An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

Risultati finali

Report on the repository of CM and tools.

Report on ab initio hazard assessment strategies for the different applications

Report on the widespread dissemination of the final outcomes at international conferences including handson and case study workshops for effective exploitation of results

Dissemination of midterm results

Report on the pro-active promotion strategies and communication strategies of mid-term results at international conferences and to all major stakeholders.

Sustainable commercialization platform

Report on the sustainable commercialization platform of the EUToxRisk project

Applicability domain of TTB for DART and RDT defined

Description of the tiered testing battery and its applicability

Central service package

Report on the EUToxRisk service package

EU-ToxRisk knowledge infrastructure sustainability

Report on the sustainability of the EUToxRisk project knowledge infrastructure beyond the project lifetime

Compound reference information resources

Report on the reference information resource containing detailed information on all project compounds.

AOPs and key events for adverse effects

Report on establishment of 15 AOPs representing key adverse outcomes for chemical risk.

Mapping ToxCast data to AOPs

Report on the mapping of available ToxCast data to the EU-ToxRisk AOPs developed in WP5.

Hazard assessment based on read across

Report on the read across strategies for the different applications based on the case studies.

Pubblicazioni

NMR microsystem for label-free characterization of 3D nanoliter microtissues

Autori: Marco Grisi, Gaurasundar M. Conley, Kyle J. Rodriguez, Erika Riva, Lukas Egli, Wolfgang Moritz, Jan Lichtenberg, Jürgen Brugger & Giovanni Boero
Pubblicato in: Scientific reports, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-75480-0

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Autori: Johannes Delp, Melina Funke, Franziska Rudolf, Andrea Cediel, Susanne Hougaard Bennekou, Wanda van der Stel, Giada Carta, Paul Jennings, Cosimo Toma, Iain Gardner, Bob van de Water, Anna Forsby, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 93/6, 2019, Pagina/e 1585-1608, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02473-y

A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases

Autori: Bjørn E.V. Koch, Herman P. Spaink, Annemarie H. Meijer
Pubblicato in: Toxicology Letters, 2021, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2021.02.005

New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies

Autori: van der Stel, Wanda, Giada Carta, Julie Eakins, Johannes Delp, Ilinca Suciu, Anna Forsby, Andrea Cediel-Ulloa, Kristina Attoff, Florentina Troger, Hennicke Kamp, Iain Gardner, Barbara Zdrazil, Martijn J. Moné, Gerhard F. Ecker, Manuel Pastor, Jose Carlos Gómez-Tamayo, Andrew White, Erik H. J. Danen, Marcel Leist, Paul Walker, Paul Jennings, Susanne Hougaard Bennekou, and Bob van de Water
Pubblicato in: ALTEX, 2021, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2103051

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

Autori: Rajinder Gupta, Yannick Schrooders, Duncan Hauser, Marcel van Herwijnen, Wiebke Albrecht, Bas ter Braak, Tim Brecklinghaus, Jose V. Castell, Leroy Elenschneider, Sylvia Escher, Patrick Guye, Jan G. Hengstler, Ahmed Ghallab, Tanja Hansen, Marcel Leist, Richard Maclennan, Wolfgang Moritz, Laia Tolosa, Tine Tricot, Catherine Verfaillie, Paul Walker, Bob van de Water, Jos Kleinjans & Florian Caiment
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02937-6

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI

Autori: Selahaddin Sezgin, Reham Hassan, Sebastian Zühlke, Lars Kuepfer, Jan G. Hengstler, Michael Spiteller & Ahmed Ghallab
Pubblicato in: Archives of Toxicology, 2018, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2271-3

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

Autori: Giulia Callegaro, Steven J. Kunnen, Panuwat Trairatphisan, Solène Grosdidier, Marije Niemeijer, Wouter den Hollander, Emre Guney, Janet Piñero Gonzalez, Laura Furlong, Yue W. Webster, Julio Saez-Rodriguez, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens & Bob van de Water
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03141-w

Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs

Autori: Ségolène Siméon, Katharina Brotzmann, Ciaran Fisher, Iain Gardner, Steve Silvester, Richard Maclennan, Paul Walker, Thomas Braunbeck, Frederic Y. Bois
Pubblicato in: Reproductive Toxicology, Numero 93, 2020, Pagina/e 219-229, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2020.02.010

Improved building up a model of toxicity towards Pimephales promelas by the Monte Carlo method

Autori: Alla P. Toropova, Andrey A. Toropov, Maria Raskova, Ivan Raska
Pubblicato in: Environmental Toxicology and Pharmacology, 2016, ISSN 1382-6689
Editore: Elsevier BV
DOI: 10.1016/j.etap.2016.11.010

Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings

Autori: Tricot, Tine, Hendrik J. Thibaut, Kayvan Abbasi, Ruben Boon, Nicky Helsen, Manoj Kumar, Johan Neyts, and Catherine Verfaillie
Pubblicato in: Biomedicines, 2022, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10020268

Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays

Autori: von Hellfeld, Rebecca, Viktoriia Ovcharova, Samantha Bevan, Maria-Agapi Lazaridi, Caroline Bauch, Paul Walker, Susanne Hougaard Bennekou, Anna Forsby, and Thomas Braunbeck
Pubblicato in: ALTEX, 2022, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2111021

Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells

Autori: Lucendo-Villarin, B., Nell, P., Hellwig, B., Filis, P., Feuerborn, D., O’Shaughnessy, P. J., Godoy, P., Rahnenführer, J., Hengstler, J. G., Cherianidou, A., Sachinidis, A., Fowler, P. A., & Hay, D. C.
Pubblicato in: EXCLI Journal, 2020, ISSN 1611-2156
Editore: University of Mainz
DOI: 10.17179/excli2020-2934

Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

Autori: Simon Gutbier, Sotiris Kyriakou, Stefan Schildknecht, Anna-Katharina Ückert, Markus Brüll, Frank Lewis, David Dickens, Liam Pearson, Joanna L. Elson, Sylvia Michel, Véronique Hubscher-Bruder, Jeremy Brandel, David Tetard, Marcel Leist, Ilse S. Pienaar
Pubblicato in: Archives of Toxicology, Numero 94/9, 2020, Pagina/e 3105-3123, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02826-y

Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain

Autori: P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, N. Yan, G. von Scheven, T. U. Mayer, M. Leist & T. Brunner
Pubblicato in: Oncogene, 2020, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-019-1142-6

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

Autori: Gisela Campos, Wolfgang Schmidt-Heck, Jonathan De Smedt, Agata Widera, Ahmed Ghallab, Larissa Pütter, Daniela González, Karolina Edlund, Cristina Cadenas, Rosemarie Marchan, Reinhard Guthke, Catherine Verfaillie, Claudio Hetz, Agapios Sachinidis, Albert Braeuning, Michael Schwarz, Thomas S. Weiß, Benjamin K. Banhart, Jan Hoek, Rajanikanth Vadigepalli, Jeffrey Willy, James L. Stevens, David C. H
Pubblicato in: Archives of Toxicology, Numero 94/1, 2020, Pagina/e 205-217, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02630-3

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

Autori: Markus Brüll
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1911111

