Optimization of Medical Accelerators

Deliverables

Use of MC codes for treatment planning and imaging

implemented and first tests realized

detector layout

completed and demonstrator available

non-invasive beam monitoring in storage rings and treatment beam lines

demonstrated

treatment database
Results from measurements on samples

available and published

Summary on most efficient 3/4 D patient recognition systems
First software version ready for tests
VELO prototype setup

Prototype ready

final monitor layout

realized, demonstrator build and paper published

Modifications to CTF3 and tests at CERN

realized and data available

studies into different detector materials

realized and assessed

Diagnostics integration

analyzed and prototypes realized

radiobiological models in patient voxel representation

available and benchmarked

Prototype design

completed

Technical framework (HW and SW) of optical tracking devices for respiratory motion modelling in 4D CT and time-resolved dose delivery

PC readout software
Conference Proceedings

published

Report on the performances and conclusion on the recommended approaches
Final design report

completed

identification of optimum materials through measurements at CCC with ULIV

Results summarized in report

Slow workflow environment prototype

available

Models for nuclear interaction

available and tested against data

Beamline diagnostics concept

developed and assessed in tests

performance in clinical environments

Report about performance in clinical environments

LDHRS results

available and published

Results from studies into recognition performance

carried out and results published

Benefit analysis

carried out and published

First integrated model for treatment planning and imaging

available, tested and benchmarked

use of high gradient rf accelerators for medical applications

assessed and findings published

Results from MC studies into detector performance with LMU and CERN

available and published

Project brochure

completed and published

Final brochure

completed and published

OMA web site

operational

Project leaflet

completed and published

Final conference

held

Outreach Symposium

held

Outreach activities

completed

Publications

Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification

Author(s): Lena Nenoff, Marlen Priegnitz, Guillaume Janssens, Johannes Petzoldt, Patrick Wohlfahrt, Anna Trezza, Julien Smeets, Guntram Pausch, Christian Richter
Published in: Radiotherapy and Oncology, Issue 125/3, 2017, Page(s) 534-540, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2017.10.013

Dielectric-Filled Reentrant Cavity Resonator as a Low-Intensity Proton Beam Diagnostic

Author(s): Sudharsan Srinivasan, Pierre-André Duperrex
Published in: Instruments, Issue 2/4, 2018, Page(s) 24, ISSN 2410-390X
Publisher: MDPR
DOI: 10.3390/instruments2040024

Correction of Geometrical Effects of a Knife-Edge Slit Camera for Prompt Gamma-Based Range Verification in Proton Therapy

Author(s): Johannes Petzoldt, Guillaume Janssens, Lena Nenoff, Christian Richter, Julien Smeets
Published in: Instruments, Issue 2/4, 2018, Page(s) 25, ISSN 2410-390X
Publisher: MDPI
DOI: 10.3390/instruments2040025

Development of the LHCb VELO Detector Modules into a Standalone, Non-Invasive Online Beam Monitor for Medical Accelerators

Author(s): Roland Schnuerer, Jacinta Yap, Hao Zhang, Tomasz Cybulski, Tony Smith, Guido Haefeli, Olivier Girard, Tomasz Szumlak, Carsten Welsch
Published in: Instruments, Issue 3/1, 2019, Page(s) 1, ISSN 2410-390X
Publisher: MDPI
DOI: 10.3390/instruments3010001

Feasibility Study of a Proton Irradiation Facility for Radiobiological Measurements at an 18 MeV Cyclotron

Author(s): Anna Baratto-Roldán, María Jiménez-Ramos, Maria Battaglia, Javier García-López, María Gallardo, Miguel Cortés-Giraldo, José Espino
Published in: Instruments, Issue 2/4, 2018, Page(s) 26, ISSN 2410-390X
Publisher: MDPI
DOI: 10.3390/instruments2040026

Toward a new treatment planning approach accounting for in vivo proton range verification

Author(s): Liheng Tian, Guillaume Landry, Georgios Dedes, Florian Kamp, Marco Pinto, Katharina Niepel, Claus Belka, Katia Parodi
Published in: Physics in Medicine & Biology, Issue 63/21, 2018, Page(s) 215025, ISSN 1361-6560
Publisher: IOP
DOI: 10.1088/1361-6560/aae749

Measurement of He 4 charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy

Author(s): Felix Horst, Giulia Aricò, Kai-Thomas Brinkmann, Stephan Brons, Alfredo Ferrari, Thomas Haberer, Andrea Mairani, Katia Parodi, Claire-Anne Reidel, Uli Weber, Klemens Zink, Christoph Schuy
Published in: Physical Review C, Issue 99/1, 2019, ISSN 2469-9985
Publisher: APS
DOI: 10.1103/physrevc.99.014603

Abstract ID: 196 Relation between dose average linear energy transfer and dose mean lineal energy calculated for proton therapy beams off axis: A study with the Geant4 toolkit.

