From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease

Project Information

CaNANObinoids

Grant agreement ID: 676841

DOI 10.3030/676841

Project closed

EC signature date 15 March 2016

Start date 1 April 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Publications

Peer reviewed articles (11)

CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

Author(s): Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60771

Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis

Author(s): Saja Baraghithy, Yael Soae, Dekel Assaf, Liad Hinden, Shiran Udi, Adi Drori, Yankel Gabet, Joseph Tam
Published in: Cells, 2021, ISSN 2073-4409
Publisher: Basel MDPI AG 2012
DOI: 10.3390/cells10020414

Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

Author(s): Shiran Udi, Liad Hinden, Majdoleen Ahmad, Adi Drori, Malliga R. Iyer, Resat Cinar, Michal Herman‐Edelstein, Joseph Tam
Published in: British Journal of Pharmacology, Issue 177/1, 2019, Page(s) 110-127, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14849

Pathogenesis of diabesity‐induced kidney disease: role of kidney nutrient sensing

Author(s): Liad Hinden, Aviram Kogot‐Levin, Joseph Tam, Gil Leibowitz
Published in: The FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15790

Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid-1 Receptor Antagonists

Author(s): Shayma El-Atawneh, Shira Hirsch, Rivka Hadar, Joseph Tam, Amiram Goldblum
Published in: Journal of Chemical Information and Modeling, Issue 59/9, 2019, Page(s) 3996-4006, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.9b00577

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Author(s): Aviram Kogot-Levin, Liad Hinden, Yael Riahi, Tal Israeli, Boaz Tirosh, Erol Cerasi, Ernesto Bernal Mizrachi, Joseph Tam, Ofri Mosenzon, Gil Leibowitz
Published in: Cell Reports, Issue 32/4, 2020, Page(s) 107954, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107954

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy

Author(s): Liad Hinden, Shiran Udi, Adi Drori, Asaad Gammal, Alina Nemirovski, Rivka Hadar, Saja Baraghithy, Anna Permyakova, Matan Geron, Merav Cohen, Sabina Tsytkin-Kirschenzweig, Yael Riahi, Gil Leibowitz, Yaakov Nahmias, Avi Priel, Joseph Tam
Published in: Journal of the American Society of Nephrology, 2017, Page(s) ASN.2017040371, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017040371

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

Author(s): Shiran Udi, Liad Hinden, Brian Earley, Adi Drori, Noa Reuveni, Rivka Hadar, Resat Cinar, Alina Nemirovski, Joseph Tam
Published in: Journal of the American Society of Nephrology, 2017, Page(s) ASN.2016101085, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2016101085

In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs

Author(s): Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y. Tshuva
Published in: ChemMedChem, 2018, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201800551

Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells

Author(s): Adi Drori, Anna Permyakova, Rivka Hadar, Shiran Udi, Alina Nemirovski, Joseph Tam
Published in: Diabetes, Obesity and Metabolism, 2018, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13497

The therapeutic potential of targeting the peripheral endocannabinoid/CB 1 receptor system

Author(s): Joseph Tam, Liad Hinden, Adi Drori, Shiran Udi, Shahar Azar, Saja Baraghithy
Published in: European Journal of Internal Medicine, Issue 49, 2018, Page(s) 23-29, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2018.01.009