PET Imaging in Drug Design and Development

Resultado final

Award of PhD degree to ESR15

Award of PhD degree to ESR15 (AZ)

Award of PhD degree to ESR2

Award of PhD degree to ESR2 (UNIABDN)

Award of PhD degree to ESR10

Award of PhD degree to ESR10 (UiB)

Award of PhD degree to ESR7

Award of PhD degree to ESR7 (CIC)

Award of PhD degree to ESR1

Award of PhD degree to ESR1 (UNIABDN)

Award of PhD degree to ESR3

Award of PhD degree to ESR3 (VUmc)

Award of PhD degree to ESR6

Award of PhD degree to ESR6 (VUB)

Award of PhD degree to ESR12

Award of PhD degree to ESR12 (WWU)

Award of PhD degree to ESR9

Award of PhD degree to ESR9 (UiB).

Award of PhD degree to ESR14

Award of PhD degree to ESR14 (IMANOVA)

Award of PhD degree to ESR13

Award of PhD degree to ESR13 (ABD)

Award of PhD degree to ESR4

Award of PhD degree to ESR4 (VUmc)

Award of PhD degree to ESR8

Award of PhD degree to ESR8 (CIC)

Award of PhD degree to ESR11

Award of PhD degree to ESR11 (WWU)

PET3D website

The PET3D website goes online

Website maintenance

Maintenance and regular update of the PET3D website

Dissemination activities

Organization of all PET3D dissemination activities, i.e. project meetings and conferences/symposia

Outreach Activities

Supervision, co-organization and management of Outreach activities

Training activities

Organization of all PET3D training activities, i.e. School and Workshops

Publicaciones

PET3D – PET Imaging in Drug Design and Development – H2020

Autores: Matteo Zanda, Dani'lle J. Vugts, Vicky Caveliers, Hans-Ren' Bj'rsvik, Juan Mareque-Rivas, Andreas Jacobs, Jan Passchier, Charles Elmore
Publicado en: Impact, Edición 2017/8, 2017, Página(s) 42-45, ISSN 2398-7073
Editor: Science Impact Ltd
DOI: 10.21820/23987073.2017.8.42

Synthesis of C-14 Labeled GABA A α2/α3 Selective Partial Agonists and the Investigation of Late-Occurring and Long-Circulating Metabolites of GABA A Receptor Modulator AZD7325

Autores: Markus Artelsmair, Chungang Gu, Richard J. Lewis, Charles S. Elmore
Publicado en: Journal of Labelled Compounds and Radiopharmaceuticals, 2018, ISSN 0362-4803
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3602

Late-occurring and long-circulating metabolites of GABA Aα2,3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: relevance to MIST analysis and application for patient compliance

Autores: Chungang Gu, Markus Artelsmair, Charles S Elmore, Richard J Lewis, Patty Davis, James E Hall, Bruce T Dembofsky, Greg Christoph, Mark A Smith, Marc Chapdelaine, Maria Sunzel
Publicado en: Drug Metabolism and Disposition, Edición 46/3, 2018, Página(s) dmd.117.078873, ISSN 0090-9556
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/dmd.117.078873

In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation

Autores: Bastian Zinnhardt, Maximilian Wiesmann, Lisa Honold, Cristina Barca, Michael Schäfers, Amanda J Kiliaan, Andreas H Jacobs
Publicado en: Theranostics, Edición 8/10, 2018, Página(s) 2603-2620, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.24128

New trends and applications in carboxylation for isotope chemistry

Autores: Ryan A. Bragg, Malvika Sardana, Markus Artelsmair, Charles S. Elmore
Publicado en: Journal of Labelled Compounds and Radiopharmaceuticals, 2018, ISSN 0362-4803
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3633

Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2

Autores: Markus Artelsmair, Patricia Miranda-Azpiazu, Lee Kingston, Jonas Bergare, Magnus Schou, Andrea Varrone, Charles S. Elmore
Publicado en: Journal of Labelled Compounds and Radiopharmaceuticals, 2019, ISSN 0362-4803
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3731

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Autores: Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Publicado en: Neuro-Oncology, Edición 22/7, 2020, Página(s) 1030-1043, ISSN 1522-8517
Editor: Duke University Press
DOI: 10.1093/neuonc/noaa023

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent

Autores: Broos, Lecocq, Xavier, Bridoux, Nguyen, Corthals, Schoonooghe, Lion, Raes, Keyaerts, Devoogdt, Breckpot
Publicado en: Cancers, Edición 11/6, 2019, Página(s) 872, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11060872

Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages

Autores: Catarina Xavier, Anneleen Blykers, Damya Laoui, Evangelia Bolli, Ilse Vaneyken, Jessica Bridoux, Henri Baudhuin, Geert Raes, Hendrik Everaert, Kiavash Movahedi, Jo A. Van Ginderachter, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte, Marleen Keyaerts
Publicado en: Molecular Imaging and Biology, Edición 21/5, 2019, Página(s) 898-906, ISSN 1536-1632
Editor: Elsevier BV
DOI: 10.1007/s11307-018-01302-5

Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [ 18 F]DPA-714 PET and MRI

Autores: Bastian Zinnhardt, Michaël Belloy, Inga B. Fricke, Jasmien Orije, Caroline Guglielmetti, Sven Hermann, Stefan Wagner, Michael Schäfers, Annemie Van der Linden, Andreas H. Jacobs
Publicado en: Theranostics, Edición 9/6, 2019, Página(s) 1523-1537, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/THNO.32461

Improved Detection of Molecular Markers of Atherosclerotic Plaques Using Sub-Millimeter PET Imaging

Autores: Jessica Bridoux, Sara Neyt, Pieterjan Debie, Benedicte Descamps, Nick Devoogdt, Frederik Cleeren, Guy Bormans, Alexis Broisat, Vicky Caveliers, Catarina Xavier, Christian Vanhove, Sophie Hernot
Publicado en: Molecules, Edición 25/8, 2020, Página(s) 1838, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081838

Design, Synthesis, Radiosynthesis and Biological Evaluation of Fenretinide Analogues as Anticancer and Metabolic Syndrome‐Preventive Agents

Autores: Ilaria Patruno, Dawn Thompson, Sergio Dall'Angelo, Albert D. Windhorst, Danielle J. Vugts, Alex J. Poot, Nimesh Mody, Matteo Zanda
Publicado en: ChemMedChem, 2019, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202000143

The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by 89 Zr-immuno-PET in xenograft bearing mice

Autores: Marion Chomet, Maxime Schreurs, Margaret Nguyen, Bruce Howng, Ruth Villanueva, Michael Krimm, Olga Vasiljeva, Guus A.M.S van Dongen, Danielle J. Vugts
Publicado en: Theranostics, Edición 10/13, 2020, Página(s) 5815-5828, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.44334

Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al18F-RESCA method

Autores: Frederik Cleeren, Joan Lecina, Jessica Bridoux, Nick Devoogdt, Térence Tshibangu, Catarina Xavier, Guy Bormans
Publicado en: Nature Protocols, Edición 13/10, 2018, Página(s) 2330-2347, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-018-0040-7

Multimodal Molecular Imaging of the Tumour Microenvironment

Autores: Claudia Foray, Cristina Barca, Philipp Backhaus, Sonja Schelhaas, Alexandra Winkeler, Thomas Viel, Michael Schäfers, Oliver Grauer, Andreas H. Jacobs, Bastian Zinnhardt
Publicado en: Tumor Microenvironment - Recent Advances, Edición 1225, 2020, Página(s) 71-87, ISBN 978-3-030-35726-9
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-35727-6_5

Antibody Conjugation With Trans-Cyclooctene And Desferoxamine To Enable In Vivo Click Reaction For Pretargeting Strategies

Autores: Feiner, Irene V. J.; Gómez-Vallejo, Vanessa; Calvo, Javier; Llop, Jordi
Publicado en: Presentation at the 2nd ySMIN Meeting, November 2017, 2018
Editor: Zenodo
DOI: 10.5281/zenodo.1240254

Immuno-Imaging & Molecular Therapy Workshop, Brussel (VUB) April 2019

Autores: Alessandro Colombano
Publicado en: Poster session @ Immuno-Imaging & Molecular Therapy Workshop, Brussel (VUB) April 2019, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.3948464

Antibody Conjugation With Trans-Cyclooctene And Desferoxamine To Enable In Vivo Click Reaction For Pretargeting Strategies Including Distribution Imaging Of The Antibody

Autores: Feiner, Irene V. J.; Gómez-Vallejo, Vanessa; Calvo, Javier; Llop, Jordi
Publicado en: Poster at the 2nd Molecular Imaging Workshop, November 2017, Donostia-San Sebastian, Edición 1, 2017
Editor: Zenodo
DOI: 10.5281/zenodo.1240248

Synthesis of new 4-HPR analogues and use of PET imaging to support the development of drug candidates

Autores: Patruno I., Thomson D., Mody N., Windhorst A. D., Poot A. J., Vugts D. J., Dall'Angelo S., Zanda M.
Publicado en: Poster at EMIM 2019, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.3952481

Towards click pre-targeted PET imaging using novel trans-Cyclooctene linkers

Autores: Beatrice Longo
Publicado en: Poster session EMBO Workshop-Chemical Biology 2018, Heidelberg, Edición 1, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.3957631

Click pre-targeted PET imaging of antibodies using novel trans-Cyclooctene derivatives

Autores: Beatrice Longo
Publicado en: Oral presentation, SINAPSE Molecular Imaging PET/SPECT focus group meeting 2018, University of Glasgow, Edición 1, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.3957643

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