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Autori: Steven Hiemstra, Sreenivasa C. Ramaiahgari, Steven Wink, Giulia Callegaro, Maarten Coonen, John Meerman, Danyel Jennen, Karen van den Nieuwendijk, Anita Dankers, Jan Snoeys, Hans de Bont, Leo Price, Bob van de Water
Pubblicato in: Archives of Toxicology, Numero 93/10, 2019, Pagina/e 2895-2911, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02552-0

The exposome – a new approach for risk assessment

Autori: Fenna Sillé
Pubblicato in: ALTEX, 2020, Pagina/e 3-23, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.2001051

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector

Autori: Maria Ballester, Miguel Bolonio, Ramon Santamaria, José V. Castell, Carmen Ribes-Koninckx, Roque Bort
Pubblicato in: Stem Cell Research & Therapy, Numero 10/1, 2019, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-019-1416-5

CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

Autori: Karreman, C., Klima, S., Holzer, A.-K. and Leist, M
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2003191

Using Machine Learning Methods and Structural Alerts for Prediction of Mitochondrial Toxicity

Autori: Jennifer Hemmerich, Florentina Troger, Barbara Füzi, Gerhard F.Ecker
Pubblicato in: Molecular Informatics, Numero 39/5, 2020, Pagina/e 2000005, ISSN 1868-1743
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/minf.202000005

Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?

Autori: Katharina Brotzmann, André Wolterbeek, Dinant Kroese & Thomas Braunbeck
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02928-7

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Autori: Dominik Loser, Maria G. Hinojosa, Jonathan Blum, Jasmin Schaefer, Markus Brüll, Ylva Johansson, Ilinca Suciu, Karin Grillberger, Timm Danker, Clemens Möller, Iain Gardner, Gerhard F. Ecker, Susanne H. Bennekou, Anna Forsby, Udo Kraushaar & Marcel Leist
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03031-1

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

Autori: Francois Busquet, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 94/6, 2020, Pagina/e 2263-2272, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02787-2

sAOP: linking chemical stressors to adverse outcomes pathway networks

Autori: Alejandro Aguayo-Orozco, Karine Audouze, Troels Siggaard, Robert Barouki, Søren Brunak, Olivier Taboureau
Pubblicato in: Bioinformatics, 2019, Pagina/e 5391-5392, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btz570

A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling

Autori: Stefanie Klima, Markus Brüll, Anna-Sophie Spreng, Ilinca Suciu, Tjalda Falt, Jens C. Schwamborn, Tanja Waldmann, Christiaan Karreman & Marcel Leist
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03024-0

Handling deviating control values in concentration-response curves

Autori: Franziska Kappenberg, Tim Brecklinghaus, Wiebke Albrecht, Jonathan Blum, Carola van der Wurp, Marcel Leist, Jan G. Hengstler & Jörg Rahnenführer
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02913-0

Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients

Autori: Diana Horta, Marta Moreno-Torres, María José Ramírez-Lázaro, Sergio Lario, Julia Kuligowski, Juan Daniel Sanjuan-Herráez, Guillermo Quintas*, Albert Villoria, and Xavier Calvet
Pubblicato in: Journal of Proteome Research, 2021, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00462

The rapid development of computational toxicology

Autori: Hermann M. Bolt, Jan G. Hengstler
Pubblicato in: Archives of Toxicology, Numero 94/5, 2020, Pagina/e 1371-1372, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02768-5

Evaluation of the global performance of eight in silico skin sensitization models using human data

Autori: Emily Golden
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1911261

The use of systems biology in chemical risk assessment

Autori: Alejandro Aguayo-Orozco, Olivier Taboureau, Søren Brunak
Pubblicato in: Current Opinion in Toxicology, Numero 15, 2019, Pagina/e 48-54, ISSN 2468-2020
Editore: Elsevier
DOI: 10.1016/j.cotox.2019.03.003

Examination of microcystin neurotoxicity using central and peripheral human neurons

Autori: Klima, S., Suciu, I., Hoelting, L., Gutbier, S., Waldmann, T., Dietrich, D. R. and Leist, M.
Pubblicato in: ALTEX, 2021, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2003182

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Autori: Sylvia E. Escher, Hennicke Kamp, Susanne H. Bennekou, Annette Bitsch, Ciarán Fisher, Rabea Graepel, Jan G. Hengstler, Matthias Herzler, Derek Knight, Marcel Leist, Ulf Norinder, Gladys Ouédraogo, Manuel Pastor, Sharon Stuard, Andrew White, Barbara Zdrazil, Bob van de Water, Dinant Kroese
Pubblicato in: Archives of Toxicology, Numero 93/12, 2019, Pagina/e 3643-3667, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02591-7

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

Autori: Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00036

Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning

Autori: Rajinder Gupta, Jos Kleinjans & Florian Caiment
Pubblicato in: BMC Cancer, 2021, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-021-08704-9

Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury

Autori: Lukas Surya Wijaya, Panuwat Trairatphisan, Attila Gabor, Marije Niemeijer, Jason Keet, Ariadna Alcalà Morera, Kirsten E. Snijders, Steven Wink, Huan Yang, Stefan Schildknecht, James L. Stevens, Peter Bouwman, Hennicke Kamp, Jan Hengstler, Joost Beltman, Marcel Leist, Sylvia Le Dévédec, Julio Saez-Rodriguez, Bob van de Water
Pubblicato in: Biochemical Pharmacology, 2021, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2021.114591

Computational approaches to chemical hazard assessment

Autori: Thomas Luechtefeld
Pubblicato in: ALTEX, 2017, Pagina/e 459-478, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1710141

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

Autori: Vidya Chandrasekaran, Giada Carta, Daniel da Costa Pereira, Rajinder Gupta, Cormac Murphy, Elisabeth Feifel, Georg Kern, Judith Lechner, Anna Lina Cavallo, Shailesh Gupta, Florian Caiment, Jos C. S. Kleinjans, Gerhard Gstraunthaler, Paul Jennings & Anja Wilmes
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-89550-4

Identifying, naming and documenting of test and tool compound stocks

Autori: Leist, Marcel
Pubblicato in: ALTEX, 2021, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2012311

Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project

Autori: Manuel Pastor, Jordi Quintana, Ferran Sanz
Pubblicato in: Frontiers in Pharmacology, Numero 9, 2018, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.01147

Multistate models of developmental toxicity: Application to valproic acid-induced malformations in the zebrafish embryo

Autori: Ségolène Siméon, Rémy Beaudouin, Katharina Brotzmann, Thomas Braunbeck, Frédéric Y. Bois
Pubblicato in: Toxicology and Applied Pharmacology, 2021, ISSN 0041-008X
Editore: Academic Press
DOI: 10.1016/j.taap.2021.115424

A quantitative AOP of mitochondrial toxicity based on data from three cell lines

Autori: Cleo Tebby, Wang Gao, Johannes Delp, Giada Carta, Wanda van der Stel, Marcel Leist, Paul Jennings, Bob van de Water, Frederic Y. Bois
Pubblicato in: Toxicology in Vitro, 2022, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2022.105345

Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”

Autori: Rebecca von Hellfeld, Pauline Pannetier & Thomas Braunbeck
Pubblicato in: Environmental Science and Pollution Research, 2022, ISSN 0944-1344
Editore: Springer Verlag
DOI: 10.1007/s11356-021-16354-4

Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line

Autori: Kristina Attoff, Ylva Johansson, Andrea Cediel-Ulloa, Jessica Lundqvist, Rajinder Gupta, Florian Caiment, Anda Gliga & Anna Forsby
Pubblicato in: Scientific Reports, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-73698-6

Strategy to replace animal-derived ECM by a modular and highly defined matrix

Autori: Nesterenko, Yevheniia, Xenia Dolde, Marcel Leist, and Olga Mayans
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2003181

Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

Autori: Anna-Katharina Holzer, Ilinca Suciu, Thomas Goj, Christiaan Karreman, Marcel Leist
Pubblicato in: bioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.02.17.479688

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Autori: Johannes Delp, Andrea Cediel-Ulloa, Ilinca Suciu, Petra Kranaster, Barbara MA van Vugt-Lussenburg, Vesna Munic Kos, Wanda van der Stel, Giada Carta, Susanne Hougaard Bennekou, Paul Jennings, Bob van de Water, Anna Forsby & Marcel Leist
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02970-5

3S - Systematic, systemic, and systems biology and toxicology

Autori: Lena Smirnova
Pubblicato in: ALTEX, 2018, Pagina/e 139-162, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1804051

Autologous induced pluripotent stem cell-derived four-organ-chip

Autori: Anja Patricia Ramme, Leopold Koenig, Tobias Hasenberg, Christine Schwenk, Corinna Magauer, Daniel Faust, Alexandra K Lorenz, Anna-Catharina Krebs, Christopher Drewell, Kerstin Schirrmann, Alexandra Vladetic, Grace-Chiaen Lin, Stephan Pabinger, Winfried Neuhaus, Frederic Bois, Roland Lauster, Uwe Marx, Eva-Maria Dehne
Pubblicato in: Future Science OA, Numero 5/8, 2019, Pagina/e FSO413, ISSN 2056-5623
Editore: Future Science
DOI: 10.2144/fsoa-2019-0065

Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Autori: Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, örg Reinders, Stefan Hoehme, Abdel-latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher-Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez-Rodriguez, Ahmed Ghallab
Pubblicato in: Hepatology Communications, 2021, ISSN 2471-254X
Editore: Wiley
DOI: 10.1002/hep4.1797

An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches

Autori: Martin Paparella, Susanne Hougaard Bennekoub, Anna Bal-Price
Pubblicato in: Reproductive Toxicology, 2020, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2020.08.002

https://www.altex.org/index.php/altex/article/view/1339

Autori: Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen
Pubblicato in: ALTEX, 2019, Pagina/e 682-699, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1909271

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Autori: Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
Pubblicato in: Frontiers in Genetics, Numero 9, 2018, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2018.00429

Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters

Autori: Bas ter Braak, Marije Niemeijer, Liesanne Wolters, Sylvia Le Dévédec, Peter Bouwman, Bob van de Water
Pubblicato in: Mutagenesis, 2021, ISSN 0267-8357
Editore: Oxford University Press
DOI: 10.1093/mutage/geab031

Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action

Autori: Sylvia E. Escher, Alejandro Aguayo-Orozco, Emilio Benfenati, Annette Bitsch, Thomas Braunbeck, Katharina Brotzmann, Frederic Bois, Bart van der Burg, Jose Castel, Thomas Exner, Domenico Gadaleta, Iain Gardner, Daria Goldmann, Oliver Hatley, Nazanin Golbamaki, Rabea Graepel, Paul Jennings, Alice Limonciel, Anthony Long, Richard Maclennan, Enrico Mombelli, Ulf Norinder, Sankalp Jain, Liliana Santos
Pubblicato in: Toxicology in Vitro, 2022, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2021.105269

Human neuronal signaling and communication assays to assess functional neurotoxicity

Autori: Dominik Loser, Jasmin Schaefer, Timm Danker, Clemens Möller, Markus Brüll, Ilinca Suciu, Anna-Katharina Ückert, Stefanie Klima, Marcel Leist & Udo Kraushaar
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02956-3

Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway

Autori: Florentina Troger, Johannes Delp, Melina Funke, Wanda van der Stel, Claire Colas, Marcel Leist, Bob van de Water, Gerhard F. Ecker
Pubblicato in: Computational Toxicology, Numero 14, 2020, Pagina/e 100123, ISSN 2468-1113
Editore: Elsevier
DOI: 10.1016/j.comtox.2020.100123

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Autori: Tim Brecklinghaus, Wiebke Albrecht, Franziska Kappenberg, Julia Duda, Nachiket Vartak, Karolina Edlund, Rosemarie Marchan, Ahmed Ghallab, Cristina Cadenas, Georgia Günther, Marcel Leist, Mian Zhang, Iain Gardner, Jörg Reinders, Frans GM. Russel, Alison J. Foster, Dominic P. Williams, Amruta Damle-Vartak, Melanie Grandits, Gerhard Ecker, Naim Kittana, Jörg Rahnenführer, Jan G. Hengstler
Pubblicato in: Chemico-Biological Interactions, 2022, ISSN 0009-2797
Editore: Elsevier BV
DOI: 10.1016/j.cbi.2021.109728

In Vitro Three-Dimensional Liver Models for Nanomaterial DNA Damage Assessment

Autori: Samantha V. Llewellyn, Marije Niemeijer, Penny Nymark, Martijn J. Moné, Bob van de Water, Gillian E. Conway, Gareth J. S. Jenkins, Shareen H. Doak
Pubblicato in: small, 2021, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006055

Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment

Autori: Liliana Capinha, Paul Jennings, Jan N.M. Commandeur
Pubblicato in: Toxicology Letters, 2021, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2021.01.021

Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction

Autori: Sankalp Jain, Ulf Norinder, Sylvia E. Escher, and Barbara Zdrazil
Pubblicato in: Chemical Research in Toxicology, 2020, ISSN 0893-228X
Editore: American Chemical Society
DOI: 10.1021/acs.chemrestox.0c00511

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Autori: Xiali Zhong; Xiali Zhong; Georgina Harris; Lena Smirnova; Valentin Zufferey; Rita de Cássia da Silveira e Sá; Fabiele Baldino Russo; Patricia Cristina Baleeiro Beltrao Braga; Patricia Cristina Baleeiro Beltrao Braga; Megan Chesnut; Marie-Gabrielle Zurich; Helena T. Hogberg; Thomas Hartung; Thomas Hartung; David Pamies; David Pamies
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 14, 2020, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00025

Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

Autori: Julia Vallverdú, Raquel A. Martínez García de la Torre, Inge Mannaerts, Stefaan Verhulst, Ayla Smout, Mar Coll, Silvia Ariño, Teresa Rubio-Tomás, Beatriz Aguilar-Bravo, Celia Martínez-Sánchez, Delia Blaya, Catherine M. Verfaillie, Leo A. van Grunsven & Pau Sancho-Bru
Pubblicato in: Nature Protocols, 2021, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00509-1

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Autori: Rebecca von Hellfeld, Katharina Brotzmann, Lisa Baumann, Ruben Strecker & Thomas Braunbeck
Pubblicato in: Environmental Sciences Europe, 2020, ISSN 2190-4707
Editore: Springer Verlag
DOI: 10.1186/s12302-020-00398-3

New Animal-free Concepts and Test Methods for Developmental Toxicity and Peripheral Neurotoxicity

