Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways

Project Information

CD4DNASP

Grant agreement ID: 677251

DOI 10.3030/677251

Project closed

EC signature date 19 May 2016

Start date 1 August 2016

End date 31 July 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (16)

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Author(s): Huiyuan Zhang, Asaf Madi, Nir Yosef, Norio Chihara, Amit Awasthi, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett, Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao Wang, Lionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev, Vijay K. Kuchroo
Published in: Cell Reports, Issue 33/8, 2020, Page(s) 108433, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108433

Harnessing TH9 cells in cancer immunotherapy

Author(s): Isis Benoit-Lizon, Lionel Apetoh
Published in: Seminars in Immunology, 2021, Page(s) 101477, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2021.101477

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

Author(s): Isis Benoit-Lizon, Elise Jacquin, Thaiz Rivera Vargas, Corentin Richard, Aurélie Roussey, Ludivine Dal Zuffo, Tiffany Martin, Andréa Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stéphane Giorgiutti, Raphaël Carapito, Romain Boidot, Frédérique Végran, Richard A Flavell, Bernhard Ryffel, Eric R Nelson, Pauline Soulas-Sprauel, Toby Lawrence and Lionel A
Published in: Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/jitc-2021-003459

TH9 cells in anti-tumor immunity

Author(s): Thaiz Rivera Vargas, Etienne Humblin, Frédérique Végran, François Ghiringhelli, Lionel Apetoh
Published in: Seminars in Immunopathology, Issue 39/1, 2017, Page(s) 39-46, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-016-0599-4

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Author(s): Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, Aurélie Roussey, Richard A. Flavell, François Ghiringhelli, Lionel Apetoh
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00468-w

Signalling strength determines proapoptotic functions of STING

Author(s): Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00573-w

Rationale for stimulator of interferon genes–targeted cancer immunotherapy

Author(s): Thaiz Rivera Vargas, Isis Benoit-Lizon, Lionel Apetoh
Published in: European Journal of Cancer, Issue 75, 2017, Page(s) 86-97, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2016.12.028

Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions

Author(s): Elise Jacquin, Lionel Apetoh
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01023

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

Author(s): Magalie Dosset, Thaiz Rivera Vargas, Anaïs Lagrange, Romain Boidot, Frédérique Végran, Aurélie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, François Martin, Bernhard Ryffel, Christophe Borg, Olivier Adotévi, François Ghiringhelli, Lionel Apetoh
Published in: OncoImmunology, Issue 7/6, 2018, Page(s) e1433981, ISSN 2162-402X
Publisher: Taylor and Francis online
DOI: 10.1080/2162402X.2018.1433981

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Author(s): Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Xia Lin, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bo
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09415-3

Danger signals: Chemotherapy enhancers?

Author(s): Thaiz Rivera Vargas, Lionel Apetoh
Published in: Immunological Reviews, Issue 280/1, 2017, Page(s) 175-193, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12581

Role of interleukin-1-family cytokines on effector CD4 T cell differentiation

Author(s): Thaiz Rivera Vargas, François Martin, Lionel Apetoh
Published in: World Journal of Immunology, Issue 7/2, 2017, Page(s) 24, ISSN 2219-2824
Publisher: Baishideng Publishing Group Inc.
DOI: 10.5411/wji.v7.i2.24

Immunotherapeutic properties of chemotherapy

Author(s): Carole Fournier, Thaiz Rivera Vargas, Tiffany Martin, Andréa Melis, Lionel Apetoh
Published in: Current Opinion in Pharmacology, Issue 35, 2017, Page(s) 83-88, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2017.05.003

Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?

Author(s): Thaiz Rivera Vargas, Lionel Apetoh
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.01181

Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors

Author(s): Magalie Dosset, Elodie Lauret-Marie Joseph, Thaiz Rivera Vargas, Lionel Apetoh
Published in: Cells, Issue 9/7, 2020, Page(s) 1727, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9071727

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Author(s): Sulayman Benmerzoug, Stéphanie Rose, Badreddine Bounab, David Gosset, Laure Duneau, Pauline Chenuet, Lucile Mollet, Marc Le Bert, Christopher Lambers, Silvana Geleff, Michael Roth, Louis Fauconnier, Delphine Sedda, Clarisse Carvalho, Olivier Perche, David Laurenceau, Bernhard Ryffel, Lionel Apetoh, Ahmet Kiziltunc, Hakan Uslu, Fadime Sultan Albez, Metin Akgun, Dieudonnée Togbe, Valerie F. J. Que
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07425-1

Non-peer reviewed articles (1)

Anticancer effects of the microbiota: how the microbiome shapes the development of IL-9-producing T cells

Author(s): Lionel Apetoh
Published in: British Journal of Cancer, Issue 123/4, 2020, Page(s) 497-498, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-020-0936-1