Author(s): Anna Baratto-Roldán, Peter Kimstrand, Álvaro Perales Molina, Alejandro Carabe, Miguel Antonio Cortés-Giraldo
Published in: Physica Medica, Issue 42, 2017, Page(s) 42-43, ISSN 1120-1797
Publisher: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2017.09.104

The AD and ELENA orbit, trajectory and intensity measurement systems

Author(s): R. Marco-Hernández, D. Alves, M.E. Angoletta, O. Marqversen, J. Molendijk, E. Oponowicz, R. Ruffieux, J. Sánchez-Quesada, L. SØby
Published in: Journal of Instrumentation, Issue 12/07, 2017, Page(s) P07024-P07024, ISSN 1748-0221
Publisher: Institute of Physics
DOI: 10.1088/1748-0221/12/07/p07024

Prompt Gamma Rays Detected With a BGO Block Compton Camera Reveal Range Deviations of Therapeutic Proton Beams

Author(s): F. Hueso-Gonzalez, G. Pausch, J. Petzoldt, K. E. Romer, W. Enghardt
Published in: IEEE Transactions on Radiation and Plasma Medical Sciences, Issue 1/1, 2017, Page(s) 76-86, ISSN 2469-7311
Publisher: IEEE
DOI: 10.1109/tns.2016.2622162

EP-1801: Prompt gamma imaging for the identification of proton range deviations due to anatomical change

Author(s): Y. Xie, J. Petzoldt, G. Janssens, L. Yin, E.H. Bentefour, J. Smeets, D. Prieels, R.L. Lustig, A. Lin, B.K. Teo
Published in: Radiotherapy and Oncology, Issue 127, 2018, Page(s) S967-S968, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/s0167-8140(18)32110-8

OC-0081: From range measurements to dose: in-vivo dosimetry using the prompt gamma camera

Author(s): S. Toscano, K. Souris, E. Sterpin, G. Janssens, J. Petzoldt, F. Vander Stappen, J. Smeets, X. Geets, K. Teo
Published in: Radiotherapy and Oncology, Issue 127, 2018, Page(s) S40, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/s0167-8140(18)30391-8

Construction and commissioning of the S-Band high gradient RF laboratory at IFIC

Author(s): D. Esperante, C. Blanch, M. Boronat, J. Fuster, D. Gonzalez Iglesias, A. Vnuchenko, B. Gimeno, N. Catalan Lasheras, G. Mcmonagle, I. Syratchev, W. Wuensch, B. Woolley, A. Faus Golfe
Published in: Journal of Physics: Conference Series, Issue 1067, 2018, Page(s) 082024, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/1067/8/082024

Processing of prompt gamma-ray timing data for proton range measurements at a clinical beam delivery

Author(s): Theresa Werner, Jonathan Berthold, Fernando Hueso-González, Toni Koegler, Johannes Petzoldt, Katja Roemer, Christian Richter, Andreas Rinscheid, Arno Straessner, Wolfgang Enghardt, Guntram Pausch
Published in: Physics in Medicine & Biology, Issue 64/10, 2019, Page(s) 105023, ISSN 1361-6560
Publisher: Institute of Physics and Engineering in Medicine
DOI: 10.1088/1361-6560/ab176d

Technical Note: Simulation of dose buildup in proton pencil beams

Author(s): Laurent Kelleter, Benjamin Zhen-Hong Tham, Ruben Saakyan, Jennifer Griffiths, Richard Amos, Simon Jolly, Adam Gibson
Published in: Medical Physics, Issue 46/8, 2019, Page(s) 3734-3738, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13660

OC-0187 Comparison of proton range predictions between Single- and Dual-Energy CT using prompt gamma imaging

Author(s): T. Boon-Keng, Y. Xie, F. O’Grady, A. Lalonde, J. Petzoldt, J. Smeets, G. Janssens
Published in: Radiotherapy and Oncology, Issue 133, 2019, Page(s) S95-S96, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/s0167-8140(19)30607-3

Dose‐averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations

Author(s): A. Bertolet, A. Baratto‐Roldán, S. Barbieri, G. Baiocco, A. Carabe, M.A. Cortés‐Giraldo
Published in: Medical Physics, Issue 46/9, 2019, Page(s) 4184-4192, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13643

Segment‐averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy

Author(s): A. Bertolet, A. Baratto‐Roldán, M. A. Cortés‐Giraldo, A. Carabe‐Fernandez
Published in: Medical Physics, Issue 46/9, 2019, Page(s) 4204-4214, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13673

OC-0566 Range verification in proton therapy: Can prompt-gamma imaging identify the source of deviation?

