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Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy

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Publications

Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis

Author(s): Shintouo CM, Ghogomu SM, Shey RA, Hotterbeekx A, Yagmur E, Mets T, Vanhamme L, Colebunders R, Souopgui J, Njemini R
Published in: Pathogens, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/life11121284

Association Between Ov16 Seropositivity and Neurocognitive Performance Among Children in Rural Cameroon: a Pilot Study

Author(s): Siewe Fodjo JN, Njamnshi WY, Ngarka L, Nfor LN, Ayuk C, Mundih NN, Ekwoge HT, Nganchfu K, Njamnshi KG, Yerema R, Ngoundjou P, Awasume E, Ashu G, Tabah EN, Colebunders R, Njamnshi AK
Published in: Journal of Pediatric Neuropsycholog, 2021, ISSN 2199-2673
Publisher: Springer Nature
DOI: 10.1007/s40817-021-00111-z

The World Health Organization road map for neglected tropical diseases 2021–2030: implications for onchocerciasis elimination programs

Author(s): Vieri, Melissa Krizia; Logora, Makoy Yibi; Rafiq, Kamran; Colebunders, Robert
Published in: Infectious Diseases of Poverty, 20, 2021, ISSN 2049-9957
Publisher: Springer
DOI: 10.1186/s40249-021-00848-x

Epilepsy in the Sanaga-Mbam valley, an onchocerciasis-endemic region in Cameroon: electroclinical and neuropsychological finding.

Author(s): Morin A, Guillaume M, Ngarka L, Tatah, GY, Siewe Fodjo JN, Wyart G, Nokam G, Tchoumi T, Nkinin MB, Njamnshi WY, Chokote ES, Boussinesq M, Colebunders R,Chesnais CB, Gargala G, Parain D, Njamnshi AK.
Published in: Epilepsia Open, 2021, Page(s) 2021 Sep;6(3):513-527., ISSN 2470-9239
Publisher: Wilay
DOI: 10.1002/epi4.12510

Ivermectin Treatment Response in Onchocerca Volvulus Infected Persons with Epilepsy: A Three-Country Short Cohort Study

Author(s): Alfred Dusabimana, Dan Bhwana, Stephen Raimon, Bruno P. Mmbando, An Hotterbeekx, Floribert Tepage, Michel Mandro, Joseph N. Siewe Fodjo, Steven Abrams, Robert Colebunders
Published in: Pathogens, 9/8, 2020, Page(s) 617, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9080617

Community perceptions and attitudes regarding epilepsy and disease cost after implementation of a community-based epilepsy treatment program in onchocerciasis-endemic communities in the Democratic Republic of Congo.

Author(s): Alfred Dusabimana; Michel Mandro; Joseph Nelson Siewe Fodjo; Husseini Dolo; Samuel Coenen; Robert Colebunders
Published in: 1525-5050, 2, 2021, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2021.107773

Risk Factors for Nodding Syndrome and Other Forms of Epilepsy in Northern Uganda: A Case-Control Study

Author(s): Gumisiriza N, Kugler M, Brusselaers N, Mubiru F, Anguzu R, Ningwa A, Ogwang R, Akun P, Mwaka AD, Abbo C, Sekibira R, Hotterbeekx A, Colebunders R, Marsh K, Idro R
Published in: Pathogen, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10111451

OV16 Seroprevalence among Persons with Epilepsy in Onchocerciasis Endemic Regions: A Multi-Country Study

Author(s): Alfred Dusabimana, Dan Bhwana, Michel Mandro, Bruno P. Mmbando, Joseph N. Siewe Fodjo, Robert Colebunders
Published in: Pathogens, 9/10, 2020, Page(s) 847, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9100847

Impact of COVID-19 on the lives and psychosocial well-being of persons with epilepsy during the third trimester of the pandemic: results from an international, online survey

Author(s): Charissa Millevert; Stijn Van Hees; Joseph Nelson Siewe Fodjo; Veerle Wijtvliet; Edlaine Faria de Moura Villela; Barbara Rosso; Antonio Gil-Nagel; Sarah Weckhuysen; Robert Colebunders
Published in: 1525-5050, 2, 2021, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2021.107800

Treatment of Pregnant Women with Ivermectin during Mass Drug Distribution: Time to Investigate Its Safety and Potential Benefits

Author(s): Erber AC, Ariyo E, Olliaro P, Nicolas P, Chaccour C, Colebunders R
Published in: Pathogens, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10121588

Onchocerca volvulus and epilepsy: A comprehensive review using the Bradford Hill criteria for causation.

