dUTPase Signalling: from Phage to Eukaryotes

Project Information

DUT-signal

Grant agreement ID: 670932

DOI

10.3030/670932

Project closed

EC signature date 10 November 2015

Start date 1 December 2015

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 246 192,00

EU contribution

€ 2 246 192,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Molecular Basis of Lysis-Lysogeny Decisions in Gram-Positive Phages

Author(s): Aisling Brady, Alonso Felipe-Ruiz, Francisca Gallego Del Sol, Alberto Marina, Nuria Quiles-Puchalt, José R Penadés
Published in: Annual Review Microbiology, 2021, ISSN 1545-3251
Publisher: ASM
DOI: 10.1146/annurev-micro-033121-020757

Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22

Author(s): Fillol-Salom, A Bacigalupe, R Humphrey, S Chiang, YN Chen, J Penades, J
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26520-4

Bacteriophages benefit from generalized transduction

Author(s): Alfred Fillol-Salom, Ahlam Alsaadi, Jorge A. Moura de Sousa, Li Zhong, Kevin R. Foster, Eduardo P. C. Rocha, José R. Penadés, Hanne Ingmer, Jakob Haaber
Published in: PLOS Pathogens, Issue 15/7, 2019, Page(s) e1007888, ISSN 1553-7374
Publisher: Plos Pathogens
DOI: 10.1371/journal.ppat.1007888

The Bacteriophage–Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases

Author(s): Carla Sanz-Frasquet, J. Rafael Ciges-Tomas, Christian Alite, José R. Penadés, Alberto Marina
Published in: Microbiology Spectrum, 2023, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.03232-22

Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit

Author(s): Alfred Fillol-Salom, Julio Bacarizo, Mohammed Alqasmi, J. Rafael Ciges-Tomas, Roser Martínez-Rubio, Aleksander W. Roszak, Richard J. Cogdell, John Chen, Alberto Marina, José R. Penadés
Published in: Molecular Cell, Issue 75/5, 2019, Page(s) 1020-1030.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.06.017

A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature

Author(s): Nasser Alqurainy, Laura Miguel-Romero, Jorge Moura de Sousa, John Chen, Eduardo P C Rocha, Alfred Fillol-Salom, José R Penadés
Published in: Cell Host Microbe, 2023, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2022.12.001

Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors

Author(s): Alfred Fillol-Salom, Jakob T Rostøl, Adaeze D Ojiogu, John Chen, Gill Douce, Suzanne Humphrey, José R Penadés
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.014

Staphylococcal phages and pathogenicity islands drive plasmid evolution

Author(s): Suzanne Humphrey, Álvaro San Millán, Macarena Toll-Riera, John Connolly, Alejandra Flor-Duro, John Chen, Carles Ubeda, Craig R MacLean, José R Penadés
Published in: Nature Communications, Issue 12(1):5845, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26101-5

Genome hypermobility by lateral transduction

Author(s): John Chen, Nuria Quiles-Puchalt, Yin Ning Chiang, Rodrigo Bacigalupe, Alfred Fillol-Salom, Melissa Su Juan Chee, J. Ross Fitzgerald, José R. Penadés
Published in: Science, Issue 362/6411, 2018, Page(s) 207-212, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat5867

Phage-inducible chromosomal islands are ubiquitous within the bacterial universe

Author(s): Alfred Fillol-Salom, Roser Martínez-Rubio, Rezheen F. Abdulrahman, John Chen, Robert Davies, José R. Penadés
Published in: The ISME Journal, Issue 12/9, 2018, Page(s) 2114-2128, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-018-0156-3

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization

Author(s): Jorge Donderis, Janine Bowring, Elisa Maiques, J. Rafael Ciges-Tomas, Christian Alite, Iltyar Mehmedov, María Angeles Tormo-Mas, José R. Penadés, Alberto Marina
Published in: PLOS Pathogens, Issue 13/9, 2017, Page(s) e1006581, ISSN 1553-7374
Publisher: Plos Pathogens
DOI: 10.1371/journal.ppat.1006581

Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80α dUTPase

Author(s): Christian Alite, Suzanne Humphrey, Jordi Donderis, Elisa Maiques, J. Rafael Ciges-Tomas, José R. Penadés, Alberto Marina
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-11234-9

Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus

Author(s): Maan M. Neamah, Ignacio Mir-Sanchis, María López-Sanz, Sonia Acosta, Ignacio Baquedano, Andreas F. Haag, Alberto Marina, Silvia Ayora, José R. Penadés
Published in: Nucleic Acids Research, Issue 45/11, 2017, Page(s) 6507-6519, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx308

Another look at the mechanism involving trimeric dUTPases in Staphylococcus aureus pathogenicity island induction involves novel players in the party

Author(s): Elisa Maiques, Nuria Quiles-Puchalt, Jorge Donderis, J. Rafael Ciges-Tomas, Christian Alite, Janine Z. Bowring, Suzanne Humphrey, José R. Penadés, Alberto Marina
Published in: Nucleic Acids Research, Issue 44/11, 2016, Page(s) 5457-5469, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw317

Convergent evolution of pathogenicity islands in helper cos phage interference

Author(s): Nuria Carpena, Keith A. Manning, Terje Dokland, Alberto Marina, José R. Penadés
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 371/1707, 2016, Page(s) 20150505, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2015.0505

Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

Author(s): Janine Bowring, Maan M Neamah, Jorge Donderis, Ignacio Mir-Sanchis, Christian Alite, J Rafael Ciges-Tomas, Elisa Maiques, Iltyar Medmedov, Alberto Marina, José R Penadés
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.26487

Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems

Author(s): Francisca Gallego del Sol, José R. Penadés, Alberto Marina
Published in: Molecular Cell, 2019, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.01.025

The impact of two-component sensorial network in staphylococcal speciation.

Author(s): Beatriz Rapún-Araiz; Andreas F. Haag; Cristina Solano; Iñigo Lasa
Published in: 1369-5274, Issue 1, 2020, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2020.02.004

A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species

Author(s): Rodrigo Bacigalupe, María Ángeles Tormo-Mas, José R. Penadés, J. Ross Fitzgerald
Published in: Science Advances, Issue 5/11, 2019, Page(s) eaax0063, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.aax0063

Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus

Author(s): Beatriz Rapún-Araiz; Andreas F. Haag; V. De Cesare; Carmen Gil; Pedro Dorado-Morales; José R. Penadés; Iñigo Lasa
Published in: mSystems, Vol 5, Iss 4, p e00511-20 (2020), Issue 1, 2020, ISSN 2379-5077
Publisher: ASM
DOI: 10.1128/msystems.00511-20

Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements

Author(s): Suzanne Humphrey, Alfred Fillol-Salom, Nuria Quiles-Puchalt, Rodrigo Ibarra-Chávez, Andreas Haag, John Chen & José R. Penadés
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26004-5

The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature

Author(s): J. Rafael Ciges-Tomas, Christian Alite, Suzanne Humphrey, J. Donderis, Janine Bowring, Xavier Salvatella, José R. Penadés, Alberto Marina
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11504-2

A regulatory cascade controls Staphylococcus aureus pathogenicity island activation

Author(s): Andreas Haag, Magdalena Podkowik, Rodrigo Ibarra-Chávez, Francisca Gallego del Sol, Geeta Ram, John Chen, Alberto Marina, Richard P. Novick & José R. Penadés
Published in: Nature Microbiology, 2021, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-021-00956-2