Personalized Cancer Therapy by Model-based Optimal Robust Control Algorithm

Publications

Peer reviewed articles (17)

Positive nonlinear control of tumor growth using angiogenic inhibition * *This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 679681).

Author(s): Dániel András Drexler, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 50/1, 2017, Page(s) 15068-15073, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2017.08.2522

Optimal discrete time control of antiangiogenic tumor therapy * *This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 679681). D.A. Drexler was also supported by a Marie Curie International Research Staff Exchange Scheme Fellowship within the 7th European Community Framework Progr

Author(s): Dániel András Drexler, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 50/1, 2017, Page(s) 13504-13509, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2017.08.2337

Modeling of Tumor Growth Incorporating the Effects of Necrosis and the Effect of Bevacizumab

Author(s): Dániel András Drexler, Johanna Sápi, Levente Kovács
Published in: Complexity, Issue 2017, 2017, Page(s) 1-10, ISSN 1076-2787
DOI: 10.1155/2017/5985031

A bicompartmental dynamic tumor growth model * *This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 679681). Dávid Csercsik received funding from the Hungarian National Fund (OTKA NF-104706).

Author(s): Dávid Csercsik, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 50/1, 2017, Page(s) 12216-12221, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2017.08.2119

Linear parameter varying (LPV) based robust control of type-I diabetes driven for real patient data

Author(s): Levente Kovács
Published in: Knowledge-Based Systems, Issue 122, 2017, Page(s) 199-213, ISSN 0950-7051
DOI: 10.1016/j.knosys.2017.02.008

A robust fixed point transformation-based approach for type 1 diabetes control

Author(s): Levente Kovács
Published in: Nonlinear Dynamics, Issue 89/4, 2017, Page(s) 2481-2493, ISSN 0924-090X
DOI: 10.1007/s11071-017-3598-7

Towards Automated Traceability Assessment through Augmented Lifecycle Space

Author(s): Miklós Biró, József Klespitz, Johannes Gmeiner, Christa Illibauer, Levente Kovács
Published in: COMMUNICATIONS IN COMPUTER AND INFORMATION SCIENCE, Issue 633, 2016, Page(s) 94-105, ISSN 1865-0929
DOI: 10.1007/978-3-319-44817-6_8

Modelling Tumor Growth under Angiogenesis Inhibition with Mixed-Effects Models

Author(s): Tamás Ferenci, Johanna Sápi, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 221-234, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.15

Potential Benefits of Discrete-Time Controller-based Treatments over Protocol-based Cancer Therapies

Author(s): Johanna Sápi, Dániel András Drexler, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 11-23, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.2

Infectious Hospital Agents: A HAI Spreading Simulation Framework

Author(s): Róbert Pethes, Tamás Ferenci, Levente Kovács
Published in: Acta Polytechnica Hungarica, Issue 14/1, 2017, Page(s) 95-110, ISSN 1785-8860
DOI: 10.12700/APH.14.1.2017.1.7

Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab

Author(s): Dávid Csercsik, Levente Kovács
Published in: Complexity, Issue 2019, 2019, Page(s) 1-18, ISSN 1076-2787
DOI: 10.1155/2019/9079104

Optimal PID Based Computed Torque Control of Tumor Growth Models ⁎ ⁎This project has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No 679681). B.G. Czak was supported by the UNKP-17-2/I. New National Excellence Program of the Ministry of Human Capacities.

