Unravelling the Mechanosensitivity of Actin Bundles in Filopodia

Project Information

BUNDLEFORCE

Grant agreement ID: 679116

DOI

10.3030/679116

Project closed

EC signature date 11 December 2015

Start date 1 March 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 190,00

EU contribution

€ 1 499 190,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

Author(s): Eric J. Schmidt, Salome Funes, Jeanne E. McKeon, Brittany R. Morgan, Sivakumar Boopathy, Lauren C. O’Connor, Osman Bilsel, Francesca Massi, Antoine Jégou, Daryl A. Bosco
Published in: Proceedings of the National Academy of Sciences, Issue 118/23, 2021, Page(s) e2024605118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2024605118

Mechanically tuning actin filaments to modulate the action of actin-binding proteins

Author(s): Antoine Jégou, Guillaume Romet-Lemonne
Published in: Current Opinion in Cell Biology, Issue 68, 2021, Page(s) 72-80, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.09.002

Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks

Author(s): Markku Hakala, Hugo Wioland, Mari Tolonen, Tommi Kotila, Antoine Jegou, Guillaume Romet-Lemonne, Pekka Lappalainen
Published in: Nature Cell Biology, Issue 23/2, 2021, Page(s) 147-159, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-00629-y

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

Author(s): Nicolas Vignier, Maria Chatzifrangkeskou, Luca Pinton, Hugo Wioland, Thibaut Marais, Mégane Lemaitre, Caroline Le Dour, Cécile Peccate, Déborah Cardoso, Alain Schmitt, Wei Wu, Maria-Grazia Biferi, Naïra Naouar, Coline Macquart, Maud Beuvin, Valérie Decostre, Gisèle Bonne, Guillaume Romet-Lemonne, Howard J. Worman, Francesco Saverio Tedesco, Antoine Jégou, Antoine Muchir
Published in: Cell Reports, Issue 36/8, 2021, Page(s) 109601, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109601

Modulation of formin processivity by profilin and mechanical tension

Author(s): Luyan Cao, Mikael Kerleau, Emiko L. Suzuki, Hugo Wioland, Sandy Jouet, Berengere Guichard, Martin Lenz, Guillaume Romet-Lemonne, Antoine Jegou
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.34176

Single Filaments to Reveal the Multiple Flavors of Actin

Author(s): Antoine Jégou, Guillaume Romet-Lemonne
Published in: Biophysical Journal, Issue 110/10, 2016, Page(s) 2138-2146, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2016.04.025

Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility

Author(s): Julien Pernier, Shashank Shekhar, Antoine Jegou, Bérengère Guichard, Marie-France Carlier
Published in: Developmental Cell, Issue 36/2, 2016, Page(s) 201-214, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2015.12.024

Quantitative Variations with pH of Actin Depolymerizing Factor/Cofilin’s Multiple Actions on Actin Filaments

Author(s): Hugo Wioland, Antoine Jegou, Guillaume Romet-Lemonne
Published in: Biochemistry, Issue 58/1, 2018, Page(s) 40-47, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.8b01001

Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing

Author(s): Hugo Wioland, Antoine Jegou, Guillaume Romet-Lemonne
Published in: Proceedings of the National Academy of Sciences, Issue 116/7, 2019, Page(s) 2595-2602, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1812053116

ADF/Cofilin Accelerates Actin Dynamics by Severing Filaments and Promoting Their Depolymerization at Both Ends

Author(s): Hugo Wioland, Berengere Guichard, Yosuke Senju, Sarah Myram, Pekka Lappalainen, Antoine Jégou, Guillaume Romet-Lemonne
Published in: Current Biology, Issue 27/13, 2017, Page(s) 1956-1967.e7, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.05.048

Geometrical Constraints Greatly Hinder Formin mDia1 Activity

Author(s): Emiko L. Suzuki; Jahnavi Chikireddy; Serge Dmitrieff; Bérengère Guichard; Guillaume Romet-Lemonne; Antoine Jégou
Published in: Nano Letters, Issue 3, 2020, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1101/671842

The advantages of microfluidics to study actin biochemistry and biomechanics

Author(s): Hugo Wioland, Emiko Suzuki, Luyan Cao, Guillaume Romet-Lemonne, Antoine Jegou
Published in: Journal of Muscle Research and Cell Motility, Issue 41/1, 2020, Page(s) 175-188, ISSN 0142-4319
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10974-019-09564-4

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Author(s): Luyan Cao, Amina Yonis, Malti Vaghela, Elias H. Barriga, Priyamvada Chugh, Matthew B. Smith, Julien Maufront, Geneviève Lavoie, Antoine Méant, Emma Ferber, Miia Bovellan, Art Alberts, Aurélie Bertin, Roberto Mayor, Ewa K. Paluch, Philippe P. Roux, Antoine Jégou, Guillaume Romet-Lemonne, Guillaume Charras
Published in: Nature Cell Biology, Issue 22/7, 2020, Page(s) 803-814, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0531-y

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Author(s): Kotila, Tommi; Wioland, Hugo; Enkavi, Giray; Kogan, Konstantin; Vattulainen, Ilpo; Jégou, Antoine; Romet-Lemonne, Guillaume; Lappalainen, Pekka
Published in: Nature Communications, Issue 5, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.5281/zenodo.3340994

The many implications of actin filament helicity

Author(s): Antoine Jegou, Guillaume Romet-Lemonne
Published in: Seminars in Cell & Developmental Biology, Issue 102, 2020, Page(s) 65-72, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.10.018

Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly

Author(s): Hugo Wioland, Stéphane Frémont, Bérengère Guichard, Arnaud Echard, Antoine Jégou, Guillaume Romet‐Lemonne
Published in: EMBO reports, Issue 22/2, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050965

Direct measurement of near‐nano‐Newton forces developed by self‐organizing actomyosin fibers bound α‐catenin

Author(s): Surabhi Sonam, Clémence Vigouroux, Antoine Jégou, Guillaume Romet‐Lemonne, Christophe Le Clainche, Benoit Ladoux, René Marc Mège
Published in: Biology of the Cell, 2021, ISSN 0248-4900
Publisher: Portland Press, Ltd.
DOI: 10.1111/boc.202100014