Multi-scale model of bacterial cell-cell interactions

Project Information

T6S

Grant agreement ID: 679209

DOI

10.3030/679209

Project closed

EC signature date 20 May 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 751 853,00

EU contribution

€ 1 751 853,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Author(s): Annika Hausmann, Desirée Böck, Petra Geiser, Dorothée L. Berthold, Stefan A. Fattinger, Markus Furter, Judith A. Bouman, Manja Barthel-Scherrer, Crispin M. Lang, Erik Bakkeren, Isabel Kolinko, Médéric Diard, Dirk Bumann, Emma Slack, Roland R. Regoes, Martin Pilhofer, Mikael E. Sellin, Wolf-Dietrich Hardt
Published in: Mucosal Immunology, Issue 13/3, 2020, Page(s) 530-544, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-019-0247-0

Structure and Function of a Bacterial Gap Junction Analog

Author(s): Gregor L. Weiss, Ann-Katrin Kieninger, Iris Maldener, Karl Forchhammer, Martin Pilhofer
Published in: Cell, Issue 178/2, 2019, Page(s) 374-384.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.05.055

Architecture and function of human uromodulin filaments in urinary tract infections

Author(s): Gregor L. Weiss, Jessica J. Stanisich, Maximilian M. Sauer, Chia-Wei Lin, Jonathan Eras, Dawid S. Zyla, Johannes Trück, Olivier Devuyst, Markus Aebi, Martin Pilhofer, Rudi Glockshuber
Published in: Science, Issue 369/6506, 2020, Page(s) 1005-1010, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz9866

Structural Determinants and Their Role in Cyanobacterial Morphogenesis.

Author(s): Benjamin Lennart Springstein; Dennis J. Nürnberg; Gregor L. Weiss; Martin Pilhofer; Karina Stucken
Published in: Life, Issue 1, 2020, ISSN 2075-1729
Publisher: nd
DOI: 10.17169/refubium-29294

Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

Author(s): Jingwei Xu, Charles F. Ericson, Yun-Wei Lien, Florentine U. N. Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer
Published in: Nature Microbiology, 2022, ISSN 2058-5276
Publisher: nd
DOI: 10.1038/s41564-022-01059-2

Cryo-Electron Tomography Reveals the Complex Ultrastructural Organization of Multicellular Filamentous Chloroflexota (Chloroflexi) Bacteria

Author(s): Vasil A. Gaisin, Romain Kooger, Denis S. Grouzdev, Vladimir M. Gorlenko, Martin Pilhofer
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2020.01373

Fully automated, sequential focused ion beam milling for cryo-electron tomography

Author(s): Tobias Zachs, Andreas Schertel, João Medeiros, Gregor L Weiss, Jannik Hugener, Joao Matos, Martin Pilhofer
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52286

Mechanistic insight into bacterial entrapment by septin cage reconstitution

Author(s): Damián Lobato-Márquez , Jingwei Xu , Gizem Özbaykal Güler , Adaobi Ojiakor , Martin Pilhofer , Serge Mostowy
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24721-5

In situ architecture, function, and evolution of a contractile injection system

Author(s): Désirée Böck, João M. Medeiros, Han-Fei Tsao, Thomas Penz, Gregor L. Weiss, Karin Aistleitner, Matthias Horn, Martin Pilhofer
Published in: Science, Issue 357/6352, 2017, Page(s) 713-717, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan7904

Robust workflow and instrumentation for cryo-focused ion beam milling of samples for electron cryotomography

Author(s): João M. Medeiros, Désirée Böck, Gregor L. Weiss, Romain Kooger, Roger A. Wepf, Martin Pilhofer
Published in: Ultramicroscopy, Issue 190, 2018, Page(s) 1-11, ISSN 0304-3991
Publisher: Elsevier BV
DOI: 10.1016/j.ultramic.2018.04.002

The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin

Author(s): Shujun Cai, Désirée Böck, Martin Pilhofer, Lu Gan
Published in: Molecular Biology of the Cell, Issue 29/20, 2018, Page(s) 2450-2457, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e18-05-0331

Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis

Author(s): Masanori Toyofuku, Gerardo Cárcamo-Oyarce, Tatsuya Yamamoto, Fabian Eisenstein, Chien-Chi Hsiao, Masaharu Kurosawa, Karl Gademann, Martin Pilhofer, Nobuhiko Nomura, Leo Eberl
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00492-w

In situ and high‐resolution cryo‐EM structure of a bacterial type VI secretion system membrane complex

Author(s): Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, Eric Cascales, Martin Pilhofer, Eric Durand, Rémi Fronzes
Published in: The EMBO Journal, Issue 38/10, 2019, Page(s) e100886, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100886

Bidirectional contraction of a type six secretion system

Author(s): Piotr Szwedziak, Martin Pilhofer
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09603-1

A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

Author(s): Charles F Ericson, Fabian Eisenstein, João M Medeiros, Kyle E Malter, Giselle S Cavalcanti, Robert W Zeller, Dianne K Newman, Martin Pilhofer, Nicholas J Shikuma
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.46845

Improved applicability and robustness of fast cryo-electron tomography data acquisition

Author(s): Fabian Eisenstein, Radostin Danev, Martin Pilhofer
Published in: Journal of Structural Biology, Issue 208/2, 2019, Page(s) 107-114, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2019.08.006

A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector

Author(s): Iara Rocchi, Charles F. Ericson, Kyle E. Malter, Sahar Zargar, Fabian Eisenstein, Martin Pilhofer, Sinem Beyhan, Nicholas J. Shikuma
Published in: Cell Reports, Issue 28/2, 2019, Page(s) 295-301.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.06.019

Effector loading onto the VgrG carrier activates type VI secretion system assembly

Author(s): Chih‐Feng Wu, Yun‐Wei Lien, Devanand Bondage, Jer‐Sheng Lin, Martin Pilhofer, Yu‐Ling Shih, Jeff H Chang, Erh‐Min Lai
Published in: EMBO reports, Issue 21/1, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201947961

Cultivation of a vampire: ‘Candidatus Absconditicoccus praedator’

Author(s): Michail M. Yakimov,Alexander Y. Merkel,Vasil A. Gaisin,Martin Pilhofer,Enzo Messina,John E. Hallsworth,Alexandra A. Klyukina,Ekaterina N. Tikhonova,Vladimir M. Gorlenko
Published in: Environmental Microbiology, 2021, ISSN 1462-2920
Publisher: tbd
DOI: 10.1111/1462-2920.15823

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

Author(s): Jessica J Stanisich, Dawid S Zyla, Pavel Afanasyev, Jingwei Xu, Anne Kipp, Eric Olinger, Olivier Devuyst, Martin Pilhofer, Daniel Boehringer, Rudi Glockshuber
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60265

The Polar Legionella Icm/Dot T4SS Establishes Distinct Contact Sites with the Pathogen Vacuole Membrane

Author(s): Désirée Böck; Dario Hüsler; Bernhard Steiner; João M. Medeiros; Amanda Welin; Katarzyna A. Radomska; Wolf-Dietrich Hardt; Martin Pilhofer; Hubert Hilbi
Published in: mBio, Issue 1, 2021, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.02180-21

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

Author(s): Stefan A. Fattinger, Desirée Böck, Maria Letizia Di Martino, Sabrina Deuring, Pilar Samperio Ventayol, Viktor Ek, Markus Furter, Saskia Kreibich, Francesco Bosia, Anna A. Müller-Hauser, Bidong D. Nguyen, Manfred Rohde, Martin Pilhofer, Wolf-Dietrich Hardt, Mikael E. Sellin
Published in: PLOS Pathogens, Issue 16/5, 2020, Page(s) e1008503, ISSN 1553-7374
Publisher: plos
DOI: 10.1371/journal.ppat.1008503

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Author(s): Gregor L. Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A. Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer
Published in: Nature Microbiology, 2022, ISSN 2058-5276
Publisher: nd
DOI: 10.1038/s41564-021-01055-y