CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
Development of structurally benign Suzuki protein chemistry for the [18F]labeling of proteins through the Tag-and-Modify Strategy
Microfluidic [11C]carbonylation screening under radical initiated conditionsDevelopment of novel [11C]carbonylation radiochemistry methodology that will further progress the possibility to radiolabel drug-like molecules using a microfluidic synthesizer in reaction screening for the [11C]labeling of a set of representative drugs in particular under radical initiated conditions (undertaken in close collaboration with experts in radiochemistry hardware BenCar and Scancys)
Development of new hydrophilic and air-resistant RuNps for [2H/3H]labeling of drugs & biologicsDevelopment of new RuNPs with variable sizes, shapes, coating and poisoning to modulate their specificity and reactivity, and to improve their use in aqueous reaction media and their handling in the air.
Improvement of employabilityImprovement of employability through training in job search, career paths, management & entrepreneurship
Development, evaluation and applications of new methods for asymmetric [18F]fluorinationDevelopment, evaluation and applications of new methods for asymmetric [18F]fluorination using chiral [18F]NF reagents, asymmetric organocatalysis and transition metal catalysts
N-Methylation/C-carbonylation from CO2 for the [14C]radiolabeling of small-molecule drugsN-Methylation/C-carbonylation from CO2 for the [14C]radiolabeling of small-molecule drugs. Evaluation of transferability to the [11C]radiolabeling of small-molecule drugs.
Cu(III)-catalyzed [18F]fluorination of arenes and heteroarenesCu(III)-catalyzed [18F]fluorination of aryl boronic esters of arenes and heteroarenes motifs found in small-molecule drugs
New methods for [2H/3H]labeling of biologicsApplication of the RuNps-catalyzed C-H activation of organic molecules to the [2H/3H] labeling of proteins, nucleic acids and other macromolecules
Communication and presentation skillsDevelopment of communication and presentation skills at group meetings and Network meeting as a preliminary training
New methods for [2H/3H]labeling of small molecules drugs and peptidesDevelopment of innovative isotopic chemistry (in particular with RuNps) for the labeling of general molecular scaffolds with 2H and 3H and application to the isotopic labeling of simple molecules and then to small molecules drugs, peptides and short polynucleotides.
Supervisory Board of the NetworkEffective nomination of the Supervisory Board of ISOTOPICS
Development of new fluoro- and difluoromethyl-sulfonyl reagents for the production of [18F]labeled alkenesDevelopment of new fluoro- and difluoromethyl-sulfonyl reagents for the GMP production of [18F]labeled alkenes using cyclotron-produced [18F-]
Patents, research and review publications, assistance for creation of start-ups and incubationPatents, research and review publications, assistance for creation of start-ups and incubation, help to the writing of research projects
Defence of PhD ThesisRedaction and defense of Thesis for the awarding of the doctoral degree (according to host regulations)
Cascade reactions to construct 14C-heterocycles and derivatizing peptides and proteins from K14CNNew cascade reactions for the 14C labeling of small molecule (heterocyclic) drugs, peptides, and structurally begnign labeling of proteins from [14C]labeled KCN.
Development of a photochemical flow process for addition of [18F]CHF to (hetero)aromaticsDevelopment of a photochemical flow process for addition of [18F]CHF to (hetero)aromatic compounds through a radical process
Training in information technology skillsTraining in information technology skills, ability to get relevant scientific information from the current databases and application to research, project and grant writing and exploitation of results and data
Results disseminationEmphasizing the importance of dissemination of results through publications, industrial valorization, public engagement and participation to symposia
Development of a novel automated radio-chemistry system for [11C]carbonylationDevelopment (in collaboration with Scansys) of a novel automated radiochemistry system that allows for [11C]carbonylation to be performed according to GMP and thus enables clinical PET studies. In addition to transition metal catalysis, UV irradiation and/or chemical initiation will be performed to undertake radical [11C]carbonylation of alkyl substrates
Scientific meeting reportsScientific meeting reports on months 4, 11, 27, 35, 43 and 48
Application of N-methylation and C-carbonylation from CO2 to [11C]labelingApplication of the carbonylation reactions from CO2 developed by CEA to the construction of [11C]labeled molecules and application to the [11C]labeling of small-molecule drugs.
Network-wide interdisciplinary scientific training composed of 5 Training Schools at months 10, 18, 26, 34, 42
Website and NewslettersWebsite and Newsletters regularly updated and sustained after the project completion (including partners websites)
Public EngagementPublic Website, press release, Folk High Schools, Open days, Embassy
Dissemination of main results throughout the consortium and outside (oral and poster presentations)
Network-wide Periodic Network meetingsNetwork-wide Periodic Network meetings at months 3, 10, 18, 26, 34, 42, 48 and associated reports at months 4, 11, 19, 27, 35, 43, 48
ESR recruitment processEffective recruitment of all ESRs according to the priniciple of transparency and non-discrimination
Publicaciones
Autores:
Mégane Valero, Annina Burhop, Kristof Jess, Remo Weck, Matthias Tamm, Jens Atzrodt, Volker Derdau
Publicado en:
Journal of Labelled Compounds and Radiopharmaceuticals, 2017, ISSN 0362-4803
Editor:
John Wiley & Sons Inc.
DOI:
10.1002/jlcr.3595
Autores:
Mateusz Imiołek, Gogulan Karunanithy, Wai-Lung Ng, Andrew J. Baldwin, Véronique Gouverneur, Benjamin G. Davis
Publicado en:
Journal of the American Chemical Society, 2018, ISSN 0002-7863
Editor:
American Chemical Society
DOI:
10.1021/jacs.7b10230
Autores:
Volker Derdau, Mégane Valero, Remo Weck, Jens Atzrodt, Stefan Güssregen
Publicado en:
Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201804010
Autores:
Gabriele Pupo, Francesco Ibba, David M. H. Ascough, Anna Chiara Vicini, Paolo Ricci, Kirsten E. Christensen, Lukas Pfeifer, John Richard Morphy, John M. Brown, Robert S. Paton, Véronique Gouverneur
Publicado en:
Science, Edición 360/6389, 2018, Página(s) 638-642, ISSN 0036-8075
Editor:
American Association for the Advancement of Science
DOI:
10.1126/science.aar7941
Autores:
Antonio Del Vecchio, Fabien Caillé, Arnaud Chevalier, Olivier Loreau, Kaisa Horkka, Christer Halldin, Magnus Schou, Nathalie Camus, Pascal Kessler, Bertrand Kuhnast, Frédéric Taran, Davide Audisio
Publicado en:
Angewandte Chemie International Edition, Edición 57/31, 2018, Página(s) 9744-9748, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201804838
Autores:
Antonio Del Vecchio, Gianluca Destro, Frédéric Taran, Davide Audisio
Publicado en:
Journal of Labelled Compounds and Radiopharmaceuticals, Edición 61/13, 2018, Página(s) 988-1007, ISSN 0362-4803
Editor:
John Wiley & Sons Inc.
