Objective
Biological production of high-value compounds such as medicines, flavors, fragrances and food ingredients, is predicted to constitute 50% of the World market by 2025 thus representing a commercial hotspot. A competitive edge for European industry within this domain is therefore important. Today, 40% of prescribed medicinal drugs originate or are derived from rare or difficult to cultivate medicinal plants which typically contain the compounds in very low amounts and in complex mixtures. We have demonstrated that by using synthetic biology we can build a solar powered platform for production of key high-value compounds within the diterpenoid class in green cells (cyanobacteria/moss/algae). The diterpenoids are excreted into the growth medium offering easy isolation. This provides a highly profitable and attainable opportunity to produce a large number of medicinal compounds at highly reduced costs. The production platform is easily adaptable to make structural analogs and entirely new structures. Combinatorial libraries can be developed to enable screening for desired new functionalities. The envisioned production platform includes the full chain from pathway discovery, host optimization, scale-up, extraction and final product isolation and offers entry points for industrial development and exit points for adaptation to existing pipelines. Based on the advances made within the ERC Advanced Grant the focus of this PoC is to optimize the scientific breakthroughs’ market adaptation, specifically focused on the compounds Forskolin and Ingenol-3-angelate as proof-of-concept of the market value of the production platform. The envisioned full-chain focus offers potent financial opportunities and a new vision for biobased production across Europe in a re-invigorated sustainable greenhouse industry offering new job opportunities in full harmony with the envisioned Europe2020 and Horizon2020 goals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.