Skip to main content

Personalized Cancer Therapy by Model-based Optimal Robust Control Algorithm

Searching for OpenAIRE data...

Publications

Positive nonlinear control of tumor growth using angiogenic inhibition * *This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 679681).

Author(s): Dániel András Drexler, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 50/1, 2017, Page(s) 15068-15073, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2017.08.2522

Modeling of Tumor Growth Incorporating the Effects of Necrosis and the Effect of Bevacizumab

Author(s): Dániel András Drexler, Johanna Sápi, Levente Kovács
Published in: Complexity, Issue 2017, 2017, Page(s) 1-10, ISSN 1076-2787
DOI: 10.1155/2017/5985031

Linear parameter varying (LPV) based robust control of type-I diabetes driven for real patient data

Author(s): Levente Kovács
Published in: Knowledge-Based Systems, Issue 122, 2017, Page(s) 199-213, ISSN 0950-7051
DOI: 10.1016/j.knosys.2017.02.008

A robust fixed point transformation-based approach for type 1 diabetes control

Author(s): Levente Kovács
Published in: Nonlinear Dynamics, Issue 89/4, 2017, Page(s) 2481-2493, ISSN 0924-090X
DOI: 10.1007/s11071-017-3598-7

Towards Automated Traceability Assessment through Augmented Lifecycle Space

Author(s): Miklós Biró, József Klespitz, Johannes Gmeiner, Christa Illibauer, Levente Kovács
Published in: COMMUNICATIONS IN COMPUTER AND INFORMATION SCIENCE, Issue 633, 2016, Page(s) 94-105, ISSN 1865-0929
DOI: 10.1007/978-3-319-44817-6_8

Modelling Tumor Growth under Angiogenesis Inhibition with Mixed-Effects Models

Author(s): Tamás Ferenci, Johanna Sápi, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 221-234, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.15

Potential Benefits of Discrete-Time Controller-based Treatments over Protocol-based Cancer Therapies

Author(s): Johanna Sápi, Dániel András Drexler, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 11-23, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.2

Infectious Hospital Agents: A HAI Spreading Simulation Framework

Author(s): Róbert Pethes, Tamás Ferenci, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 95-110, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.7

Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab

Author(s): Dávid Csercsik, Levente Kovács
Published in: Complexity, Issue 2019, 2019, Page(s) 1-18, ISSN 1076-2787
DOI: 10.1155/2019/9079104

Nonlinear Model Predictive Control Using Robust Fixed Point Transformation-Based Phenomena for Controlling Tumor Growth

Author(s): Bence Czakó, Levente Kovács
Published in: Machines, Issue 6/4, 2018, Page(s) 49, ISSN 2075-1702
DOI: 10.3390/machines6040049

A TP-LPV-LMI based control for Tumor Growth Inhibition

Author(s): Levente Kovács, György Eigner
Published in: IFAC-PapersOnLine, Issue 51/26, 2018, Page(s) 155-160, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.11.146

Tensor Product Model Transformation-based Parallel Distributed Control of Tumor Growth

Author(s): Levente Kovács, G. Eigner
Published in: Acta Polytechnica Hungarica, Issue 15/3, 2018, ISSN 1785-8860
DOI: 10.12700/aph.15.3.2018.3.7

H∞ control of nonlinear systems with positive input with application to antiangiogenic therapy

Author(s): Dániel A. Drexler, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 51/25, 2018, Page(s) 146-151, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.11.096

Robust Fixed Point Transformation based Proportional-Derivative Control of Angiogenic Tumor Growth

Author(s): Levente Kovács, György Eigner, József K. Tar, Imre Rudas
Published in: IFAC-PapersOnLine, Issue 51/4, 2018, Page(s) 894-899, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.06.110

A minimal model of tumor growth with angiogenic inhibition using bevacizumab

Author(s): Daniel Andras Drexler, Johanna Sapi, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000185-000190
DOI: 10.1109/SAMI.2017.7880300

Nonlinear identification of a tumor growth model for validating cancer treatments

Author(s): Gyorgy Eigner, Gabor Szogi, Peter Pausits, Imre Rudas, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 3159-3163
DOI: 10.1109/SMC.2017.8123113

Linear matrix inequality based control of tumor growth

Author(s): Gyorgy Eigner, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 1734-1739
DOI: 10.1109/SMC.2017.8122866

Tensor product based modeling of tumor growth

Author(s): Gyorgy Eigner, Imre Rudas, Aniko Szakal, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 900-905
DOI: 10.1109/SMC.2017.8122724

Cyber-medical systems: Challenges and possibilities

Author(s): Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Intelligent Systems and Informatics (SISY), 2017, Page(s) 000015-000016
DOI: 10.1109/SISY.2017.8080527

