Overcoming the epigenetic and therapeutic barrier of EVI1-overexpressing cancers

Project Information

EVI1inCancer

Grant agreement ID: 677209

DOI

10.3030/677209

Project closed

EC signature date 29 February 2016

Start date 1 June 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 094,00

EU contribution

€ 1 499 094,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

Author(s): Sophie Ottema, Roger Mulet-Lazaro, Claudia Erpelinck-Verschueren, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25862-3

Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia

Author(s): Sandra Kiehlmeier, Mahmoud-Reza Rafiee, Ali Bakr, Jagoda Mika, Sabrina Kruse, Judith Müller, Sabrina Schweiggert, Carl Herrmann, Gianluca Sigismondo, Peter Schmezer, Jeroen Krijgsveld, Stefan Gröschel
Published in: Leukemia, 2021, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-021-01235-z

Derepression of retroelements in acute myeloid leukemia with 3q aberrations

Author(s): Jagoda Mika, Sophie Ottema, Sandra Kiehlmeier, Sabrina Kruse, Leonie Smeenk, Judith Müller, Sabrina Schweiggert, Carl Herrmann, Mathijs Sanders, Ruud Delwel, Stefan Gröschel
Published in: Haematologica, 2021, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2020.277400

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.

Author(s): Stefan Gröschel; Daniel Hübschmann; Francesco Raimondi; Peter Horak; Gregor Warsow; Martina Fröhlich; Barbara Klink; Laura Gieldon; Barbara Hutter; Kortine Kleinheinz; David Bonekamp; Oliver Marschal; Priya Chudasama; Jagoda Mika; Marie Groth; Sebastian Uhrig; Stephen Krämer; Christoph Heining; Christoph E. Heilig; Daniela Richter; Eva Reisinger; Katrin Pfütze; Roland Eils; Stephan Wolf; Chri
Published in: Nature Communications, Issue 1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09633-9