Myelinic nanochannels in neurodegenerative diseases

Project Information

MyeliNANO

Grant agreement ID: 671048

DOI 10.3030/671048

Project closed

EC signature date 9 November 2015

Start date 1 April 2016

End date 31 July 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (36)

CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge

Author(s): Umer Javed Butt, Imam Hassouna, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Constanze Depp, Nadine Barnkothe, Matthias R. Zillmann, Anja Ronnenberg, Viktoria Bonet, Sandra Goebbels, Klaus-Armin Nave, Hannelore Ehrenreich
Published in: International journal of molecular sciences., Issue 22(6), 2021, Page(s) 3164, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063164

Hippocampal neurons respond to brain activity with functional hypoxia

Author(s): Umer Javed Butt, Agnes A. Steixner-Kumar, Constanze Depp, Ting Sun, Imam Hassouna, Liane Wüstefeld, Sahab Arinrad, Matthias R. Zillmann, Nadine Schopf, Laura Fernandez Garcia-Agudo, Leonie Mohrmann, Ulli Bode, Anja Ronnenberg, Martin Hindermann, Sandra Goebbels, Stefan Bonn, Dörthe M. Katschinski, Kamilla W. Miskowiak, Klaus-Armin Nave, Hannelore Ehrenreich
Published in: Molecular Psychiatry, Issue 26(6), 2020, Page(s) 1790-1807, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-00988-w

Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis

Author(s): Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Published in: Acta Neuropathologica Communications, Issue 9, 2021, Page(s) 121, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01214-6

A role of oligodendrocytes in information processing

Author(s): Sharlen Moore, Martin Meschkat, Torben Ruhwedel, Andrea Trevisiol, Iva D. Tzvetanova, Arne Battefeld, Kathrin Kusch, Maarten H. P. Kole, Nicola Strenzke, Wiebke Möbius, Livia de Hoz, Klaus-Armin Nave
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19152-7

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

Author(s): Andrea Trevisiol, Kathrin Kusch, Anna M. Steyer, Ingo Gregor, Christos Nardis, Ulrike Winkler, Susanne Köhler, Alejandro Restrepo, Wiebke Möbius, Hauke B. Werner, Klaus-Armin Nave, Johannes Hirrlinger
Published in: PLOS Biology, Issue 18(11), 2020, ISSN 1545-7885
Publisher: San Francisco, CA : Public Library of Science, [2003]-
DOI: 10.1371/journal.pbio.3000943

Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

Author(s): Justus B. H. Wilke, Martin Hindermann, Stefan A. Berghoff, Svenja Zihsler, Sahab Arinrad, Anja Ronnenberg, Nadine Barnkothe, Agnes A. Steixner-Kumar, Stefan Röglin, Winfried Stöcker, Michael Hollmann, Klaus-Armin Nave, Fred Lühder, Hannelore Ehrenreich
Published in: Title Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01238-3

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Author(s): Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A. Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R. Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B. Werner, Henrik Martens, Kamilla Miskowiak, Sonja M. Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15041-1

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2

Author(s): Katja A. Lüders, Julia Patzig, Mikael Simons, Klaus-Armin Nave, Hauke B. Werner
Published in: Glia, Issue 65(11), 2017, Page(s) 1762 - 1776, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23193

Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats

Author(s): Thomas Prukop, Stephanie Wernick, Lydie Boussicault, David Ewers, Karoline Jäger, Julia Adam, Lorenz Winter, Susanne Quintes, Lisa Linhoff, Alonso Barrantes‐Freer, Michael Bartl, Dirk Czesnik, Jana Zschüntzsch, Jens Schmidt, Gwenaël Primas, Julien Laffaire, Philippe Rinaudo, Anthony Brureau, Serguei Nabirotchkin, Markus H. Schwab, Klaus‐Armin Nave, Rodolphe Hajj, Daniel Cohen, Michael W. Se
Published in: Journal of Neuroscience Research, Issue 98/10, 2020, Page(s) 1933-1952, ISSN 0360-4012
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24679

Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy

Author(s): Anna M. Steyer, Torben Ruhwedel, Christos Nardis, Hauke B. Werner, Klaus-Armin Nave, Wiebke Möbius
Published in: Journal of Structural Biology, Issue 210/2, 2020, Page(s) 107492, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2020.107492

