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A mathematical platform for Abdominal Aortic Aneurism risk assessment and surgical planning

Objective

Abdominal Aneurysm of the Aorta (AAA) is a degenerative disease of the last segment of the abdominal aorta, representing the 14th leading cause of death for the 60 to 85 year-old age group in US. An estimated 80 million people aged 60 years and older are at risk in Western Europe. To date the most commonly used clinical protocol for surgical acceptance is based on the estimate of AAA diameter. The report prepared for the Agency for Healthcare Research and Quality came to the conclusion that: the annual risk of rupture is 1% or lower for a diameter less than 5.5 cm; the 1-year risk of rupture increases with the aneurysm size; it may exceed 10% in the individuals with diameters above 6 cm.

Assessment of AAA rupture risk has long been a topic of interest in clinical research setting. The ability to estimate patient specific probability of AAA rupture can lead to reduced health care costs, adequate and timely patient diagnostic and comfort.

Math4AAArisk aims at the realization of a mathematical platform to support clinicians through the following steps: (A1) From medical imaging to sizing and morphological characterization of AAA, (A2) Preliminary risk evaluation, (A3) Computer simulation and enhanced risk assessment, (B1) Automatic surgery planner, (C1) Anonymous data base storage.

The proposed mathematical platform yields quantitative physical indicators in real time at the sole request of inputting a few clinical measurements; it is patient adapted, as it integrates with patient’s radiological images, under full control of clinicians; it is aimed at improving the diagnostic analysis and possibly the surgical planning. We wish to establish the viability for a market exploitation of the math4AAArisk platform and identify possible later stage funding opportunities.

Field of science

  • /medical and health sciences/clinical medicine/angiology/vascular diseases
  • /engineering and technology/medical engineering/diagnostic imaging
  • /natural sciences/mathematics/applied mathematics/mathematical model

Call for proposal

ERC-2015-PoC
See other projects for this call

Funding Scheme

ERC-POC - Proof of Concept Grant

Host institution

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 51 250

Beneficiaries (3)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 51 250
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
MOXOFF SPA
Italy
EU contribution
€ 85 300
Address
Via Simone Schaffino 11/19
20158 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 10 850
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments