Mosaic loss of chromosome Y (LOY) in blood cells - a new biomarker for risk of cancer and Alzheimer’s disease in men

Project Information

DIALOY

Grant agreement ID: 679744

DOI 10.3030/679744

Project closed

EC signature date 19 February 2016

Start date 1 March 2016

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 525 000,00

EU contribution € 1 525 000,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

Publications

Peer reviewed articles (16)

Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome

Author(s): Panagiotis Baliakas, Lars A. Forsberg
Published in: Haematologica, Issue 106/2, 2021, Page(s) 329-331, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2020.266601

Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?

Author(s): Viktor Ljungström, Jonas Mattisson, Jonatan Halvardson, Tatjana Pandzic, Hanna Davies, Edyta Rychlicka-Buniowska, Marcus Danielsson, Paul Lacaze, Lucia Cavelier, Jan P. Dumanski, Panagiotis Baliakas, Lars A. Forsberg
Published in: Leukemia, 2021, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-021-01456-2

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Author(s): Jan P. Dumanski, Jonatan Halvardson, Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson, Behrooz Torabi Moghadam, Noemi Nagy, Kazimierz Węglarczyk, Karolina Bukowska-Strakova, Marcus Danielsson, Paweł Olszewski, Arkadiusz Piotrowski, Erin Oerton, Aleksandra Ambicka, Marcin Przewoźnik, Łukasz Bełch, Tomasz Grodzicki, Piotr L. Chłosta, Stefan Imreh, Vilmantas Giedraitis, Lena Kilander, J
Published in: Cellular and Molecular Life Sciences, Issue 78/8, 2021, Page(s) 4019-4033, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-021-03822-w

Reply to Veitia

Author(s): Marcus Danielsson, Jonatan Halvardson, Jonas Mattisson, Lars A. Forsberg
Published in: European Journal of Human Genetics, Issue 177, 2021, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-020-00802-9

Mosaic loss of chromosome Y in leukocytes matters

Author(s): Lars A. Forsberg, Jonatan Halvardson, Edyta Rychlicka-Buniowska, Marcus Danielsson, Behrooz Torabi Moghadam, Jonas Mattisson, Chiara Rasi, Hanna Davies, Lars Lind, Vilmantas Giedraitis, Lars Lannfelt, Lena Kilander, Martin Ingelsson and Jan P. Dumanski
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0267-9

Back to the drawing board—loss of chromosome Y (LOY) in leukocytes is associated with age-related macular degeneration

Author(s): Lars A. Forsberg
Published in: European Journal of Human Genetics, 2018, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-018-0261-9

Genetic predisposition to mosaic Y chromosome loss in blood

Author(s): Deborah J. Thompson, Giulio Genovese, Jonatan Halvardson, Jacob C. Ulirsch, Daniel J. Wright, Chikashi Terao, Olafur B. Davidsson, Felix R. Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm G. Dunlop, Douglas F. Easton, Victoria A. Fisher, Florian Zink, Richard S. Houlston, Martin Ingelsson, Siddhartha Kar, Nicola D. Kerrison, Ben Kinnersley, Ragnar P. Kristja
Published in: Nature, Issue 575/7784, 2019, Page(s) 652-657, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1765-3

Loss of Chromosome Y in Leukocytes and Major Cardiovascular Events

Author(s): Jan P. Dumanski, Johan Sundström, Lars A. Forsberg
Published in: Circulation: Cardiovascular Genetics, Issue 10/4, 2017, Page(s) e001820, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001820

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Author(s): Jan P. Dumanski, Jean-Charles Lambert, Chiara Rasi, Vilmantas Giedraitis, Hanna Davies, Benjamin Grenier-Boley, Cecilia M. Lindgren, Dominique Campion, Carole Dufouil, Florence Pasquier, Philippe Amouyel, Lars Lannfelt, Martin Ingelsson, Lena Kilander, Lars Lind, Lars A. Forsberg
Published in: The American Journal of Human Genetics, Issue 98/6, 2016, Page(s) 1208-1219, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2016.05.014

Mosaicism in health and disease — clones picking up speed

Author(s): Lars A. Forsberg, David Gisselsson, Jan P. Dumanski
Published in: Nature Reviews Genetics, Issue 18/2, 2016, Page(s) 128-142, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/nrg.2016.145

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

Author(s): Lars A. Forsberg
Published in: Human Genetics, Issue 136/5, 2017, Page(s) 657-663, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-017-1799-2

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Author(s): Marcus Danielsson, Jonatan Halvardson, Hanna Davies, Behrooz Torabi Moghadam, Jonas Mattisson, Edyta Rychlicka-Buniowska, Janusz Jaszczyński, Julia Heintz, Lars Lannfelt, Vilmantas Giedraitis, Martin Ingelsson, Jan P. Dumanski, Lars A. Forsberg
Published in: European Journal of Human Genetics, Issue 28/3, 2020, Page(s) 349-357, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-019-0533-z

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99

Author(s): Jonas Mattisson, Marcus Danielsson, Maria Hammond, Hanna Davies, Caroline J. Gallant, Jessica Nordlund, Amanda Raine, Malin Edén, Lena Kilander, Martin Ingelsson, Jan P. Dumanski, Jonatan Halvardson, Lars A. Forsberg
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-94588-5

A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors

Author(s): Jan P Dumanski, Chiara Rasi, Peyman Björklund, Hanna Davies, Abir S Ali, Malin Grönberg, Staffan Welin, Halfdan Sorbye, Henning Grønbæk, Janet L Cunningham, Lars A Forsberg, Lars Lind, Erik Ingelsson, Peter Stålberg, Per Hellman, Eva Tiensuu Janson
Published in: Endocrine-Related Cancer, Issue 24/8, 2017, Page(s) 427-443, ISSN 1351-0088
Publisher: Society for Endocrinology
DOI: 10.1530/erc-17-0196

Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men: A longitudinal study over 40 years

Author(s): Xiao Tan, Jonathan Cedernaes, Lars A. Forsberg, Helgi B. Schiöth, Christian Benedict
Published in: Journal of Sleep Research, Issue 27/6, 2018, Page(s) e12708, ISSN 0962-1105
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jsr.12708

Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture

Author(s): Sara Pijuan-Galitó, Christoffer Tamm, Jens Schuster, Maria Sobol, Lars Forsberg, Catherine L. R. Merry, Cecilia Annerén
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms12170

Intellectual Property Rights

Patent (2)

PREDICTING INCREASED RISK FOR CANCER

Application/Publication number: EP 14789193
Date: 2014-10-07

PREDICTING INCREASED RISK FOR ALZHEIMER'S DISEASE

Application/Publication number: EP 15705264
Date: 2015-02-11