Skip to main content

Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy

Searching for OpenAIRE data...

Publications

Nodding syndrome: Preventable and treatable

Author(s): Robert Colebunders, Maarten J. Titulaer
Published in: Science Translational Medicine, Issue 9/377, 2017, Page(s) eaam8532, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aam8532

Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial

Author(s): Robert Colebunders, Michel Mandro, Deby Mukendi, Housseini Dolo, Patrick Suykerbuyk, Marieke Van Oijen
Published in: JMIR Research Protocols, Issue 6/8, 2017, Page(s) e137, ISSN 1929-0748
DOI: 10.2196/resprot.7186

The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania

Author(s): Adam Hendy, Andreas Krüger, Kenneth Pfarr, Jacobus De Witte, Addow Kibweja, Upendo Mwingira, Jean-Claude Dujardin, Rory Post, Robert Colebunders, Sarah O’Neill, Akili Kalinga
Published in: Acta Tropica, Issue 181, 2018, Page(s) 50-59, ISSN 0001-706X
DOI: 10.1016/j.actatropica.2018.01.009

High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo

Author(s): Bethany Levick, Anne Laudisoit, Floribert Tepage, Chellafe Ensoy-Musoro, Michel Mandro, Caroline Bonareri Osoro, Patrick Suykerbuyk, Jean Marie Kashama, Michel Komba, Alliance Tagoto, Dadi Falay, Michael Begon, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, Issue 11/7, 2017, Page(s) e0005732, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0005732

Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications

Author(s): Robert Colebunders, Alfred K. Njamnshi, Marieke van Oijen, Deby Mukendi, Jean Marie Kashama, Michel Mandro, Nolbert Gumisiriza, Pierre-Marie Preux, Patrick Suykerbuyk, Richard Idro
Published in: Epilepsia Open, Issue 2/2, 2017, Page(s) 145-152, ISSN 2470-9239
DOI: 10.1002/epi4.12054

Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus

Author(s): R. Colebunders, P. Suykerbuyk, S.T. Jacob, M. van Oijen
Published in: Journal of the Neurological Sciences, Issue 372, 2017, Page(s) 439-440, ISSN 0022-510X
DOI: 10.1016/j.jns.2016.10.008

Nodding syndrome—we can now prevent it

Author(s): Robert Colebunders, Julia Irani, Rory Post
Published in: International Journal of Infectious Diseases, Issue 44, 2016, Page(s) 61-63, ISSN 1201-9712
DOI: 10.1016/j.ijid.2016.01.016

Nodding Syndrome in Onchocerciasis Endemic Areas

Author(s): R. Colebunders, A. Hendy, M. van Oijen
Published in: Trends in Parasitology, Issue 32/8, 2016, Page(s) 581-583, ISSN 1471-4922
DOI: 10.1016/j.pt.2016.05.013

Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case–control study

Author(s): Robert Colebunders, Michel Mandro, John L. Mokili, Gisele Mucinya, Germain Mambandu, Kenneth Pfarr, Ingrid Reiter-Owona, Achim Hoerauf, Floribert Tepage, Bethanie Levick, Michael Begon, Anne Laudisoit
Published in: International Journal of Infectious Diseases, Issue 49, 2016, Page(s) 1-8, ISSN 1201-9712
DOI: 10.1016/j.ijid.2016.05.018

Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs

Author(s): Robert Colebunders, F.J. Nelson Siewe, An Hotterbeekx
Published in: Trends in Parasitology, Issue 34/3, 2018, Page(s) 208-216, ISSN 1471-4922
DOI: 10.1016/j.pt.2017.11.009

Evolution of epilepsy prevalence and incidence in a Tanzanian area endemic for onchocerciasis and the potential impact of community-directed treatment with ivermectin: a cross-sectional study and comparison over 28 years

Author(s): Helena Greter, Bruno Mmbando, Williams Makunde, Mohamed Mnacho, William Matuja, Advocatus Kakorozya, Patrick Suykerbuyk, Robert Colebunders
Published in: BMJ Open, Issue 8/3, 2018, Page(s) e017188, ISSN 2044-6055
DOI: 10.1136/bmjopen-2017-017188

From river blindness control to elimination: bridge over troubled water

Author(s): Robert Colebunders, Maria-Gloria Basáñez, Katja Siling, Rory J. Post, Anke Rotsaert, Bruno Mmbando, Patrick Suykerbuyk, Adrian Hopkins
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0406-7

Report of the first international workshop on onchocerciasis-associated epilepsy

Author(s): Robert Colebunders, Michel Mandro, Alfred K. Njamnshi, Michel Boussinesq, An Hotterbeekx, Joseph Kamgno, Sarah O’Neill, Adrian Hopkins, Patrick Suykerbuyk, Maria-Gloria Basáñez, Rory J. Post, Belén Pedrique, Pierre-Marie Preux, Wilma A. Stolk, Thomas B. Nutman, Richard Idro
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0400-0