Author(s): Robert Colebunders; Alfred K. Njamnshi; Sonia Menon; Charles R. Newton; An Hotterbeekx; Pierre-Marie Preux; Adrian Hopkins; Michel Vaillant; Joseph Nelson Siewe Fodjo
Published in: PLoS Neglected Tropical Diseases, 1, 2021, ISSN 1935-2735
Publisher: Plos
DOI: 10.1371/journal.pntd.0008965

Evidence for significant COVID-19 community transmission in Somalia using a clinical case definition

Author(s): Mohammed A.M. Ahmed, Robert Colebunders, Joseph Nelson Siewe Fodjo
Published in: International Journal of Infectious Diseases, 98, 2020, Page(s) 206-207, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2020.06.068

Surveillance for Onchocerciasis-Associated Epilepsy and OV16 IgG4 Testing of Children 6–10 Years Old Should Be Used to Identify Areas Where Onchocerciasis Elimination Programs Need Strengthening

Author(s): Dusabimana A, Siewe Fodjo JN, Ndahura MM, Mmbando BP, Jada SR, Boven A, De Smet E, Ukety T, Njamnshi AK, Laudisoit A, Abrams S, Colebunders R
Published in: Pathogens, 2022, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens11030281

No Evidence Known Viruses Play a Role in the Pathogenesis of Onchocerciasis-Associated Epilepsy. An Explorative Metagenomic Case-Control Study

Author(s): Michael Roach, Adrian Cantu, Melissa Krizia Vieri, Matthew Cotten, Paul Kellam, My Phan, Lia van der Hoek, Michel Mandro, Floribert Tepage, Germain Mambandu, Gisele Musinya, Anne Laudisoit, Robert Colebunders, Robert Edwards, John L. Mokili
Published in: Pathogens, 10/7, 2021, Page(s) 787, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070787

Onchocerciasis Prevalence among Persons with Epilepsy in an Onchocerciasis Hypo-Endemic Area in the Democratic Republic of Congo: A Cross-Sectional Study

Author(s): An Hotterbeekx, Kristien Verdonck, Deby Mukendi, Jean-Roger Lilo-Kalo, Pascal Lutumba, Marleen Boelaert, Liselotte Hardy, Barbara Barbé, Jan Jacobs, Emmanuel Bottieau, Robert Colebunders
Published in: Pathogens, 10/4, 2021, Page(s) 389, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10040389

Potential parasitic causes of epilepsy in an onchocerciasis endemic area in the Ituri province, Democratic Republic of Congo

Author(s): Melissa Krizia Vieri; Michel Mandro; Chiara Simona Cardellino; Pierantonio Orza; Niccolò Ronzoni; Joseph Nelson Siewe Fodjo; An Hotterbeekx; Robert Colebunders
Published in: 2076-0817, 4, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10030359

COVID-19 in Somalia: Adherence to Preventive Measures and Evolution of the Disease Burden

Author(s): Mohammed A. M. Ahmed, Joseph Nelson Siewe Fodjo, Abdi A. Gele, Abdiqani A. Farah, Shariff Osman, Ibraahim Abdullahi Guled, Abdiaziz Mohamed Ali, Robert Colebunders
Published in: Pathogens, 9/9, 2020, Page(s) 735, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9090735

Onchocerca volvulus transmission in the Mbam valley of Cameroon following 16 years of annual community-directed treatment with ivermectin, and the description of a new cytotype of Simulium squamosum

Author(s): Hendy A, Krit M, Pfarr K, Laemmer C, De Witte J, Nwane P, Kamgno J, Nana-Djeunga HC, Boussinesq M, Dujardin JC, Post R, Colebunders R, O'Neill S, Enyong P, Njamnshi AK
Published in: Parasites and Vectors, 2021, ISSN 1756-3305
Publisher: BioMed Central
DOI: 10.1186/s13071-021-05072-y

Neuropathological Changes in Nakalanga Syndrome—A Case Report

Author(s): An Hotterbeekx, Martin Lammens, Sylvester Onzivua, Robert Lukande, Francis Olwa, Samir Kumar-Singh, Stijn Van Hees, Richard Idro, Robert Colebunders
Published in: Pathogens, 10/2, 2021, Page(s) 116, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10020116

"""Slash and Clear"", a Community-Based Vector Control Method to Reduce Onchocerciasis Transmission by Simulium sirbanum in Maridi, South Sudan: A Prospective Study"

Author(s): Raimon S, Lakwo TL, Sebit WJ, Siewe Fodjo JN, Alinda P, Carter JY, Post RJ, Colebunders R.
Published in: Pathogens, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10101329

Ivermectin Should Not Be Recommended to Treat Severe Acute Respiratory Syndrome 2 Infection

Author(s): Boven AG, Kenyon C, Colebunders R
Published in: Open Forum Infectious Diseases, 2021, ISSN 2328-8957
Publisher: Oxford University Press
DOI: 10.1093/ofid/ofab456.

Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus

Author(s): R. Colebunders, P. Suykerbuyk, S.T. Jacob, M. van Oijen
Published in: Journal of the Neurological Sciences, 372, 2017, Page(s) 439-440, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2016.10.008

Follow-Up Survey of the Impact of COVID-19 on People Living with HIV during the Second Semester of the Pandemic

Author(s): Joseph Nelson Siewe Fodjo, Edlaine Faria de Moura Villela, Stijn Van Hees, Pieter Vanholder, Patrick Reyntiens, Robert Colebunders
Published in: International Journal of Environmental Research and Public Health, 18/9, 2021, Page(s) 4635, ISSN 1660-4601
Publisher: BMC
DOI: 10.3390/ijerph18094635

Factors associated with adherence to COVID-19 prevention measures in the Democratic Republic of the Congo (DRC): results of an online survey.

Author(s): John Ditekemena; Dalau Mukadi Nkamba; Dalau Mukadi Nkamba; Dalau Mukadi Nkamba; Hypolite Mavoko Muhindo; Joseph Nelson Fodjo Siewe; Christophe Luhata; Rafael Van den Bergh; Antoinette Tshefu Kitoto; Wim Van Damme; Jean Jacques Muyembe; Robert Colebunders
Published in: BMJ open, 1, 2021, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-043356

Nodding syndrome research re-visited.

Author(s): Melissa Krizia Vieri; Adam Hendy; John L. Mokili; Robert Colebunders
Published in: International Journal Infectious Diseases, 1, 2021, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2021.02.006

Access to healthcare and prevalence of anxiety and depression in persons with epilepsy during the COVID-19 pandemic: A multicountry online survey

Author(s): Stijn Van Hees, Joseph Nelson Siewe Fodjo, Veerle Wijtvliet, Rafael Van den Bergh, Edlaine Faria de Moura Villela, Carolina Ferreira da Silva, Sarah Weckhuysen, Robert Colebunders
Published in: Epilepsy & Behavior, 112, 2020, Page(s) 107350, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2020.107350

Prevalence and risk factors associated with epilepsy in six health districts of Mali: a community-based cross-sectional and nested case-control study.

Author(s): AB, Fomba Z, Gari M, Kotchene CE, Orsot KE, Diarra D, Colebunders R, Coulibaly YI, Sangho H, Maiga YM, Doumbia S.
Published in: Neuroepidemiology, 2022, ISSN 0251-5350
Publisher: S. Karger AG
DOI: 10.1159/000522021

COVID-19 Preventive Behaviours in Cameroon: A Six-Month Online National Survey

Author(s): Joseph Nelson Siewe Fodjo, Leonard Ngarka, Wepnyu Y. Njamnshi, Leonard N. Nfor, Michel K. Mengnjo, Edwige L. Mendo, Samuel A. Angwafor, Jonas Guy Atchou Basseguin, Cyrille Nkouonlack, Edith N. Njit, Nene Ahidjo, Eric Samuel Chokote, Fidèle Dema, Julius Y. Fonsah, Godwin Y. Tatah, Nancy Palmer, Paul F. Seke Etet, Dennis Palmer, Dickson S. Nsagha, Daniel E. Etya’ale, Stephen Perrig, Roman Sztajze
Published in: International Journal of Environmental Research and Public Health, 18/5, 2021, Page(s) 2554, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18052554

Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: A focus on the children

Author(s): Colebunders R, Kaiser C, Basáñez MG, Olliaro P, Lakwo T, Fodjo JNS
Published in: International Journal Infectious Diseases, 2022, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2022.01.042

Serotonin Levels in the Serum of Persons with Onchocerciasis-Associated Epilepsy: A Case-Control Study

Author(s): Melissa Krizia Vieri; An Hotterbeekx; Michel Mandro; Joseph Nelson Siewe Fodjo; Alfred Dusabimana; Francoise Nyisi; Deby Mukendi; Joe Gwatsvaira; Samir Kumar-Singh; Robert Colebunders
Published in: Pathogens, Vol 10, Iss 720, p 720 (2021), 2, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10060720

A peer support group intervention to decrease epilepsy-related stigma in an onchocerciasis-endemic area in Mahenge, Tanzania: A pilot study

Author(s): Bhwana D, Das L, Siewe Fodjo JN, Francis F, Challe DP, Makunde HW, Mmbando BP, Colebunders R
Published in: Epilepsy and Behaviour, 2021, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2021.108372

Epilepsy in the Sanaga-Mbam valley, an onchocerciasis-endemic region in Cameroon: electroclinical and neuropsychological findings

Author(s): Morin A, Guillaume M, Ngarka L, Tatah GY, Siewe Fodjo JN, Wyart G, Nokam G, Tchoumi T, Nkinin MB, Njamnshi WY, Chokote ES, Boussinesq M, Colebunders R, Chesnais CB, Gargala G, Parain D, Njamnshi AK
Published in: Epilepsia Open, 2022, ISSN 2470-9239
Publisher: Willay
DOI: 10.1002/epi4.12510.