Autori: Marcel Leist
Pubblicato in: ATLA - Alternatives To Laboratory Animals, 2017, ISSN 0261-1929
Editore: Fund for the Replacement of Animals in Medical Experiments
DOI: 10.1177/026119291704500505

In Vitro Research Reproducibility: Keeping Up High Standards

Autori: Cordula Hirsch, Stefan Schildknecht
Pubblicato in: Frontiers in Pharmacology, Numero 10, 2019, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.01484

Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

Autori: R. Graepel, B. Ter Braak, S.E. Escher, C. Fisher, I. Gardner, H. Kamp, D. Kroese, M. Leist, M.J. Moné, M. Pastor, B. van de Water
Pubblicato in: Current Opinion in Toxicology, Numero 15, 2019, Pagina/e 33-39, ISSN 2468-2020
Editore: Elsevier
DOI: 10.1016/j.cotox.2019.03.005

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

Autori: Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman
Pubblicato in: iScience, Numero 23/2, 2020, Pagina/e 100860, ISSN 2589-0042
Editore: iScience
DOI: 10.1016/j.isci.2020.100860

Automated Integration of Structural, Biological and Metabolic Similarities to Sustain Read-Across

Autori: Domenico Gadaleta
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.2002281

Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents

Autori: Sabine Guth, Angelika Roth, Barbara Engeli, Dirk W. Lachenmeier, Alexander T. Cartus, Stephanie Hüser, Matthias Baum, Patrick Diel, Gerhard Eisenbrand, Jan G. Hengstler, Hans-Ulrich Humpf, Hans-Georg Joost, Alfonso Lampen, Marcel Leist, Doris Marko, Pablo Steinberg, Angela Mally, Jürg A. Zarn,
Pubblicato in: Food and Chemical Toxicology, 2020, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/j.fct.2020.111784

Ten simple rules for creating reusable pathway models for computational analysis and visualization

Autori: Kristina Hanspers ,Martina Kutmon ,Susan L. Coort, Daniela Digles, Lauren J. Dupuis, Friederike Ehrhart, Finterly Hu, Elisson N. Lopes, Marvin Martens, Nhung Pham, Woosub Shin, Denise N. Slenter, Andra Waagmeester, Egon L. Willighagen, Laurent A. Winckers, Chris T. Evelo, Alexander R. Pico
Pubblicato in: PLOS Computational Biology, 2021, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1009226

Road Map for Development of Stem Cell-Based Alternative Test Methods

Autori: Agapios Sachinidis Wiebke Albrecht Patrick Nell Anna Cherianidou Nicola J. Hewitt Karolina Edlund Jan G. Hengstler
Pubblicato in: Trends in Molecular Medicine, 2019, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2019.04.003

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

Autori: Costanza Rovida
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1912181

FuSe: a tool to move RNA-Seq analyses from chromosomal/gene loci to functional grouping of mRNA transcripts

Autori: Rajinder Gupta, Yannick Schrooders, Marcha Verheijen, Adrian Roth, Jos Kleinjans, Florian Caiment
Pubblicato in: Bioinformatics, 2021, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa735

HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity

Autori: Ghosh, Sreya, Jonathan De Smedt, Tine Tricot, Susana Proença, Manoj Kumar, Fatemeharefeh Nami, Thomas Vanwelden, Niels Vidal, Paul Jennings, Nynke I. Kramer, and Catherine M. Verfaillie
Pubblicato in: Toxics, 2022, ISSN 2305-6304
Editore: Basel: MDPI AG
DOI: 10.3390/toxics10010001

Extrapolation of drug induced liver injury responses from cancer cell lines using machine learning approaches

Autori: Alejandro Aguayo-Orozco, Søren Brunak, Olivier Taboureau
Pubblicato in: Computational Toxicology, 2021, ISSN 2468-1113
Editore: Elsevier BV
DOI: 10.1016/j.comtox.2020.100147

Integrating in silico models and read-across methods for predicting toxicity of chemicals: A step-wise strategy

Autori: Emilio Benfenati, Qasim Chaudhry, Giuseppina Gini, Jean Lou Dorne
Pubblicato in: Environment International, 2019, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105060

Optimizing drug discovery by Investigative Toxicology: Current and future trends

Autori: Mario Beilmann
Pubblicato in: ALTEX, Numero 36/2, 2018, Pagina/e 3-17, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1808181

Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes

Autori: Bas ter Braak, Marije Niemeijer, Ruben Boon, Céline Parmentier, Audrey Baze, Lysiane Richert, Suzanna Huppelschoten, Steven Wink, Catherine Verfaillie, Bob van de Water
Pubblicato in: Toxicology in Vitro, 2021, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2021.105107

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Autori: Wiebke Albrecht, Franziska Kappenberg, Tim Brecklinghaus, Regina Stoeber, Rosemarie Marchan, Mian Zhang, Kristina Ebbert, Hendrik Kirschner, Marianna Grinberg, Marcel Leist, Wolfgang Moritz, Cristina Cadenas, Ahmed Ghallab, Jörg Reinders, Nachiket Vartak, Christoph van Thriel, Klaus Golka, Laia Tolosa, José V. Castell, Georg Damm, Daniel Seehofer, Alfonso Lampen, Albert Braeuning, Thorsten Buhrk
Pubblicato in: Archives of Toxicology, Numero 93/6, 2019, Pagina/e 1609-1637, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02492-9

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response

Autori: Alexandra Maertens, Vy Tran, Andre Kleensang, Thomas Hartung
Pubblicato in: Frontiers in Genetics, Numero 9, 2018, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2018.00508

A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model

Autori: Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon, Francois Chesnais, Jonathan De Smedt, Tine Tricot, Teresa Izuel Idoype, Marco Canella, Pierre Tilliole, Jolan De Boeck, Manmohan Bajaj, Adrian Ranga, Francesca Maria Bosisio, Tania Roskams, Leo A. van Grunsven, Catherine M. Verfaillie,
Pubblicato in: Biomaterials, 2021, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121006

QSAR Development for Plasma Protein Binding: Influence of the Ionization State

Autori: Cosimo Toma, Domenico Gadaleta, Alessandra Roncaglioni, Andrey Toropov, Alla Toropova, Marco Marzo, Emilio Benfenati
Pubblicato in: Pharmaceutical Research, Numero 36/2, 2019, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-018-2561-8

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta

Autori: Giorgia Pallocca, Johanna Nyffeler, Xenia Dolde, Marianna Grinberg, Gerhard Gstraunthaler, Tanja Waldmann, Jörg Rahnenführer, Agapios Sachinidis, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 91/10, 2017, Pagina/e 3385-3402, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-1966-1

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Autori: Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken, Paul Jennings
Pubblicato in: Archives of Toxicology, Numero 92/8, 2018, Pagina/e 2517-2531, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2256-2

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Autori: Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 92/12, 2018, Pagina/e 3487-3503, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2326-5

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Autori: David Pamies
Pubblicato in: ALTEX, 2018, Pagina/e 353-378, ISSN 1868-596X
Editore: Springer Spektrum; Springer-Verlag GmbH
DOI: 10.14573/altex.1710081

QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis

Autori: Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli
Pubblicato in: Journal of Chemical Information and Modeling, Numero 58/8, 2018, Pagina/e 1501-1517, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.8b00297

