Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways

Informazioni relative al progetto

CD4DNASP

ID dell’accordo di sovvenzione: 677251

DOI 10.3030/677251

Progetto chiuso

Data della firma CE 19 Maggio 2016

Data di avvio 1 Agosto 2016

Data di completamento 31 Luglio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Pubblicazioni

Peer reviewed articles (16)

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Autori: Huiyuan Zhang, Asaf Madi, Nir Yosef, Norio Chihara, Amit Awasthi, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett, Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao Wang, Lionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev, Vijay K. Kuchroo
Pubblicato in: Cell Reports, Numero 33/8, 2020, Pagina/e 108433, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108433

Harnessing TH9 cells in cancer immunotherapy

Autori: Isis Benoit-Lizon, Lionel Apetoh
Pubblicato in: Seminars in Immunology, 2021, Pagina/e 101477, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2021.101477

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

Autori: Isis Benoit-Lizon, Elise Jacquin, Thaiz Rivera Vargas, Corentin Richard, Aurélie Roussey, Ludivine Dal Zuffo, Tiffany Martin, Andréa Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stéphane Giorgiutti, Raphaël Carapito, Romain Boidot, Frédérique Végran, Richard A Flavell, Bernhard Ryffel, Eric R Nelson, Pauline Soulas-Sprauel, Toby Lawrence and Lionel A
Pubblicato in: Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Editore: BMJ Publishing Group Ltd
DOI: 10.1136/jitc-2021-003459

TH9 cells in anti-tumor immunity

Autori: Thaiz Rivera Vargas, Etienne Humblin, Frédérique Végran, François Ghiringhelli, Lionel Apetoh
Pubblicato in: Seminars in Immunopathology, Numero 39/1, 2017, Pagina/e 39-46, ISSN 1863-2297
Editore: Springer Verlag
DOI: 10.1007/s00281-016-0599-4

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Autori: Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, Aurélie Roussey, Richard A. Flavell, François Ghiringhelli, Lionel Apetoh
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00468-w

Signalling strength determines proapoptotic functions of STING

Autori: Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00573-w

Rationale for stimulator of interferon genes–targeted cancer immunotherapy

Autori: Thaiz Rivera Vargas, Isis Benoit-Lizon, Lionel Apetoh
Pubblicato in: European Journal of Cancer, Numero 75, 2017, Pagina/e 86-97, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2016.12.028

Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions

Autori: Elise Jacquin, Lionel Apetoh
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.01023

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

Autori: Magalie Dosset, Thaiz Rivera Vargas, Anaïs Lagrange, Romain Boidot, Frédérique Végran, Aurélie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, François Martin, Bernhard Ryffel, Christophe Borg, Olivier Adotévi, François Ghiringhelli, Lionel Apetoh
Pubblicato in: OncoImmunology, Numero 7/6, 2018, Pagina/e e1433981, ISSN 2162-402X
Editore: Taylor and Francis online
DOI: 10.1080/2162402X.2018.1433981

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Autori: Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Xia Lin, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bo
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09415-3

Danger signals: Chemotherapy enhancers?

Autori: Thaiz Rivera Vargas, Lionel Apetoh
Pubblicato in: Immunological Reviews, Numero 280/1, 2017, Pagina/e 175-193, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.12581

Role of interleukin-1-family cytokines on effector CD4 T cell differentiation

Autori: Thaiz Rivera Vargas, François Martin, Lionel Apetoh
Pubblicato in: World Journal of Immunology, Numero 7/2, 2017, Pagina/e 24, ISSN 2219-2824
Editore: Baishideng Publishing Group Inc.
DOI: 10.5411/wji.v7.i2.24

Immunotherapeutic properties of chemotherapy

Autori: Carole Fournier, Thaiz Rivera Vargas, Tiffany Martin, Andréa Melis, Lionel Apetoh
Pubblicato in: Current Opinion in Pharmacology, Numero 35, 2017, Pagina/e 83-88, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2017.05.003

Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?

Autori: Thaiz Rivera Vargas, Lionel Apetoh
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2019.01181

Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors

Autori: Magalie Dosset, Elodie Lauret-Marie Joseph, Thaiz Rivera Vargas, Lionel Apetoh
Pubblicato in: Cells, Numero 9/7, 2020, Pagina/e 1727, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9071727

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Autori: Sulayman Benmerzoug, Stéphanie Rose, Badreddine Bounab, David Gosset, Laure Duneau, Pauline Chenuet, Lucile Mollet, Marc Le Bert, Christopher Lambers, Silvana Geleff, Michael Roth, Louis Fauconnier, Delphine Sedda, Clarisse Carvalho, Olivier Perche, David Laurenceau, Bernhard Ryffel, Lionel Apetoh, Ahmet Kiziltunc, Hakan Uslu, Fadime Sultan Albez, Metin Akgun, Dieudonnée Togbe, Valerie F. J. Que
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07425-1

Non-peer reviewed articles (1)

Anticancer effects of the microbiota: how the microbiome shapes the development of IL-9-producing T cells

Autori: Lionel Apetoh
Pubblicato in: British Journal of Cancer, Numero 123/4, 2020, Pagina/e 497-498, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-020-0936-1