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An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century


Compound reference information resources

Report on the reference information resource containing detailed information on all project compounds.

AOPs and key events for adverse effects

Report on establishment of 15 AOPs representing key adverse outcomes for chemical risk.

Mapping ToxCast data to AOPs

Report on the mapping of available ToxCast data to the EU-ToxRisk AOPs developed in WP5.

Searching for OpenAIRE data...


QSAR Development for Plasma Protein Binding: Influence of the Ionization State

Author(s): Cosimo Toma, Domenico Gadaleta, Alessandra Roncaglioni, Andrey Toropov, Alla Toropova, Marco Marzo, Emilio Benfenati
Published in: Pharmaceutical Research, Issue 36/2, 2019, ISSN 0724-8741
DOI: 10.1007/s11095-018-2561-8

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta

Author(s): Giorgia Pallocca, Johanna Nyffeler, Xenia Dolde, Marianna Grinberg, Gerhard Gstraunthaler, Tanja Waldmann, Jörg Rahnenführer, Agapios Sachinidis, Marcel Leist
Published in: Archives of Toxicology, Issue 91/10, 2017, Page(s) 3385-3402, ISSN 0340-5761
DOI: 10.1007/s00204-017-1966-1

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Author(s): Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken, Paul Jennings
Published in: Archives of Toxicology, Issue 92/8, 2018, Page(s) 2517-2531, ISSN 0340-5761
DOI: 10.1007/s00204-018-2256-2

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Author(s): Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann, Marcel Leist
Published in: Archives of Toxicology, Issue 92/12, 2018, Page(s) 3487-3503, ISSN 0340-5761
DOI: 10.1007/s00204-018-2326-5

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Author(s): David Pamies
Published in: ALTEX, 2018, Page(s) 353-378, ISSN 1868-596X
DOI: 10.14573/altex.1710081

QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis

Author(s): Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli
Published in: Journal of Chemical Information and Modeling, Issue 58/8, 2018, Page(s) 1501-1517, ISSN 1549-9596
DOI: 10.1021/acs.jcim.8b00297

A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications

Author(s): Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
Published in: Journal of Cheminformatics, Issue 10/1, 2018, ISSN 1758-2946
DOI: 10.1186/s13321-018-0315-6

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Author(s): Anna Bal-Price
Published in: ALTEX, 2018, Page(s) 306-352, ISSN 1868-596X
DOI: 10.14573/altex.1712081

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Author(s): Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia Vallverdú, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan José Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru
Published in: Cell Stem Cell, Issue 23/1, 2018, Page(s) 101-113.e7, ISSN 1934-5909
DOI: 10.1016/j.stem.2018.05.027

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Author(s): Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer, Ursula Klingmüller
Published in: npj Systems Biology and Applications, Issue 4/1, 2018, ISSN 2056-7189
DOI: 10.1038/s41540-018-0058-z

Essential components of methods papers

Author(s): Marcel Leist
Published in: ALTEX, 2018, Page(s) 429-432, ISSN 1868-596X
DOI: 10.14573/altex.1807031

Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

Author(s): Alejandro Aguayo-Orozco, Frederic Yves Bois, Søren Brunak, Olivier Taboureau
Published in: Frontiers in Genetics, Issue 9, 2018, ISSN 1664-8021
DOI: 10.3389/fgene.2018.00396

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Author(s): Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht
Published in: Archives of Toxicology, Issue 92/1, 2018, Page(s) 41-82, ISSN 0340-5761
DOI: 10.1007/s00204-017-2133-4

A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

Author(s): Johannes Delp
Published in: ALTEX, 2018, Page(s) 235-253, ISSN 1868-596X
DOI: 10.14573/altex.1712182

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Author(s): Johannes Delp, Simon Gutbier, Martin Cerff, Christin Zasada, Sebastian Niedenführ, Liang Zhao, Lena Smirnova, Thomas Hartung, Hanna Borlinghaus, Falk Schreiber, Jörg Bergemann, Jochem Gätgens, Martin Beyss, Salah Azzouzi, Tanja Waldmann, Stefan Kempa, Katharina Nöh, Marcel Leist
Published in: Toxicology and Applied Pharmacology, Issue 354, 2018, Page(s) 64-80, ISSN 0041-008X
DOI: 10.1016/j.taap.2017.12.013