Nodding syndrome: Preventable and treatable

Author(s): Robert Colebunders, Maarten J. Titulaer
Published in: Science Translational Medicine, 9/377, 2017, Page(s) eaam8532, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam8532

Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial

Author(s): Robert Colebunders, Michel Mandro, Deby Mukendi, Housseini Dolo, Patrick Suykerbuyk, Marieke Van Oijen
Published in: JMIR Research Protocols, 6/8, 2017, Page(s) e137, ISSN 1929-0748
Publisher: Creative Commons Attribution License
DOI: 10.2196/resprot.7186

The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania

Author(s): Adam Hendy, Andreas Krüger, Kenneth Pfarr, Jacobus De Witte, Addow Kibweja, Upendo Mwingira, Jean-Claude Dujardin, Rory Post, Robert Colebunders, Sarah O’Neill, Akili Kalinga
Published in: Acta Tropica, 181, 2018, Page(s) 50-59, ISSN 0001-706X
Publisher: Elsevier BV
DOI: 10.1016/j.actatropica.2018.01.009

High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo

Author(s): Bethany Levick, Anne Laudisoit, Floribert Tepage, Chellafe Ensoy-Musoro, Michel Mandro, Caroline Bonareri Osoro, Patrick Suykerbuyk, Jean Marie Kashama, Michel Komba, Alliance Tagoto, Dadi Falay, Michael Begon, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, 11/7, 2017, Page(s) e0005732, ISSN 1935-2735
Publisher: Public Library of Science
DOI: 10.1371/journal.pntd.0005732

Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications

Author(s): Robert Colebunders, Alfred K. Njamnshi, Marieke van Oijen, Deby Mukendi, Jean Marie Kashama, Michel Mandro, Nolbert Gumisiriza, Pierre-Marie Preux, Patrick Suykerbuyk, Richard Idro
Published in: Epilepsia Open, 2/2, 2017, Page(s) 145-152, ISSN 2470-9239
Publisher: Wiley Online Library
DOI: 10.1002/epi4.12054

Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus

Author(s): R. Colebunders, P. Suykerbuyk, S.T. Jacob, M. van Oijen
Published in: Journal of the Neurological Sciences, 372, 2017, Page(s) 439-440, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2016.10.008

Nodding syndrome—we can now prevent it

Author(s): Robert Colebunders, Julia Irani, Rory Post
Published in: International Journal of Infectious Diseases, 44, 2016, Page(s) 61-63, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2016.01.016

Nodding Syndrome in Onchocerciasis Endemic Areas

Author(s): R. Colebunders, A. Hendy, M. van Oijen
Published in: Trends in Parasitology, 32/8, 2016, Page(s) 581-583, ISSN 1471-4922
Publisher: Elsevier BV
DOI: 10.1016/j.pt.2016.05.013

Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case–control study

Author(s): Robert Colebunders, Michel Mandro, John L. Mokili, Gisele Mucinya, Germain Mambandu, Kenneth Pfarr, Ingrid Reiter-Owona, Achim Hoerauf, Floribert Tepage, Bethanie Levick, Michael Begon, Anne Laudisoit
Published in: International Journal of Infectious Diseases, 49, 2016, Page(s) 1-8, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2016.05.018

Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs

Author(s): Robert Colebunders, F.J. Nelson Siewe, An Hotterbeekx
Published in: Trends in Parasitology, 34/3, 2018, Page(s) 208-216, ISSN 1471-4922
Publisher: Elsevier BV
DOI: 10.1016/j.pt.2017.11.009

Evolution of epilepsy prevalence and incidence in a Tanzanian area endemic for onchocerciasis and the potential impact of community-directed treatment with ivermectin: a cross-sectional study and comparison over 28 years

Author(s): Helena Greter, Bruno Mmbando, Williams Makunde, Mohamed Mnacho, William Matuja, Advocatus Kakorozya, Patrick Suykerbuyk, Robert Colebunders
Published in: BMJ Open, 8/3, 2018, Page(s) e017188, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2017-017188

From river blindness control to elimination: bridge over troubled water

Author(s): Robert Colebunders, Maria-Gloria Basáñez, Katja Siling, Rory J. Post, Anke Rotsaert, Bruno Mmbando, Patrick Suykerbuyk, Adrian Hopkins
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: BioMed Central
DOI: 10.1186/s40249-018-0406-7

Report of the first international workshop on onchocerciasis-associated epilepsy

Author(s): Robert Colebunders, Michel Mandro, Alfred K. Njamnshi, Michel Boussinesq, An Hotterbeekx, Joseph Kamgno, Sarah O’Neill, Adrian Hopkins, Patrick Suykerbuyk, Maria-Gloria Basáñez, Rory J. Post, Belén Pedrique, Pierre-Marie Preux, Wilma A. Stolk, Thomas B. Nutman, Richard Idro
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: BioMed Central
DOI: 10.1186/s40249-018-0400-0

