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Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Deliverables

All ESRs recruited

All ESRs recruited

Training by research and network-wide training completed

Training by research and network-wide training completed

Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)

Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)

Public engagement activities completed

Public engagement activities completed

Conference M30 (Gantt Chart)

Conference M30 (Gantt Chart)

Progress reports and periodic reports to EC

Progress reports and periodic reports to EC (months 1-48)

Rotations and SECs completed

Rotations and SECs completed

Searching for OpenAIRE data...

Publications

Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

Author(s): Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Published in: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
DOI: 10.1016/j.ijpharm.2018.06.008

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

Author(s): Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Published in: Current Gene Therapy, Issue 17/5, 2018, ISSN 1566-5232
DOI: 10.2174/1566523218666180105122626

Diverse Functions of Macrophages in Different Tumor Microenvironments

Author(s): Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Published in: Cancer Research, Issue 78/19, 2018, Page(s) 5492-5503, ISSN 0008-5472
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Author(s): Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Published in: Journal of Controlled Release, Issue 285, 2018, Page(s) 56-66, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2018.07.011

Memory CD4+ T cells are generated in the human fetal intestine

Author(s): Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Published in: Nature Immunology, 2019, ISSN 1529-2908
DOI: 10.1038/s41590-018-0294-9

Opportunities of bacterial cellulose to treat epithelial tissues

Author(s): Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Published in: Current Drug Targets, Issue 20, 2018, Page(s) 808-822, ISSN 1389-4501
DOI: 10.2174/1389450120666181129092144

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Author(s): Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Published in: Journal of Chromatography A, 2019, Page(s) 460622, ISSN 0021-9673
DOI: 10.1016/j.chroma.2019.460622

Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging

Author(s): Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Published in: Nanoscale Research Letters, Issue 14/1, 2019, ISSN 1931-7573
DOI: 10.1186/s11671-019-2986-y

Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance

Author(s): Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Published in: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642
DOI: 10.1007/s00216-019-02148-8

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Author(s): Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
Published in: Journal of The American Society for Mass Spectrometry, Issue 30/10, 2019, Page(s) 2041-2050, ISSN 1044-0305
DOI: 10.1007/s13361-019-02265-9

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Author(s): Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426
DOI: 10.1186/s40425-019-0700-3

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Author(s): Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Published in: Computational and Structural Biotechnology Journal, Issue 16, 2018, Page(s) 435-442, ISSN 2001-0370
DOI: 10.1016/j.csbj.2018.10.004

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Author(s): Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
Published in: Genome Biology, Issue 20/1, 2019, ISSN 1474-760X
DOI: 10.1186/s13059-019-1795-z

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry

Author(s): Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.01932

Cytomegalovirus infection and progressive differentiation of effector-memory T cells

Author(s): Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Published in: F1000Research, Issue 7, 2018, Page(s) 1554, ISSN 2046-1402
DOI: 10.12688/f1000research.15753.1

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Author(s): Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
Published in: Gut, 2019, Page(s) gutjnl-2019-318672, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-318672

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections

Author(s): Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 142, 2019, Page(s) 322-333, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2019.07.006

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Author(s): Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Published in: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Issue 4, 2018, ISSN 1999-4923
DOI: 10.20944/PREPRINTS201807.0233.V1

Cosmetic Formulation Based on an Açai Extract

Author(s): Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Published in: Cosmetics, Issue 5/3, 2018, Page(s) 48, ISSN 2079-9284
DOI: 10.3390/cosmetics5030048

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Author(s): Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Published in: Oral Oncology, Issue 78, 2018, Page(s) 1-7, ISSN 1368-8375
DOI: 10.1016/j.oraloncology.2017.12.006

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Author(s): Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02542-9

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Author(s): Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Published in: Marine Drugs, Issue 17/6, 2019, Page(s) 369, ISSN 1660-3397
DOI: 10.3390/md17060369

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

Author(s): Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Published in: Frontiers in Immunology, Issue 9, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.03097

CyTOFmerge: integrating mass cytometry data across multiple panels

Author(s): Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Published in: Bioinformatics, Issue 35/20, 2019, Page(s) 4063-4071, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btz180

Predicting Cell Populations in Single Cell Mass Cytometry Data


Published in: ISSN 1552-4922
DOI: 10.1002/cyto.a.23738

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Author(s): Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Published in: Theranostics, Issue 9/22, 2019, Page(s) 6485-6500, ISSN 1838-7640
DOI: 10.7150/thno.34429

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Author(s): Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 847, ISSN 2079-4991
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
DOI: 10.3389/fchem.2020.00496

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Author(s): Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Published in: Scientific Reports, Issue 7, 2017, Page(s) 45633, ISSN 2045-2322
DOI: 10.1038/srep45633

One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles

Author(s): Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Published in: Biosensors and Bioelectronics, Issue 92, 2017, Page(s) 335-341, ISSN 0956-5663
DOI: 10.1016/j.bios.2016.11.003

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Author(s): Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep38617

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Author(s): Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik
Published in: Trends in Biotechnology, Issue 35/7, 2017, Page(s) 640-652, ISSN 0167-7799
DOI: 10.1016/j.tibtech.2017.03.012

Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Author(s): N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Published in: Tumour Microenvironment, 2018, Page(s) A328.2-A329
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Author(s): Antonio Lapenna, Michele De Palma, Claire E. Lewis
Published in: Nature Reviews Immunology, 2018, ISSN 1474-1733
DOI: 10.1038/s41577-018-0056-9