Deliverables Other (1) All ESRs recruited All ESRs recruited Documents, reports (6) Training by research and network-wide training completed Training by research and network-wide training completed Dissemination plan (M7) and Project publications including review articles written by ESRs (M48) Dissemination plan (M7) and Project publications including review articles written by ESRs (M48) Public engagement activities completed Public engagement activities completed Conference M30 (Gantt Chart) Conference M30 (Gantt Chart) Progress reports and periodic reports to EC Progress reports and periodic reports to EC (months 1-48) Rotations and SECs completed Rotations and SECs completed Websites, patent fillings, videos etc. (1) Project website live Project website live Publications Peer reviewed articles (39) Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach Author(s): Maria Rosa Gigliobianco, Barbara Campisi, Dolores Vargas Peregrina, Roberta Censi, Gulzhan Khamitova, Simone Angeloni, Giovanni Caprioli, Marco Zannotti, Stefano Ferraro, Rita Giovannetti, Cristina Angeloni, Giulio Lupidi, Letizia Pruccoli, Andrea Tarozzi, Dario Voinovich, Piera Di Martino Published in: Antioxidants, Issue 9/5, 2020, Page(s) 370, ISSN 2076-3921 Publisher: x DOI: 10.3390/antiox9050370 Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging Author(s): Giorgia Zambito, Natasa Gaspar, Yanto Ridwan, Mary P. Hall, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte Published in: Molecular Imaging and Biology, 2020, ISSN 1536-1632 Publisher: Elsevier BV DOI: 10.1007/s11307-020-01523-7 The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage Author(s): Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata Published in: Polymers, Issue 13/6, 2021, Page(s) 907, ISSN 2073-4360 Publisher: MDPI DOI: 10.3390/polym13060907 Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins Author(s): Raimundo De Ara�jo Jr, Jonas Pessoa, Luis Cruz, Alan Chan, Em�lio De Castro Miguel, R�mulo Cavalcante, Gerly Anne Brito, Heloiza Fernada Silva, Luiz Gasparotto, Paulo Guedes, Aurigena Ara�jo Published in: International Journal of Oncology, 2017, ISSN 1019-6439 Publisher: Demetrios A. Spandidos Ed. & Pub. DOI: 10.3892/ijo.2017.4179 Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats Author(s): Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior Published in: International Journal of Pharmaceutics, 2018, ISSN 0378-5173 Publisher: Elsevier BV DOI: 10.1016/j.ijpharm.2018.06.008 Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis Author(s): Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas Published in: Current Gene Therapy, Issue 17/5, 2018, ISSN 1566-5232 Publisher: Bentham Science Publishers DOI: 10.2174/1566523218666180105122626 Diverse Functions of Macrophages in Different Tumor Microenvironments Author(s): Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis Published in: Cancer Research, Issue 78/19, 2018, Page(s) 5492-5503, ISSN 0008-5472 Publisher: American Association for Cancer Research DOI: 10.1158/0008-5472.CAN-18-1367 Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences Author(s): Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Published in: Journal of Controlled Release, Issue 285, 2018, Page(s) 56-66, ISSN 0168-3659 Publisher: Elsevier BV DOI: 10.1016/j.jconrel.2018.07.011 Memory CD4+ T cells are generated in the human fetal intestine Author(s): Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning Published in: Nature Immunology, 2019, ISSN 1529-2908 Publisher: Nature Publishing Group DOI: 10.1038/s41590-018-0294-9 Opportunities of bacterial cellulose to treat epithelial tissues Author(s): Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch Published in: Current Drug Targets, Issue 20, 2018, Page(s) 808-822, ISSN 1389-4501 Publisher: Bentham Science Publishers DOI: 10.2174/1389450120666181129092144 Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry Author(s): Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino Published in: Journal of Chromatography A, 2019, Page(s) 460622, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2019.460622 Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging Author(s): Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior Published in: Nanoscale Research Letters, Issue 14/1, 2019, ISSN 1931-7573 Publisher: Springer Verlag DOI: 10.1186/s11671-019-2986-y Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance Author(s): Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel Published in: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642 Publisher: Springer Verlag DOI: 10.1007/s00216-019-02148-8 MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment Author(s): Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren Published in: Journal of The American Society for Mass Spectrometry, Issue 30/10, 2019, Page(s) 2041-2050, ISSN 1044-0305 Publisher: Elsevier BV DOI: 10.1007/s13361-019-02265-9 PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors Author(s): Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426 Publisher: J Immunother Cancer DOI: 10.1186/s40425-019-0700-3 Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations Author(s): Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens Published in: Computational and Structural Biotechnology Journal, Issue 16, 2018, Page(s) 435-442, ISSN 2001-0370 Publisher: Comput Struct Biotechnol J DOI: 10.1016/j.csbj.2018.10.004 A comparison of automatic cell identification methods for single-cell RNA sequencing data Author(s): Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz Published in: Genome Biology, Issue 20/1, 2019, ISSN 1474-760X Publisher: Genome Biol DOI: 