From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease

Project Information

CaNANObinoids

Grant agreement ID: 676841

DOI

10.3030/676841

Project closed

EC signature date 15 March 2016

Start date 1 April 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

Author(s): Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60771

Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis

Author(s): Saja Baraghithy, Yael Soae, Dekel Assaf, Liad Hinden, Shiran Udi, Adi Drori, Yankel Gabet, Joseph Tam
Published in: Cells, 2021, ISSN 2073-4409
Publisher: Basel MDPI AG 2012
DOI: 10.3390/cells10020414

Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

Author(s): Shiran Udi, Liad Hinden, Majdoleen Ahmad, Adi Drori, Malliga R. Iyer, Resat Cinar, Michal Herman‐Edelstein, Joseph Tam
Published in: British Journal of Pharmacology, Issue 177/1, 2019, Page(s) 110-127, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14849

Pathogenesis of diabesity‐induced kidney disease: role of kidney nutrient sensing

Author(s): Liad Hinden, Aviram Kogot‐Levin, Joseph Tam, Gil Leibowitz
Published in: The FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15790

Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid-1 Receptor Antagonists

Author(s): Shayma El-Atawneh, Shira Hirsch, Rivka Hadar, Joseph Tam, Amiram Goldblum
Published in: Journal of Chemical Information and Modeling, Issue 59/9, 2019, Page(s) 3996-4006, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.9b00577

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Author(s): Aviram Kogot-Levin, Liad Hinden, Yael Riahi, Tal Israeli, Boaz Tirosh, Erol Cerasi, Ernesto Bernal Mizrachi, Joseph Tam, Ofri Mosenzon, Gil Leibowitz
Published in: Cell Reports, Issue 32/4, 2020, Page(s) 107954, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107954

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy

Author(s): Liad Hinden, Shiran Udi, Adi Drori, Asaad Gammal, Alina Nemirovski, Rivka Hadar, Saja Baraghithy, Anna Permyakova, Matan Geron, Merav Cohen, Sabina Tsytkin-Kirschenzweig, Yael Riahi, Gil Leibowitz, Yaakov Nahmias, Avi Priel, Joseph Tam
Published in: Journal of the American Society of Nephrology, 2017, Page(s) ASN.2017040371, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017040371

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

Author(s): Shiran Udi, Liad Hinden, Brian Earley, Adi Drori, Noa Reuveni, Rivka Hadar, Resat Cinar, Alina Nemirovski, Joseph Tam
Published in: Journal of the American Society of Nephrology, 2017, Page(s) ASN.2016101085, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2016101085

In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs

Author(s): Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y. Tshuva
Published in: ChemMedChem, 2018, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201800551

Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells

Author(s): Adi Drori, Anna Permyakova, Rivka Hadar, Shiran Udi, Alina Nemirovski, Joseph Tam
Published in: Diabetes, Obesity and Metabolism, 2018, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13497

The therapeutic potential of targeting the peripheral endocannabinoid/CB 1 receptor system

Author(s): Joseph Tam, Liad Hinden, Adi Drori, Shiran Udi, Shahar Azar, Saja Baraghithy
Published in: European Journal of Internal Medicine, Issue 49, 2018, Page(s) 23-29, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2018.01.009