Author(s): Bence G. Czakó, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 51/4, 2018, Page(s) 900-905, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.06.109

Nonlinear Model Predictive Control Using Robust Fixed Point Transformation-Based Phenomena for Controlling Tumor Growth

Author(s): Bence Czakó, Levente Kovács
Published in: Machines, Issue 6/4, 2018, Page(s) 49, ISSN 2075-1702
DOI: 10.3390/machines6040049

A TP-LPV-LMI based control for Tumor Growth Inhibition

Author(s): Levente Kovács, György Eigner
Published in: IFAC-PapersOnLine, Issue 51/26, 2018, Page(s) 155-160, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.11.146

Tensor Product Model Transformation-based Parallel Distributed Control of Tumor Growth

Author(s): Levente Kovács, G. Eigner
Published in: Acta Polytechnica Hungarica, Issue 15/3, 2018, ISSN 1785-8860
DOI: 10.12700/aph.15.3.2018.3.7

H∞ control of nonlinear systems with positive input with application to antiangiogenic therapy

Author(s): Dániel A. Drexler, Johanna Sápi, Levente Kovács
Published in: IFAC-PapersOnLine, Issue 51/25, 2018, Page(s) 146-151, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.11.096

Robust Fixed Point Transformation based Proportional-Derivative Control of Angiogenic Tumor Growth

Author(s): Levente Kovács, György Eigner, József K. Tar, Imre Rudas
Published in: IFAC-PapersOnLine, Issue 51/4, 2018, Page(s) 894-899, ISSN 2405-8963
DOI: 10.1016/j.ifacol.2018.06.110

Conference proceedings (38)

A minimal model of tumor growth with angiogenic inhibition using bevacizumab

Author(s): Daniel Andras Drexler, Johanna Sapi, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000185-000190
DOI: 10.1109/SAMI.2017.7880300

Nonlinear identification of a tumor growth model for validating cancer treatments

Author(s): Gyorgy Eigner, Gabor Szogi, Peter Pausits, Imre Rudas, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 3159-3163
DOI: 10.1109/SMC.2017.8123113

Linear matrix inequality based control of tumor growth

Author(s): Gyorgy Eigner, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 1734-1739
DOI: 10.1109/SMC.2017.8122866

Tensor product based modeling of tumor growth

Author(s): Gyorgy Eigner, Imre Rudas, Aniko Szakal, Levente Kovacs
Published in: 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2017, Page(s) 900-905
DOI: 10.1109/SMC.2017.8122724

Cyber-medical systems: Challenges and possibilities

Author(s): Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Intelligent Systems and Informatics (SISY), 2017, Page(s) 000015-000016
DOI: 10.1109/SISY.2017.8080527

Model-based Optimal Control Method for Cancer Treatment Using Model Predictive Control and Robust Fixed Point Method

Author(s): Bence Czakó, Johanna Sápi, Levente Kovács
Published in: INES 2017, IEEE 21st International Conference on Intelligent Engineering Systems: Proceedings., 2017, Page(s) 271-276

Positive control of a minimal model of tumor growth with bevacizumab treatment

Author(s): Daniel Andras Drexler, Johanna Sapi, Levente Kovacs
Published in: 2017 12th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2017, Page(s) 2084-2087
DOI: 10.1109/ICIEA.2017.8283181

Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose

Author(s): David Csercsik, Johanna Sapi, Tamas Gonczy, Levente Kovacs
Published in: 2017 IEEE 56th Annual Conference on Decision and Control (CDC), 2017, Page(s) 4698-4702
DOI: 10.1109/CDC.2017.8264353

Nonlinear Identification of Glucose Absorption Related to Diabetes Mellitus

Author(s): György Eigner, Katalin Koppány, Péter Pausits, Levente Kovács
Published in: INES 2017, IEEE 21st International Conference on Intelligent Engineering Systems: Proceedings, 2017, Page(s) 265-270

Control of nonlinear physiological systems via LPV framework

Author(s): Gyorgy Eigner, Daniel Andras Drexler, Levente Kovacs
Published in: 2017 12th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2017, Page(s) 2088-2093
DOI: 10.1109/ICIEA.2017.8283182

Enhanced traceability and consistency with Augmented Lifecycle Space

Author(s): Jozsef Klespitz, Miklos Biro, Levente Kovacs
Published in: 2016 IEEE 20th Jubilee International Conference on Intelligent Engineering Systems (INES), 2016, Page(s) 207-212
DOI: 10.1109/INES.2016.7555121