A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications

Autori: Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
Pubblicato in: Journal of Cheminformatics, Numero 10/1, 2018, ISSN 1758-2946
Editore: Chemistry Central
DOI: 10.1186/s13321-018-0315-6

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Autori: Anna Bal-Price
Pubblicato in: ALTEX, 2018, Pagina/e 306-352, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1712081

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Autori: Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia Vallverdú, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan José Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru
Pubblicato in: Cell Stem Cell, Numero 23/1, 2018, Pagina/e 101-113.e7, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2018.05.027

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Autori: Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer, Ursula Klingmüller
Pubblicato in: npj Systems Biology and Applications, Numero 4/1, 2018, ISSN 2056-7189
Editore: -
DOI: 10.1038/s41540-018-0058-z

Essential components of methods papers

Autori: Marcel Leist
Pubblicato in: ALTEX, 2018, Pagina/e 429-432, ISSN 1868-596X
Editore: -
DOI: 10.14573/altex.1807031

Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

Autori: Alejandro Aguayo-Orozco, Frederic Yves Bois, Søren Brunak, Olivier Taboureau
Pubblicato in: Frontiers in Genetics, Numero 9, 2018, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2018.00396

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Autori: Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht
Pubblicato in: Archives of Toxicology, Numero 92/1, 2018, Pagina/e 41-82, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-2133-4

A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

Autori: Johannes Delp
Pubblicato in: ALTEX, 2018, Pagina/e 235-253, ISSN 1868-596X
Editore: -
DOI: 10.14573/altex.1712182

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Autori: Johannes Delp, Simon Gutbier, Martin Cerff, Christin Zasada, Sebastian Niedenführ, Liang Zhao, Lena Smirnova, Thomas Hartung, Hanna Borlinghaus, Falk Schreiber, Jörg Bergemann, Jochem Gätgens, Martin Beyss, Salah Azzouzi, Tanja Waldmann, Stefan Kempa, Katharina Nöh, Marcel Leist
Pubblicato in: Toxicology and Applied Pharmacology, Numero 354, 2018, Pagina/e 64-80, ISSN 0041-008X
Editore: Academic Press
DOI: 10.1016/j.taap.2017.12.013

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Autori: Georgina Harris, Melanie Eschment, Sebastian Perez Orozco, J. Michael McCaffery, Richard Maclennan, Daniel Severin, Marcel Leist, Andre Kleensang, David Pamies, Alexandra Maertens, Helena T. Hogberg, Dana Freeman, Alfredo Kirkwood, Thomas Hartung, Lena Smirnova
Pubblicato in: Archives of Toxicology, Numero 92/8, 2018, Pagina/e 2587-2606, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2250-8

Development and validation of computational models for predicting oxidative stress responses using comprehensive series of drug-like compounds

Autori: M. Pastor, G.J.P. Westen, J.C. Gómez-Tamayo, B.E. Lenselink, C.-C. Lam, B. Water, U. Norinder, S. Manganelli, D. Gadaleta, A. Roncaglioni
Pubblicato in: Toxicology Letters, Numero 295, 2018, Pagina/e S62-S63, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2018.06.062

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

Autori: Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen
Pubblicato in: Frontiers in Genetics, Numero 9, 2018, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2018.00661

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

Autori: Simon Gutbier, Anna-Sophie Spreng, Johannes Delp, Stefan Schildknecht, Christiaan Karreman, Ilinca Suciu, Thomas Brunner, Marcus Groettrup, Marcel Leist
Pubblicato in: Cell Death & Differentiation, Numero 25/12, 2018, Pagina/e 2101-2117, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-018-0229-x

Normalization of data for viability and relative cell function curves

Autori: Alice Krebs
Pubblicato in: ALTEX, 2018, Pagina/e 268-271, ISSN 1868-596X
Editore: -
DOI: 10.14573/1803231

Chemical concentrations in cell culture compartments (C5) – concentration definitions

Autori: Jaffar Kisitu
Pubblicato in: ALTEX, Numero 36/1, 2019, Pagina/e 154-160, ISSN 1868-596X
Editore: -
DOI: 10.14573/altex.1901031

The BioStudies database—one stop shop for all data supporting a life sciences study

Autori: Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre
Pubblicato in: Nucleic Acids Research, Numero 46/D1, 2017, Pagina/e D1266-D1270, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkx965

VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays

Autori: C. Fisher, S. Siméon, M. Jamei, I. Gardner, Y.F. Bois
Pubblicato in: Toxicology in Vitro, 2018, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2018.12.017

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Autori: Xiaolong Gu, Wiebke Albrecht, Karolina Edlund, Franziska Kappenberg, Jörg Rahnenführer, Marcel Leist, Wolfgang Moritz, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Tim Brecklinghaus, Laia Tolosa Pardo, José V. Castell, Iain Gardner, Bo Han, Jan G. Hengstler, Regina Stoeber
Pubblicato in: Archives of Toxicology, Numero 92/12, 2018, Pagina/e 3505-3515, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2302-0

Finding synergies for 3Rs – Toxicokinetics and read-across: Report from an EPAA partners' Forum

Autori: Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. Müller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon v
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 99, 2018, Pagina/e 5-21, ISSN 0273-2300
Editore: Academic Press
DOI: 10.1016/j.yrtph.2018.08.006

In Vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach

Autori: C.P. Fisher, O. Hatley, B. van Vugt, F. Bois, S. Escher, I. Gardner
Pubblicato in: Toxicology Letters, Numero 295, 2018, Pagina/e S246, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2018.06.1015

Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

Autori: Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung
Pubblicato in: Toxicological Sciences, Numero 165/1, 2018, Pagina/e 198-212, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfy152

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Autori: Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings
Pubblicato in: Frontiers in Genetics, Numero 9, 2018, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2018.00558

Regulatory acceptance of read-across

Autori: Megan Chesnut
Pubblicato in: ALTEX, 2018, Pagina/e 413-419, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1805081

A structure–activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

Autori: Johanna Nyffeler, Petra Chovancova, Xenia Dolde, Anna-Katharina Holzer, Vladimir Purvanov, Ilona Kindinger, Anna Kerins, David Higton, Steve Silvester, Barbara M. A. van Vugt-Lussenburg, Enrico Glaab, Bart van der Burg, Richard Maclennan, Daniel F. Legler, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 92/3, 2018, Pagina/e 1225-1247, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-2125-4

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Autori: Steven Wink, Steven W. Hiemstra, Suzanne Huppelschoten, Janna E. Klip, Bob van de Water
Pubblicato in: Archives of Toxicology, Numero 92/5, 2018, Pagina/e 1797-1814, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2178-z

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

Autori: Luc J. M. Bischoff, Isoude A. Kuijper, Johannes P. Schimming, Liesanne Wolters, Bas ter Braak, Jan P. Langenberg, Daan Noort, Joost B. Beltman, Bob van de Water
Pubblicato in: Archives of Toxicology, Numero 93/2, 2019, Pagina/e 435-451, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2353-2

Current EU research activities on combined exposure to multiple chemicals

Autori: Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Pubblicato in: Environment International, Numero 120, 2018, Pagina/e 544-562, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2018.07.037

Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary

Autori: C. Mahony, R. Currie, G. Daston, N. Kleinstreuer, B. van de Water
Pubblicato in: Archives of Toxicology, Numero 92/2, 2018, Pagina/e 1015-1020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-2145-0

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Autori: Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park
Pubblicato in: Archives of Toxicology, Numero 93/2, 2019, Pagina/e 385-399, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2354-1

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Autori: Marianna Grinberg, Regina M. Stöber, Wiebke Albrecht, Karolina Edlund, Markus Schug, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Alfonso Lampen, Albert Braeuning, Thorsten Buhrke, Marcel Leist, Axel Oberemm, Birte Hellwig, Hennicke Kamp, Iain Gardner, Sylvia Escher, Olivier Taboureau, Alejandro Aguayo-Orozco, Agapios Sachinidis, Heidrun Ellinger-Ziegelbauer, Jörg Rahnenführer, Jan G. H
Pubblicato in: Archives of Toxicology, Numero 92/12, 2018, Pagina/e 3517-3533, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2352-3

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Autori: Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F. Hofmann, Peter L.M. Jansen, Jan G. Hengstler, Raymond Reif
Pubblicato in: Hepatology, Numero 69/2, 2019, Pagina/e 666-683, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30213

Adverse outcome pathways: opportunities, limitations and open questions

Autori: Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patricio Godoy, Frederic Y. Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk Drasdo, Stefan Höhme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost B
Pubblicato in: Archives of Toxicology, Numero 91/11, 2017, Pagina/e 3477-3505, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-2045-3

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Autori: Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Antoni
Pubblicato in: EFSA Journal, Numero 15/3, 2017, ISSN 1831-4732
Editore: Wiley
DOI: 10.2903/j.efsa.2017.4691

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

Autori: Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, Jürgen Hescheler, Jörg Rahnenführer, Marianna Grinberg, Johannes Meisig, Nils Blüthgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler, Agapios Sachinidis
Pubblicato in: Stem Cell Research & Therapy, Numero 7/1, 2016, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-016-0449-2

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Autori: Lisa Hoelting, Stefanie Klima, Christiaan Karreman, Marianna Grinberg, Johannes Meisig, Margit Henry, Tamara Rotshteyn, Jörg Rahnenführer, Nils Blüthgen, Agapios Sachinidis, Tanja Waldmann, Marcel Leist
Pubblicato in: STEM CELLS Translational Medicine, Numero 5/4, 2016, Pagina/e 476-487, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.5966/sctm.2015-0108

Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation

Autori: Liudmila Efremova, Petra Chovancova, Martina Adam, Simon Gutbier, Stefan Schildknecht, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 91/1, 2017, Pagina/e 231-246, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1702-2

Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants

Autori: Johanna Nyffeler
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1605031

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

Autori: J. Meiser, S. Delcambre, A. Wegner, C. Jäger, J. Ghelfi, A. Fouquier d'Herouel, X. Dong, D. Weindl, C. Stautner, Y. Nonnenmacher, A. Michelucci, O. Popp, F. Giesert, S. Schildknecht, L. Krämer, J.G. Schneider, D. Woitalla, W. Wurst, A. Skupin, D.M. Vogt Weisenhorn, R. Krüger, M. Leist, K. Hiller
Pubblicato in: Neurobiology of Disease, Numero 89, 2016, Pagina/e 112-125, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2016.01.019

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

Autori: Vaibhav Shinde, Lisa Hoelting, Sureshkumar Perumal Srinivasan, Johannes Meisig, Kesavan Meganathan, Smita Jagtap, Marianna Grinberg, Julia Liebing, Nils Bluethgen, Jörg Rahnenführer, Eugen Rempel, Regina Stoeber, Stefan Schildknecht, Sunniva Förster, Patricio Godoy, Christoph van Thriel, John Antonydas Gaspar, Jürgen Hescheler, Tanja Waldmann, Jan G. Hengstler, Marcel Leist, Agapios Sachinidis
Pubblicato in: Archives of Toxicology, Numero 91/2, 2017, Pagina/e 839-864, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1741-8

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants

Autori: Cordula Hirsch, Britta Striegl, Stephanie Mathes, Christian Adlhart, Michael Edelmann, Epifania Bono, Sabyasachi Gaan, Khalifah A. Salmeia, Lisa Hoelting, Alice Krebs, Johanna Nyffeler, Regina Pape, Alexander Bürkle, Marcel Leist, Peter Wick, Stefan Schildknecht
Pubblicato in: Archives of Toxicology, Numero 91/1, 2017, Pagina/e 407-425, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1680-4

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity

Autori: Tanja Waldmann, Marianna Grinberg, André König, Eugen Rempel, Stefan Schildknecht, Margit Henry, Anna-Katharina Holzer, Nadine Dreser, Vaibhav Shinde, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Marcel Leist
Pubblicato in: Chemical Research in Toxicology, Numero 30/4, 2017, Pagina/e 905-922, ISSN 0893-228X
Editore: American Chemical Society
DOI: 10.1021/acs.chemrestox.6b00259

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis

Autori: João V. Sá, Susanne Kleiderman, Catarina Brito, Ursula Sonnewald, Marcel Leist, Ana P. Teixeira, Paula M. Alves
Pubblicato in: Neurochemical Research, Numero 42/1, 2017, Pagina/e 244-253, ISSN 0364-3190
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-016-1907-z

The ascending pathophysiology of cholestatic liver disease

Autori: Peter L.M. Jansen, Ahmed Ghallab, Nachiket Vartak, Raymond Reif, Frank G. Schaap, Jochen Hampe, Jan G. Hengstler
Pubblicato in: Hepatology, Numero 65/2, 2017, Pagina/e 722-738, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28965

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Autori: Béla Z. Schmidt, Martin Lehmann, Simon Gutbier, Erastus Nembo, Sabrina Noel, Lena Smirnova, Anna Forsby, Jürgen Hescheler, Hasan X. Avci, Thomas Hartung, Marcel Leist, Julianna Kobolák, András Dinnyés
Pubblicato in: Archives of Toxicology, Numero 91/1, 2017, Pagina/e 1-33, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1805-9

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

Autori: Abinaya Chandrasekaran, Hasan X. Avci, Marcel Leist, Julianna Kobolák, Andras Dinnyés
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 10, 2016, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2016.00215

A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

Autori: Fabiola Pizzo, Anna Lombardo, Alberto Manganaro, Emilio Benfenati
Pubblicato in: Frontiers in Pharmacology, Numero 7, 2016, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2016.00442

CORAL: Binary classifications (active/inactive) for drug-induced liver injury

Autori: Alla P. Toropova, Andrey A. Toropov
Pubblicato in: Toxicology Letters, Numero 268, 2017, Pagina/e 51-57, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2017.01.011

The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?

Autori: Alla P. Toropova, Andrey A. Toropov
Pubblicato in: Science of The Total Environment, Numero 586, 2017, Pagina/e 466-472, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2017.01.198

Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles

Autori: Alla P. Toropova, Andrey A. Toropov
Pubblicato in: Toxicology Letters, Numero 275, 2017, Pagina/e 57-66, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2017.03.023

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models

Autori: Alla P. Toropova, Andrey A. Toropov, Marco Marzo, Sylvia E. Escher, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati
Pubblicato in: Food and Chemical Toxicology, 2017, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/j.fct.2017.03.060

The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?