Model-based Optimal Control Method for Cancer Treatment Using Model Predictive Control and Robust Fixed Point Method

Author(s): Bence Czakó, Johanna Sápi, Levente Kovács
Published in: INES 2017, IEEE 21st International Conference on Intelligent Engineering Systems: Proceedings., 2017, Page(s) 271-276

Positive control of a minimal model of tumor growth with bevacizumab treatment

Author(s): Daniel Andras Drexler, Johanna Sapi, Levente Kovacs
Published in: 2017 12th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2017, Page(s) 2084-2087
DOI: 10.1109/ICIEA.2017.8283181

Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose

Author(s): David Csercsik, Johanna Sapi, Tamas Gonczy, Levente Kovacs
Published in: 2017 IEEE 56th Annual Conference on Decision and Control (CDC), 2017, Page(s) 4698-4702
DOI: 10.1109/CDC.2017.8264353

Nonlinear Identification of Glucose Absorption Related to Diabetes Mellitus

Author(s): György Eigner, Katalin Koppány, Péter Pausits, Levente Kovács
Published in: INES 2017, IEEE 21st International Conference on Intelligent Engineering Systems: Proceedings, 2017, Page(s) 265-270

Control of nonlinear physiological systems via LPV framework

Author(s): Gyorgy Eigner, Daniel Andras Drexler, Levente Kovacs
Published in: 2017 12th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2017, Page(s) 2088-2093
DOI: 10.1109/ICIEA.2017.8283182

Enhanced traceability and consistency with Augmented Lifecycle Space

Author(s): Jozsef Klespitz, Miklos Biro, Levente Kovacs
Published in: 2016 IEEE 20th Jubilee International Conference on Intelligent Engineering Systems (INES), 2016, Page(s) 207-212
DOI: 10.1109/INES.2016.7555121

Physiological control systems for high-quality interdisciplinary researches

Author(s): Levente Kovacs
Published in: 2016 IEEE 11th International Symposium on Applied Computational Intelligence and Informatics (SACI), 2016, Page(s) 11-12
DOI: 10.1109/SACI.2016.7507350

Control engineering approaches at Obuda University for physiological problems

Author(s): Levente Kovacs
Published in: 2016 IEEE 20th Jubilee International Conference on Intelligent Engineering Systems (INES), 2016, Page(s) 19-20
DOI: 10.1109/INES.2016.7555125

Comparison of protocol based cancer therapies and discrete controller based treatments in the case of endostatin administration

Author(s): Johanna Sapi, Daniel Andras Drexler, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003830-003835
DOI: 10.1109/SMC.2016.7844831

Modelling xenograft tumor growth under antiangiogenic inhibitation with mixed-effects models

Author(s): Tamas Ferenci, Johanna Sapi, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003912-003917
DOI: 10.1109/SMC.2016.7844845

A novel completed LPV controller and observer scheme in order to control nonlinear compartmental systems

Author(s): Gyorgy Eigner, Peter Pausits, Levente Kovacs
Published in: 2016 IEEE 14th International Symposium on Intelligent Systems and Informatics (SISY), 2016, Page(s) 85-92
DOI: 10.1109/SISY.2016.7601476

Infectious hospital agents: An individual-based simulation framework

Author(s): Robert Pethes, Tamas Ferenci, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003434-003439
DOI: 10.1109/SMC.2016.7844765

Taming Cancer: Is it Possible?

Author(s): Levente Kovács, Zoltán Sápi, Dániel A. Drexler, Johanna Sápi
Published in: BIT's 10th Annual World Cancer Congress 2017, 2017, Page(s) 137

Investigation of the TP modeling possibilities of the Hovorka T1DM model

Author(s): Gyorgy Eigner, Istvan Bojthe, Peter Pausits, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000259-000264
DOI: 10.1109/SAMI.2017.7880314

Robust nonlinear model predictive control of diabetes mellitus

Author(s): Levente Kovacs, Csaba Maszlag, Miklos Mezei, Gyorgy Eigner
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000055-000060
DOI: 10.1109/SAMI.2017.7880363

LPV-based control of nonlinear compartmental model with input uncertainty

Author(s): Gyorgy Eigner, Arpad Varga, Miklos Mezei, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Intelligent Systems and Informatics (SISY), 2017, Page(s) 000017-000022
DOI: 10.1109/SISY.2017.8080538

Cyber-Medical Systems: the Digitalized Healthcare Approach and Its Trends

Author(s): Levente Kovács
Published in: MACRo 2017: 6th International Conference on Recent Achievements in Mechatronics, Automation, Computer Science and Robotics, 2017, Page(s) 1-2

Animal experiments in cancer research: Wasteful or unavoidable?