Physiological control systems for high-quality interdisciplinary researches

Author(s): Levente Kovacs
Published in: 2016 IEEE 11th International Symposium on Applied Computational Intelligence and Informatics (SACI), 2016, Page(s) 11-12
DOI: 10.1109/SACI.2016.7507350

Control engineering approaches at Obuda University for physiological problems

Author(s): Levente Kovacs
Published in: 2016 IEEE 20th Jubilee International Conference on Intelligent Engineering Systems (INES), 2016, Page(s) 19-20
DOI: 10.1109/INES.2016.7555125

Comparison of protocol based cancer therapies and discrete controller based treatments in the case of endostatin administration

Author(s): Johanna Sapi, Daniel Andras Drexler, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003830-003835
DOI: 10.1109/SMC.2016.7844831

Modelling xenograft tumor growth under antiangiogenic inhibitation with mixed-effects models

Author(s): Tamas Ferenci, Johanna Sapi, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003912-003917
DOI: 10.1109/SMC.2016.7844845

A novel completed LPV controller and observer scheme in order to control nonlinear compartmental systems

Author(s): Gyorgy Eigner, Peter Pausits, Levente Kovacs
Published in: 2016 IEEE 14th International Symposium on Intelligent Systems and Informatics (SISY), 2016, Page(s) 85-92
DOI: 10.1109/SISY.2016.7601476

Infectious hospital agents: An individual-based simulation framework

Author(s): Robert Pethes, Tamas Ferenci, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003434-003439
DOI: 10.1109/SMC.2016.7844765

Taming Cancer: Is it Possible?

Author(s): Levente Kovács, Zoltán Sápi, Dániel A. Drexler, Johanna Sápi
Published in: BIT's 10th Annual World Cancer Congress 2017, 2017, Page(s) 137

Investigation of the TP modeling possibilities of the Hovorka T1DM model

Author(s): Gyorgy Eigner, Istvan Bojthe, Peter Pausits, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000259-000264
DOI: 10.1109/SAMI.2017.7880314

Robust nonlinear model predictive control of diabetes mellitus

Author(s): Levente Kovacs, Csaba Maszlag, Miklos Mezei, Gyorgy Eigner
Published in: 2017 IEEE 15th International Symposium on Applied Machine Intelligence and Informatics (SAMI), 2017, Page(s) 000055-000060
DOI: 10.1109/SAMI.2017.7880363

LPV-based control of nonlinear compartmental model with input uncertainty

Author(s): Gyorgy Eigner, Arpad Varga, Miklos Mezei, Levente Kovacs
Published in: 2017 IEEE 15th International Symposium on Intelligent Systems and Informatics (SISY), 2017, Page(s) 000017-000022
DOI: 10.1109/SISY.2017.8080538

Cyber-Medical Systems: the Digitalized Healthcare Approach and Its Trends

Author(s): Levente Kovács
Published in: MACRo 2017: 6th International Conference on Recent Achievements in Mechatronics, Automation, Computer Science and Robotics, 2017, Page(s) 1-2

Animal experiments in cancer research: Wasteful or unavoidable?

Author(s): Johanna Sapi
Published in: 2017 IEEE 30th Neumann Colloquium (NC), 2017, Page(s) 000157-000162
DOI: 10.1109/NC.2017.8263274

Investigation of the TP-based modeling possibility of a nonlinear ICU diabetes model

Author(s): Gyorgy Eigner, Imre J. Rudas, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003405-003410
DOI: 10.1109/SMC.2016.7844760

Second-order and implicit methods in numerical integration improve tracking performance of the closed-loop inverse kinematics algorithm

Author(s): Daniel Andras Drexler, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003362-003367
DOI: 10.1109/SMC.2016.7844753

Control of T1DM via tensor product-based framework

Author(s): Gyorgy Eigner, Peter Pausits, Levente Kovacs
Published in: 2016 IEEE 17th International Symposium on Computational Intelligence and Informatics (CINTI), 2016, Page(s) 000055-000060
DOI: 10.1109/CINTI.2016.7846379

