s) 725-738.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.03.017

A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes

Author(s): Sofía Muñoz, Masashi Minamino, Corella S. Casas-Delucchi, Harshil Patel, Frank Uhlmann
Published in: Molecular Cell, Issue 74/4, 2019, Page(s) 664-673.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.02.027

A Brownian ratchet model for DNA loop extrusion by the cohesin complex.

Author(s): Torahiko L Higashi; Georgii Pobegalov; Georgii Pobegalov; Minzhe Tang; Maxim I Molodtsov; Maxim I Molodtsov; Frank Uhlmann
Published in: Elife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.67530

Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage

Author(s): Yasutaka Kakui; Yasutaka Kakui; Christopher Barrington; David J. Barry; Tereza Gerguri; Xiao Fu; Paul A. Bates; Bhavin S Khatri; Bhavin S Khatri; Frank Uhlmann
Published in: Genome Biology, Issue 1, 2020, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.12965306.v1

Book chapters (1)

An in vitro assay for monitoring topological DNA entrapment by the chromosomal cohesin complex

Author(s): Yasuto Murayama, Frank Uhlmann
Published in: Methods in Molecular Biology, Issue 1515, 2017, Page(s) 23-35
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6545-8_2