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Peptide-derived bioavailable macrocycles as inhibitors of protein-RNA and protein-protein interactions

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Publications

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Author(s): Laura Dietrich, Bernd Rathmer, Kenneth Ewan, Tanja Bange, Stefan Heinrichs, Trevor C. Dale, Dennis Schade, Tom N. Grossmann
Published in: Cell Chemical Biology, Issue 24/8, 2017, Page(s) 958-968.e5, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2017.06.013

Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions

Author(s): Dennis M. Krüger, Adrian Glas, David Bier, Nicole Pospiech, Kerstin Wallraven, Laura Dietrich, Christian Ottmann, Oliver Koch, Sven Hennig, Tom N. Grossmann
Published in: Journal of Medicinal Chemistry, 2017, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.7b01221

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis

Author(s): Philipp M. Cromm, Kerstin Wallraven, Adrian Glas, David Bier, Alois Fürstner, Christian Ottmann, Tom N. Grossmann
Published in: ChemBioChem, Issue 17/20, 2016, Page(s) 1915-1919, ISSN 1439-4227
DOI: 10.1002/cbic.201600362

Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates

Author(s): Adrian Glas, Eike-Christian Wamhoff, Dennis M. Krüger, Christoph Rademacher, Tom N. Grossmann
Published in: Chemistry - A European Journal, 2017, ISSN 0947-6539
DOI: 10.1002/chem.201702776

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Author(s): Marta Pelay-Gimeno, Tanja Bange, Sven Hennig, Tom N. Grossmann
Published in: Angewandte Chemie, Issue 130/35, 2018, Page(s) 11334-11340, ISSN 0044-8249
DOI: 10.1002/ange.201804506

Protein–RNA interactions: structural characteristics and hotspot amino acids

Author(s): Dennis M. Krüger, Saskia Neubacher, Tom N. Grossmann
Published in: RNA, Issue 24/11, 2018, Page(s) 1457-1465, ISSN 1355-8382
DOI: 10.1261/rna.066464.118

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Author(s): Carolin Mueller, Tom N. Grossmann
Published in: Angewandte Chemie International Edition, Issue 57/52, 2018, Page(s) 17079-17083, ISSN 1433-7851
DOI: 10.1002/anie.201811515