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ALK Activation as a target of TRAanslational Science (ALKATRAS): Break free from cancer

Deliverables

Research article publication

Research articles will be published detailing the research findings from the ALKATRAS network

ALK review

A series of review articles will be prepared and published in the scientific literature

Dissemination reporting

A report will be prepared containing an overview of all outreach and dissemination activities carried out and achieved during the course of the ETN

ALCL transcriptome database

A database will be developed that details the transcriptome of ALCL. This will be available to the wider scientific community.

Therapies for resistant disease database

A database will be produced detailing therapies that can be used for the treatment of ALK-related cancers that are resistant to other forms of therapy

Therapy Synergism database

A database will be developed to aid clinicians in the treatment of patients with ALK-related malignancies. The database will detail those therapeutic compounds that have synergy

Mutations database

A database will be produced detailing somatic and acquired mutations in ALCL.

Epigenetics database

A database will be developed detailing deregulated cpG islands in ALK-related cancers which will be available to the wider scientific community

Podcasts

Students will produce podcasts detailing their research that will be accessible to teh general public and the scientific community.

ALKATRAS website developed and updated

An ALKATRAS website will be developed and continually updated

Outreach

Students will undertake outreach activities to present their research to the scientific community and the general public

Award of PhD degrees

All students would have been awarded their PhD degrees and this will be announced on the ALKATRAS website.

Publications

The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL)

Author(s): Ivonne Montes-Mojarro, Julia Steinhilber, Irina Bonzheim, Leticia Quintanilla-Martinez, Falko Fend
Published in: Cancers, Issue 10/4, 2018, Page(s) 107, ISSN 2072-6694
DOI: 10.3390/cancers10040107

Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes

Author(s): Geeta Sharma, Ines Mota, Luca Mologni, Enrico Patrucco, Carlo Gambacorti-Passerini, Roberto Chiarle
Published in: Cancers, Issue 10/3, 2018, Page(s) 62, ISSN 2072-6694
DOI: 10.3390/cancers10030062

Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond

Author(s): Nina Prokoph, Hugo Larose, Megan Lim, G. Burke, Suzanne Turner
Published in: Cancers, Issue 10/4, 2018, Page(s) 99, ISSN 2072-6694
DOI: 10.3390/cancers10040099

The Role of Oncogenic Tyrosine Kinase NPM-ALK in Genomic Instability

Author(s): Cosimo Lobello, Vasilis Bikos, Andrea Janikova, Sarka Pospisilova
Published in: Cancers, Issue 10/3, 2018, Page(s) 64, ISSN 2072-6694
DOI: 10.3390/cancers10030064

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

Author(s): Ines Garces de los Fayos Alonso, Huan-Chang Liang, Suzanne Turner, Sabine Lagger, Olaf Merkel, Lukas Kenner
Published in: Cancers, Issue 10/4, 2018, Page(s) 93, ISSN 2072-6694
DOI: 10.3390/cancers10040093

Immune Response against ALK in Children with ALK-Positive Anaplastic Large Cell Lymphoma

Author(s): Serena Stadler, Vijay Singh, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann
Published in: Cancers, Issue 10/4, 2018, Page(s) 114, ISSN 2072-6694
DOI: 10.3390/cancers10040114

Targeting Autophagy in ALK-Associated Cancers

Author(s): Julie Frentzel, Domenico Sorrentino, Sylvie Giuriato
Published in: Cancers, Issue 9/12, 2017, Page(s) 161, ISSN 2072-6694
DOI: 10.3390/cancers9120161

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma

Author(s): Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R. Griffin, Roberto Piva, Henrike L. Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D. Turner, Eva Kaergel, Linda von Hoff, Micha
Published in: Leukemia, Issue 32/9, 2018, Page(s) 1994-2007, ISSN 0887-6924
DOI: 10.1038/s41375-018-0045-9

Comment on “ALK is a therapeutic target for lethal sepsis”

Author(s): Rafael B. Blasco, Enrico Patrucco, Ines Mota, Wei-Tien Tai, Roberto Chiarle
Published in: Science Translational Medicine, Issue 10/471, 2018, Page(s) eaar4321, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aar4321

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Author(s): Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C. Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A. Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich Jäger, Phi
Published in: Leukemia, Issue 33/3, 2019, Page(s) 696-709, ISSN 0887-6924
DOI: 10.1038/s41375-018-0239-1