The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan: a study protocol

Author(s): Gasim Abd-Elfarag, Makoy Yibi Logora, Jane Y. Carter, Morrish Ojok, Jackson Songok, Sonia Menon, Ferdinand Wit, Richard Lako, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0496-2

Burden of onchocerciasis-associated epilepsy: first estimates and research priorities

Author(s): Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0481-9

High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with ivermectin

Author(s): Bruno P. Mmbando, Patrick Suykerbuyk, Mohamed Mnacho, Advocatus Kakorozya, William Matuja, Adam Hendy, Helena Greter, Williams H. Makunde, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0450-3

Community perceptions of epilepsy and its treatment in an onchocerciasis endemic region in Ituri, Democratic Republic of Congo

Author(s): Housseini Dolo, Michel Mandro, Deogratias Wonya’Rossi, Francoise Ngave, Jessica Fraeyman, Joseph N. Siewe, Patrick Suykerbuyk, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0498-0

High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo

Author(s): Evy Lenaerts, Michel Mandro, Deby Mukendi, Patrick Suykerbuyk, Housseini Dolo, Deogratias Wonya’Rossi, Françoise Ngave, Chellafe Ensoy-Musoro, Anne Laudisoit, An Hotterbeekx, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0452-1

Histological examination of post-mortem brains of children with nodding syndrome

Author(s): An Hotterbeekx, Sylvester Onzivua, Sonia Menon, Robert Colebunders
Published in: Annals of Translational Medicine, Issue 6/7, 2018, Page(s) 134-134, ISSN 2305-5839
DOI: 10.21037/atm.2018.02.04

High prevalence of epilepsy in an onchocerciasis endemic health zone in the Democratic Republic of the Congo, despite 14 years of community-directed treatment with ivermectin: A mixed-method assessment

Author(s): Deby Mukendi, Floribert Tepage, Innocent Akonda, Joseph Nelson Fodjo Siewe, Anke Rotsaert, Carl Nwana Ndibmun, Anne Laudisoit, Simon Couvreur, Blandine Kabutako, Sonia Menon, An Hotterbeekx, Robert Colebunders
Published in: International Journal of Infectious Diseases, Issue 79, 2019, Page(s) 187-194, ISSN 1201-9712
DOI: 10.1016/J.IJID.2018.10.021

Clinical characteristics of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan

Author(s): Robert Colebunders, Gasim Abd-Elfarag, Jane Y. Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora
Published in: Seizure, Issue 62, 2018, Page(s) 108-115, ISSN 1059-1311
DOI: 10.1016/J.SEIZURE.2018.10.004

High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan: A community-based survey

Author(s): Robert Colebunders, Jane Y Carter, Peter Claver Olore, Kai Puok, Samit Bhattacharyya, Sonia Menon, Gasim Abd-Elfarag, Morrish Ojok, Chellafe Ensoy-Musoro, Richard Lako, Makoy Yibi Logora
Published in: Seizure, Issue 63, 2018, Page(s) 93-101, ISSN 1059-1311
DOI: 10.1016/J.SEIZURE.2018.11.004

Nodding Syndrome May Be Only the Ears of the Hippo

Author(s): Joseph Francis Wamala, Mugagga Malimbo, Floribert Tepage, Luswa Lukwago, Charles Lukoya Okot, Robert O. Cannon, Anne Laudisoit, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, Issue 9/8, 2015, Page(s) e0003880, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0003880

Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures

Author(s): Nolbert Gumisiriza, Frank Mubiru, Joseph Nelson Siewe Fodjo, Martin Mbonye Kayitale, An Hotterbeekx, Richard Idro, Issa Makumbi, Tom Lakwo, Bernard Opar, Joice Kaducu, Joseph Francis Wamala, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 9/1, 2020, ISSN 2049-9957
DOI: 10.1186/S40249-020-0628-3

Low ivermectin use among 5- to 6-year-old children: observations from door-to-door surveys in onchocerciasis-endemic regions in Africa

Author(s): J N Siewe Fodjo, F Mubiru, C Ukaga, M Y Logora, B P Mmbando, M Mandro, A K Njamnshi, R Colebunders
Published in: International Health, Issue 12/1, 2019, Page(s) 72-75, ISSN 1876-3413
DOI: 10.1093/INTHEALTH/IHZ044

Prevalence of River Epilepsy in the Orientale Province in the Democratic Republic of the Congo

