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Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Objective

The basic concept of our proposal is to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

Coordinator

PERCUROS BV
Net EU contribution
€ 255 374,28
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage
Netherlands

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Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Participants (13)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 680 998,08
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
Net EU contribution
€ 212 811,90
Address
Stevinweg 1
2628 CN Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI CAMERINO
Italy
Net EU contribution
€ 258 061,32
Address
Piazza Cavour 19f
62032 Camerino

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Region
Centro (IT) Marche Macerata
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECOBIOSCIENCES GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Bussardstrasse 35
84036 Landshut

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Niederbayern Landshut, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITEIT VAN AMSTERDAM
Netherlands
Net EU contribution
€ 127 687,14
Address
Spui 21
1012WX Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITETET I BERGEN
Norway
Net EU contribution
€ 286 275,24
Address
Museplassen 1
5020 Bergen

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Region
Norge Vestlandet Vestland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HELSE BERGEN HF
Norway
Net EU contribution
€ 286 275,24
Address
Jonas Lies Vei 65
5021 Bergen

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Region
Norge Vestlandet Vestland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 546 575,76
Address
Firth Court Western Bank
S10 2TN Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 127 687,14
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
JENACELL GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Goschwitzer Str. 22
07745 Jena

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MEDRES-MEDICAL RESEARCH GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Gleueler Strasse 50
50931 Koln

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 127 687,14
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00