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Author(s): Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bo
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09838-y

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

Author(s): Matteo Menotti, Chiara Ambrogio, Taek-Chin Cheong, Chiara Pighi, Ines Mota, Seth H. Cassel, Mara Compagno, Qi Wang, Riccardo Dall’Olio, Valerio G. Minero, Teresa Poggio, Geeta Geeta Sharma, Enrico Patrucco, Cristina Mastini, Ramesh Choudhari, Achille Pich, Alberto Zamo, Roberto Piva, Silvia Giliani, Luca Mologni, Clayton K. Collings, Cigall Kadoch, Carlo Gambacorti-Passerini, Luigi D. Notarangel
Published in: Nature Medicine, Issue 25/1, 2019, Page(s) 130-140, ISSN 1078-8956
DOI: 10.1038/s41591-018-0262-9

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Author(s): Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bo
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09415-3

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Author(s): Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O’Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark Bartholomä, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dier
Published in: Science Translational Medicine, Issue 10/429, 2018, Page(s) eaam7729, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aam7729

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

Author(s): Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta
Published in: Haematologica, 2019, Page(s) haematol.2019.216986, ISSN 0390-6078
DOI: 10.3324/haematol.2019.216986

Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells

Author(s): Luca Mologni, Mariantonia Costanza, Geeta Geeta Sharma, Michela Viltadi, Luca Massimino, Stefania Citterio, Stefania Purgante, Hima Raman, Alessandra Pirola, Massimo Zucchetti, Rocco Piazza, Carlo Gambacorti-Passerini
Published in: Neoplasia, Issue 20/5, 2018, Page(s) 467-477, ISSN 1476-5586
DOI: 10.1016/j.neo.2018.02.009

NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma

Author(s): Vijay Kumar Singh, Sebastian Werner, Simone Schwalm, Volker Lennerz, Stephanie Ruf, Serena Stadler, Holger Hackstein, Alfred Reiter, Thomas Wölfel, Christine Damm-Welk, Wilhelm Woessmann
Published in: OncoImmunology, Issue 8/9, 2019, Page(s) e1625688, ISSN 2162-402X
DOI: 10.1080/2162402x.2019.1625688

An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Author(s): Lobello C, Janikova A, Kren L, Hermanova M, Sprlakova-Pukova A, Krejci J, Pospisilova S, Pytlik R, Hamouzova M, Belada D, Prochazka V, Duras J, Mocikova H, Trneny M
Published in: Journal of Cancer Research & Therapy, Issue 5/10, 2017, Page(s) 66-71, ISSN 2052-4994
DOI: 10.14312/2052-4994.2017-13

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

Author(s): Jimmy Van den Eynden, Ganesh Umapathy, Arghavan Ashouri, Diana Cervantes-Madrid, Joanna Szydzik, Kristina Ruuth, Jan Koster, Erik Larsson, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Published in: Science Signaling, Issue 11/557, 2018, Page(s) eaar5680, ISSN 1937-9145
DOI: 10.1126/scisignal.aar5680

Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells

Author(s): Diana Cervantes-Madrid, Joanna Szydzik, Dan Emil Lind, Marcus Borenäs, Mats Bemark, Jean Cui, Ruth Helen Palmer, Bengt Hallberg
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-55060-7

Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

Author(s): Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux, Alexander Keller, Cornelius Miething, Marie Follo, Dietmar Pfeifer, Khalid Shoumariyeh, Claudia Lengerke, Irene Gonzalez-Menendez, Falko Fend, Robert Zeiser, Suzanne D. Turner, Leticia Quintanilla-Martinez, Melanie Boerries, Justus Duyster, Anna L. Illert
Published in: Leukemia, 2020, ISSN 0887-6924
DOI: 10.1038/s41375-020-0789-x

NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Author(s): Alina Rudorf, Tony Andreas Müller, Cathrin Klingeberg, Stefanie Kreutmair, Teresa Poggio, Sivahari Prasad Gorantla, Tamina Rückert, Annette Schmitt-Graeff, Anina Gengenbacher, Peter Paschka, Claudia Baldus, Robert Zeiser, George S. Vassiliou, Allan Bradley, Justus Duyster, Anna Lena Illert
Published in: Blood, Issue 134/4, 2019, Page(s) 383-388, ISSN 0006-4971
DOI: 10.1182/blood.2018883140

