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Preventing and mitigating farmed bivalve diseases

Deliverables

Guidelines with recommendations to reduce mortalities

Guidelines with recommendations to reduce mortalities

Reports on farmed clams and related data in the key and additional sites

Reports on farmed clams and related data in the key and additional sites

Comparison of loci identified in controlled experiments with the data from wild populations

Comparison of loci identified in controlled experiments with the data from wild populations

Estimation of genetic correlations for resistance to diseases in the Manila clam

Estimation of genetic correlations for resistance to diseases in the Manila clam

Characterisation of patho-biome and description of pathogen diversity and virulence traits

Characterisation of patho-biome and description of pathogen diversity and virulence traits

Comparison of Vibriome and physiological pathways for selected/non selected animals

Comparison of Vibriome and physiological pathways for selected/non selected animals

Characterisation of OsHV-1 and variants and determining their pathogenicity

Characterisation of OsHV-1 and variants and determining their pathogenicity

Identification of signatures of selection and underlying genetic variants in wild populations

Identification of signatures of selection and underlying genetic variants in wild populations

Application of the disease spread model to the identified UE sites

Application of the disease spread model to the identified UE sites

Identification of optimal husbandry practices

Identification of optimal husbandry practices

Comparative bivalve microbiota and identification of health bioindicators

Comparative bivalve microbiota and identification of health bioindicators

DNA methylation profile description in oysters and mussels

DNA methylation profile description in oysters and mussels

Discovery and characterisation of novel pathogens

Discovery and characterisation of novel pathogens

User guide to risk ranking model and Development of risk ranking model

User guide to risk ranking model and Development of risk ranking model

Identification of the most relevant pathways in the host response obtained by bioinformatics analysis

Identification of the most relevant pathways in the host response obtained by bioinformatics analysis

Selection and qPCR validation of candidate resistance markers

Selection and qPCR validation of candidate resistance markers

Estimation of genetic parameters and correlations in C. gigas

Estimation of genetic parameters and correlations in C. gigas

Distribution and lesions of several pathogens in oysters, mussels and clams

Distribution and lesions of several pathogens in oysters, mussels and clams

Effect of the interaction vibrio/plankton on the vibrio virulence

Effect of the interaction vibrio/plankton on the vibrio virulence

Effect of plankton on the intake of vibrios and the outcome of the disease

Effect of plankton on the intake of vibrios and the outcome of the disease

Identification of key environmental factors associated with surviving capacity of bivalves

Identification of key environmental factors associated with surviving capacity of bivalves

Stakeholder identification map for participating EU and third countries

Stakeholder identification map for participating EU and third countries

Cellular/Molecular/microscopy protocols for pathogen detection, isolation and diagnostics

Cellular/Molecular/microscopy protocols for pathogen detection, isolation and diagnostics

Identification of pathogen reservoirs and determination of transmission stages

Identification of pathogen reservoirs and determination of transmission stages

Synthesis of the impact of environmental parameters and stressors on pathogen development or suppression

Synthesis of the impact of environmental parameters and stressors on pathogen development or suppression

Disease management strategies ranking by stakeholder groups

Disease management strategies ranking by stakeholder groups

Website available

Website available

Video on the project results

Video on the project results

Open industry workshop to share results and evaluate interests of stakeholders

Open industry workshop to share results and evaluate interests of stakeholders

Press releases

Press releases

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Publications

Vibrio tapetis Displays an Original Type IV Secretion System in Strains Pathogenic for Bivalve Molluscs

Author(s): Graciela M. Dias, Adeline Bidault, Patrick Le Chevalier, Gwenaëlle Choquet, Clio Der Sarkissian, Ludovic Orlando, Claudine Medigue, Valerie Barbe, Sophie Mangenot, Cristiane C. Thompson, Fabiano L. Thompson, Annick Jacq, Vianney Pichereau, Christine Paillard
Published in: Frontiers in Microbiology, Issue 9, 2018, ISSN 1664-302X
DOI: 10.3389/fmicb.2018.00227