The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan: a study protocol

Author(s): Gasim Abd-Elfarag, Makoy Yibi Logora, Jane Y. Carter, Morrish Ojok, Jackson Songok, Sonia Menon, Ferdinand Wit, Richard Lako, Robert Colebunders
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: Springer Nature
DOI: 10.1186/s40249-018-0496-2

Burden of onchocerciasis-associated epilepsy: first estimates and research priorities

Author(s): Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: Springer Nature
DOI: 10.1186/s40249-018-0481-9

High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with ivermectin

Author(s): Bruno P. Mmbando, Patrick Suykerbuyk, Mohamed Mnacho, Advocatus Kakorozya, William Matuja, Adam Hendy, Helena Greter, Williams H. Makunde, Robert Colebunders
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: Springer Nature
DOI: 10.1186/s40249-018-0450-3

Community perceptions of epilepsy and its treatment in an onchocerciasis endemic region in Ituri, Democratic Republic of Congo

Author(s): Housseini Dolo, Michel Mandro, Deogratias Wonya’Rossi, Francoise Ngave, Jessica Fraeyman, Joseph N. Siewe, Patrick Suykerbuyk, Robert Colebunders
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: Springer Nature
DOI: 10.1186/s40249-018-0498-0

High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo

Author(s): Evy Lenaerts, Michel Mandro, Deby Mukendi, Patrick Suykerbuyk, Housseini Dolo, Deogratias Wonya’Rossi, Françoise Ngave, Chellafe Ensoy-Musoro, Anne Laudisoit, An Hotterbeekx, Robert Colebunders
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: Springernature
DOI: 10.1186/s40249-018-0452-1

Histological examination of post-mortem brains of children with nodding syndrome

Author(s): An Hotterbeekx, Sylvester Onzivua, Sonia Menon, Robert Colebunders
Published in: Annals of Translational Medicine, 6/7, 2018, Page(s) 134-134, ISSN 2305-5839
Publisher: Elsevier
DOI: 10.21037/atm.2018.02.04

High prevalence of epilepsy in an onchocerciasis endemic health zone in the Democratic Republic of the Congo, despite 14 years of community-directed treatment with ivermectin: A mixed-method assessment

Author(s): Deby Mukendi, Floribert Tepage, Innocent Akonda, Joseph Nelson Fodjo Siewe, Anke Rotsaert, Carl Nwana Ndibmun, Anne Laudisoit, Simon Couvreur, Blandine Kabutako, Sonia Menon, An Hotterbeekx, Robert Colebunders
Published in: International Journal of Infectious Diseases, 79, 2019, Page(s) 187-194, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/J.IJID.2018.10.021

Clinical characteristics of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan

Author(s): Robert Colebunders, Gasim Abd-Elfarag, Jane Y. Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora
Published in: Seizure, 62, 2018, Page(s) 108-115, ISSN 1059-1311
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/J.SEIZURE.2018.10.004

High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan: A community-based survey

Author(s): Robert Colebunders, Jane Y Carter, Peter Claver Olore, Kai Puok, Samit Bhattacharyya, Sonia Menon, Gasim Abd-Elfarag, Morrish Ojok, Chellafe Ensoy-Musoro, Richard Lako, Makoy Yibi Logora
Published in: Seizure, 63, 2018, Page(s) 93-101, ISSN 1059-1311
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/J.SEIZURE.2018.11.004

Nodding Syndrome May Be Only the Ears of the Hippo

Author(s): Joseph Francis Wamala, Mugagga Malimbo, Floribert Tepage, Luswa Lukwago, Charles Lukoya Okot, Robert O. Cannon, Anne Laudisoit, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, 9/8, 2015, Page(s) e0003880, ISSN 1935-2735
Publisher: Plos
DOI: 10.1371/journal.pntd.0003880

Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures

Author(s): Nolbert Gumisiriza, Frank Mubiru, Joseph Nelson Siewe Fodjo, Martin Mbonye Kayitale, An Hotterbeekx, Richard Idro, Issa Makumbi, Tom Lakwo, Bernard Opar, Joice Kaducu, Joseph Francis Wamala, Robert Colebunders
Published in: Infectious Diseases of Poverty, 9/1, 2020, ISSN 2049-9957
Publisher: Elsevier
DOI: 10.1186/S40249-020-0628-3

Low ivermectin use among 5- to 6-year-old children: observations from door-to-door surveys in onchocerciasis-endemic regions in Africa

Author(s): J N Siewe Fodjo, F Mubiru, C Ukaga, M Y Logora, B P Mmbando, M Mandro, A K Njamnshi, R Colebunders
Published in: International Health, 12/1, 2019, Page(s) 72-75, ISSN 1876-3413
Publisher: Elsevier BV
DOI: 10.1093/INTHEALTH/IHZ044

Neuroinflammation and Not Tauopathy Is a Predominant Pathological Signature of Nodding Syndrome

