Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease

Project Information

Ubl-Code

Grant agreement ID: 677748

DOI

10.3030/677748

Project closed

EC signature date 26 April 2016

Start date 1 May 2016

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (7)

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

Author(s): Reznik, N, Kozer, N, Eisenberg-Lerner, A, Barr, H, Merbl, Y & London, N
Published in: ACS Chemical Biology, 2019
Publisher: ACS Chemical Biology
DOI: 10.1021/acschembio.9b00667

Altered Protein Abundance and Localization Inferred from Sites of Alternative Modification by Ubiquitin and SUMO

Author(s): Ulman A, Levin Tal, Dassa Bareket, Javitt Aaron, Kacen Assaf, Fishllevich Simon, Sheban Daoud, Levy Emmanuel, Merbl Y
Published in: JMB, 2021
Publisher: JMB
DOI: 10.1016/j.jmb.2021.167219

Golgi organization is regulated by proteasomal degradation.

Author(s): Eisenberg-Lerner, A, Benyair, R, Hizkiahou, N, Nudel, N, Maor, R, Kramer, MP, Shmueli, MD, Zigdon, I, Lev, MC, Ulman, A, Sagiv, JY, Dayan, M, Dassa, B, Rosenwald, M, Shachar, I, Li, J, Wang, Y, Dezorella, N, Khan, S, Porat, Z, Shimoni, E, Avinoam, O & Merbl, Y
Published in: Nature Communications, 2020
Publisher: Nature Communications
DOI: 10.1038/s41467-019-14038-9

Gatekeepers of the Gut: The Roles of Proteasomes at the Gastrointestinal Barrier

Author(s): Mohapatra G, Eisenberg-Lerner A. , Merbl Y
Published in: Biomolecules, 2021
Publisher: Biomolecules
DOI: 10.3390/biom11070989

Histone Degradation by the Proteasome Regulates Chromatin and Cellular Plasticity

Author(s): Shmueli, M, Sheban D, Eisenberg-Lerner, A, Merbl Y
Published in: 2021
Publisher: FEBS
DOI: 10.1111/febs.15903

Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression

Author(s): Javitt, A, Barnea, E, Kramer, MP, Wolf-Levy, H, Levin, Y, Admon, A & Merbl, Y
Published in: Frontiers in Immunology, 2019
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.00141

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

Author(s): Sheban D., Shani Tom, Maor Roey, Alejandro Aguilera-Castrejon, Nofar Mor, Jakob Hebert, Sergey Viukov, Merav Shmueli, Vladislav Krupalnik, Valeriya Chugaeva, Alejandra Rodriguez de Larosa, Mirie Zerbib, Adi Ulman, Solaiman Massarwa, Meital Kupervaser, Yishai Levin, Efrat Shema, Yael David, Noa Novershtern, Hanna Jacob H., Merbl Y
Published in: Molecular Cell, 2021
Publisher: Molecular Cell
DOI: 10.1016/j.molcel.2021.11.011

Peer reviewed articles (3)

Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

Author(s): Assaf Kacen, Aaron Javitt, Matthias P. Kramer, David Morgenstern, Tomer Tsaban, Merav D. Shmueli, Guo Ci Teo, Felipe da Veiga Leprevost, Eilon Barnea, Fengchao Yu, Arie Admon, Lea Eisenbach, Yardena Samuels, Ora Schueler-Furman, Yishai Levin, Alexey I. Nesvizhskii, Yifat Merbl
Published in: Nature Biotechnology, Issue 41, 2023, Page(s) 239-251, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01464-2

Post-translational modification profiling – A novel tool for mapping the protein modification landscape in cancer

Author(s): Avital Eisenberg-Lerner, Aaron Ciechanover, Yifat Merbl
Published in: Experimental Biology and Medicine, Issue 241/14, 2016, Page(s) 1475-1482, ISSN 1535-3702
Publisher: Society for Experimental Biology and Medicine
DOI: 10.1177/1535370216651732

Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides

Author(s): Hila Wolf-Levy, Aaron Javitt, Avital Eisenberg-Lerner, Assaf Kacen, Adi Ulman, Daoud Sheban, Bareket Dassa, Vered Fishbain-Yoskovitz, Carmelo Carmona-Rivera, Matthias P Kramer, Neta Nudel, Ifat Regev, Liron Zahavi, Dalia Elinger, Mariana J Kaplan, David Morgenstern, Yishai Levin, Yifat Merbl
Published in: Nature Biotechnology, Issue 36/11, 2018, Page(s) 1110-1116, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.4279

Book chapters (1)

Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation

Author(s): Avital Eisenberg-Lerner, Ifat Regev, Yifat Merbl
Published in: Methods in Molecular Biology, 2017, Page(s) 139-152
Publisher: Springer New York
DOI: 10.1007/978-1-4939-7201-2_9