A literature review as an aid to identify strategies for mitigating ostreid herpesvirus 1 in Crassostrea gigas hatchery and nursery systems

Author(s): Chris Rodgers, Isabelle Arzul, Noèlia Carrasco, Dolores Furones Nozal
Published in: Reviews in Aquaculture, 2018, ISSN 1753-5123
DOI: 10.1111/raq.12246

Marteilia refringens and Marteilia pararefringens sp. nov. are distinct parasites of bivalves and have different European distributions

Author(s): R. Kerr, G. M. Ward, G. D. Stentiford, A. Alfjorden, S. Mortensen, J. P. Bignell, S. W. Feist, A. Villalba, M. J. Carballal, A. Cao, I. Arzul, D. Ryder, D. Bass
Published in: Parasitology, Issue 145/11, 2018, Page(s) 1483-1492, ISSN 0031-1820
DOI: 10.1017/S003118201800063X

Molecular Characterization of an Endozoicomonas -Like Organism Causing Infection in the King Scallop ( Pecten maximus L.)

Author(s): Irene Cano, Ronny van Aerle, Stuart Ross, David W. Verner-Jeffreys, Richard K. Paley, Georgina S. E. Rimmer, David Ryder, Patrick Hooper, David Stone, Stephen W. Feist
Published in: Applied and Environmental Microbiology, Issue 84/3, 2018, ISSN 0099-2240
DOI: 10.1128/AEM.00952-17

Comparative 16SrDNA Gene-Based Microbiota Profiles of the Pacific Oyster (Crassostrea gigas) and the Mediterranean Mussel (Mytilus galloprovincialis) from a Shellfish Farm (Ligurian Sea, Italy)

Author(s): Luigi Vezzulli, L. Stagnaro, C. Grande, G. Tassistro, L. Canesi, C. Pruzzo
Published in: Microbial Ecology, Issue 75/2, 2018, Page(s) 495-504, ISSN 0095-3628
DOI: 10.1007/s00248-017-1051-6

Ecologically realistic model of infection for exploring the host damage caused by Vibrio aestuarianus

Author(s): Leila Parizadeh, Delphine Tourbiez, Céline Garcia, Philippe Haffner, Lionel Dégremont, Frédérique Le Roux, Marie-Agnès Travers
Published in: Environmental Microbiology, 2018, ISSN 1462-2912
DOI: 10.1111/1462-2920.14350

Identification of a newly described OsHV-1 µvar from the North Adriatic Sea (Italy)

Author(s): Miriam Abbadi, Gianpiero Zamperin, Michele Gastaldelli, Francesco Pascoli, Umberto Rosani, Adelaide Milani, Alessia Schivo, Emanuele Rossetti, Edoardo Turolla, Lorenzo Gennari, Anna Toffan, Giuseppe Arcangeli, Paola Venier
Published in: Journal of General Virology, Issue 99/5, 2018, Page(s) 693-703, ISSN 0022-1317
DOI: 10.1099/jgv.0.001042

Early gametogenesis in the Pacific oyster: new insights using stem cell and mitotic markers

Author(s): Patricia Cavelier, Julien Cau, Nathalie Morin, Claude Delsert
Published in: The Journal of Experimental Biology, Issue 220/21, 2017, Page(s) 3988-3996, ISSN 0022-0949
DOI: 10.1242/jeb.167734

Bivalve transcriptomics reveal pathogen sequences and a powerful immune response of the Mediterranean mussel (Mytilus galloprovincialis)

Author(s): Rebeca Moreira, Pablo Balseiro, Gabriel Forn-Cuní, Massimo Milan, Luca Bargelloni, Beatriz Novoa, Antonio Figueras
Published in: Marine Biology, Issue 165/4, 2018, ISSN 0025-3162
DOI: 10.1007/s00227-018-3308-0

Rapid capture and detection of ostreid herpesvirus-1 from Pacific oyster Crassostrea gigas and seawater using magnetic beads

