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Endoplasmic Reticulum Stress in Health and Disease

Objective

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the shortage of scientists with interdisciplinary training that can navigate with ease between the academic, industrial and clinical sectors, and that have the scientific and complementary skills, together with an innovative outlook, to convert research findings into commercial and clinical applications. This proposal will bring young researchers together with world-leading academics, clinicians and industry personnel, who are united in (1) their goal of forming a network of excellence aimed at understanding the ER stress response mechanistically and quantitatively and (2) applying this understanding to identify and validate the most suitable intervention points in order to provide innovative knowledge-driven strategies for the treatment of ER stress-associated diseases.
The TRAIN-ERS network will provide early stage researchers (ESRs) with high quality scientific and complementary skills training combined with international, intersectoral work experience. This will produce highly trained, innovative, creative and entrepreneurial ESRs with greatly enhanced career prospects, who will continue to advance the state of the art in the Biomedical field in their further careers, and will confidently navigate at the interface of academic, clinical and private sector research. The TRAIN-ERS research programme will provide the ESR’s with the knowledge and the cutting edge scientific and technical skills that will drive our understanding and exploitation of the ER stress response for therapeutic and diagnostic purposes.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/clinical medicine/critical care medicine
  • /medical and health sciences/clinical medicine/cancer/breast cancer
  • /medical and health sciences/basic medicine/neurology/amyotrophic lateral sclerosis
  • /medical and health sciences/health sciences/inflammatory diseases

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 797 023,80

Participants (11)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 525 751,20
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 249 216,48
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
RANDOX TEORANTA
Ireland
EU contribution
€ 265 674,60
Address
An Clochan Liath
F94 TV06 Donegall
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 263 659,32
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 247 872,96
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
EU contribution
€ 255 934,08
Address
Nussdorfer Strasse 64/6
1090 Wien
Activity type
Research Organisations
ROYAL COLLEGE OF SURGEONS IN IRELAND

Participation ended

Ireland
EU contribution
€ 0
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 501 120
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 273 287,88
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
OPTIMATA LTD

Participation ended

Israel
EU contribution
€ 0
Address
20 Zichron Yaa'kov St.
6299920 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET STUTTGART
Germany
EU contribution
€ 249 216,48
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments

Partners (6)

MANNKIND CORPORATION
United States
Address
North Avenue Paine 28903
91355 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Carpmaels & Ransford LLP
United Kingdom
Address
One Southampton Row
WC1B 5HA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LALUI SPOL SRO
Czechia
Address
Ponesicka 1709
37341 Hluboka Nad Vltavou
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
Address
Templergraben 55
52062 Aachen
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
BioScale, Inc.
United States
Address
4 Maguire Road
MA 02421 Lexington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)