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Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD).

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Publications

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author(s): Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut
Published in: Nature Medicine, Issue 24/3, 2018, Page(s) 282-291, ISSN 1078-8956
DOI: 10.1038/nm.4484

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Author(s): Jan Hülsdünker, Katja J. Ottmüller, Hannes P. Neeff, Motoko Koyama, Zhan Gao, Oliver S. Thomas, Marie Follo, Ali Al-Ahmad, Gabriele Prinz, Sandra Duquesne, Heide Dierbach, Susanne Kirschnek, Tim Lämmermann, Martin J. Blaser, Brian T. Fife, Bruce R. Blazar, Andreas Beilhack, Geoffrey R. Hill, Georg Häcker, Robert Zeiser
Published in: Blood, Issue 131/16, 2018, Page(s) 1858-1869, ISSN 0006-4971
DOI: 10.1182/blood-2017-10-812891

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

Author(s): N Stickel, K Hanke, D Marschner, G Prinz, M Köhler, W Melchinger, D Pfeifer, A Schmitt-Graeff, T Brummer, A Heine, P Brossart, D Wolf, N von Bubnoff, J Finke, J Duyster, J Ferrara, U Salzer, R Zeiser
Published in: Leukemia, Issue 31/12, 2017, Page(s) 2732-2741, ISSN 0887-6924
DOI: 10.1038/leu.2017.137

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Author(s): Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O’Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark Bartholomä, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dier
Published in: Science Translational Medicine, Issue 10/429, 2018, Page(s) eaam7729, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aam7729

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Author(s): A. Schonle, F. A. Hartl, J. Mentzel, T. Noltner, K. S. Rauch, A. Prestipino, S. A. Wohlfeil, P. Apostolova, A.-K. Hechinger, W. Melchinger, K. Fehrenbach, M. C. Guadamillas, M. Follo, G. Prinz, A.-K. Ruess, D. Pfeifer, M. Angel del Pozo, A. Schmitt-Graeff, J. Duyster, K. I. Hippen, B. R. Blazar, K. Schachtrup, S. Minguet, R. Zeiser
Published in: Blood, Issue 127/15, 2016, Page(s) 1930-1939, ISSN 0006-4971
DOI: 10.1182/blood-2015-09-672428

"Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression"

Author(s): Hana Andrlová, Justin Mastroianni, Josef Madl, Johannes S. Kern, Wolfgang Melchinger, Heide Dierbach, Florian Wernet, Marie Follo, Kristin Technau-Hafsi, Cristina Has, Venugopal Rao Mittapalli, Marco Idzko, Ricarda Herr, Tilman Brummer, Hendrik Ungefroren, Hauke Busch, Melanie Boerries, Andreas Narr, Gabriele Ihorst, Claire Vennin, Annette Schmitt-Graeff, Susana Minguet, Paul Timpson, Justus Duys
Published in: Oncotarget, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.17160