Autori: Andrey A. Toropov, Alla P. Toropova
Pubblicato in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Numero 819, 2017, Pagina/e 31-37, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/j.mrgentox.2017.05.008

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library

Autori: Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist
Pubblicato in: Archives of Toxicology, 2017, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-017-1977-y

Human Environmental Disease Network: A computational model to assess toxicology of contaminants

Autori: Olivier Taboureau
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1607201

In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

Autori: Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak, Olivier Taboureau
Pubblicato in: Current Pharmaceutical Design, Numero 22/46, 2017, Pagina/e 6895-6902, ISSN 1381-6128
Editore: Bentham Science Publishers
DOI: 10.2174/1381612822666160907093215

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Autori: Mardas Daneshian, Hennicke Kamp, Jan Hengstler, Marcel Leist, Bob van de Water
Pubblicato in: Archives of Toxicology, Numero 90/5, 2016, Pagina/e 1021-1024, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1698-7

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

Autori: Christopher Goldring, Daniel J. Antoine, Frank Bonner, Jonathan Crozier, Chris Denning, Robert J. Fontana, Neil A. Hanley, David C. Hay, Magnus Ingelman-Sundberg, Satu Juhila, Neil Kitteringham, Beatriz Silva-Lima, Alan Norris, Chris Pridgeon, James A. Ross, Rowena Sison Young, Danilo Tagle, Belen Tornesi, Bob van de Water, Richard J. Weaver, Fang Zhang, B. Kevin Park
Pubblicato in: Hepatology, Numero 65/2, 2017, Pagina/e 710-721, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28886

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling

Autori: Isoude A. Kuijper, Huan Yang, Bob Van De Water, Joost B. Beltman
Pubblicato in: Expert Opinion on Drug Metabolism & Toxicology, Numero 13/1, 2016, Pagina/e 5-17, ISSN 1742-5255
Editore: Ashley Publications Ltd.
DOI: 10.1080/17425255.2017.1234607

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Autori: Steven Wink, Steven Hiemstra, Bram Herpers, Bob van de Water
Pubblicato in: Archives of Toxicology, Numero 91/3, 2017, Pagina/e 1367-1383, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1781-0

Toward Good Read-Across Practice (GRAP) guidance

Autori: Nicholas Ball
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1601251

Analysis of public oral toxicity data from REACH registrations 2008-2014

Autori: Thomas Luechtefeld
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1510054

Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

Autori: Thomas Luechtefeld
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1510053

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014

Autori: Thomas Luechtefeld
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1510052

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

Autori: Thomas Luechtefeld
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1510055

Supporting read-across using biological data

Autori: Hao Zhu
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1601252

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Autori: Michael Aschner
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1604201

Good Cell Culture Practice for stem cells and stem-cell-derived models

Autori: David Pamies
Pubblicato in: ALTEX, 2016, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1607121

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

Autori: Wanda van der Stel, Giada Carta, Julie Eakins, Salihanur Darici, Johannes Delp, Anna Forsby, Susanne Hougaard Bennekou, Iain Gardner, Marcel Leist, Erik H. J. Danen, Paul Walker, Bob van de Water, Paul Jennings
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02792-5

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare

Autori: Uwe Marx
Pubblicato in: ALTEX, 2020, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.2001241

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autori: Wanda van der Stel, Huan Yang, Nanette G. Vrijenhoek, Johannes P. Schimming, Giulia Callegaro, Giada Carta, Salihanur Darici, Johannes Delp, Anna Forsby, Andrew White, Sylvia le Dévédec, Marcel Leist, Paul Jennings, Joost B. Beltman, Bob van de Water & Erik H. J. Danen
Pubblicato in: Archives of Toxicology, 2022, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03160-7

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Autori: Alice Krebs, Barbara M. A. van Vugt-Lussenburg, Tanja Waldmann, Wiebke Albrecht, Jan Boei, Bas ter Braak, Maja Brajnik, Thomas Braunbeck, Tim Brecklinghaus, Francois Busquet, Andras Dinnyes, Joh Dokler, Xenia Dolde, Thomas E. Exner, Ciarán Fisher, David Fluri, Anna Forsby, Jan G. Hengstler, Anna-Katharina Holzer, Zofia Janstova, Paul Jennings, Jaffar Kisitu, Julianna Kobolak, Manoj Kumar, Alice L
Pubblicato in: Archives of Toxicology, Numero 94/7, 2020, Pagina/e 2435-2461, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02802-6

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

Autori: Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 94/1, 2020, Pagina/e 151-171, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02612-5

A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

Autori: Marta Moreno-Torres, Manoj Kumar, Guillem García-Llorens, Guillermo Quintás, Tine Tricot, Ruben Boon, Laia Tolosa, Burak Toprakhisar, Francois Chesnais, Catherine Verfaillie, and José V. Castell
Pubblicato in: Journal of Proteome Research, 2022, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00779

Application of three approaches for quantitative AOP development to renal toxicity

Autori: Elias Zgheib, Wang Gao, Alice Limonciel, Hristo Aladjov, Huan Yang, Cleo Tebby, Ghislaine Gayraud, Paul Jennings, Magdalini Sachana, Joost B. Beltman, Frederic Y. Bois
Pubblicato in: Computational Toxicology, Numero 11, 2019, Pagina/e 1-13, ISSN 2468-1113
Editore: Elsevier
DOI: 10.1016/j.comtox.2019.02.001

The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

Autori: Laia Tolosa, Teresa Martínez-Sena, Johannes P. Schimming, Erika Moro, Sylvia E. Escher, Bas ter Braak, Bob van der Water, M. A. Miranda, Barbara M. A. van Vugt-Lussenburg & José V. Castell
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03036-w

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

Autori: Susana Proença, Beate I. Escher, Fabian C. Fischer, Ciarán Fisher, Sébastien Grégoire, Nicky J. Hewitt, Beate Nicol, Alicia Paini, Nynke I. Kramer
Pubblicato in: Toxicology in Vitro, 2021, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2021.105133

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

Autori: Pieter S. Hiemstra, Gwendolynn Grootaers, Anne M. van der Does, Cyrille A.M. Krul, Ingeborg M. Kooter
Pubblicato in: Toxicology in Vitro, Numero 47, 2018, Pagina/e 137-146, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2017.11.005

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autori: Dominik Loser, Karin Grillberger, Maria G. Hinojosa, Jonathan Blum, Yves Haufe, Timm Danker, Ylva Johansson, Clemens Möller, Annette Nicke, Susanne H. Bennekou, Iain Gardner, Caroline Bauch, Paul Walker, Anna Forsby, Gerhard F. Ecker, Udo Kraushaar & Marcel Leist
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03168-z

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Autori: Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmel
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15058-6

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

Autori: Alice Krebs
Pubblicato in: ALTEX, Numero 37/1, 2019, Pagina/e 155-163, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1912021

Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals

Autori: Tine Tricot ,Nicky Helsen, Suzanne J. F. Kaptein, Johan Neyts,Catherine M. Verfaillie
Pubblicato in: PLOS ONE, 2018, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0209097

NAM-supported read-across: From case studies to regulatory guidance in safety assessment

