Deliverables Documents, reports (1) ESR recruitment Report on recruitment of ESRs Websites, patent fillings, videos etc. (3) Training materials & educational animation Selected raining materials from schools and workshops & educational animation available for public dissemination TRAIN-ERS Facebook and Twitter accounts Creation of Facebook and Twitter account Website and data sharing platform Development of Website and data sharing platform Publications Peer reviewed articles (29) Dual IRE1 RNase functions dictate glioblastoma development Author(s): Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B P Published in: EMBO Molecular Medicine, Issue 10/3, 2018, Page(s) e7929, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201707929 Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes Author(s): L. Montibeller, J. de Belleroche Published in: Cell Stress and Chaperones, 2018, ISSN 1355-8145 Publisher: Cell Stress Society International DOI: 10.1007/s12192-018-0897-y Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Author(s): Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-05763-8 RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells Author(s): Rola Jaafar, Katarzyna Mnich, Sarah Dolan, Jennifer Hillis, Aitor Almanza, Susan E. Logue, Afshin Samali, Adrienne M. Gorman Published in: Biochemical and Biophysical Research Communications, Issue 497/1, 2018, Page(s) 115-121, ISSN 0006-291X Publisher: Academic Press DOI: 10.1016/j.bbrc.2018.02.034 Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications Author(s): Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re Published in: The FEBS Journal, 2018, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14608 The Unfolded Protein Response and Membrane Contact Sites: Tethering as a Matter of Life and Death? Author(s): Alexander R. van Vliet, Maria Livia Sassano, Patrizia Agostinis Published in: Contact, Issue 1, 2018, Page(s) 251525641877051, ISSN 2515-2564 Publisher: SAGE PUBLISHING DOI: 10.1177/2515256418770512 Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance Author(s): Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner, Markus Rehm Published in: Cell Death & Disease, Issue 9/4, 2018, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-018-0464-6 Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation Author(s): Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif Published in: EMBO Molecular Medicine, Issue 11/6, 2019, Page(s) e10120, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201810120 Alterations of EDEM 1 functions enhance ATF 6 pro‐survival signaling Author(s): Alexandra Papaioannou, Arisa Higa, Gwénaële Jégou, Florence Jouan, Raphael Pineau, Laure Saas, Tony Avril, Olivier Pluquet, Eric Chevet Published in: The FEBS Journal, Issue 285/22, 2018, Page(s) 4146-4164, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14669 Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease Author(s): Cynthia Lebeaupin, Deborah Vallée, Younis Hazari, Claudio Hetz, Eric Chevet, Béatrice Bailly-Maitre Published in: Journal of Hepatology, Issue 69/4, 2018, Page(s) 927-947, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2018.06.008 Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors Author(s): Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-019-39939-z The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors Author(s): Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh Published in: Cell Death & Disease, Issue 10/4, 2019, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-019-1523-3 Selective Inhibition of IRE1 Signalling mediated by MKC9989: New Insights from Molecular Docking and Molecular Dynamics Simulations Author(s): Antonio Carlesso, Leif A. Eriksson Published in: ChemistrySelect, Issue 4/11, 2019, Page(s) 3199-3203, ISSN 2365-6549 Publisher: Wiley-VCH DOI: 10.1002/slct.201900810 Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain Author(s): Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson Published in: ACS Omega, Issue 3/10, 2018, Page(s) 13313-13322, ISSN 2470-1343 Publisher: American Chemical Society DOI: 10.1021/acsomega.8b01404 Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress Author(s): Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi, Patrizia Agostinis, Simone Fulda Published in: Cell Death & Disease, Issue 10/3, 2019, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-019-1381-z Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers Author(s): T Avril, E Vauléon, E Chevet Published in: Oncogenesis, Issue 6/8, 2017, Page(s) e373-e373, ISSN 2157-9024 Publisher: Nature Publishing Group DOI: 10.1038/oncsis.2017.72 Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Author(s): Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr Published in: Nature Cell Biology, Issue 21/6, 2019, Page(s) 755-767, ISSN 1465-7392 Publisher: Nature Publishing Group DOI: 10.1038/s41556-019-0329-y CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Author(s): Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R. Colen, Brett L. Carlson, Paul A. Decker, Jann N. Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien Published in: Clinical Cancer Research, Issue 23/23, 2017, Page(s) 7360-7374, ISSN 1078-0432 Publisher: American Association for Cancer Research DOI: 10.1158/1078-0432.ccr-17-1549 Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma Author(s): Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm Published in: BMC Cell Biology, Issue 19/1, 2018, ISSN 1471-2121 Publisher: BioMed Central DOI: 10.1186/s12860-018-0180-1 NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis Author(s): Behnaz Ahangarian Abhari, Nicole McCarthy, Patrizia Agostinis, Simone Fulda Published in: Apoptosis, Issue 24/3-4, 2019, Page(s) 269-277, ISSN 1360-8185 Publisher: Kluwer Academic Publishers DOI: 10.1007/s10495-018-1507-2 Regulation of tumor-stroma interactions by the unfolded protein response Author(s): Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet Published in: The FEBS Journal, Issue 286/2, 2019, Page(s) 279-296, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14359 Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression Author(s): Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia Luís, Andrey Kozlov, Johannes Haybaeck, Mathias Müller, Xiaonan Han, Richard Moriggl Published in: Cytokine, 2018, ISSN 1043-4666 Publisher: Academic Press DOI: 10.1016/j.cyto.2018.10.010 Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases Author(s): J. Catharina Duvigneau, Andreia Luís, Adrienne M. Gorman, Afshin Samali, Doris Kaltenecker, Richard Moriggl, Andrey V. Kozlov Published in: Cytokine, 2018, ISSN 1043-4666 Publisher: Academic Press DOI: 10.1016/j.cyto.2018.10.018 Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling Author(s): Camila Rubio-Patiño, Jozef P. Bossowski, Eric Chevet, Jean-Ehrland Ricci Published in: Trends in Molecular Medicine, Issue 24/7, 2018, Page(s) 607-614, ISSN 1471-4914 Publisher: Elsevier BV DOI: 10.1016/j.molmed.2018.05.005 Control of the Unfolded Protein Response in Health and Disease Author(s): Dimitrios Doultsinos, Tony Avril, Stéphanie Lhomond, Nicolas Dejeans, Philippe Guédat, Eric Chevet Published in: SLAS DISCOVERY: Advancing Life Sciences R&D, Issue 22/7, 2017, Page(s) 787-800, ISSN 2472-5552 Publisher: SAGE publishing DOI: 10.1177/2472555217701685 Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate Author(s): Maria Livia Sassano, Alexander R. van Vliet, Patrizia Agostinis Published in: Frontiers in Oncology, Issue 7, 2017, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2017.00174 In the Hunger Games, the Winner Takes Everything Author(s): Franziska Püschel, Cristina Muñoz-Pinedo Published in: Trends in Biochemical Sciences, 2017, ISSN 0968-0004 Publisher: Elsevier BV DOI: 10.1016/j.tibs.2017.08.004 Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors Author(s): Raffaella Iurlaro, Franziska Püschel, Clara Lucía León-Annicchiarico, Hazel O'Connor, Seamus J. Martin, Daniel Palou-Gramón, Estefanía Lucendo, Cristina Muñoz-Pinedo Published in: Molecular and Cellular Biology, Issue 37/10, 2017, Page(s) e00479-16, ISSN 0270-7306 Publisher: American Society for Microbiology DOI: 10.1128/MCB.00479-16 Trial Watch: Immunogenic cell death induction by anticancer chemotherapeutics Author(s): Abhishek D. Garg, Sanket More, Nicole Rufo, Odeta Mece, Maria Livia Sassano, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi Published in: OncoImmunology, Issue 12 issues per year, 2017, Page(s) 00-00, ISSN 2162-402X Publisher: Taylor & Francis DOI: 10.1080/2162402X.2017.1386829 Other (2) Constitutive IRE1α signaling maintains glioblastoma cell differentiation Author(s): Doultsinos D, McMahon M, Voutetaki K, Obacz J, Pineau R, Jouan F, Le Reste P-J, Obiedat A, Samal J, Patterson JB, Zheng Q, Samali A, Pandit A, Tirosh B, Chatziioannou A, Chevet E, Avril T. Published in: BioRXiv, 2019 Publisher: Cold Spring Harbor Laboratory DOI: 10.1101/59463 Control of glioblastoma differentiated-to-stem cell reprogramming by IRElα/XBPls signaling Author(s): Dimitrios Doultsinos, Mari McMahon, Konstantinos Voutetakis, Joanna Obacz, Raphael Pineau, Florence Jouan, Pierre-Jean Le Reste, Akram Obiedat, Juhi Samal, John B. Patterson, Qingping Zheng, Afshin Samali, Abhay Pandit, Boaz Tirosh, Aristotelis Chatziioannou, View ORCID ProfileEric Chevet, Tony Avril Published in: BioRXiv, 2019 Publisher: Cold Spring Harbor DOI: 10.1101/594630 Book chapters (1) Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling Author(s): Alexandra Papaioannou, Eric Chevet Published in: Current Topics in Microbiology and Immunology, 2017 Publisher: Springer Berlin Heidelberg DOI: 10.1007/82_2017_36 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