Author(s): An Hotterbeekx, Martin Lammens, Richard Idro, Pamela R Akun, Robert Lukande, Geoffrey Akena, Avindra Nath, Joneé Taylor, Francis Olwa, Samir Kumar-Singh, Robert Colebunders
Published in: Journal of Neuropathology & Experimental Neurology, 78/11, 2019, Page(s) 1049-1058, ISSN 0022-3069
Publisher: American Association of Neuropathologists, Inc.
DOI: 10.1093/jnen/nlz090

Prevalence of River Epilepsy in the Orientale Province in the Democratic Republic of the Congo

Author(s): Robert Colebunders, Floribert Tepage, Ente Rood, Michel Mandro, Emmanuel Nji Abatih, Gisele Musinya, Germain Mambandu, José Kabeya, Michel Komba, Bethany Levick, John L Mokili, Anne Laudisoit
Published in: PLOS Neglected Tropical Diseases, 10/5, 2016, Page(s) e0004478, ISSN 1935-2735
Publisher: Plos
DOI: 10.1371/journal.pntd.0004478

Ivermectin use in children below 15 kg: potential benefits for onchocerciasis and scabies elimination programmes

Author(s): R. Colebunders, S.T. Wafula, A. Hotterbeekx, J. N. Siewe‐Fodjo
Published in: British Journal of Dermatology, 182/4, 2020, Page(s) 1064-1064, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/BJD.18685

Low prevalence of epilepsy and onchocerciasis after more than 20 years of ivermectin treatment in the Imo River Basin in Nigeria

Author(s): Joseph N. F. Siewe, Chinyere N. Ukaga, Ernest O. Nwazor, Murphy O. Nwoke, Modebelu C. Nwokeji, Blessing C. Onuoha, Simon O. Nwanjor, Joel Okeke, Kate Osahor, Lilian Chimechefulam, Ann I. Ogomaka, Augustine A. Amaechi, Chika I. Ezenwa, Monika N. Ezike, Chidimma Ikpeama, Ogechi Nwachukwu, Austine I. Eriama-Joseph, Berthram E. B. Nwoke, Robert Colebunders
Published in: Infectious Diseases of Poverty, 8/1, 2019, ISSN 2049-9957
Publisher: Elsevier
DOI: 10.1186/s40249-019-0517-9

Onchocerca volvulus is not detected in the cerebrospinal fluid of persons with onchocerciasis-associated epilepsy

Author(s): An Hotterbeekx, Stephen Raimon, Gasim Abd-Elfarag, Jane Y. Carter, Wilson Sebit, Abozer Suliman, Joseph Nelson Siewe Fodjo, Peter De Witte, Makoy Yibi Logora, Robert Colebunders, Samir Kumar-Singh
Published in: International Journal of Infectious Diseases, 91, 2020, Page(s) 119-123, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/J.IJID.2019.11.029

Onchocerca volvulus as a risk factor for developing epilepsy in onchocerciasis endemic regions in the Democratic Republic of Congo: a case control study

Author(s): Michel Mandro, Patrick Suykerbuyk, Floribert Tepage, Degratias Rossy, Francoise Ngave, Mirza Nazmul Hasan, An Hotterbeekx, Germain Mambandu, Jean Marie Kashama, Anne Laudisoit, Robert Colebunders
Published in: Infectious Diseases of Poverty, 7/1, 2018, ISSN 2049-9957
Publisher: ELsevier
DOI: 10.1186/s40249-018-0465-9

From river blindness to river epilepsy: Implications for onchocerciasis elimination programmes

Author(s): Robert Colebunders, Joseph Nelson Siewe Fodjo, Adrian Hopkins, An Hotterbeekx, Thomson L. Lakwo, Akili Kalinga, Makoy Yibi Logora, Maria-Gloria Basáñez
Published in: PLOS Neglected Tropical Diseases, 13/7, 2019, Page(s) e0007407, ISSN 1935-2735
Publisher: PLOS
DOI: 10.1371/journal.pntd.0007407

Impact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in Cameroon

Author(s): Charlotte Boullé, Alfred K. Njamnshi, Fidèle Dema, Michel K. Mengnjo, Joseph Nelson Siewe Fodjo, Anne-Cécile Zoung-Kanyi Bissek, Patrick Suykerbuyk, Cédric G. Lenou-Nanga, Hugues C. Nana-Djeunga, Joseph Kamgno, Cédric B. Chesnais, Michel Boussinesq, Robert Colebunders
Published in: Parasites & Vectors, 12/1, 2019, ISSN 1756-3305
Publisher: BioMed Central
DOI: 10.1186/s13071-019-3345-7

Nodding syndrome since 2012: recent progress, challenges and recommendations for future research

Author(s): R. Colebunders, R. Post, S. O'Neill, G. Haesaert, B. Opar, T. Lakwo, A. Laudisoit, A. Hendy
Published in: Tropical Medicine & International Health, 20/2, 2015, Page(s) 194-200, ISSN 1360-2276
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tmi.12421

