How Infection History Shapes the Immune System: Pathogen-induced Changes in Regulatory T Cells

Project Information

Immune Regulation

Grant agreement ID: 677200

DOI

10.3030/677200

Project closed

EC signature date 3 May 2016

Start date 1 June 2016

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 755,00

EU contribution

€ 1 499 755,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

Author(s): Sheng Xiao, Lloyd Bod, Nathalie Pochet, Savithri Balasubramanian Kota, Dan Hu, Asaf Madi, Jessica Kilpatrick, Jingwen Shi, Allen Ho, Huiyuan Zhang, Raymond Sobel, Howard L. Weiner, Terry B. Strom, Francisco J. Quintana, Nicole Joller, Vijay K. Kuchroo
Published in: Cell Reports, Issue 32/2, 2020, Page(s) 107892, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107892

CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections

Author(s): Anna Estrada Brull, Felix Rost, Josua Oderbolz, Florian R. Kirchner, Salomé Leibundgut-Landmann, Annette Oxenius, Nicole Joller
Published in: International Journal of Molecular Sciences, Issue 22/1, 2021, Page(s) 31, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010031

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Author(s): Eva Maria Pastor Arroyo; Nima Yassini; Elif Sakiri; Giancarlo Russo; Soline Bourgeois; Nilufar Mohebbi; Kerstin Amann; Nicole Joller; Carsten A. Wagner; Pedro Henrique Imenez Silva
Published in: Clinical Science, 2022, ISSN 0143-5221
Publisher: Portland Press, Ltd.
DOI: 10.1042/cs20220095

Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues

Author(s): Anna Estrada Brull, Camilla Panetti, Nicole Joller
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.864628

Regulatory T cells: balancing protection versus pathology

Author(s): N Rakebrandt, K Littringer, N Joller
Published in: Swiss Medical Weekly, 2016, ISSN 1424-7860
Publisher: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2016.14343

Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity

Author(s): Yasuhiro Kishi, Takaaki Kondo, Sheng Xiao, Nir Yosef, Jellert Gaublomme, Chuan Wu, Chao Wang, Norio Chihara, Aviv Regev, Nicole Joller, Vijay K. Kuchroo
Published in: The Journal of Experimental Medicine, Issue 213/11, 2016, Page(s) 2489-2501, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20151118

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection

Author(s): Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E. Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann
Published in: PLOS Pathogens, Issue 14/5, 2018, Page(s) e1007069, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1007069

Common Features of Regulatory T Cell Specialization During Th1 Responses

Author(s): Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson, Nicole Joller
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01344

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity

Author(s): Karen O. Dixon, Michelle Schorer, James Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A. Sobel, Dai Fukumura, Rakesh K. Jain, Ana C. Anderson, Vijay K. Kuchroo, Nicole Joller
Published in: The Journal of Immunology, Issue 200/8, 2018, Page(s) 3000-3007, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1700407

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

Author(s): Florian Sparber, Corinne De Gregorio, Simone Steckholzer, Filipa M. Ferreira, Tamas Dolowschiak, Fiorella Ruchti, Florian R. Kirchner, Sarah Mertens, Immo Prinz, Nicole Joller, Thorsten Buch, Martin Glatz, Federica Sallusto, Salomé LeibundGut-Landmann
Published in: Cell Host & Microbe, Issue 25/3, 2019, Page(s) 389-403.e6, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.02.002

Infection History Determines Susceptibility to Unrelated Diseases

Author(s): Nikolas Rakebrandt, Nicole Joller
Published in: BioEssays, Issue 41/6, 2019, Page(s) 1800191, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201800191

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Author(s): Michelle Schorer, Katharina Lambert, Nikolas Rakebrandt, Felix Rost, Kung-Chi Kao, Alexander Yermanos, Roman Spörri, Josua Oderbolz, Miro E. Raeber, Christian W. Keller, Jan D. Lünemann, Gerhard Rogler, Onur Boyman, Annette Oxenius, Nicole Joller
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15309-6

TIGIT limits immune pathology during viral infections

Author(s): Michelle Schorer, Nikolas Rakebrandt, Katharina Lambert, Annika Hunziker, Katharina Pallmer, Annette Oxenius, Anja Kipar, Silke Stertz, Nicole Joller
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15025-1

Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression

Author(s): Florian R. Kirchner, Katharina Littringer, Simon Altmeier, Van Du T. Tran, Franziska Schönherr, Christina Lemberg, Marco Pagni, Dominique Sanglard, Nicole Joller, Salomé LeibundGut-Landmann
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00330

Dampening antiviral immunity can protect the host

Author(s): Camilla Panetti; Kung-Chi Kao; Nicole Joller
Published in: The FEBS Journal, Issue 3, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15756

Preceding Viral Infections Do Not Imprint Long-Term Changes in Regulatory T Cell Function

Author(s): Felix Rost, Katharina Lambert, Nikolas Rakebrandt, Nicole Joller
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65212-9

Book chapters (1)

Tim-3, Lag-3, and TIGIT.

Author(s): Nicole Joller, Vijay K. Kuchroo
Published in: Current Topics in Microbiology and Immunology, 2017, Page(s) 127-156
Publisher: Springer International Publishing
DOI: 10.1007/82_2017_62