Author(s): Anna Toldrà, Karl B. Andree, Edgar Bertomeu, Ana Roque, Noèlia Carrasco, Ignasi Gairín, M. Dolores Furones, Mònica Campàs
Published in: PLOS ONE, Issue 13/10, 2018, Page(s) e0205207, ISSN 1932-6203
DOI: 10.1371/journal.pone.0205207

Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters

Author(s): Julien de Lorgeril, Aude Lucasson, Bruno Petton, Eve Toulza, Caroline Montagnani, Camille Clerissi, Jeremie Vidal-Dupiol, Cristian Chaparro, Richard Galinier, Jean-Michel Escoubas, Philippe Haffner, Lionel Dégremont, Guillaume M. Charrière, Maxime Lafont, Abigaïl Delort, Agnès Vergnes, Marlène Chiarello, Nicole Faury, Tristan Rubio, Marc A. Leroy, Adeline Pérignon, Denis Régler, Benjamin M
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-06659-3

Oyster Farming, Temperature, and Plankton Influence the Dynamics of Pathogenic Vibrios in the Thau Lagoon

Author(s): Carmen Lopez-Joven, Jean-Luc Rolland, Philippe Haffner, Audrey Caro, Cécile Roques, Claire Carré, Marie-Agnès Travers, Eric Abadie, Mohamed Laabir, Delphine Bonnet, Delphine Destoumieux-Garzón
Published in: Frontiers in Microbiology, Issue 9, 2018, ISSN 1664-302X
DOI: 10.3389/fmicb.2018.02530

A study of autophagy in hemocytes of the Pacific oyster, Crassostrea gigas

Author(s): Sandy Picot, Benjamin Morga, Nicole Faury, Bruno Chollet, Lionel Dégremont, Marie-Agnès Travers, Tristan Renault, Isabelle Arzul
Published in: Autophagy, 2019, Page(s) 1-9, ISSN 1554-8627
DOI: 10.1080/15548627.2019.1596490

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

Author(s): Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Published in: Science of The Total Environment, Issue 670, 2019, Page(s) 129-137, ISSN 0048-9697
DOI: 10.1016/j.scitotenv.2019.03.133

High individual variability in the transcriptomic response of Mediterranean mussels to Vibrio reveals the involvement of myticins in tissue injury

Author(s): Magalí Rey-Campos, Rebeca Moreira, Valentina Valenzuela-Muñoz, Cristian Gallardo-Escárate, Beatriz Novoa, Antonio Figueras
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-39870-3

Revealing Mytilus galloprovincialis transcriptomic profiles during ontogeny


Published in: ISSN 0145-305X
DOI: 10.1016/j.dci.2018.01.016

Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas

Author(s): Umberto Rosani, Tim Young, Chang-Ming Bai, Andrea C. Alfaro, Paola Venier
Published in: Evolutionary Bioinformatics, Issue 15, 2019, Page(s) 117693431983130, ISSN 1176-9343
DOI: 10.1177/1176934319831305

Autophagic processes in Mytilus galloprovincialis hemocytes: Effects of Vibrio tapetis


Published in: ISSN 1050-4648
DOI: 10.1016/j.fsi.2017.12.003

Detection and characterisation of haplosporidian parasites of the blue mussel Mytilus edulis, including description of the novel parasite Minchinia mytili n. sp.

Author(s): GM Ward, SW Feist, P Noguera, M Marcos-López, S Ross, M Green, A Urrutia, D Bass
Published in: Diseases of Aquatic Organisms, Issue 133/1, 2019, Page(s) 57-68, ISSN 0177-5103
DOI: 10.3354/dao03326

Immune-related genes in gastropods and bivalves: a comparative overview

Author(s): Gerdol, Marco
Published in: Invertebrate Survival Journal, Issue 1, 2017, ISSN 1824-307X

Immune Tolerance in Mytilus galloprovincialis Hemocytes After Repeated Contact With Vibrio splendidus