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Author(s): Georgina Harris, Melanie Eschment, Sebastian Perez Orozco, J. Michael McCaffery, Richard Maclennan, Daniel Severin, Marcel Leist, Andre Kleensang, David Pamies, Alexandra Maertens, Helena T. Hogberg, Dana Freeman, Alfredo Kirkwood, Thomas Hartung, Lena Smirnova
Published in: Archives of Toxicology, Issue 92/8, 2018, Page(s) 2587-2606, ISSN 0340-5761
DOI: 10.1007/s00204-018-2250-8

Development and validation of computational models for predicting oxidative stress responses using comprehensive series of drug-like compounds

Author(s): M. Pastor, G.J.P. Westen, J.C. Gómez-Tamayo, B.E. Lenselink, C.-C. Lam, B. Water, U. Norinder, S. Manganelli, D. Gadaleta, A. Roncaglioni
Published in: Toxicology Letters, Issue 295, 2018, Page(s) S62-S63, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2018.06.062

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

Author(s): Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen
Published in: Frontiers in Genetics, Issue 9, 2018, ISSN 1664-8021
DOI: 10.3389/fgene.2018.00661

Normalization of data for viability and relative cell function curves

Author(s): Alice Krebs
Published in: ALTEX, 2018, Page(s) 268-271, ISSN 1868-596X
DOI: 10.14573/1803231

Chemical concentrations in cell culture compartments (C5) – concentration definitions

Author(s): Jaffar Kisitu
Published in: ALTEX, Issue 36/1, 2019, Page(s) 154-160, ISSN 1868-596X
DOI: 10.14573/altex.1901031

The BioStudies database—one stop shop for all data supporting a life sciences study

Author(s): Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre
Published in: Nucleic Acids Research, Issue 46/D1, 2017, Page(s) D1266-D1270, ISSN 0305-1048
DOI: 10.1093/nar/gkx965

VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays

Author(s): C. Fisher, S. Siméon, M. Jamei, I. Gardner, Y.F. Bois
Published in: Toxicology in Vitro, 2018, ISSN 0887-2333
DOI: 10.1016/j.tiv.2018.12.017

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Author(s): Xiaolong Gu, Wiebke Albrecht, Karolina Edlund, Franziska Kappenberg, Jörg Rahnenführer, Marcel Leist, Wolfgang Moritz, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Tim Brecklinghaus, Laia Tolosa Pardo, José V. Castell, Iain Gardner, Bo Han, Jan G. Hengstler, Regina Stoeber
Published in: Archives of Toxicology, Issue 92/12, 2018, Page(s) 3505-3515, ISSN 0340-5761
DOI: 10.1007/s00204-018-2302-0

Finding synergies for 3Rs – Toxicokinetics and read-across: Report from an EPAA partners' Forum

Author(s): Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. Müller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon v
Published in: Regulatory Toxicology and Pharmacology, Issue 99, 2018, Page(s) 5-21, ISSN 0273-2300
DOI: 10.1016/j.yrtph.2018.08.006

In Vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach

Author(s): C.P. Fisher, O. Hatley, B. van Vugt, F. Bois, S. Escher, I. Gardner
Published in: Toxicology Letters, Issue 295, 2018, Page(s) S246, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2018.06.1015

Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

Author(s): Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung
Published in: Toxicological Sciences, Issue 165/1, 2018, Page(s) 198-212, ISSN 1096-6080
DOI: 10.1093/toxsci/kfy152

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Author(s): Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings
Published in: Frontiers in Genetics, Issue 9, 2018, ISSN 1664-8021
DOI: 10.3389/fgene.2018.00558

Regulatory acceptance of read-across

Author(s): Megan Chesnut
Published in: ALTEX, 2018, Page(s) 413-419, ISSN 1868-596X
DOI: 10.14573/altex.1805081

A structure–activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

Author(s): Johanna Nyffeler, Petra Chovancova, Xenia Dolde, Anna-Katharina Holzer, Vladimir Purvanov, Ilona Kindinger, Anna Kerins, David Higton, Steve Silvester, Barbara M. A. van Vugt-Lussenburg, Enrico Glaab, Bart van der Burg, Richard Maclennan, Daniel F. Legler, Marcel Leist
Published in: Archives of Toxicology, Issue 92/3, 2018, Page(s) 1225-1247, ISSN 0340-5761
DOI: 10.1007/s00204-017-2125-4

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Author(s): Steven Wink, Steven W. Hiemstra, Suzanne Huppelschoten, Janna E. Klip, Bob van de Water
Published in: Archives of Toxicology, Issue 92/5, 2018, Page(s) 1797-1814, ISSN 0340-5761
DOI: 10.1007/s00204-018-2178-z

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

Author(s): Luc J. M. Bischoff, Isoude A. Kuijper, Johannes P. Schimming, Liesanne Wolters, Bas ter Braak, Jan P. Langenberg, Daan Noort, Joost B. Beltman, Bob van de Water
Published in: Archives of Toxicology, Issue 93/2, 2019, Page(s) 435-451, ISSN 0340-5761
DOI: 10.1007/s00204-018-2353-2

Current EU research activities on combined exposure to multiple chemicals

Author(s): Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Published in: Environment International, Issue 120, 2018, Page(s) 544-562, ISSN 0160-4120
DOI: 10.1016/j.envint.2018.07.037

Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary

Author(s): C. Mahony, R. Currie, G. Daston, N. Kleinstreuer, B. van de Water
Published in: Archives of Toxicology, Issue 92/2, 2018, Page(s) 1015-1020, ISSN 0340-5761
DOI: 10.1007/s00204-017-2145-0

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Author(s): Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park
Published in: Archives of Toxicology, Issue 93/2, 2019, Page(s) 385-399, ISSN 0340-5761
DOI: 10.1007/s00204-018-2354-1

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Author(s): Marianna Grinberg, Regina M. Stöber, Wiebke Albrecht, Karolina Edlund, Markus Schug, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Alfonso Lampen, Albert Braeuning, Thorsten Buhrke, Marcel Leist, Axel Oberemm, Birte Hellwig, Hennicke Kamp, Iain Gardner, Sylvia Escher, Olivier Taboureau, Alejandro Aguayo-Orozco, Agapios Sachinidis, Heidrun Ellinger-Ziegelbauer, Jörg Rahnenführer, Jan G. H
Published in: Archives of Toxicology, Issue 92/12, 2018, Page(s) 3517-3533, ISSN 0340-5761
DOI: 10.1007/s00204-018-2352-3

Adverse outcome pathways: opportunities, limitations and open questions

Author(s): Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patricio Godoy, Frederic Y. Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk Drasdo, Stefan Höhme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost B
Published in: Archives of Toxicology, Issue 91/11, 2017, Page(s) 3477-3505, ISSN 0340-5761
DOI: 10.1007/s00204-017-2045-3

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Author(s): Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Antoni
Published in: EFSA Journal, Issue 15/3, 2017, ISSN 1831-4732
DOI: 10.2903/j.efsa.2017.4691

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Author(s): Lisa Hoelting, Stefanie Klima, Christiaan Karreman, Marianna Grinberg, Johannes Meisig, Margit Henry, Tamara Rotshteyn, Jörg Rahnenführer, Nils Blüthgen, Agapios Sachinidis, Tanja Waldmann, Marcel Leist
Published in: STEM CELLS Translational Medicine, Issue 5/4, 2016, Page(s) 476-487, ISSN 2157-6564
DOI: 10.5966/sctm.2015-0108

Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation

Author(s): Liudmila Efremova, Petra Chovancova, Martina Adam, Simon Gutbier, Stefan Schildknecht, Marcel Leist
Published in: Archives of Toxicology, Issue 91/1, 2017, Page(s) 231-246, ISSN 0340-5761
DOI: 10.1007/s00204-016-1702-2

Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants

Author(s): Johanna Nyffeler
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1605031

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

Author(s): J. Meiser, S. Delcambre, A. Wegner, C. Jäger, J. Ghelfi, A. Fouquier d'Herouel, X. Dong, D. Weindl, C. Stautner, Y. Nonnenmacher, A. Michelucci, O. Popp, F. Giesert, S. Schildknecht, L. Krämer, J.G. Schneider, D. Woitalla, W. Wurst, A. Skupin, D.M. Vogt Weisenhorn, R. Krüger, M. Leist, K. Hiller
Published in: Neurobiology of Disease, Issue 89, 2016, Page(s) 112-125, ISSN 0969-9961
DOI: 10.1016/j.nbd.2016.01.019

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

Author(s): Vaibhav Shinde, Lisa Hoelting, Sureshkumar Perumal Srinivasan, Johannes Meisig, Kesavan Meganathan, Smita Jagtap, Marianna Grinberg, Julia Liebing, Nils Bluethgen, Jörg Rahnenführer, Eugen Rempel, Regina Stoeber, Stefan Schildknecht, Sunniva Förster, Patricio Godoy, Christoph van Thriel, John Antonydas Gaspar, Jürgen Hescheler, Tanja Waldmann, Jan G. Hengstler, Marcel Leist, Agapios Sachinidis
Published in: Archives of Toxicology, Issue 91/2, 2017, Page(s) 839-864, ISSN 0340-5761
DOI: 10.1007/s00204-016-1741-8

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants

Author(s): Cordula Hirsch, Britta Striegl, Stephanie Mathes, Christian Adlhart, Michael Edelmann, Epifania Bono, Sabyasachi Gaan, Khalifah A. Salmeia, Lisa Hoelting, Alice Krebs, Johanna Nyffeler, Regina Pape, Alexander Bürkle, Marcel Leist, Peter Wick, Stefan Schildknecht
Published in: Archives of Toxicology, Issue 91/1, 2017, Page(s) 407-425, ISSN 0340-5761
DOI: 10.1007/s00204-016-1680-4

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity

Author(s): Tanja Waldmann, Marianna Grinberg, André König, Eugen Rempel, Stefan Schildknecht, Margit Henry, Anna-Katharina Holzer, Nadine Dreser, Vaibhav Shinde, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Marcel Leist
Published in: Chemical Research in Toxicology, Issue 30/4, 2017, Page(s) 905-922, ISSN 0893-228X
DOI: 10.1021/acs.chemrestox.6b00259

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis

Author(s): João V. Sá, Susanne Kleiderman, Catarina Brito, Ursula Sonnewald, Marcel Leist, Ana P. Teixeira, Paula M. Alves
Published in: Neurochemical Research, Issue 42/1, 2017, Page(s) 244-253, ISSN 0364-3190
DOI: 10.1007/s11064-016-1907-z

The ascending pathophysiology of cholestatic liver disease

Published in: ISSN 0270-9139
DOI: 10.1002/hep.28965

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Author(s): Béla Z. Schmidt, Martin Lehmann, Simon Gutbier, Erastus Nembo, Sabrina Noel, Lena Smirnova, Anna Forsby, Jürgen Hescheler, Hasan X. Avci, Thomas Hartung, Marcel Leist, Julianna Kobolák, András Dinnyés
Published in: Archives of Toxicology, Issue 91/1, 2017, Page(s) 1-33, ISSN 0340-5761
DOI: 10.1007/s00204-016-1805-9

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

Author(s): Abinaya Chandrasekaran, Hasan X. Avci, Marcel Leist, Julianna Kobolák, Andras Dinnyés
Published in: Frontiers in Cellular Neuroscience, Issue 10, 2016, ISSN 1662-5102
DOI: 10.3389/fncel.2016.00215

A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

Author(s): Fabiola Pizzo, Anna Lombardo, Alberto Manganaro, Emilio Benfenati
Published in: Frontiers in Pharmacology, Issue 7, 2016, ISSN 1663-9812
DOI: 10.3389/fphar.2016.00442

CORAL: Binary classifications (active/inactive) for drug-induced liver injury

Author(s): Alla P. Toropova, Andrey A. Toropov
Published in: Toxicology Letters, Issue 268, 2017, Page(s) 51-57, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2017.01.011

The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?