Author(s): C. Khamfongkhruea, G. Janssens, J. Petzoldt, J. Smeets, G. Pausch, C. Richter
Published in: Radiotherapy and Oncology, Issue 133, 2019, Page(s) S296-S297, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/s0167-8140(19)30986-7

Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification

Author(s): Felix Horst, Wihan Adi, Giulia Aricò, Kai-Thomas Brinkmann, Marco Durante, Claire-Anne Reidel, Marta Rovituso, Uli Weber, Hans-Georg Zaunick, Klemens Zink, Christoph Schuy
Published in: Physics in Medicine & Biology, Issue 64/20, 2019, Page(s) 205012, ISSN 1361-6560
Publisher: IOP
DOI: 10.1088/1361-6560/ab4511

First benchmarking of the BIANCA model for cell survival prediction in a clinical hadron therapy scenario

Author(s): M P Carante, G Aricò, A Ferrari, W Kozlowska, A Mairani, F Ballarini
Published in: Physics in Medicine & Biology, Issue 64/21, 2019, Page(s) 215008, ISSN 1361-6560
Publisher: IOP
DOI: 10.1088/1361-6560/ab490f

Upgrade Study of the MedAustron Ion Beam Center

Author(s): A. De Franco et al.
Published in: Proceedings IPAC’17, 8th International Particle Accelerator Conference, Copenhagen, Denmark, 2017
Publisher: JACoW
DOI: 10.18429/jacow-ipac2017-thpva074

Optimized Cryogenic Current Comparator for CERN's Low-Energy Antiproton Facilities

Author(s): M. Fernandes, A. Lees, D. Alves, T. Koettig, E. Oponowicz, J. Tan, C. Welsch, R. Geithner, R. Neubert, T. Stöhlker, M. Schwickert
Published in: Proceedings IBIC’16, 5th International Beam Instrumentation Conference, Barcelona, Spain, 2016
Publisher: JACoW
DOI: 10.18429/jacow-ibic2016-mopg48

Range Verification in Proton Therapy by Prompt Gamma-Ray Timing (PGT): Steps towards Clinical Implementation

Author(s): Theresa Werner, Jonathan Berthold, Wolfgang Enghardt, Fernando Hueso-Gonzalez, Toni Kogler, Johannes Petzoldt, Christian Richter, Andreas Rinscheid, Katja Romer, Kai Ruhnau, Julien Smeets, Jurgen Stein, Arno Straessner, Andreas Wolf, Guntram Pausch
Published in: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2017, Page(s) 1-5, ISBN 978-1-5386-2282-7
Publisher: IEEE
DOI: 10.1109/nssmic.2017.8532807

Non-Invasive beam monitoring using LHCb VELO

Author(s): R. Schnuerer, J S.L. Yap, H. Zhang, C.P. Welsch
Published in: Proceedings IPAC’17, 8th International Particle Accelerator Conference, Copenhagen, Denmark, 2017
Publisher: JACoW
DOI: 10.18429/jacow-ipac2017-thpva1

Superconducting Gantry Design for Proton Tomography

Author(s): E. Oponowicz, H. Owen
Published in: Proceedings IPAC’17, 8th International Particle Accelerator Conference, Copenhagen, Denmark, 2017
Publisher: JACoW
DOI: 10.18429/jacow-ipac2017-thpva140

First Optics Design and Beam Performance Simulation of PRAE: Platform for Research and Applications with Electrons at Orsay

Author(s): A. Faus-Golfe, S. Barsuk, B. Borgo, D. Douillet, A. Vnuchenko et al.
Published in: Proceedings IPAC’17, 8th International Particle Accelerator Conference, Copenhagen, Denmark, 2017
Publisher: JACoW
DOI: 10.18429/jacow-ipac2017-thpva079

Design and Construction of a High-Gradient RF Lab at IFIC-Valencia

Author(s): A. Vnuchenko, N. Catalan Lasheras, G. Mcmonagle, I. Syratchev, W. Wuensch, A. Faus Golfe, T. Argyropoulos, C. Blanch, D. Esperante, J. Giner
Published in: Proceedings IPAC’17, 8th International Particle Accelerator Conference, Copenhagen, Denmark, 2017
Publisher: JACoW
DOI: 10.18429/jacow-ipac2017-thpik081

