Systems Biology of Membrane Trafficking

Project Information

SYSMET

Grant agreement ID: 670881

DOI 10.3030/670881

Project closed

EC signature date 12 October 2015

Start date 1 January 2016

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 241 250,00

EU contribution € 2 241 250,00

Coordinated by

FONDAZIONE TELETHON ETS
Italy

Publications

Peer reviewed articles (15)

VAPB depletion alters neuritogenesis and phosphoinositide balance in motoneuron-like cells: relevance to VAPB-linked amyotrophic lateral sclerosis

Author(s): Paola Genevini; Maria Nicol Colombo; Rossella Venditti; Stefania Marcuzzo; Sara Francesca Colombo; Pia Bernasconi; Maria Antonietta De Matteis; Nica Borgese; Francesca Navone
Published in: Journal of Celle Science, Issue 14779137, 2019, ISSN 1477-9137
Publisher: The Company of Biologist
DOI: 10.1242/jcs.220061

The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.

Author(s): Ricciardi S, Guarino AM, Giaquinto L, Polishchuk EV, Santoro M, Di Tullio G, Wilson C, Panariello F, Soares VC, Dias SSG, Santos JC, Souza TML, Fusco G, Viscardi M, Brandi S, Bozza PT, Polishchuk RS, Venditti R, De Matteis MA.
Published in: Nature, Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04835-6

GADD34 is a modulator of autophagy during starvation

Author(s): Gennaro Gambardella; Leopoldo Staiano; Maria Nicoletta Moretti; Rossella De Cegli; Luca Fagnocchi; Giuseppe Di Tullio; Sara Polletti; Clarissa Braccia; Andrea Armirotti; Alessio Zippo; Andrea Ballabio; Andrea Ballabio; Maria Antonietta De Matteis; Diego di Bernardo
Published in: Science Advances, Issue 23752548, 2020, ISSN 2375-2548
Publisher: American Association for the Advancement of Science.
DOI: 10.1126/sciadv.abb0205

Regulation and physiology of membrane contact sites.

Author(s): Rossella Venditti; Cathal Wilson; Maria Antonietta De Matteis
Published in: Current Opinion in Cell Biology, Issue 09550674, 2021, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2021.03.004

Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis.

Author(s): Bellomo F, De Leo E, Taranta A, Giaquinto L, Di Giovamberardino G, Montefusco S, Rega LR, Pastore A, Medina DL, Di Bernardo D, De Matteis MA, Emma F.
Published in: Int J Mol Sci., Issue 14220067, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312829

Molecular determinants of ER–Golgi contacts identified through a new FRET–FLIM system

Author(s): Rossella Venditti, Laura Rita Rega, Maria Chiara Masone, Michele Santoro, Elena Polishchuk, Daniela Sarnataro, Simona Paladino, Sabato D’Auria, Antonio Varriale, Vesa M. Olkkonen, Giuseppe Di Tullio, Roman Polishchuk, Maria Antonietta De Matteis
Published in: Journal of Cell Biology, Issue 218/3, 2019, Page(s) 1055-1065, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201812020

Oculocerebrorenal syndrome of Lowe protein controls cytoskeletal reorganisation during human platelet spreading.

Author(s): Bura A, De Matteis MA, Bender M, Swinkels M, Versluis J, Jansen AJG, Jurak Begonja A.
Published in: Br J Haematol, Issue 00071048, 2022, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.18478

The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1

Author(s): Rossella Venditti; Maria Chiara Masone; Laura Rita Rega; Giuseppe Di Tullio; Michele Santoro; Elena Polishchuk; Iván Castelló Serrano; Vesa M. Olkkonen; Vesa M. Olkkonen; Akihiro Harada; Diego L. Medina; Raffaele La Montagna; Maria Antonietta De Matteis
Published in: The Journal of Cell Biology, Issue 00219525, 2019, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.5281/zenodo.2527821

Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Author(s): Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L. Medina, Andrea Ballabio, Maria Antonietta De Matteis
Published in: Nature Cell Biology, Issue 18/8, 2016, Page(s) 839-850, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3386

TRAPPing Rab18 in lipid droplets

Author(s): Francesca Zappa, Rossella Venditti, Maria Antonietta De Matteis
Published in: The EMBO Journal, Issue 36/4, 2017, Page(s) 394-396, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201696287

The TRAPP complex mediates secretion arrest induced by stress granule assembly.

Author(s): Francesca Zappa; Cathal Wilson; Giuseppe Di Tullio; Michele Santoro; Piero Pucci; Maria Chiara Monti; Davide D'Amico; Sandra Pisonero Vaquero; Rossella De Cegli; Alessia Romano; Moin A. Saleem; Elena Polishchuk; Mario Failli; Laura Giaquinto; Maria Antonietta De Matteis
Published in: EMBO J, Issue 14602075, 2019, ISSN 1460-2075
Publisher: EMBO PRESS
DOI: 10.15252/embj.2019101704

COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay

Author(s): Marom R, Burrage LC, Venditti R, Clément A, Blanco-Sánchez B, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Lee YC, Song IW, Sliepka JM, Batkovskyte D, Washington M, Dawson BC, Jin Z, Jiang MM, Chen S, Chen Y, Tran AA, Emrick LT, Murdock DR, Hanchard NA, Zapata GE, Mehta NR, Weis MA, Scott AA, Tremp
Published in: Am J Hum Genet., Issue 00029297, 2021, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2021.08.002

OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.

Author(s): Festa BP, Berquez M, Gassama A, Amrein I, Ismail HM, Samardzija M, Staiano L, Luciani A, Grimm C, Nussbaum RL, De Matteis MA, Dorchies OM, Scapozza L, Wolfer DP, Devuyst O.
Published in: Hum Mol Genet, Issue 09646906, 2019, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy449

Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina.

Author(s): Tornabene P, Trapani I, Minopoli R, Centrulo M, Lupo M, de Simone S, Tiberi P, Dell'Aquila F, Marrocco E, Iodice C, Iuliano A, Gesualdo C, Rossi S, Giaquinto L, Albert S, Hoyng CB, Polishchuk E, Cremers FPM, Surace EM, Simonelli F, De Matteis MA, Polishchuk R, Auricchio A.
Published in: Sci Transl Med, Issue 19466234, 2019, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aav4523

Coming together to define membrane contact sites

Author(s): Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09253-3