Autori: Rovida, Costanza, Sylvia E. Escher, Matthias Herzler, Susanne H. Bennekou, Hennicke Kamp, Dinant E. Kroese, Lidka Maslankiewicz, Martijn J. Moné, Grace Patlewicz, Nisha Sipes, Leon van Aerts, Andrew White, Takashi Yamada, and Bob van de Water
Pubblicato in: ALTEX, 2021, ISSN 1868-596X
Editore: Springer-Verlag
DOI: 10.14573/altex.2010062

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Autori: Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne Hougaard Bennekou, Jacob van Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg, Hilko van der Voet, A. Michael Warhurst, Bob van de Water, Ku
Pubblicato in: Environment International, Numero 134, 2020, Pagina/e 105267, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105267

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

Autori: Britt Duijndam, Annabel Goudriaan, Tineke van den Hoorn, Wanda van der Stel, Sylvia Le Dévédec, Peter Bouwman, Jan Willem van der Laan, Bob van de Water
Pubblicato in: Toxicological Sciences, 2021, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfab037

Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience

Autori: M. J. Moné, G. Pallocca, S. E. Escher, T. Exner, M. Herzler, S. Hougaard Bennekou, H. Kamp, E. D. Kroese, Marcel Leist, T. Steger-Hartmann & B. van de Water
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02866-4

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

Autori: Christiaan Karreman
Pubblicato in: ALTEX, 2019, Pagina/e 518-520, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.1906251

Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

Autori: Kirsten E. Snijders, Anita Fehér, Zsuzsanna Táncos, István Bock, Annamária Téglási, Linda van den Berk, Marije Niemeijer, Peter Bouwman, Sylvia E. Le Dévédec, Martijn J. Moné, Rob Van Rossom, Manoj Kumar, Anja Wilmes, Paul Jennings, Catherine M. Verfaillie, Julianna Kobolák, Bas ter Braak, András Dinnyés & Bob van de Water
Pubblicato in: Archives of Toxicology, 2021, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03127-8

ELIXIR and Toxicology: a community in development

Autori: Marvin Martens, Rob Stierum, Emma L. Schymanski, Chris T. Evelo, Reza Aalizadeh, Hristo Aladjov, Kasia Arturi, Karine Audouze, Pavel Babica, Karel Berka, Jos Bessems, Ludek Blaha, Evan E. Bolton, Montserrat Cases, Dimitrios Ε. Damalas, Kirtan Dave, Marco Dilger, Thomas Exner, Daan P. Geerke, Roland Grafström, Alasdair Gray, John M. Hancock, Henner Hollert, Nina Jeliazkova, Danyel Jennen, Fabien
Pubblicato in: F1000Research, 2021, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Autori: Yongjie Zhang, Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Steven Hiemstra, Nico P. E. Vermeulen, Bob van de Water, Jan N. M. Commandeur, J. C. Vos
Pubblicato in: Frontiers in Pharmacology, Numero 9, 2018, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00388

Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity

Autori: Petra Kranaster, Christiaan Karreman, Jeremias E. G. A. Dold, Alice Krebs, Melina Funke, Anna-Katharina Holzer, Stefanie Klima, Johanna Nyffeler, Stefan Helfrich, Valentin Wittmann, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 94/2, 2020, Pagina/e 449-467, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02642-z

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Autori: Thomas Luechtefeld, Craig Rowlands, Thomas Hartung
Pubblicato in: Toxicology Research, 2018, ISSN 2045-452X
Editore: Royal Society of Chemistry
DOI: 10.1039/c8tx00051d

Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

Autori: Lukas S. Wijaya, Carina Rau, Theresa S. Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, Wiebke Albrecht, Tim Brecklinghaus, Hennicke Kamp, Joost B. Beltman, Jan G. Hengstler, Bob van de Water, Marcel Leist & Stefan Schildknecht
Pubblicato in: Cell Biology and Toxicology, 2021, ISSN 0742-2091
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10565-021-09610-3

Réseaux Bayésiens Dynamiques : méthodologie pour l’inférence sur les schémas de mode d’Action en Toxicologie

Autori: Bois , Frédéric Y.; Gao , Wang; Gayraud , Ghislaine
Pubblicato in: Actes des 9èmes Journées Francophones sur les Réseaux Bayésiens et les Modèles Graphiques Probabilistes, Numero 2, 2018, Pagina/e 1-11
Editore: Revue d’intelligence artificielle (Lavoisier)

Predicting toxicity of chemicals: software beats animal testing

Autori: Thomas Hartung
Pubblicato in: EFSA Journal, 2019, ISSN 1831-4732
Editore: Wiley-Blackwell Publishing Ltd
DOI: 10.2903/j.efsa.2019.e170710

Use of publicly available transcriptomics data to support the steatosis AOP development

Autori: Oana Florean, Lucian Farcal, Noffisat Oki, Thomas Exner, Barry Hardy and Tatyana Doktorova
Pubblicato in: ALTEX Proceedings (EUSAAT 2018), 2018, Pagina/e 214, ISSN 2194-0479
Editore: Springer

Computational Toxicology and Reach

Autori: Benfenati, Emilio Lombardo, Anna Roncaglioni, Alessandra
Pubblicato in: Computational Toxicology: Risk Assessment for Chemicals, 2018, ISBN 9781119282563
Editore: Wiley

System Microscopy of Stress Response Pathways in Cholestasis Research

Autori: Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, Bob van de Water
Pubblicato in: Methods in Molecular Biology, 2019, ISBN 978-1-4939-9419-9
Editore: Humana
DOI: 10.1007/978-1-4939-9420-5_13

Systems microscopy approaches in unravelling and predicting drug-induced liver injury (DILI)

Autori: Niemeijer M, Hiemstra S, Wink S, den Hollander W, ter Braak B, van de Water B
Pubblicato in: Methods in Pharmacology and Toxicology, 2018, Pagina/e 611-625
Editore: Springer Science+Business Media

Factors that Influence the Quality of Metabolomics Data in in Vitro Cell Toxicity Studies: A Systematic Survey

Autori: Marta Moreno-Torres, Guillem García-Llorens, Erika Moro, Rebeca Méndez, Guillermo Quintás, José Vicente Castell
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-724307/v1

New European Union statistics on laboratory animal use – what really counts!

Autori: Francois Busquet
Pubblicato in: ALTEX, 2020, Pagina/e 167-186, ISSN 1868-596X
Editore: Springer
DOI: 10.14573/altex.2003241

Flame: An Open Source Framework for Model Development, Hosting, and Usage in Production Environments

Autori: Manuel Pastor, José Carlos Gómez-Tamayo, Ferran Sanz
Pubblicato in: Journal of Cheminformatics, 2021, ISSN 1758-2946
Editore: Chemistry Central
DOI: 10.21203/rs.3.rs-107430/v1

Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

Autori: Julianna Kobolak, Annamaria Teglasi, Tamas Bellak, Zofia Janstova, Kinga Molnar, Melinda Zana, Istvan Bock, Lajos Laszlo, Andras Dinnyes
Pubblicato in: Cells, Numero 9/5, 2020, Pagina/e 1122, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells9051122

Structure learning of Bayesian networks involving cyclic structures

Autori: Wiecek, Witold; Bois, Frederic Y.; Gayraud, Ghislaine
Pubblicato in: https://hal.archives-ouvertes.fr/hal-02130362, Numero 1, 2019
Editore: HAL archives ouvertes

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