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Deciphering the Metabolism of Haematological Cancers

Objetivo

It has long been realised that metabolism is central to cellular development, proliferation and homeostasis. Collectively, aberrations in metabolism are now recognised as a major hallmark of cancer, opening new avenues for personalised medicine. As haematological malignancies are multi-factorial diseases, our main emphasis will be on the integration of biomedical multi-omics data and computational systems modelling with the ultimate aim to understand metabolic regulation in haematological cancers. HaemMetabolism is design to unravel the regulatory mechanisms that link cell cycle control and metabolism. For this we will screen a panel of haematological cancer cell lines for the metabolic phenotypes and against a library of inhibitors. Gene-function analyses will be performed using shRNA libraries directed against key metabolome regulators. Validation will occur in primary patient samples in vitro and in vivo in preclinical humanized niche xenograft mouse models. A systems biomedicine approach will be integrated build genome-scale transcriptional models that explain deregulated metabolic pathways relevant for the development of haematological malignancies. This work will not only open new avenues for drug discovery but will also provide a multi-disciplinary framework for student training in biomedical technologies.

Ámbito científico

  • /ciencias naturales/ciencias químicas/química analítica/espectrometría de masas
  • /ciencias médicas y de la salud/medicina básica/farmacología y farmacia/farmacorresistencia
  • /ciencias naturales/ciencias biológicas/biología celular/metabolismo celular
  • /ciencias naturales/ciencias biológicas/genética y herencia genética/mutación

Convocatoria de propuestas

H2020-MSCA-ITN-2015
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MSCA-ITN-EJD - European Joint Doctorates

Coordinador

THE UNIVERSITY OF BIRMINGHAM
Dirección
Edgbaston
B15 2TT Birmingham
United Kingdom
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 819 863,64

Participantes (3)

ACADEMISCH ZIEKENHUIS GRONINGEN
Países Bajos
Aportación de la UE
€ 510 748,56
Dirección
Hanzeplein 1
9713 GZ Groningen
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
España
Aportación de la UE
€ 743 618,88
Dirección
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Tipo de actividad
Higher or Secondary Education Establishments
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Alemania
Aportación de la UE
€ 498 432,96
Dirección
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Tipo de actividad
Higher or Secondary Education Establishments

Socios (3)

BRUKER BIOSPIN GMBH
Alemania
Dirección
Am Silberstreifen
76287 Rheinstetten
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TavarGenix
Alemania
Dirección

Heidelberg
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIFEGLIMMER GMBH
Alemania
Dirección
Markelstrasse 38
12163 Berlin
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)