Implementation of a non-invasive online beam monitor at a 60 MeV proton therapy beamline

Author(s): R. Schnuerer, J S.L. Yap, H. Zhang, G.J. Haefeli, O. Girard and C.P. Welsch
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-mopml024

High Power and High Repetition Rate X-band Power Source Using Multiple Klystrons

Author(s): M. Volpi, M. Boland, C. Serpico, A. Vnuchenko, W. Wuensch et al.
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-thpmk104

Reentrant cavity resonator for low intensities proton beam measurements

Author(s): S. Srinivasan, P. A. Duperrex
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-wepal069

High Power Conditioning of X-Band RF Components

Author(s): N. Catalan-Lasheras, H. Damerau, R. Gerard, V. del Pozo Romano, A. Vnuchenko et al.
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-wepmf074

Initial Testing of Techniques for Large Scale Rf Conditioning for the Compact Linear Collider

Author(s): T. G. Lucas, M. Boland, A. Grudiev, A. Vnuchenko, W. Wuensch, R. Zennaro, et al.
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-thpmk103

High Gradient Performance of an S-Band Backward Traveling Wave Accelerating Structure for Medical Hadron Therapy Accelerators

Author(s): A. Vnuchenko, S. Benedetti, C. Blanch Gutiérrez, N. Catalán Lasheras, D. Esperante Pereira, A. Faus-Golfe, A. Grudiev, B. Koubek, T. Lucas, G. McMonagle, I. Syratchev, B. J. Woolley, W. Wuensch
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-mopml043

Start-to-End Beam Dynamic Simulations for PRAE

Author(s): A. Vnuchenko, A. Latina, C. Bruni, M. El Khaldi, A. Faus Golfe, P. Lepercq, C. Vallerand
Published in: Proceedings IPAC’18, 9th International Particle Accelerator Conference, Vancouver, Canada, 2018
Publisher: JACoW
DOI: 10.18429/jacow-ipac2018-mopml044

Beam Characterisation Using MEDIPIX3 and EBT3 Film at the Clatterbridge Proton Therapy Beamline

Author(s): J. S.L. Yap, N. J. S. Bal, A. Kacperek, J. Resta-Lopez, C.P. Welsch et al.
Published in: Proceedings IPAC'19, 10th International Particle Accelerator Conference, Melbourne, Australia, 2019
Publisher: JACoW
DOI: 10.18429/jacow-ipac2019-thpmp033

Non-Invasive beam monitoring using LHCb VELO with 40 MeV protons

Author(s): R. Schnuerer, J S.L. Yap, H. Zhang, T. Szumlak, T. Price and C.P. Welsch
Published in: Proceedings IPAC'19, 10th International Particle Accelerator Conference, Melbourne, Australia, 2019
Publisher: JACoW
DOI: 10.18429/jacow-ipac2019-thpmp043

Quadrated dielectric-filled reentrant cavity resonator as a proton beam position diagnostic

Author(s): S. Srinivasan, P. A. Duperrex, J. M. Schippers
Published in: Proceedings IPAC'19, 10th International Particle Accelerator Conference, Melbourne, Australia, 2019
Publisher: JACoW
DOI: 10.18429/jacow-ipac2019-wepgw083

Superconducting Dipole Design for a Proton Computed Tomography Gantry

Author(s): E. Oponowicz, H. Owen
Published in: Proceedings IPAC'19, 10th International Particle Accelerator Conference, Melbourne, Australia, 2019
Publisher: JACoW
DOI: 10.18429/jacow-ipac2019-thpmp054

Developments of the nuclear reaction and fragmentation models in FLUKA for ion collisions at therapeutic energies

Author(s): G. Aricò, A. Ferrari, F. Horst, A. Mairani, C.-A. Reidel, C. Schuy, U. Weber
Published in: Proceedings of the 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italia, (2018), CERN Proceedings, Issue 1, 2019, Page(s) 321 - 326
Publisher: CERN

Dark Current Analysis at CERN’s X-band Facility

Author(s): D. Banon-Caballero, A. Vnuchenko, M. Boronat, N. Catalán Lasheras, A. Faus-Golfe, B. Gimeno, W. Wuensch et al.
Published in: Proceedings IPAC'19, 10th International Particle Accelerator Conference, Melbourne, Australia, 2019
Publisher: JACoW
DOI: 10.18429/jacow-ipac2019-weprb059

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