Author(s): Johanna Sapi
Published in: 2017 IEEE 30th Neumann Colloquium (NC), 2017, Page(s) 000157-000162
DOI: 10.1109/NC.2017.8263274

Investigation of the TP-based modeling possibility of a nonlinear ICU diabetes model

Author(s): Gyorgy Eigner, Imre J. Rudas, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003405-003410
DOI: 10.1109/SMC.2016.7844760

Second-order and implicit methods in numerical integration improve tracking performance of the closed-loop inverse kinematics algorithm

Author(s): Daniel Andras Drexler, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003362-003367
DOI: 10.1109/SMC.2016.7844753

Control of T1DM via tensor product-based framework

Author(s): Gyorgy Eigner, Peter Pausits, Levente Kovacs
Published in: 2016 IEEE 17th International Symposium on Computational Intelligence and Informatics (CINTI), 2016, Page(s) 000055-000060
DOI: 10.1109/CINTI.2016.7846379

Augmented Lifecycle Space for traceability and consistency enhancement

Author(s): Jozsef Klespitz, Miklos Biro, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003973-003977
DOI: 10.1109/SMC.2016.7844854

Convex polytopic modeling of diabetes mellitus: A Tensor Product based approach

Author(s): Levente Kovacs, Gyorgy Eigner
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003393-003398
DOI: 10.1109/SMC.2016.7844758

Regularization of the differential inverse orientation problem of generic serial revolute joint manipulators

Author(s): Daniel Andras Drexler
Published in: 2017 22nd International Conference on Methods and Models in Automation and Robotics (MMAR), 2017, Page(s) 402-407
DOI: 10.1109/mmar.2017.8046861

Model-Based Simulation and Comparison of Open-Loop and Closed-Loop Combined Therapies for Tumor Treatment

Author(s): David Csercsik, Johanna Sapi, Levente Kovacs
Published in: 2018 IEEE Conference on Control Technology and Applications (CCTA), 2018, Page(s) 1383-1388
DOI: 10.1109/ccta.2018.8511526

A hybrid cellular automaton model of tumor-induced angiogenesis

Author(s): Tamas Gonczy, David Csercsik, Levente Kovacs
Published in: 2018 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2018, Page(s) 1-6
DOI: 10.1109/aqtr.2018.8402781

Control of tumor growth by modern control methodologies

Author(s): Gyorgy Eigner, Levente Kovacs
Published in: 2018 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2018, Page(s) 1-6
DOI: 10.1109/aqtr.2018.8402782

Tumor Growth Control by TP-LPV-LMI Based Controller

Author(s): Gyorgy Eigner, Daniel Andras Drexler, Levente Kovacs
Published in: 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2018, Page(s) 2564-2569
DOI: 10.1109/smc.2018.00439

Qualitative analysis of a closed-loop model of tumor growth control

Author(s): Dániel András Drexler, Ilona Nagy, Valery Romanovski, János Tóth, Levente Kovács
Published in: IEEE 18th International Symposium on Computational Intelligence and Informatics (CINTI 2018), 2018, Page(s) 329-334

Discrete LPV Modeling of Diabetes Mellitus for Control Purposes

Author(s): Gyorgy Eigner, Mate Siket, Aniko Szakal, Imre Rudas, Levente Kovacs
Published in: 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2018, Page(s) 2558-2563
DOI: 10.1109/smc.2018.00438

Modeling of tumor growth incorporating the effect of pegylated liposomal doxorubicin

Author(s): Dániel András Drexler, Tamás Ferenci, Anna Lovrics, Levente Kovács
Published in: IEEE 23nd International Conference on Intelligent Engineering Systems : proceedings, 2019, Page(s) 369-373

Robust H∞ controller design for T1DM based on relaxed LMI conditions

Author(s): György Eigner, István Böjthe, Alajos Mészárosy, Levente Kovács
Published in: IEEE 23nd International Conference on Intelligent Engineering Systems : proceedings, 2019, Page(s) 363-368

Comparison of Michaelis-Menten kinetics modeling alternatives in cancer chemotherapy modeling

Author(s): Dániel András Drexler, Tamás Ferenci, Anna Lovrics, Levente Kovács
Published in: IEEE 13th International Symposium on Applied Computational Intelligence and Informatics : PROCEEDINGS, 2019, Page(s) 27-32

Cross-Tool Interoperability in Heterogeneous Application Lifecycle Management Systems

Author(s): József Klespitz, Miklós Bíró, Levente Kovács
Published in: New Trends in Software Methodologies, Tools and Techniques: 5th International Conference on New Trends in Intelligent Software Methodology Tools and Techniques (SoMeT 16), Issue Volume 268, 2016, Page(s) 213 - 220
DOI: 10.3233/978-1-61499-674-3-213