Author(s): Robert Colebunders, Floribert Tepage, Ente Rood, Michel Mandro, Emmanuel Nji Abatih, Gisele Musinya, Germain Mambandu, José Kabeya, Michel Komba, Bethany Levick, John L Mokili, Anne Laudisoit
Published in: PLOS Neglected Tropical Diseases, Issue 10/5, 2016, Page(s) e0004478, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0004478

Ivermectin use in children below 15 kg: potential benefits for onchocerciasis and scabies elimination programmes

Author(s): R. Colebunders, S.T. Wafula, A. Hotterbeekx, J. N. Siewe‐Fodjo
Published in: British Journal of Dermatology, Issue 182/4, 2020, Page(s) 1064-1064, ISSN 0007-0963
DOI: 10.1111/BJD.18685

Low prevalence of epilepsy and onchocerciasis after more than 20 years of ivermectin treatment in the Imo River Basin in Nigeria

Author(s): Joseph N. F. Siewe, Chinyere N. Ukaga, Ernest O. Nwazor, Murphy O. Nwoke, Modebelu C. Nwokeji, Blessing C. Onuoha, Simon O. Nwanjor, Joel Okeke, Kate Osahor, Lilian Chimechefulam, Ann I. Ogomaka, Augustine A. Amaechi, Chika I. Ezenwa, Monika N. Ezike, Chidimma Ikpeama, Ogechi Nwachukwu, Austine I. Eriama-Joseph, Berthram E. B. Nwoke, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 8/1, 2019, ISSN 2049-9957
DOI: 10.1186/s40249-019-0517-9

Onchocerca volvulus is not detected in the cerebrospinal fluid of persons with onchocerciasis-associated epilepsy

Author(s): An Hotterbeekx, Stephen Raimon, Gasim Abd-Elfarag, Jane Y. Carter, Wilson Sebit, Abozer Suliman, Joseph Nelson Siewe Fodjo, Peter De Witte, Makoy Yibi Logora, Robert Colebunders, Samir Kumar-Singh
Published in: International Journal of Infectious Diseases, Issue 91, 2020, Page(s) 119-123, ISSN 1201-9712
DOI: 10.1016/J.IJID.2019.11.029

Onchocerca volvulus as a risk factor for developing epilepsy in onchocerciasis endemic regions in the Democratic Republic of Congo: a case control study

Author(s): Michel Mandro, Patrick Suykerbuyk, Floribert Tepage, Degratias Rossy, Francoise Ngave, Mirza Nazmul Hasan, An Hotterbeekx, Germain Mambandu, Jean Marie Kashama, Anne Laudisoit, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 7/1, 2018, ISSN 2049-9957
DOI: 10.1186/s40249-018-0465-9

From river blindness to river epilepsy: Implications for onchocerciasis elimination programmes

Author(s): Robert Colebunders, Joseph Nelson Siewe Fodjo, Adrian Hopkins, An Hotterbeekx, Thomson L. Lakwo, Akili Kalinga, Makoy Yibi Logora, Maria-Gloria Basáñez
Published in: PLOS Neglected Tropical Diseases, Issue 13/7, 2019, Page(s) e0007407, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0007407

Epidemiological evidence concerning the association between onchocerciasis and epilepsy

Author(s): J.N. Siewe Fodjo, F. Tepage, R. Colebunders
Published in: International Journal of Infectious Diseases, Issue 82, 2019, Page(s) 77-78, ISSN 1201-9712
DOI: 10.1016/J.IJID.2019.03.015

Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania

Author(s): Bhwana, Dan; Mmbando, Bruno P.; Dekker, Marieke C.J.; Mnacho, Mohamed; Makunde, Williams H.; Weckhuysen, Sarah; Colebunders, Robert
Published in: Epileptic disorders, Issue 1, 2019, ISSN 1950-6945
DOI: 10.1684/EPD.2019.1093

Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?

Author(s): Joseph Nelson Siewe Fodjo, Marina Kugler, An Hotterbeekx, Adam Hendy, Jean-Pierre Van Geertruyden, Robert Colebunders
Published in: Infectious Diseases of Poverty, Issue 8/1, 2019, ISSN 2049-9957
DOI: 10.1186/s40249-019-0588-7

Elimination of onchocerciasis in Africa by 2025: an ambitious target requires ambitious interventions

Author(s): Robert Colebunders, Wilma A. Stolk, Joseph Nelson Siewe Fodjo, Charles D. Mackenzie, Adrian Hopkins
Published in: Infectious Diseases of Poverty, Issue 8/1, 2019, ISSN 2049-9957
DOI: 10.1186/s40249-019-0593-x

Nodding syndrome—a new hypothesis and new direction for research

Author(s): Robert Colebunders, Adam Hendy, Miriam Nanyunja, Joseph Francis Wamala, Marieke van Oijen
Published in: International Journal of Infectious Diseases, Issue 27, 2014, Page(s) 74-77, ISSN 1201-9712
DOI: 10.1016/j.ijid.2014.08.001

Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo

Author(s): An Hotterbeekx, Jolien Perneel, Michel Mandro, Germain Abhafule, Joseph Nelson Siewe Siewe Fodjo, Alfred Dusabimana, Steven Abrams, Samir Kumar-Singh, Robert Colebunders
Published in: Pathogens, Issue 9/6, 2020, Page(s) 435, ISSN 2076-0817
DOI: 10.3390/pathogens9060435

Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic

Author(s): Eric de Smet, Salvatore Metanmo, Pascal Mbelesso, Benoit Kemata, Joseph N. Siewe Fodjo, Farid Boumédiène, Hilda T. Ekwoge, Emmanuel Yangatimbi, Daniel Ajzenberg, Orphee Badibanga, Pierre-Marie Preux, Robert Colebunders
Published in: Pathogens, Issue 9/5, 2020, Page(s) 337, ISSN 2076-0817
DOI: 10.3390/pathogens9050337

The Role of the Maridi Dam in Causing an Onchocerciasis-Associated Epilepsy Epidemic in Maridi, South Sudan: An Epidemiological, Sociological, and Entomological Study

Author(s): T. L. Lakwo, S. Raimon, M. Tionga, J. N. Siewe Fodjo, P. Alinda, W. J. Sebit, J. Y. Carter, R. Colebunders
Published in: Pathogens, Issue 9/4, 2020, Page(s) 315, ISSN 2076-0817
DOI: 10.3390/pathogens9040315

From nodding syndrome to onchocerciasis-associated epilepsy

Author(s): A. Hotterbeekx, S. Van Hees, J.N. Siewe Fodjo, R. Colebunders
Published in: Revue Neurologique, Issue 176/5, 2020, Page(s) 405-406, ISSN 0035-3787
DOI: 10.1016/j.neurol.2019.12.011

Single versus Multiple Dose Ivermectin Regimen in Onchocerciasis-Infected Persons with Epilepsy Treated with Phenobarbital: A Randomized Clinical Trial in the Democratic Republic of Congo

Author(s): Michel Mandro, Joseph Nelson Siewe Fodjo, Alfred Dusabimana, Deby Mukendi, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, D Wonya’rossi, An Hotterbeekx, Steven Abrams, Robert Colebunders
Published in: Pathogens, Issue 9/3, 2020, Page(s) 205, ISSN 2076-0817
DOI: 10.3390/pathogens9030205

Urinary N-acetyltyramine-O,β-glucuronide in Persons with Onchocerciasis-Associated Epilepsy

Author(s): An Hotterbeekx, Alfred Dusabimana, Michel Mandro, Germain M Abhafule, Wonya’Rossy Deogratias, Joseph N. Siewe Fodjo, Steven Abrams, Robert Colebunders
Published in: Pathogens, Issue 9/3, 2020, Page(s) 191, ISSN 2076-0817
DOI: 10.3390/pathogens9030191

Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control

Author(s): Joseph Nelson Siewe Fodjo, Jan H F Remme, Pierre-Marie Preux, Robert Colebunders
Published in: International Health, Issue 12/3, 2020, Page(s) 192-202, ISSN 1876-3413
DOI: 10.1093/inthealth/ihaa012

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial

Author(s): Michel Mandro, Joseph Nelson Siewe Fodjo, Deby Mukendi, Alfred Dusabimana, Sonia Menon, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, Deogratias Wonya’Rossi, Jean Marie Jakwong, Patrick Suykerbuyk, Jacques Meganck, An Hotterbeekx, Robert Colebunders
Published in: PLOS Neglected Tropical Diseases, Issue 14/1, 2020, Page(s) e0007966, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0007966

Safety of ivermectin during pregnancy

Author(s): Stijn Van Hees, Stephen Raimon, Joseph Nelson Siewe Fodjo, Robert Colebunders
Published in: The Lancet Global Health, Issue 8/3, 2020, Page(s) e338, ISSN 2214-109X
DOI: 10.1016/s2214-109x(19)30555-8

Nodding syndrome research, lessons learned from the NSETHIO project

Author(s): D. Geelhand de Merxem, J. N. Siewe Fodjo, S. Menon, A. Hotterbeekx, R. Colebunders
Published in: Global Mental Health, Issue 6, 2019, ISSN 2054-4251
DOI: 10.1017/gmh.2019.24

Epilepsy prevention

Author(s): Joseph Nelson Siewe Fodjo, Yibi Logora Makoy, Robert Colebunders
Published in: The Lancet, Issue 394/10214, 2019, Page(s) 2072, ISSN 0140-6736
DOI: 10.1016/s0140-6736(19)31906-3