Author(s): Alla P. Toropova, Andrey A. Toropov
Published in: Science of The Total Environment, Issue 586, 2017, Page(s) 466-472, ISSN 0048-9697
DOI: 10.1016/j.scitotenv.2017.01.198

Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles

Author(s): Alla P. Toropova, Andrey A. Toropov
Published in: Toxicology Letters, Issue 275, 2017, Page(s) 57-66, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2017.03.023

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models

Author(s): Alla P. Toropova, Andrey A. Toropov, Marco Marzo, Sylvia E. Escher, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati
Published in: Food and Chemical Toxicology, 2017, ISSN 0278-6915
DOI: 10.1016/j.fct.2017.03.060

The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?

Author(s): Andrey A. Toropov, Alla P. Toropova
Published in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Issue 819, 2017, Page(s) 31-37, ISSN 1383-5718
DOI: 10.1016/j.mrgentox.2017.05.008

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library

Author(s): Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist
Published in: Archives of Toxicology, 2017, ISSN 0340-5761
DOI: 10.1007/s00204-017-1977-y

Human Environmental Disease Network: A computational model to assess toxicology of contaminants

Author(s): Olivier Taboureau
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1607201

In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

Author(s): Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak, Olivier Taboureau
Published in: Current Pharmaceutical Design, Issue 22/46, 2017, Page(s) 6895-6902, ISSN 1381-6128
DOI: 10.2174/1381612822666160907093215

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Author(s): Mardas Daneshian, Hennicke Kamp, Jan Hengstler, Marcel Leist, Bob van de Water
Published in: Archives of Toxicology, Issue 90/5, 2016, Page(s) 1021-1024, ISSN 0340-5761
DOI: 10.1007/s00204-016-1698-7

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling

Published in: ISSN 1742-5255
DOI: 10.1080/17425255.2017.1234607

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Author(s): Steven Wink, Steven Hiemstra, Bram Herpers, Bob van de Water
Published in: Archives of Toxicology, Issue 91/3, 2017, Page(s) 1367-1383, ISSN 0340-5761
DOI: 10.1007/s00204-016-1781-0

Toward Good Read-Across Practice (GRAP) guidance

Author(s): Nicholas Ball
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1601251

Analysis of public oral toxicity data from REACH registrations 2008-2014

Author(s): Thomas Luechtefeld
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1510054

Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

Author(s): Thomas Luechtefeld
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1510053

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014

Author(s): Thomas Luechtefeld
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1510052

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

Author(s): Thomas Luechtefeld
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1510055

Supporting read-across using biological data

Author(s): Hao Zhu
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1601252

Good Cell Culture Practice for stem cells and stem-cell-derived models

Author(s): David Pamies
Published in: ALTEX, 2016, ISSN 1868-596X
DOI: 10.14573/altex.1607121

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

Author(s): Wanda van der Stel, Giada Carta, Julie Eakins, Salihanur Darici, Johannes Delp, Anna Forsby, Susanne Hougaard Bennekou, Iain Gardner, Marcel Leist, Erik H. J. Danen, Paul Walker, Bob van de Water, Paul Jennings
Published in: Archives of Toxicology, 2020, ISSN 0340-5761
DOI: 10.1007/s00204-020-02792-5

Use of publicly available transcriptomics data to support the steatosis AOP development

Author(s): Oana Florean, Lucian Farcal, Noffisat Oki, Thomas Exner, Barry Hardy and Tatyana Doktorova
Published in: ALTEX Proceedings (EUSAAT 2018), 2018, Page(s) 214, ISSN 2194-0479

Systems microscopy approaches in unravelling and predicting drug-induced liver injury (DILI)

Author(s): Niemeijer M, Hiemstra S, Wink S, den Hollander W, ter Braak B, van de Water B
Published in: Methods in Pharmacology and Toxicology, 2018, Page(s) 611-625