Author(s): Magalí Rey-Campos, Rebeca Moreira, Marco Gerdol, Alberto Pallavicini, Beatriz Novoa, Antonio Figueras
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.01894

Integrated transcriptomic and functional immunological approach for assessing the invasiveness of bivalve alien species

Author(s): Alejandro Romero, Raquel Aranguren, Rebeca Moreira, Beatriz Novoa, Antonio Figueras
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-56421-y

Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome of Vibrio infections

Author(s): Tristan Rubio, Daniel Oyanedel, Yannick Labreuche, Eve Toulza, Xing Luo, Maxime Bruto, Cristian Chaparro, Marta Torres, Julien de Lorgeril, Philippe Haffner, Jeremie Vidal-Dupiol, Arnaud Lagorce, Bruno Petton, Guillaume Mitta, Annick Jacq, Frédérique Le Roux, Guillaume M. Charrière, Delphine Destoumieux-Garzón
Published in: Proceedings of the National Academy of Sciences, Issue 116/28, 2019, Page(s) 14238-14247, ISSN 0027-8424
DOI: 10.1073/pnas.1905747116

Detection of isothermally amplified ostreid herpesvirus 1 DNA in Pacific oyster (Crassostrea gigas) using a miniaturised electrochemical biosensor

Author(s): Anna Toldrà, M. Dolors Furones, Ciara K. O'Sullivan, Mònica Campàs
Published in: Talanta, Issue 207, 2020, Page(s) 120308, ISSN 0039-9140
DOI: 10.1016/j.talanta.2019.120308

Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C

Author(s): Magalí Rey-Campos, Rebeca Moreira, Alejandro Romero, Regla M. Medina-Gali, Beatriz Novoa, María Gasset, Antonio Figueras
Published in: Biomolecules, Issue 10/1, 2020, Page(s) 133, ISSN 2218-273X
DOI: 10.3390/biom10010133

A GM1b/asialo‐GM1 oligosaccharide‐binding R‐type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases

Author(s): Yuki Fujii, Marco Gerdol, Sarkar M. A. Kawsar, Imtiaj Hasan, Francesca Spazzali, Tatsusada Yoshida, Yukiko Ogawa, Sultana Rajia, Kenichi Kamata, Yasuhiro Koide, Shigeki Sugawara, Masahiro Hosono, Jeremy R. H. Tame, Hideaki Fujita, Alberto Pallavicini, Yasuhiro Ozeki
Published in: The FEBS Journal, 2019, ISSN 1742-464X
DOI: 10.1111/febs.15154

Extensive Tandem Duplication Events Drive the Expansion of the C1q-Domain-Containing Gene Family in Bivalves

Author(s): Marco Gerdol, Samuele Greco, Alberto Pallavicini
Published in: Marine Drugs, Issue 17/10, 2019, Page(s) 583, ISSN 1660-3397
DOI: 10.3390/md17100583

Resistance of the oyster pathogen Vibrio tasmaniensis LGP32 against grazing by Vannella sp. marine amoeba involves Vsm and CopA virulence factors

Author(s): Etienne Robino, Aurore C. Poirier, Hajar Amraoui, Sandra Le Bissonnais, Angélique Perret, Carmen Lopez‐Joven, Jean‐Christophe Auguet, Tristan P. Rubio, Chantal Cazevieille, Jean‐Luc Rolland, Yann Héchard, Delphine Destoumieux‐Garzón, Guillaume M. Charrière
Published in: Environmental Microbiology, 2019, ISSN 1462-2912
DOI: 10.1111/1462-2920.14770

Molecular Diversity of Mytilin-Like Defense Peptides in Mytilidae (Mollusca, Bivalvia)

Author(s): Samuele Greco, Marco Gerdol, Paolo Edomi, Alberto Pallavicini
Published in: Antibiotics, Issue 9/1, 2020, Page(s) 37, ISSN 2079-6382
DOI: 10.3390/antibiotics9010037

Nanoplastics: From tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination

Author(s): M. Sendra, A. Saco, M.P. Yeste, A. Romero, B. Novoa, A. Figueras
Published in: Journal of Hazardous Materials, 2019, Page(s) 121788, ISSN 0304-3894
DOI: 10.1016/j.jhazmat.2019.121788

Dynamics of the Pacific oyster pathobiota during mortality episodes in Europe assessed by 16S rRNA gene profiling and a new target enrichment next‐generation sequencing strategy

Author(s): Aide Lasa, Andrea di Cesare, Giovanni Tassistro, Alessio Borello, Stefano Gualdi, Dolors Furones, Noelia Carrasco, Deborah Cheslett, Amanda Brechon, Christine Paillard, Adeline Bidault, Fabrice Pernet, Laura Canesi, Paolo Edomi, Alberto Pallavicini, Carla Pruzzo, Luigi Vezzulli
Published in: Environmental Microbiology, Issue 21/12, 2019, Page(s) 4548-4562, ISSN 1462-2912
DOI: 10.1111/1462-2920.14750

cDNA and Gene Structure of MytiLec-1, A Bacteriostatic R-Type Lectin from the Mediterranean Mussel (Mytilus galloprovincialis)

Author(s): Imtiaj Hasan, Marco Gerdol, Yuki Fujii, Sultana Rajia, Yasuhiro Koide, Daiki Yamamoto, Sarkar Kawsar, Yasuhiro Ozeki
Published in: Marine Drugs, Issue 14/5, 2016, Page(s) 92, ISSN 1660-3397
DOI: 10.3390/md14050092

An Evolutionary Perspective of Dopachrome Tautomerase Enzymes in Metazoans

Author(s): Rosani, Domeneghetti, Maso, Wegner, Venier
Published in: Genes, Issue 10/7, 2019, Page(s) 495, ISSN 2073-4425
DOI: 10.3390/genes10070495

Adsorption of norovirus and ostreid herpesvirus type 1 to polymer membranes for the development of passive samplers

Author(s): F. Vincent-Hubert, B. Morga, T. Renault, F.S. Le Guyader
Published in: Journal of Applied Microbiology, Issue 122/4, 2017, Page(s) 1039-1047, ISSN 1364-5072
DOI: 10.1111/jam.13394

Whole-Genome Enrichment Provides Deep Insights into Vibrio cholerae Metagenome from an African River

Author(s): L. Vezzulli, C. Grande, G. Tassistro, I. Brettar, M. G. H?fle, R. P. A. Pereira, D. Mushi, A. Pallavicini, P. Vassallo, C. Pruzzo
Published in: Microbial Ecology, Issue 73/3, 2017, Page(s) 734-738, ISSN 0095-3628
DOI: 10.1007/s00248-016-0902-x

Microbiota Composition and Evenness Predict Survival Rate of Oysters Confronted to Pacific Oyster Mortality Syndrome

Author(s): Camille Clerissi, Julien de Lorgeril, Bruno Petton, Aude Lucasson, Jean-Michel Escoubas, Yannick Gueguen, Lionel Dégremont, Guillaume Mitta, Eve Toulza
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
DOI: 10.3389/fmicb.2020.00311

A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas

Author(s): Maxime Lafont, Agnès Vergnes, Jeremie Vidal-Dupiol, Julien de Lorgeril, Yannick Gueguen, Philippe Haffner, Bruno Petton, Cristian Chaparro, Celia Barrachina, Delphine Destoumieux-Garzon, Guillaume Mitta, Benjamin Gourbal, Caroline Montagnani
Published in: mBio, Issue 11/2, 2020, ISSN 2150-7511
DOI: 10.1128/mBio.02777-19

Expansion and loss events characterized the occurrence of MIF-like genes in bivalves


Published in: ISSN 1050-4648
DOI: 10.1016/j.fsi.2019.07.019

Identification of the autophagy pathway in a mollusk bivalve, Crassostrea gigas

Author(s): Sandy Picot, Nicole Faury, Isabelle Arzul, Bruno Chollet, Tristan Renault, Benjamin Morga
Published in: Autophagy, 2020, Page(s) 1-19, ISSN 1554-8627
DOI: 10.1080/15548627.2020.1713643

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

Author(s): Umberto Rosani, Chang-Ming Bai, Lorenzo Maso, Maxwell Shapiro, Miriam Abbadi, Stefania Domeneghetti, Chong-Ming Wang, Laura Cendron, Thomas MacCarthy, Paola Venier
Published in: BMC Evolutionary Biology, Issue 19/1, 2019, ISSN 1471-2148
DOI: 10.1186/s12862-019-1472-6

Shedding and survival of an intracellular pathogenic Endozoicomonas-like organism infecting king scallop Pecten maximus

Author(s): PM Hooper, SH Ross, SW Feist, I Cano
Published in: Diseases of Aquatic Organisms, Issue 134/2, 2019, Page(s) 167-173, ISSN 0177-5103
DOI: 10.3354/dao03375

Oyster hemolymph is a complex and dynamic ecosystem hosting bacteria, protists and viruses

Author(s): S. Dupont, A. Lokmer, E. Corre, J.-C. Auguet, B. Petton, E. Toulza, C. Montagnani, G. Tanguy, D. Pecqueur, C. Salmeron, L. Guillou, C. Desnues, B. La Scola, J. Bou Khalil, J. de Lorgeril, G. Mitta, Y. Gueguen, J.-M. Escoubas
Published in: Animal Microbiome, Issue 2/1, 2020, ISSN 2524-4671
DOI: 10.1186/s42523-020-00032-w

Rapid and efficient protocol to introduce exogenous DNA in Vibrio harveyi and Pseudoalteromonas sp.

Author(s): François Delavat, Adeline Bidault, Vianney Pichereau, Christine Paillard
Published in: Journal of Microbiological Methods, Issue 154, 2018, Page(s) 1-5, ISSN 0167-7012
DOI: 10.1016/j.mimet.2018.09.022

Toward reference intervals for shellfish: An illustrative case of feeding and respiratory activities in the Pacific cupped oyster, Crassostrea gigas

Author(s): Cyrille François, Joël Haure, Jean‐Christophe Billy, Tristan Renault
Published in: Veterinary Clinical Pathology, 2020, ISSN 0275-6382
DOI: 10.1111/vcp.12853

Oyster RNA-seq Data Support the Development of Malacoherpesviridae Genomics

Author(s): Umberto Rosani, Paola Venier
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
DOI: 10.3389/fmicb.2017.01515

Haemocytes from Crassostrea gigas and OsHV-1: A promising in vitro system to study host/virus interactions

Author(s): Benjamin Morga, Nicole Faury, Stéphane Guesdon, Bruno Chollet, Tristan Renault
Published in: Journal of Invertebrate Pathology, 2017, ISSN 0022-2011
DOI: 10.1016/j.jip.2017.09.007

Myticalins: A Novel Multigenic Family of Linear, Cationic Antimicrobial Peptides from Marine Mussels (Mytilus spp.)

Author(s): Gabriele Leoni, Andrea De Poli, Mario Mardirossian, Stefano Gambato, Fiorella Florian, Paola Venier, Daniel Wilson, Alessandro Tossi, Alberto Pallavicini, Marco Gerdol
Published in: Marine Drugs, Issue 15/8, 2017, Page(s) 261, ISSN 1660-3397
DOI: 10.3390/md15080261

Diversity and stability of microbiota are key factors associated to healthy and diseased Crassostrea gigas oysters

Author(s): Camille Clerissi, Julien de Lorgeril, Bruno Petton, Aude Lucasson, Jean-Michel Escoubas, Yannick Gueguen, Lionel Dégremont, Guillaume Mitta, Eve Toulza
Published in: BioRxiv, 2019
DOI: 10.1101/378125