From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease

Informazioni relative al progetto

CaNANObinoids

ID dell’accordo di sovvenzione: 676841

DOI 10.3030/676841

Progetto chiuso

Data della firma CE 15 Marzo 2016

Data di avvio 1 Aprile 2016

Data di completamento 30 Settembre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Pubblicazioni

Peer reviewed articles (11)

CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

Autori: Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.60771

Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis

Autori: Saja Baraghithy, Yael Soae, Dekel Assaf, Liad Hinden, Shiran Udi, Adi Drori, Yankel Gabet, Joseph Tam
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: Basel MDPI AG 2012
DOI: 10.3390/cells10020414

Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

Autori: Shiran Udi, Liad Hinden, Majdoleen Ahmad, Adi Drori, Malliga R. Iyer, Resat Cinar, Michal Herman‐Edelstein, Joseph Tam
Pubblicato in: British Journal of Pharmacology, Numero 177/1, 2019, Pagina/e 110-127, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.14849

Pathogenesis of diabesity‐induced kidney disease: role of kidney nutrient sensing

Autori: Liad Hinden, Aviram Kogot‐Levin, Joseph Tam, Gil Leibowitz
Pubblicato in: The FEBS Journal, 2021, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15790

Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid-1 Receptor Antagonists

Autori: Shayma El-Atawneh, Shira Hirsch, Rivka Hadar, Joseph Tam, Amiram Goldblum
Pubblicato in: Journal of Chemical Information and Modeling, Numero 59/9, 2019, Pagina/e 3996-4006, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.9b00577

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Autori: Aviram Kogot-Levin, Liad Hinden, Yael Riahi, Tal Israeli, Boaz Tirosh, Erol Cerasi, Ernesto Bernal Mizrachi, Joseph Tam, Ofri Mosenzon, Gil Leibowitz
Pubblicato in: Cell Reports, Numero 32/4, 2020, Pagina/e 107954, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107954

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy

Autori: Liad Hinden, Shiran Udi, Adi Drori, Asaad Gammal, Alina Nemirovski, Rivka Hadar, Saja Baraghithy, Anna Permyakova, Matan Geron, Merav Cohen, Sabina Tsytkin-Kirschenzweig, Yael Riahi, Gil Leibowitz, Yaakov Nahmias, Avi Priel, Joseph Tam
Pubblicato in: Journal of the American Society of Nephrology, 2017, Pagina/e ASN.2017040371, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017040371

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

Autori: Shiran Udi, Liad Hinden, Brian Earley, Adi Drori, Noa Reuveni, Rivka Hadar, Resat Cinar, Alina Nemirovski, Joseph Tam
Pubblicato in: Journal of the American Society of Nephrology, 2017, Pagina/e ASN.2016101085, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2016101085

In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs

Autori: Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y. Tshuva
Pubblicato in: ChemMedChem, 2018, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201800551

Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells

Autori: Adi Drori, Anna Permyakova, Rivka Hadar, Shiran Udi, Alina Nemirovski, Joseph Tam
Pubblicato in: Diabetes, Obesity and Metabolism, 2018, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.13497

The therapeutic potential of targeting the peripheral endocannabinoid/CB 1 receptor system

Autori: Joseph Tam, Liad Hinden, Adi Drori, Shiran Udi, Shahar Azar, Saja Baraghithy
Pubblicato in: European Journal of Internal Medicine, Numero 49, 2018, Pagina/e 23-29, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2018.01.009