Epidemiological evidence concerning the association between onchocerciasis and epilepsy

Author(s): J.N. Siewe Fodjo, F. Tepage, R. Colebunders
Published in: International Journal of Infectious Diseases, 82, 2019, Page(s) 77-78, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/J.IJID.2019.03.015

Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania

Author(s): Bhwana, Dan; Mmbando, Bruno P.; Dekker, Marieke C.J.; Mnacho, Mohamed; Makunde, Williams H.; Weckhuysen, Sarah; Colebunders, Robert
Published in: Epileptic disorders, 1, 2019, ISSN 1950-6945
Publisher: John Wiley and sons
DOI: 10.1684/EPD.2019.1093

Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?

Author(s): Joseph Nelson Siewe Fodjo, Marina Kugler, An Hotterbeekx, Adam Hendy, Jean-Pierre Van Geertruyden, Robert Colebunders
Published in: Infectious Diseases of Poverty, 8/1, 2019, ISSN 2049-9957
Publisher: Elsevier
DOI: 10.1186/s40249-019-0588-7

Elimination of onchocerciasis in Africa by 2025: an ambitious target requires ambitious interventions

Author(s): Robert Colebunders, Wilma A. Stolk, Joseph Nelson Siewe Fodjo, Charles D. Mackenzie, Adrian Hopkins
Published in: Infectious Diseases of Poverty, 8/1, 2019, ISSN 2049-9957
Publisher: Elsevier
DOI: 10.1186/s40249-019-0593-x

Nodding syndrome—a new hypothesis and new direction for research

Author(s): Robert Colebunders, Adam Hendy, Miriam Nanyunja, Joseph Francis Wamala, Marieke van Oijen
Published in: International Journal of Infectious Diseases, 27, 2014, Page(s) 74-77, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2014.08.001

Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo

Author(s): An Hotterbeekx, Jolien Perneel, Michel Mandro, Germain Abhafule, Joseph Nelson Siewe Siewe Fodjo, Alfred Dusabimana, Steven Abrams, Samir Kumar-Singh, Robert Colebunders
Published in: Pathogens, 9/6, 2020, Page(s) 435, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9060435

Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic

Author(s): Eric de Smet, Salvatore Metanmo, Pascal Mbelesso, Benoit Kemata, Joseph N. Siewe Fodjo, Farid Boumédiène, Hilda T. Ekwoge, Emmanuel Yangatimbi, Daniel Ajzenberg, Orphee Badibanga, Pierre-Marie Preux, Robert Colebunders
Published in: Pathogens, 9/5, 2020, Page(s) 337, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9050337

The Role of the Maridi Dam in Causing an Onchocerciasis-Associated Epilepsy Epidemic in Maridi, South Sudan: An Epidemiological, Sociological, and Entomological Study

Author(s): T. L. Lakwo, S. Raimon, M. Tionga, J. N. Siewe Fodjo, P. Alinda, W. J. Sebit, J. Y. Carter, R. Colebunders
Published in: Pathogens, 9/4, 2020, Page(s) 315, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9040315

From nodding syndrome to onchocerciasis-associated epilepsy

Author(s): A. Hotterbeekx, S. Van Hees, J.N. Siewe Fodjo, R. Colebunders
Published in: Revue Neurologique, 176/5, 2020, Page(s) 405-406, ISSN 0035-3787
Publisher: Elsevier Masson
DOI: 10.1016/j.neurol.2019.12.011

Single versus Multiple Dose Ivermectin Regimen in Onchocerciasis-Infected Persons with Epilepsy Treated with Phenobarbital: A Randomized Clinical Trial in the Democratic Republic of Congo

Author(s): Michel Mandro, Joseph Nelson Siewe Fodjo, Alfred Dusabimana, Deby Mukendi, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, D Wonya’rossi, An Hotterbeekx, Steven Abrams, Robert Colebunders
Published in: Pathogens, 9/3, 2020, Page(s) 205, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9030205

Urinary N-acetyltyramine-O,β-glucuronide in Persons with Onchocerciasis-Associated Epilepsy

Author(s): An Hotterbeekx, Alfred Dusabimana, Michel Mandro, Germain M Abhafule, Wonya’Rossy Deogratias, Joseph N. Siewe Fodjo, Steven Abrams, Robert Colebunders
Published in: Pathogens, 9/3, 2020, Page(s) 191, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens9030191

Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control

Author(s): Joseph Nelson Siewe Fodjo, Jan H F Remme, Pierre-Marie Preux, Robert Colebunders
Published in: International Health, 12/3, 2020, Page(s) 192-202, ISSN 1876-3413
Publisher: Elsevier BV
DOI: 10.1093/inthealth/ihaa012

