dUTPase Signalling: from Phage to Eukaryotes

Project Information

DUT-signal

Grant agreement ID: 670932

DOI 10.3030/670932

Project closed

EC signature date 10 November 2015

Start date 1 December 2015

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 246 192,00

EU contribution € 2 246 192,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Publications

Peer reviewed articles (23)

Molecular Basis of Lysis-Lysogeny Decisions in Gram-Positive Phages

Author(s): Aisling Brady, Alonso Felipe-Ruiz, Francisca Gallego Del Sol, Alberto Marina, Nuria Quiles-Puchalt, José R Penadés
Published in: Annual Review Microbiology, 2021, ISSN 1545-3251
Publisher: ASM
DOI: 10.1146/annurev-micro-033121-020757

Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22

Author(s): Fillol-Salom, A Bacigalupe, R Humphrey, S Chiang, YN Chen, J Penades, J
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26520-4

Bacteriophages benefit from generalized transduction

Author(s): Alfred Fillol-Salom, Ahlam Alsaadi, Jorge A. Moura de Sousa, Li Zhong, Kevin R. Foster, Eduardo P. C. Rocha, José R. Penadés, Hanne Ingmer, Jakob Haaber
Published in: PLOS Pathogens, Issue 15/7, 2019, Page(s) e1007888, ISSN 1553-7374
Publisher: Plos Pathogens
DOI: 10.1371/journal.ppat.1007888

The Bacteriophage–Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases

Author(s): Carla Sanz-Frasquet, J. Rafael Ciges-Tomas, Christian Alite, José R. Penadés, Alberto Marina
Published in: Microbiology Spectrum, 2023, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.03232-22

Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit

Author(s): Alfred Fillol-Salom, Julio Bacarizo, Mohammed Alqasmi, J. Rafael Ciges-Tomas, Roser Martínez-Rubio, Aleksander W. Roszak, Richard J. Cogdell, John Chen, Alberto Marina, José R. Penadés
Published in: Molecular Cell, Issue 75/5, 2019, Page(s) 1020-1030.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.06.017

A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature

Author(s): Nasser Alqurainy, Laura Miguel-Romero, Jorge Moura de Sousa, John Chen, Eduardo P C Rocha, Alfred Fillol-Salom, José R Penadés
Published in: Cell Host Microbe, 2023, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2022.12.001

Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors

Author(s): Alfred Fillol-Salom, Jakob T Rostøl, Adaeze D Ojiogu, John Chen, Gill Douce, Suzanne Humphrey, José R Penadés
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.014

Staphylococcal phages and pathogenicity islands drive plasmid evolution

Author(s): Suzanne Humphrey, Álvaro San Millán, Macarena Toll-Riera, John Connolly, Alejandra Flor-Duro, John Chen, Carles Ubeda, Craig R MacLean, José R Penadés
Published in: Nature Communications, Issue 12(1):5845, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26101-5

Genome hypermobility by lateral transduction

Author(s): John Chen, Nuria Quiles-Puchalt, Yin Ning Chiang, Rodrigo Bacigalupe, Alfred Fillol-Salom, Melissa Su Juan Chee, J. Ross Fitzgerald, José R. Penadés
Published in: Science, Issue 362/6411, 2018, Page(s) 207-212, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat5867

Phage-inducible chromosomal islands are ubiquitous within the bacterial universe

Author(s): Alfred Fillol-Salom, Roser Martínez-Rubio, Rezheen F. Abdulrahman, John Chen, Robert Davies, José R. Penadés
Published in: The ISME Journal, Issue 12/9, 2018, Page(s) 2114-2128, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-018-0156-3

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization

Author(s): Jorge Donderis, Janine Bowring, Elisa Maiques, J. Rafael Ciges-Tomas, Christian Alite, Iltyar Mehmedov, María Angeles Tormo-Mas, José R. Penadés, Alberto Marina
Published in: PLOS Pathogens, Issue 13/9, 2017, Page(s) e1006581, ISSN 1553-7374
Publisher: Plos Pathogens
DOI: 10.1371/journal.ppat.1006581

Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80α dUTPase

Author(s): Christian Alite, Suzanne Humphrey, Jordi Donderis, Elisa Maiques, J. Rafael Ciges-Tomas, José R. Penadés, Alberto Marina
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-11234-9

Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus

Author(s): Maan M. Neamah, Ignacio Mir-Sanchis, María López-Sanz, Sonia Acosta, Ignacio Baquedano, Andreas F. Haag, Alberto Marina, Silvia Ayora, José R. Penadés
Published in: Nucleic Acids Research, Issue 45/11, 2017, Page(s) 6507-6519, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx308

Another look at the mechanism involving trimeric dUTPases in Staphylococcus aureus pathogenicity island induction involves novel players in the party

Author(s): Elisa Maiques, Nuria Quiles-Puchalt, Jorge Donderis, J. Rafael Ciges-Tomas, Christian Alite, Janine Z. Bowring, Suzanne Humphrey, José R. Penadés, Alberto Marina
Published in: Nucleic Acids Research, Issue 44/11, 2016, Page(s) 5457-5469, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw317

Convergent evolution of pathogenicity islands in helper cos phage interference

Author(s): Nuria Carpena, Keith A. Manning, Terje Dokland, Alberto Marina, José R. Penadés
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 371/1707, 2016, Page(s) 20150505, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2015.0505

Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

Author(s): Janine Bowring, Maan M Neamah, Jorge Donderis, Ignacio Mir-Sanchis, Christian Alite, J Rafael Ciges-Tomas, Elisa Maiques, Iltyar Medmedov, Alberto Marina, José R Penadés
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.26487

Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems

Author(s): Francisca Gallego del Sol, José R. Penadés, Alberto Marina
Published in: Molecular Cell, 2019, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.01.025

The impact of two-component sensorial network in staphylococcal speciation.

Author(s): Beatriz Rapún-Araiz; Andreas F. Haag; Cristina Solano; Iñigo Lasa
Published in: 1369-5274, Issue 1, 2020, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2020.02.004

A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species

Author(s): Rodrigo Bacigalupe, María Ángeles Tormo-Mas, José R. Penadés, J. Ross Fitzgerald
Published in: Science Advances, Issue 5/11, 2019, Page(s) eaax0063, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.aax0063

Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus

Author(s): Beatriz Rapún-Araiz; Andreas F. Haag; V. De Cesare; Carmen Gil; Pedro Dorado-Morales; José R. Penadés; Iñigo Lasa
Published in: mSystems, Vol 5, Iss 4, p e00511-20 (2020), Issue 1, 2020, ISSN 2379-5077
Publisher: ASM
DOI: 10.1128/msystems.00511-20

Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements

Author(s): Suzanne Humphrey, Alfred Fillol-Salom, Nuria Quiles-Puchalt, Rodrigo Ibarra-Chávez, Andreas Haag, John Chen & José R. Penadés
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26004-5

The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature

Author(s): J. Rafael Ciges-Tomas, Christian Alite, Suzanne Humphrey, J. Donderis, Janine Bowring, Xavier Salvatella, José R. Penadés, Alberto Marina
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11504-2

A regulatory cascade controls Staphylococcus aureus pathogenicity island activation

Author(s): Andreas Haag, Magdalena Podkowik, Rodrigo Ibarra-Chávez, Francisca Gallego del Sol, Geeta Ram, John Chen, Alberto Marina, Richard P. Novick & José R. Penadés
Published in: Nature Microbiology, 2021, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-021-00956-2