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Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Objective

The basic concept of our proposal is to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

PERCUROS BV
Address
Plesmanlaan 1
2333 BZ Leiden
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 255 374,28

Participants (13)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 680 998,08
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 212 811,90
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI CAMERINO
Italy
EU contribution
€ 258 061,32
Address
Piazza Cavour 19F
62032 Camerino
Activity type
Higher or Secondary Education Establishments
TECOBIOSCIENCES GMBH
Germany
EU contribution
€ 249 216,48
Address
Bussardstrasse 35
84036 Landshut
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 127 687,14
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 286 275,24
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
HELSE BERGEN HF*HAUKELAND UNIVERSITY HOSPITAL
Norway
EU contribution
€ 286 275,24
Address
Jonas Lies Vei 65
5021 Bergen
Activity type
Higher or Secondary Education Establishments
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 546 575,76
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 127 687,14
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
JENACELL GMBH
Germany
EU contribution
€ 249 216,48
Address
Goschwitzer Str. 22
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDRES-MEDICAL RESEARCH GMBH
Germany
EU contribution
€ 249 216,48
Address
Gleueler Strasse 50
50931 Koln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 127 687,14
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments