Modulation of cortical circuits and predictive neural coding by serotonin

Project Information

5HTCircuits

Grant agreement ID: 671251

DOI

10.3030/671251

Project closed

EC signature date 2 October 2015

Start date 1 January 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 486 074,00

EU contribution

€ 2 486 074,00

Coordinated by

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Thesis and dissertations (5)

Probabilistic decision-making in rodent foraging behavior: contribution of distinct prefrontal cortex regions

Author(s): Beatriz Godinho
Published in: 2018
Publisher: IST

Latent variable decoding in biological and artificial agents: Towards a unified approach

Author(s): Pietro Vertechi
Published in: 2020
Publisher: ITQB-UNL

An unsupervised generative strategy for detection and characterization of rare behavioural events in mice in open field to assess effect of optogenetic activation of serotonergic neurons in the dorsal raphe nuclei

Author(s): Lucas Soares
Published in: 2019
Publisher: Universidade de Lisboa

The Role of Prefrontal Cortex and Serotonin in Foraging Decisions

Author(s): Dario Sarra
Published in: 2021
Publisher: ITQB-UNL

Spatial goals and actions in the orbitofrontal cortex

Author(s): Niccolò Bonacchi
Published in: 2017
Publisher: ITQB-UNL

Peer reviewed articles (11)

Metastable attractors explain the variable timing of stable behavioral action sequences

Author(s): Recanatesi S, Pereira-Obilinovic U, Murakami M, Mainen ZF, Mazucatto L
Published in: Neuron, 2021, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1101/2020.01.24.919217

The impact of learning on perceptual decisions and its implication for speed-accuracy tradeoffs

Author(s): André G. Mendonça, Jan Drugowitsch, M. Inês Vicente, Eric E. J. DeWitt, Alexandre Pouget, Zachary F. Mainen
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16196-7

Phasic activation of dorsal raphe serotonergic neurons increases pupil-linked arousal

Author(s): Cazettes F, Reato D, Morais JP, Renart A, Mainen ZF
Published in: Current Biology, 2020, Page(s) 192-197, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.09.090

Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex

Author(s): Murakami M, Shteingart H, Loewenstein Y, Mainen ZF
Published in: Neuron, 2017, Page(s) 908-919, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.04.040

An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals

Author(s): Kiyohito Iigaya, Madalena S. Fonseca, Masayoshi Murakami, Zachary F. Mainen, Peter Dayan
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04840-2

Activity patterns of serotonin neurons underlying cognitive flexibility

Author(s): Sara Matias, Eran Lottem, Guillaume P Dugué, Zachary F Mainen
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.20552

Activation of serotonin neurons promotes active persistence in a probabilistic foraging task

Author(s): Eran Lottem, Dhruba Banerjee, Pietro Vertechi, Dario Sarra, Matthijs oude Lohuis, Zachary F. Mainen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03438-y

Stereotaxic Adeno-associated Virus Injection and Cannula Implantation in the Dorsal Raphe Nucleus of Mice

Author(s): Patrícia Correia, Sara Matias, Zachary Mainen
Published in: BIO-PROTOCOL, Issue 7/18, 2017, ISSN 2331-8325
Publisher: bio-protocol LLC
DOI: 10.21769/BioProtoc.2549

Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

Author(s): Patrícia A Correia, Eran Lottem, Dhruba Banerjee, Ana S Machado, Megan R Carey, Zachary F Mainen
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.20975

Learning optimal decisions with confidence

Author(s): Jan Drugowitsch, André G. Mendonça, Zachary F. Mainen, Alexandre Pouget
Published in: Proceedings of the National Academy of Sciences, Issue 116/49, 2019, Page(s) 24872-24880, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1906787116

Inference-Based Decisions in a Hidden State Foraging Task: Differential Contributions of Prefrontal Cortical Areas

Author(s): Pietro Vertechi, Eran Lottem, Dario Sarra, Beatriz Godinho, Isaac Treves, Tiago Quendera, Matthijs Nicolai Oude Lohuis, Zachary F. Mainen
Published in: Neuron, Issue 106/1, 2020, Page(s) 166-176.e6, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.01.017

Other (2)

Functional MRI of large scale activity in behaving mice

Author(s): Fonseca MS, Bergomi M, Mainen ZF, Shemesh N
Published in: bioRxiv, 2020, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2020.04.16.044941

Reservoir of decision strategies in the mouse brain

Author(s): Cazettes F, Murakami M, Renart A, Mainen ZF
Published in: bioRxiv, 2021, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2021.04.01.438090