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial

Author(s): Michel Mandro, Joseph Nelson Siewe Fodjo, Deby Mukendi, Alfred Dusabimana, Sonia Menon, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, Deogratias Wonya’Rossi, Jean Marie Jakwong, Patrick Suykerbuyk, Jacques Meganck, An Hotterbeekx, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, 14/1, 2020, Page(s) e0007966, ISSN 1935-2735
Publisher: Plos
DOI: 10.1371/journal.pntd.0007966

Safety of ivermectin during pregnancy

Author(s): Stijn Van Hees, Stephen Raimon, Joseph Nelson Siewe Fodjo, Robert Colebunders
Published in: The Lancet Global Health, 8/3, 2020, Page(s) e338, ISSN 2214-109X
Publisher: Elsevier BV
DOI: 10.1016/s2214-109x(19)30555-8

Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo

Author(s): Sofie Velghe, Lisa Delahaye, Rodney Ogwang, An Hotterbeekx, Robert Colebunders, Michel Mandro, Richard Idro, Christophe P. Stove
Published in: Therapeutic Drug Monitoring, 42/3, 2020, Page(s) 481-490, ISSN 0163-4356
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ftd.0000000000000720

Nodding syndrome research, lessons learned from the NSETHIO project

Author(s): D. Geelhand de Merxem, J. N. Siewe Fodjo, S. Menon, A. Hotterbeekx, R. Colebunders
Published in: Global Mental Health, 6, 2019, ISSN 2054-4251
Publisher: Oxford
DOI: 10.1017/gmh.2019.24

Epilepsy prevention

Author(s): Joseph Nelson Siewe Fodjo, Yibi Logora Makoy, Robert Colebunders
Published in: The Lancet, 394/10214, 2019, Page(s) 2072, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(19)31906-3

Community perception of epilepsy and its treatment in onchocerciasis-endemic villages of Maridi county, western equatoria state, South Sudan.

Author(s): Jada SR, Tionga MS, Siewe Fodjo JN, Carter JY, Logora MY, Colebunders R.
Published in: Epilepsy Behav, 2022, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2021.108537

Impact of COVID-19 on the lives and psychosocial well-being of persons with epilepsy during the third trimester of the pandemic: Results from an international, online survey

Author(s): Charissa Millevert, Stijn Van Hees, Joseph Nelson Siewe Fodjo, Veerle Wijtvliet, Edlaine Faria de Moura Villela, Barbara Rosso, Antonio Gil-Nagel, Sarah Weckhuysen, Robert Colebunders
Published in: Epilepsy & Behavior, 116, 2021, Page(s) 107800, ISSN 1525-5050
Publisher: Academic Press
DOI: 10.1016/j.yebeh.2021.107800

High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey

Author(s): Stephen Raimon; Alfred Dusabimana; Gasim Abd-Elfarag; Samuel Okaro; Jane Y. Carter; Charles R. Newton; Makoy Yibi Logora; Robert Colebunders
Published in: Pathogens, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10050599

The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy

Author(s): An Hotterbeekx; An Hotterbeekx; Jolien Perneel; Jolien Perneel; Melissa Krizia Vieri; Melissa Krizia Vieri; Robert Colebunders; Samir Kumar-Singh
Published in: 2235-2988, 3, 2021, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.662766

Epilepsy-related stigma and cost in two onchocerciasis-endemic areas in South Sudan: A pilot descriptive study

Author(s): Stephen Raimon Jada, Joseph Nelson Siewe Fodjo, Gasim Abd-Elfarag, Moses Tionga, Jane Y. Carter, Makoy Yibi Logora, Charles Newton, Robert Colebunders
Published in: Seizure, 81, 2020, Page(s) 151-156, ISSN 1059-1311
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.seizure.2020.08.003

Nodding syndrome, many questions remain but we can prevent it by eliminating onchocerciasis.

Author(s): Nolbert Gumisiriza; Melissa Krizia Vieri; Robert Colebunders
Published in: Brain Communications, 1, 2021, ISSN 2632-1297
Publisher: Oxford Academic
DOI: 10.1093/braincomms/fcaa228

No Evidence for the Involvement of Leiomodin-1 Antibodies in the Pathogenesis of Onchocerciasis-Associated Epilepsy

Author(s): An Hotterbeekx, Melissa Krizia Vieri, Melanie Ramberger, Ashraf Jozefzoon-Aghai, Michel Mandro, Floribert Tepage, Alfred Dusabimana, Samir Kumar-Singh, Maarten J. Titulaer, Robert Colebunders
Published in: Pathogens, 10/7, 2021, Page(s) 845, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070845

Cytokines and Onchocerciasis-Associated Epilepsy, a Pilot Study and Review of the Literature

Author(s): Melissa Krizia Vieri; An Hotterbeekx; Stephen Raimon; Gasim Abd-Elfarag; Deby Mukendi; Jane Y. Carter; Samir Kumar-Singh; Robert Colebunders
Published in: 2076-0817, 7, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10030310