Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy

Project Information

ICARO

Grant agreement ID: 678109

DOI 10.3030/678109

Project closed

EC signature date 22 February 2016

Start date 1 March 2016

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 160 000,00

EU contribution € 1 160 000,00

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Confining Iron Oxide Nanocubes inside Submicrometric Cavities as a Key Strategy To Preserve Magnetic Heat Losses in an Intracellular Environment

Author(s): Mikhail V. Zyuzin, Marco Cassani, Markus J. Barthel, Helena Gavilan, Niccolò Silvestri, Alberto Escudero, Alice Scarpellini, Federica Lucchesi, Francisco J. Teran, Wolfgang J. Parak, Teresa Pellegrino
Published in: ACS Applied Materials & Interfaces, Issue 11/45, 2019, Page(s) 41957-41971, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b15501

Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

Author(s): Preethi Bala Balakrishnan, Niccolò Silvestri, Tamara Fernandez‐Cabada, Federica Marinaro, Soraia Fernandes, Sergio Fiorito, Mario Miscuglio, David Serantes, Sergiu Ruta, Karen Livesey, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino
Published in: Advanced Materials, Issue 32/45, 2020, Page(s) 2003712, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202003712

Esterase-Cleavable 2D Assemblies of Magnetic Iron Oxide Nanocubes: Exploiting Enzymatic Polymer Disassembling To Improve Magnetic Hyperthermia Heat Losses

Author(s): Sahitya Kumar Avugadda, Maria Elena Materia, Rinat Nigmatullin, David Cabrera, Roberto Marotta, Tamara Fernandez Cabada, Elena Marcello, Simone Nitti, Emilio J. Artés-Ibañez, Pooja Basnett, Claire Wilhelm, Francisco J. Teran, Ipsita Roy, Teresa Pellegrino
Published in: Chemistry of Materials, Issue 31/15, 2019, Page(s) 5450-5463, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.9b00728

Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles

Author(s): Alessandra Quarta, Manuel Amorín, María José Aldegunde, Laura Blasi, Andrea Ragusa, Simone Nitti, Giammarino Pugliese, Giuseppe Gigli, Juan R. Granja, Teresa Pellegrino
Published in: Nanoscale, Issue 11/48, 2019, Page(s) 23482-23497, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr07015j

Fe 2+ Deficiencies, FeO Subdomains, and Structural Defects Favor Magnetic Hyperthermia Performance of Iron Oxide Nanocubes into Intracellular Environment

Author(s): Aidin Lak, Marco Cassani, Binh T. Mai, Naomi Winckelmans, David Cabrera, Elaheh Sadrollahi, Sergio Marras, Hilke Remmer, Sergio Fiorito, Lucia Cremades-Jimeno, Fred Jochen Litterst, Frank Ludwig, Liberato Manna, Francisco J. Teran, Sara Bals, Teresa Pellegrino
Published in: Nano Letters, Issue 18/11, 2018, Page(s) 6856-6866, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.8b02722

Unveiling the Dynamical Assembly of Magnetic Nanocrystal Zig‐Zag Chains via In Situ TEM Imaging in Liquid

Author(s): Milena P. Arciniegas, Andrea Castelli, Rosaria Brescia, David Serantes, Sergiu Ruta, Ondrej Hovorka, Akira Satoh, Roy Chantrell, Teresa Pellegrino
Published in: Small, Issue 16/25, 2020, Page(s) 1907419, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201907419

Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters

Author(s): Sahitya Kumar Avugadda, Sameera Wickramasinghe, Dina Niculaes, Minseon Ju, Aidin Lak, Niccolò Silvestri, Simone Nitti, Ipsita Roy, Anna Cristina S. Samia, Teresa Pellegrino
Published in: Nanomaterials, Issue 11/1, 2021, Page(s) 62, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11010062

Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Author(s): Maria Elena Materia, Manuel Pernia Leal, Marco Scotto, Preethi Bala Balakrishnan, Sahitya Avugadda Kumar, María Luisa García-Martín, Bruce E Cohen, Emory M. Chan, Teresa Pellegrino
Published in: Bioconjugate Chemistry, 2017, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.7b00432

Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases

Author(s): Alessandra Quarta, Marina Rodio, Marco Cassani, Giuseppe Gigli, Teresa Pellegrino, Loretta L. del Mercato
Published in: ACS Applied Materials & Interfaces, Issue 9/40, 2017, Page(s) 35095-35104, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.7b05709

Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge

Author(s): Silvia Dante, Alessia Petrelli, Enrica Maria Petrini, Roberto Marotta, Alessandro Maccione, Alessandro Alabastri, Alessandra Quarta, Francesco De Donato, Tiziana Ravasenga, Ayyappan Sathya, Roberto Cingolani, Remo Proietti Zaccaria, Luca Berdondini, Andrea Barberis, Teresa Pellegrino
Published in: ACS Nano, Issue 11/7, 2017, Page(s) 6630-6640, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b00397

Gold–iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency

Author(s): P. Guardia, S. Nitti, M. E. Materia, G. Pugliese, N. Yaacoub, J.-M. Greneche, C. Lefevre, L. Manna, T. Pellegrino
Published in: J. Mater. Chem. B, Issue 5/24, 2017, Page(s) 4587-4594, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7tb00968b

Colloidal CuFeS 2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency

Author(s): Sandeep Ghosh, Tommaso Avellini, Alessia Petrelli, Ilka Kriegel, Roberto Gaspari, Guilherme Almeida, Giovanni Bertoni, Andrea Cavalli, Francesco Scotognella, Teresa Pellegrino, Liberato Manna
Published in: Chemistry of Materials, Issue 28/13, 2016, Page(s) 4848-4858, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.6b02192

Facile transformation of FeO/Fe3O4 core-shell nanocubes to Fe3O4 via magnetic stimulation

Author(s): Aidin Lak, Dina Niculaes, George C. Anyfantis, Giovanni Bertoni, Markus J. Barthel, Sergio Marras, Marco Cassani, Simone Nitti, Athanassia Athanassiou, Cinzia Giannini, Teresa Pellegrino
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep33295

Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity

Author(s): Preethi Bala Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli
Published in: Colloids and Surfaces B: Biointerfaces, Issue 161, 2018, Page(s) 488-496, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2017.11.014

Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance

Author(s): Dina Niculaes, Aidin Lak, George C. Anyfantis, Sergio Marras, Oliver Laslett, Sahitya K. Avugadda, Marco Cassani, David Serantes, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino
Published in: ACS Nano, Issue 11/12, 2016, Page(s) 12121-12133, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b05182

Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspectives

Author(s): Binh T. Mai, Soraia Fernandes, Preethi B. Balakrishnan, Teresa Pellegrino
Published in: Accounts of Chemical Research, Issue 51/5, 2018, Page(s) 999-1013, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.7b00549

Cation Exchange Protocols to Radiolabel Aqueous Stabilized ZnS, ZnSe, and CuFeS 2 Nanocrystals with 64 Cu for Dual Radio‐ and Photo‐Thermal Therapy

Author(s): Tommaso Avellini, Nisarg Soni, Niccolò Silvestri, Sergio Fiorito, Francesco De Donato, Claudia De Mei, Martin Walther, Marco Cassani, Sandeep Ghosh, Liberato Manna, Holger Stephan, Teresa Pellegrino
Published in: Advanced Functional Materials, Issue 30/28, 2020, Page(s) 2002362, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202002362

Crosslinked pH-responsive polymersome via Diels-Alder click chemistry: A reversible pH-dependent vesicular nanosystem

Author(s): Binh T. Mai, Markus Barthel, Roberto Marotta, Teresa Pellegrino
Published in: Polymer, Issue 165, 2019, Page(s) 19-27, ISSN 0032-3861
Publisher: Elsevier BV
DOI: 10.1016/j.polymer.2019.01.022

Thermoresponsive Iron Oxide Nanocubes for an Effective Clinical Translation of Magnetic Hyperthermia and Heat-Mediated Chemotherapy

Author(s): Binh T. Mai, Preethi B. Balakrishnan, Markus J. Barthel, Federica Piccardi, Dina Niculaes, Federica Marinaro, Soraia Fernandes, Alberto Curcio, Hamilton Kakwere, Gwennhael Autret, Roberto Cingolani, Florence Gazeau, Teresa Pellegrino
Published in: ACS Applied Materials & Interfaces, Issue 11/6, 2019, Page(s) 5727-5739, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b16226

Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes

Author(s): D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Published in: Nanoscale, Issue 9/16, 2017, Page(s) 5094-5101, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr00810d

Intellectual Property Rights

Patent (3)

PROCESS FOR THE SYNTHESIS OF STIMULUS-RESPONSIVE MAGNETIC NANOPARTICLES

Application/Publication number: 18 705731
Date: 2018-01-26
Applicant(s): FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

METHOD FOR THE GRAM-SCALE PREPARATION OF CUBIC FERRITE NANOCRYSTALS FOR BIOMEDICAL APPLICATIONS

Application/Publication number: 20 20054028
Date: 2020-04-29
Applicant(s): FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

MAGNETIC NANOPARTICLES FOR USE IN THE TREATMENT OF TUMORS

Application/Publication number: 20 1917051329
Date: 2019-05-03
Applicant(s): FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA