Peptide-derived bioavailable macrocycles as inhibitors of protein-RNA and protein-protein interactions

Project Information

PEP-PRO-RNA

Grant agreement ID: 678623

DOI 10.3030/678623

Project closed

EC signature date 25 February 2016

Start date 1 March 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 268,75

EU contribution € 1 499 268,75

Coordinated by

STICHTING VU
Netherlands

Publications

Peer reviewed articles (16)

Constrained Peptides with Fine‐Tuned Flexibility Inhibit NF‐Y Transcription Factor Assembly

Author(s): Sadasivam Jeganathan, Mathias Wendt, Sebastian Kiehstaller, Diego Brancaccio, Arne Kuepper, Nicole Pospiech, Alfonso Carotenuto, Ettore Novellino, Sven Hennig, Tom N. Grossmann
Published in: Angewandte Chemie, Issue 131/48, 2019, Page(s) 17512-17519, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201907901

Protein Macrocyclization for Tertiary Structure Stabilization

Author(s): Haim, Anissa; Neubacher, Saskia; Grossmann, Tom N.
Published in: Chembiochem, Issue 2, 2021, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100111

In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

Author(s): Saskia Neubacher, Jordy M. Saya, Alessia Amore, Tom N. Grossmann
Published in: The Journal of Organic Chemistry, Issue 85/3, 2019, Page(s) 1476-1483, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.9b02490

Synergistic DNA- and Protein-Based Recognition Promote an RNA-Templated Bio-orthogonal Reaction

Author(s): McLoughlin, Niall M.; Kuepper, Arne; Neubacher, Saskia; Grossmann, Tom N.
Published in: Chemistry a European Journal, Issue 1, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202101103

Constrained peptides mimic a viral suppressor of RNA silencing

Author(s): Arne Kuepper; Niall M McLoughlin; Saskia Neubacher; Alejandro Yeste-Vázquez; Estel Collado Camps; Chandran Nithin; Sunandan Mukherjee; Lucas Bethge; Janusz M Bujnicki; Roland Brock; Stefan Heinrichs; Tom N Grossmann
Published in: Nucleic acids research, Issue 1, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab1149

Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis.

Author(s): Sandra Ortega Ugalde; Kerstin Wallraven; Alexander Speer; Wilbert Bitter; Tom N. Grossmann; Jan N. M. Commandeur
Published in: Biochemical Pharmacology, Issue 1, 2020, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2020.113938

Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling

Author(s): Wendt, Mathias; Bellavita, Rosa; Gerber, Alan; Efrém, Nina‐Louisa; van Ramshorst, Thirza; Pearce, Nicholas M.; Davey, Paul R. J.; Everard, Isabel; Vazquez‐Chantada, Mercedes; Chiarparin, Elisabetta; Grieco, Paolo; Hennig, Sven; Grossmann, Tom N.
Published in: Angewandte Chemie International Edition in English, n/a(n/a). John Wiley and Sons Ltd, Issue 2, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202102082

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Author(s): Laura Dietrich, Bernd Rathmer, Kenneth Ewan, Tanja Bange, Stefan Heinrichs, Trevor C. Dale, Dennis Schade, Tom N. Grossmann
Published in: Cell Chemical Biology, Issue 24/8, 2017, Page(s) 958-968.e5, ISSN 2451-9456
Publisher: Cell Press
DOI: 10.1016/j.chembiol.2017.06.013

Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions

Author(s): Dennis M. Krüger, Adrian Glas, David Bier, Nicole Pospiech, Kerstin Wallraven, Laura Dietrich, Christian Ottmann, Oliver Koch, Sven Hennig, Tom N. Grossmann
Published in: Journal of Medicinal Chemistry, 2017, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01221

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis

Author(s): Philipp M. Cromm, Kerstin Wallraven, Adrian Glas, David Bier, Alois Fürstner, Christian Ottmann, Tom N. Grossmann
Published in: ChemBioChem, Issue 17/20, 2016, Page(s) 1915-1919, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201600362

Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates

Author(s): Adrian Glas, Eike-Christian Wamhoff, Dennis M. Krüger, Christoph Rademacher, Tom N. Grossmann
Published in: Chemistry - A European Journal, 2017, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702776

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Author(s): Marta Pelay-Gimeno, Tanja Bange, Sven Hennig, Tom N. Grossmann
Published in: Angewandte Chemie, Issue 130/35, 2018, Page(s) 11334-11340, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201804506

Protein–RNA interactions: structural characteristics and hotspot amino acids

Author(s): Dennis M. Krüger, Saskia Neubacher, Tom N. Grossmann
Published in: RNA, Issue 24/11, 2018, Page(s) 1457-1465, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1261/rna.066464.118

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Author(s): Carolin Mueller, Tom N. Grossmann
Published in: Angewandte Chemie International Edition, Issue 57/52, 2018, Page(s) 17079-17083, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811515

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

Author(s): Cromm, Philipp M.; Adihou, Hélène; Kapoor, Shobhna; Vazquez‐Chantada, Mercedes; Davey, Paul; Longmire, David; Hennes, Elisabeth; Hofer, Walter; Küchler, Philipp; Chiarparin, Elisabetta; Waldmann, Herbert; Grossmann, Tom N.
Published in: ChemBioChem, 20(24), 2987 - 2990., 2019, ISSN 1439-7633
Publisher: Wiley VCH
DOI: 10.1002/cbic.201900615

Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc04705k

Author(s): Wallraven, Kerstin; Holmelin, Fredrik L.; Glas, Adrian; Hennig, Sven; Frolov, Andrey I.; Grossmann, Tom N.
Published in: Chemical Science, 2020, ISSN 2041-6539
Publisher: RSC
DOI: 10.1039/c9sc04705k