Augmented Lifecycle Space for traceability and consistency enhancement

Author(s): Jozsef Klespitz, Miklos Biro, Levente Kovacs
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003973-003977
DOI: 10.1109/SMC.2016.7844854

Convex polytopic modeling of diabetes mellitus: A Tensor Product based approach

Author(s): Levente Kovacs, Gyorgy Eigner
Published in: 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2016, Page(s) 003393-003398
DOI: 10.1109/SMC.2016.7844758

Regularization of the differential inverse orientation problem of generic serial revolute joint manipulators

Author(s): Daniel Andras Drexler
Published in: 2017 22nd International Conference on Methods and Models in Automation and Robotics (MMAR), 2017, Page(s) 402-407
DOI: 10.1109/mmar.2017.8046861

Model-Based Simulation and Comparison of Open-Loop and Closed-Loop Combined Therapies for Tumor Treatment

Author(s): David Csercsik, Johanna Sapi, Levente Kovacs
Published in: 2018 IEEE Conference on Control Technology and Applications (CCTA), 2018, Page(s) 1383-1388
DOI: 10.1109/ccta.2018.8511526

A hybrid cellular automaton model of tumor-induced angiogenesis

Author(s): Tamas Gonczy, David Csercsik, Levente Kovacs
Published in: 2018 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2018, Page(s) 1-6
DOI: 10.1109/aqtr.2018.8402781

Control of tumor growth by modern control methodologies

Author(s): Gyorgy Eigner, Levente Kovacs
Published in: 2018 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2018, Page(s) 1-6
DOI: 10.1109/aqtr.2018.8402782

Tumor Growth Control by TP-LPV-LMI Based Controller

Author(s): Gyorgy Eigner, Daniel Andras Drexler, Levente Kovacs
Published in: 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2018, Page(s) 2564-2569
DOI: 10.1109/smc.2018.00439

Qualitative analysis of a closed-loop model of tumor growth control

Author(s): Dániel András Drexler, Ilona Nagy, Valery Romanovski, János Tóth, Levente Kovács
Published in: IEEE 18th International Symposium on Computational Intelligence and Informatics (CINTI 2018), 2018, Page(s) 329-334

Discrete LPV Modeling of Diabetes Mellitus for Control Purposes

Author(s): Gyorgy Eigner, Mate Siket, Aniko Szakal, Imre Rudas, Levente Kovacs
Published in: 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2018, Page(s) 2558-2563
DOI: 10.1109/smc.2018.00438

Modeling of tumor growth incorporating the effect of pegylated liposomal doxorubicin

Author(s): Dániel András Drexler, Tamás Ferenci, Anna Lovrics, Levente Kovács
Published in: IEEE 23nd International Conference on Intelligent Engineering Systems : proceedings, 2019, Page(s) 369-373

Robust H∞ controller design for T1DM based on relaxed LMI conditions

Author(s): György Eigner, István Böjthe, Alajos Mészárosy, Levente Kovács
Published in: IEEE 23nd International Conference on Intelligent Engineering Systems : proceedings, 2019, Page(s) 363-368

Comparison of Michaelis-Menten kinetics modeling alternatives in cancer chemotherapy modeling

Author(s): Dániel András Drexler, Tamás Ferenci, Anna Lovrics, Levente Kovács
Published in: IEEE 13th International Symposium on Applied Computational Intelligence and Informatics : PROCEEDINGS, 2019, Page(s) 27-32

Book chapters (1)

Cross-Tool Interoperability in Heterogeneous Application Lifecycle Management Systems

Author(s): József Klespitz, Miklós Bíró, Levente Kovács
Published in: New Trends in Software Methodologies, Tools and Techniques: 5th International Conference on New Trends in Intelligent Software Methodology Tools and Techniques (SoMeT 16), Issue Volume 268, 2016, Page(s) 213 - 220
DOI: 10.3233/978-1-61499-674-3-213