Current Immunotherapeutic Approaches in T Cell Non-Hodgkin Lymphomas

Author(s): Teresa Poggio, Justus Duyster, Anna Illert
Published in: Cancers, Issue 10/9, 2018, Page(s) 339, ISSN 2072-6694
DOI: 10.3390/cancers10090339

Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues

Author(s): Anina Gengenbacher, Alina Müller-Rudorf, Teresa Poggio, Linda Gräßel, Veronica I. Dumit, Stefanie Kreutmair, Lena J. Lippert, Justus Duyster, Anna L. Illert
Published in: International Journal of Molecular Sciences, Issue 20/16, 2019, Page(s) 4060, ISSN 1422-0067
DOI: 10.3390/ijms20164060

Epstein - Barr virus positive T and NK-cell lymphoproliferations: Morphological features and differential diagnosis

Author(s): Ivonne A. Montes-Mojarro, Wook Youn Kim, Falko Fend, Leticia Quintanilla-Martinez
Published in: Seminars in Diagnostic Pathology, Issue 37/1, 2020, Page(s) 32-46, ISSN 0740-2570
DOI: 10.1053/j.semdp.2019.12.004

EMMPRIN (CD147) is induced by C/EBPβ and is differentially expressed in ALK+ and ALK− anaplastic large-cell lymphoma

Author(s): Janine Schmidt, Irina Bonzheim, Julia Steinhilber, Ivonne A Montes-Mojarro, Carlos Ortiz-Hidalgo, Wolfram Klapper, Falko Fend, Leticia Quintanilla-Martínez
Published in: Laboratory Investigation, Issue 97/9, 2017, Page(s) 1095-1102, ISSN 0023-6837
DOI: 10.1038/labinvest.2017.54

Mutational profile and EBV strains of extranodal NK/T-cell lymphoma, nasal type in Latin America

Author(s): Ivonne A. Montes-Mojarro, Bo-Jung Chen, Ana F. Ramirez-Ibarguen, Carmen M. Quezada-Fiallos, Wendy B. Pérez-Báez, Daniela Dueñas, Sandro Casavilca-Zambrano, Marcela Ortiz-Mayor, Erica Rojas-Bilbao, Hernan García-Rivello, Maria F. Metrebian, Marina Narbaitz, Carlos Barrionuevo, Carmen Lome-Maldonado, Irina Bonzheim, Falko Fend, Julia Steinhilber, Leticia Quintanilla-Martinez
Published in: Modern Pathology, Issue 33/5, 2020, Page(s) 781-791, ISSN 0893-3952
DOI: 10.1038/s41379-019-0415-5

Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases

Author(s): Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
Published in: Frontiers in Pediatrics, Issue 7, 2019, ISSN 2296-2360
DOI: 10.3389/fped.2019.00071

A Compound L1196M/G1202R ALK Mutation in a Patient with ALK-Positive Lung Cancer with Acquired Resistance to Brigatinib Also Confers Primary Resistance to Lorlatinib

Author(s): Geeta G. Sharma, Diego Cortinovis, Francesco Agustoni, Giulia Arosio, Matteo Villa, Nicoletta Cordani, Paolo Bidoli, William H. Bisson, Fabio Pagni, Rocco Piazza, Carlo Gambacorti-Passerini, Luca Mologni
Published in: Journal of Thoracic Oncology, Issue 14/11, 2019, Page(s) e257-e259, ISSN 1556-0864
DOI: 10.1016/j.jtho.2019.06.028

We shall overcome (drug resistance) some day

Author(s): Geeta G. Sharma, Luca Mologni
Published in: Oncotarget, Issue 10/2, 2019, Page(s) 84-85, ISSN 1949-2553
DOI: 10.18632/oncotarget.26550

Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer

Author(s): Sara Redaelli, Monica Ceccon, Marina Zappa, Geeta G. Sharma, Cristina Mastini, Mario Mauri, Marion Nigoghossian, Luca Massimino, Nicoletta Cordani, Francesca Farina, Rocco Piazza, Carlo Gambacorti-Passerini, Luca Mologni
Published in: Cancer Research, Issue 78/24, 2018, Page(s) 6866-6880, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-18-1867

Datasets

BRG1 shRNA knockdown in ALCL cell lines

Author(s): Turner, Suzanne
Published in: Zenodo