10.1186/s13059-019-1795-z Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry Author(s): Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Front Immunol DOI: 10.3389/fimmu.2019.01932 Cytomegalovirus infection and progressive differentiation of effector-memory T cells Author(s): Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens Published in: F1000Research, Issue 7, 2018, Page(s) 1554, ISSN 2046-1402 Publisher: F1000 Research Ltd. DOI: 10.12688/f1000research.15753.1 High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity Author(s): Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda Published in: Gut, 2019, Page(s) gutjnl-2019-318672, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2019-318672 Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections Author(s): Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 142, 2019, Page(s) 322-333, ISSN 0939-6411 Publisher: Elsevier BV DOI: 10.1016/j.ejpb.2019.07.006 Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures Author(s): Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang Published in: Angewandte Chemie International Edition, Issue 57/12, 2018, Page(s) 3054-3058, ISSN 1433-7851 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/anie.201711606 Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability Author(s): Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta Published in: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Issue 4, 2018, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.20944/PREPRINTS201807.0233.V1 Cosmetic Formulation Based on an Açai Extract Author(s): Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino Published in: Cosmetics, Issue 5/3, 2018, Page(s) 48, ISSN 2079-9284 Publisher: Cosmetics 2018 DOI: 10.3390/cosmetics5030048 Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase Author(s): Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik Published in: Oral Oncology, Issue 78, 2018, Page(s) 1-7, ISSN 1368-8375 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.oraloncology.2017.12.006 Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging Author(s): Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-017-02542-9 Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science Author(s): Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino Published in: Marine Drugs, Issue 17/6, 2019, Page(s) 369, ISSN 1660-3397 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/md17060369 A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function Author(s): Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik Published in: Frontiers in Immunology, Issue 9, 2019, ISSN 1664-3224 Publisher: Front. Immunol DOI: 10.3389/fimmu.2018.03097 CyTOFmerge: integrating mass cytometry data across multiple panels Author(s): Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz Published in: Bioinformatics, Issue 35/20, 2019, Page(s) 4063-4071, ISSN 1367-4803 Publisher: Oxford University Press DOI: 10.1093/bioinformatics/btz180 Predicting Cell Populations in Single Cell Mass Cytometry Data Author(s): Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz Published in: Cytometry Part A, Issue 95/7, 2019, Page(s) 769-781, ISSN 1552-4922 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cyto.a.23738 Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles Author(s): Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz Published in: Theranostics, Issue 9/22, 2019, Page(s) 6485-6500, ISSN 1838-7640 Publisher: Ivyspring International Publisher DOI: 10.7150/thno.34429 Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities Author(s): Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 847, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano10050847 Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules25092219 Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646 Publisher: Frontiers in Chemistry DOI: 10.3389/fchem.2020.00496 Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers Author(s): Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong Published in: Scientific Reports, Issue 7, 2017, Page(s) 45633, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep45633 One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles Author(s): Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong Published in: Biosensors and Bioelectronics, Issue 92, 2017, Page(s) 335-341, ISSN 0956-5663 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.bios.2016.11.003 Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe Author(s): Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep38617 In Vivo Molecular Bioluminescence Imaging: New Tools and Applications Author(s): Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik Published in: Trends in Biotechnology, Issue 35/7, 2017, Page(s) 640-652, ISSN 0167-7799 Publisher: Elsevier BV DOI: 10.1016/j.tibtech.2017.03.012 SpaGE: Spatial Gene Enhancement using scRNA-seq Author(s): Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders Published in: Nucleic Acids Research, Issue 48/18, 2020, Page(s) e107-e107, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkaa740 Conference proceedings (1) Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes Author(s): N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda Published in: Tumour Microenvironment, 2018, Page(s) A328.2-A329 Publisher: BMJ Publishing Group Ltd DOI: 10.1136/esmoopen-2018-EACR25.775 Other (1) Perivascular macrophages in health and disease Author(s): Antonio Lapenna, Michele De Palma, Claire E. Lewis Published in: Nature Reviews Immunology, 2018, ISSN 1474-1733 Publisher: Nature Publishing Group DOI: 10.1038/s41577-018-0056-9 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