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Author(s): Maria A. Eichel, Vasiliki-Ilya Gargareta, Elisa D’Este, Robert Fledrich, Theresa Kungl, Tobias J. Buscham, Katja A. Lüders, Cristina Miracle, Ramona B. Jung, Ute Distler, Kathrin Kusch, Wiebke Möbius, Swen Hülsmann, Stefan Tenzer, Klaus-Armin Nave, Hauke B. Werner
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18172-7

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

Author(s): Chaitali Mukherjee, Tina Kling, Belisa Russo, Kerstin Miebach, Eva Kess, Martina Schifferer, Liliana D. Pedro, Ulrich Weikert, Maryam K. Fard, Nirmal Kannaiyan, Moritz Rossner, Marie-Louise Aicher, Sandra Goebbels, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Anja Schneider, Mikael Simons
Published in: Cell Metabolism, Issue 32/2, 2020, Page(s) 259-272.e10, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.019

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

Author(s): Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Gesine Saher
Published in: Cell Reports, Issue 37(4), 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109889

Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease

Author(s): Fredrik I Gruenenfelder, Mark McLaughlin, Ian R Griffiths, James Garbern, Gemma Thomson, Peter Kuzman, Jennifer A Barrie, Maj-lis McCulloch, Jacques Penderis, Ruth Stassart, Klaus-Armin Nave, Julia M Edgar
Published in: Brain, Issue 143/5, 2020, Page(s) 1383-1399, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa080

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

Author(s): Ileana Micu, Jason R. Plemel, Andrew V. Caprariello, Klaus-Armin Nave, Peter K. Stys
Published in: Nature Reviews Neuroscience, Issue 19/1, 2018, Page(s) 49-58, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/nrn.2017.128

Myelin dynamics: protecting and shaping neuronal functions

Author(s): Aiman S Saab, Klaus-Armin Nave
Published in: Current Opinion in Neurobiology, Issue 47, 2017, Page(s) 104 - 112, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2017.09.013

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Author(s): Sandra Kleinecke, Sarah Richert, Livia de Hoz, Britta Brügger, Theresa Kungl, Ebrahim Asadollahi, Susanne Quintes, Judith Blanz, Rhona McGonigal, Kobra Naseri, Michael W Sereda, Timo Sachsenheimer, Christian Lüchtenborg, Wiebke Möbius, Hugh Willison, Myriam Baes, Klaus-Armin Nave, Celia Michèle Kassmann
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.23332

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

Author(s): Lotti M. Supplie, Tim Düking, Graham Campbell, Francisca Diaz, Carlos T. Moraes, Magdalena Götz, Bernd Hamprecht, Susann Boretius, Don Mahad, Klaus-Armin Nave
Published in: The Journal of Neuroscience, Issue 37/16, 2017, Page(s) 4231-4242, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.0756-16.2017

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

Author(s): Julia Patzig, Michelle S Erwig, Stefan Tenzer, Kathrin Kusch, Payam Dibaj, Wiebke Möbius, Sandra Goebbels, Nicole Schaeren-Wiemers, Klaus-Armin Nave, Hauke B Werner
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.17119

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Author(s): Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Published in: Cell Reports, Issue 18/2, 2017, Page(s) 314-323, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.12.053

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

Author(s): Aiman S. Saab, Iva D. Tzvetavona, Andrea Trevisiol, Selva Baltan, Payam Dibaj, Kathrin Kusch, Wiebke Möbius, Bianka Goetze, Hannah M. Jahn, Wenhui Huang, Heinz Steffens, Eike D. Schomburg, Alberto Pérez-Samartín, Fernando Pérez-Cerdá, Davood Bakhtiari, Carlos Matute, Siegrid Löwel, Christian Griesinger, Johannes Hirrlinger, Frank Kirchhoff, Klaus-Armin Nave
Published in: Neuron, Issue 91/1, 2016, Page(s) 119-132, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2016.05.016

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice

Author(s): Jan Winchenbach, Tim Düking, Stefan A. Berghoff, Sina K. Stumpf, Swen Hülsmann, Klaus-Armin Nave, Gesine Saher
Published in: F1000Research, Issue 5, 2016, Page(s) 2934, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.10509.1

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Author(s): Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda, Klaus-Armin Nave
Published in: Nature Neuroscience, Issue 19/8, 2016, Page(s) 1050-1059, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4321

Monitoring ATP dynamics in electrically active white matter tracts

Author(s): Andrea Trevisiol, Aiman S Saab, Ulrike Winkler, Grit Marx, Hiromi Imamura, Wiebke Möbius, Kathrin Kusch, Klaus-Armin Nave, Johannes Hirrlinger
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.24241

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Author(s): Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett
Published in: Neuron, Issue 93/6, 2017, Page(s) 1296-1313, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.02.005

Microglia ablation alleviates myelin-associated catatonic signs in mice

Author(s): Hana Janova, Sahab Arinrad, Evan Balmuth, Marina Mitjans, Johannes Hertel, Mohamad Habes, Robert A. Bittner, Hong Pan, Sandra Goebbels, Martin Begemann, Ulrike C. Gerwig, Sönke Langner, Hauke B. Werner, Sarah Kittel-Schneider, Georg Homuth, Christos Davatzikos, Henry Völzke, Brian L. West, Andreas Reif, Hans Jörgen Grabe, Susann Boretius, Hannelore Ehrenreich, Klaus-Armin Nave
Published in: Journal of Clinical Investigation, Issue 128/2, 2018, Page(s) 734-745, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI97032

Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia

Author(s): Marie-Theres Weil, Saskia Heibeck, Mareike Töpperwien, Susanne tom Dieck, Torben Ruhwedel, Tim Salditt, María C. Rodicio, Jennifer R. Morgan, Klaus-Armin Nave, Wiebke Möbius, Hauke B. Werner
Published in: The Journal of Neuroscience, Issue 38/29, 2018, Page(s) 6586-6596, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1034-18.2018

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Author(s): R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R. U. Rahman, D. Hermes, D. Ewers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W. C. Müller, S. Bonn, I. Bechmann, K. A. Nave, R. M. Stassart, M. W. Sereda
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05420-0

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Author(s): Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.36428

The Axon-Myelin Unit in Development and Degenerative Disease

Author(s): Ruth M. Stassart, Wiebke Möbius, Klaus-Armin Nave, Julia M. Edgar
Published in: Frontiers in Neuroscience, Issue 12, 2018, ISSN 1662-453X
Publisher: Frontiers Media SA
DOI: 10.3389/fnins.2018.00467

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Author(s): Robert Fledrich, Dagmar Akkermann, Vlad Schütza, Tamer A. Abdelaal, Doris Hermes, Erik Schäffner, M. Clara Soto-Bernardini, Tilmann Götze, Axel Klink, Kathrin Kusch, Martin Krueger, Theresa Kungl, Clara Frydrychowicz, Wiebke Möbius, Wolfgang Brück, Wolf C. Mueller, Ingo Bechmann, Michael W. Sereda, Markus H. Schwab, Klaus-Armin Nave, Ruth M. Stassart
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09385-6

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Author(s): Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.43888

Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease

Author(s): Sina K. Stumpf, Stefan A. Berghoff, Andrea Trevisiol, Lena Spieth, Tim Düking, Lennart V. Schneider, Lennart Schlaphoff, Steffi Dreha-Kulaczewski, Annette Bley, Dinah Burfeind, Kathrin Kusch, Miso Mitkovski, Torben Ruhwedel, Philipp Guder, Heiko Röhse, Jonas Denecke, Jutta Gärtner, Wiebke Möbius, Klaus-Armin Nave, Gesine Saher
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-01985-2

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Author(s): Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Düking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti-Castelvetri, Andrew O. Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Möbius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Si
Published in: Nature neuroscience., Issue 24(1), 2021, Page(s) 47-60, ISSN 1546-1726
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-00757-6

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons

Author(s): Katja A. Lüders, Stefan Nessler, Kathrin Kusch, Julia Patzig, Ramona B. Jung, Wiebke Möbius, Klaus-Armin Nave, Hauke B. Werner
Published in: Glia, Issue 67(4), 2019, Page(s) 634 - 649, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23549

Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit

Author(s): Charles C.H. Cohen, Marko A. Popovic, Jan Klooster, Marie-Theres Weil, Wiebke Möbius, Klaus-Armin Nave, Maarten H.P. Kole
Published in: Cell, Issue 180/2, 2020, Page(s) 311-322.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.11.039