DOI:
10.1002/jlcr.3666
Autores:
Gianluca Destro, Olivier Loreau, Elodie Marcon, Frédéric Taran, Thibault Cantat, Davide Audisio
Publicado en:
Journal of the American Chemical Society, 2018, ISSN 0002-7863
Editor:
American Chemical Society
DOI:
10.1021/jacs.8b12140
Autores:
Philipp Gotico, Antonio Del Vecchio, Davide Audisio, Annamaria Quaranta, Zakaria Halime, Winfried Leibl, Ally Aukauloo
Publicado en:
ChemPhotoChem, Edición 2/8, 2018, Página(s) 715-719, ISSN 2367-0932
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/cptc.201800012
Autores:
Matthew K. Bilyard, Henry J. Bailey, Lluís Raich, Maria A. Gafitescu, Takuya Machida, Javier Iglésias-Fernández, Seung Seo Lee, Christopher D. Spicer, Carme Rovira, Wyatt W. Yue, Benjamin G. Davis
Publicado en:
Nature, Edición 563/7730, 2018, Página(s) 235-240, ISSN 0028-0836
Editor:
Nature Publishing Group
DOI:
10.1038/s41586-018-0644-7
Autores:
Gabriele Pupo, Anna Chiara Vicini, David M. H. Ascough, Francesco Ibba, Kirsten E. Christensen, Amber L. Thompson, John M. Brown, Robert S. Paton, Véronique Gouverneur
Publicado en:
Journal of the American Chemical Society, Edición 141/7, 2019, Página(s) 2878-2883, ISSN 0002-7863
Editor:
American Chemical Society
DOI:
10.1021/jacs.8b12568
Autores:
Alberto Palazzolo, Sophie Feuillastre, Viktor Pfeifer, Sébastien Garcia-Argote, Donia Bouzouita, Simon Tricard, Céline Chollet, Elodie Marcon, David-Alexandre Buisson, Sophie Cholet, François Fenaille, Guy Lippens, Bruno Chaudret, Grégory Pieters
Publicado en:
Angewandte Chemie International Edition, Edición 58/15, 2019, Página(s) 4891-4895, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201813946
Autores:
Agostinho Lemos, Christian Lemaire, André Luxen
Publicado en:
Advanced Synthesis & Catalysis, Edición 361/7, 2019, Página(s) 1500-1537, ISSN 1615-4150
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/adsc.201801121
Autores:
Niels Rothermel, Donia Bouzouita, Tobias Röther, Iker de Rosal, Simon Tricard, Romuald Poteau, Torsten Gutmann, Bruno Chaudret, Hans‐Heinrich Limbach, Gerd Buntkowsky
Publicado en:
ChemCatChem, Edición 10/19, 2018, Página(s) 4243-4247, ISSN 1867-3880
Editor:
Wiley - VCH Verlag GmbH & CO. KGaA
DOI:
10.1002/cctc.201801022
Autores:
Karen Hinsinger, Grégory Pieters
Publicado en:
Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201905368
Autores:
Mégane Valero, Volker Derdau
Publicado en:
Journal of Labelled Compounds and Radiopharmaceuticals, 2019, ISSN 0362-4803
Editor:
John Wiley & Sons Inc.
DOI:
10.1002/jlcr.3783
Autores:
Mégane Valero, Anurag Mishra, Jennifer Blass, Remo Weck, Volker Derdau
Publicado en:
ChemistryOpen, 2019, ISSN 2191-1363
Editor:
Wiley
DOI:
10.1002/open.201900204
Autores:
Mégane Valero, Daniel Becker, Kristof Jess, Remo Weck, Jens Atzrodt, Thomas Bannenberg, Volker Derdau, Matthias Tamm
Publicado en:
Chemistry – A European Journal, Edición 25/26, 2019, Página(s) 6517-6522, ISSN 0947-6539
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/chem.201901449
Autores:
Donia Bouzouita, Guy Lippens, Edwin A. Baquero, Pier F. Fazzini, Gregory Pieters, Yannick Coppel, Pierre Lecante, Simon Tricard, Luis M. Martínez-Prieto, Bruno Chaudret
Publicado en:
Nanoscale, 2019, ISSN 2040-3364
Editor:
Royal Society of Chemistry
DOI:
10.1039/c9nr04149d
Autores:
Laura Trump, Agostinho Lemos, Bénédicte Lallemand, Patrick Pasau, Joël Mercier, Christian Lemaire, André Luxen, Christophe Genicot
Publicado en:
Angewandte Chemie International Edition, Edición 58/37, 2019, Página(s) 13149-13154, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201907488
Autores:
Kaisa Horkka, Kenneth Dahl, Jonas Bergare, Charles S. Elmore, Christer Halldin, Magnus Schou
Publicado en:
ChemistrySelect, Edición 4/6, 2019, Página(s) 1846-1849, ISSN 2365-6549
Editor:
WILEY-VCH Verlag GmbH & Co.
DOI:
10.1002/slct.201803561
Autores:
Ryan A. Bragg, Malvika Sardana, Markus Artelsmair, Charles S. Elmore
Publicado en:
Journal of Labelled Compounds and Radiopharmaceuticals, Edición 61/13, 2018, Página(s) 934-948, ISSN 0362-4803
Editor:
John Wiley & Sons Inc.
DOI:
10.1002/jlcr.3633
Autores:
Juan M. Asensio, Donia Bouzouita, Piet W. N. M. van Leeuwen, Bruno Chaudret
Publicado en:
Chemical Reviews, 2019, ISSN 0009-2665
Editor:
American Chemical Society
DOI:
10.1021/acs.chemrev.9b00368
Autores:
Malvika Sardana, Joakim Bergman, Cecilia Ericsson, Lee Peter Kingston, Magnus Schou, Christophe Dugave, Davide Audisio, Charles S. Elmore
Publicado en:
The Journal of Organic Chemistry, 2019, ISSN 0022-3263
Editor:
American Chemical Society
DOI:
10.1021/acs.joc.9b02575
Autores:
Mélodie Ferrat, Kenneth Dahl, Christer Halldin, Magnus Schou
Publicado en:
Journal of Labelled Compounds and Radiopharmaceuticals, 2019, ISSN 0362-4803
Editor:
John Wiley & Sons Inc.
DOI:
10.1002/jlcr.3805
Autores:
Mégane Valero, Donia Bouzouita, Alberto Palazzolo, Jens Atzrodt, Christophe Dugave, Simon Tricard, Sophie Feuillastre, Grégory Pieters, Bruno Chaudret, Volker Derdau
Publicado en:
Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201914369
Autores:
Grégory Pieters, Viktor Pfeifer, Marie Certiat, Donia Bouzouita, Alberto Palazzolo, Sébastien Garcia-Argote, Elodie Marcon, David-Alexandre Buisson, Philippe Lesot, Laurent Maron, Bruno Chaudret, Simon Tricard, Iker del Rosal, Romuald Poteau, Sophie Feuillastre
Publicado en:
Chemistry – A European Journal, 2019, ISSN 0947-6539
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/chem.201905651
Autores:
Mégane Valero, Thomas Kruissink, Jennifer Blass, Remo Weck, Stefan Güssregen, Alleyn T. Plowright, Volker Derdau
Publicado en:
Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Editor:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201914220
Autores:
Laura Trump, Agostinho Lemos, Jérôme Jacq, Patrick Pasau, Bénédicte Lallemand, Joël Mercier, Christophe Genicot, André Luxen, Christian Lemaire
Publicado en:
Organic Process Research & Development, 2020, ISSN 1083-6160
Editor:
American Chemical Society
DOI:
10.1021/acs.oprd.9b00442
Autores:
Choon Wee Kee, Osman Tack, Florian Guibbal, Thomas C. Wilson, Patrick G. Isenegger, Mateusz Imiołek, Stefan Verhoog, Michael Tilby, Giulia Boscutti, Sharon Ashworth, Juliette Chupin, Roxana Kashani, Adeline W. J. Poh, Jane K. Sosabowski, Sven Macholl, Christophe Plisson, Bart Cornelissen, Michael C. Willis, Jan Passchier, Benjamin G. Davis, Véronique Gouverneur
Publicado en:
Journal of the American Chemical Society, Edición 142/3, 2020, Página(s) 1180-1185, ISSN 0002-7863
Editor:
American Chemical Society
DOI:
10.1021/jacs.9b11709
Autores:
Agostinho Luís Pereira Lemos, Laura Trump, Bénédicte Lallemand, Patrick Pasau, Joël Mercier, Christian Lemaire, Jean-Christophe Monbaliu, Christophe Genicot, André Luxen
Publicado en:
Catalysts, Edición 10/3, 2020, Página(s) 275, ISSN 2073-4344
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/catal10030275
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