Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD).

Project Information

GvHDCure

Grant agreement ID: 681012

DOI 10.3030/681012

Project closed

EC signature date 16 February 2016

Start date 1 March 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 987 500,00

EU contribution € 1 987 500,00

Coordinated by

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Publications

Peer reviewed articles (10)

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Author(s): Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niem
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15497-1

Immunization against poly- N -acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

Author(s): Jan Hülsdünker, Oliver S. Thomas, Eileen Haring, Susanne Unger, Nicolás Gonzalo Núñez, Sonia Tugues, Zhan Gao, Sandra Duquesne, Colette Cywes-Bentley, Ozlem Oyardi, Susanne Kirschnek, Annette Schmitt-Graeff, Oliver Pabst, Christian Koenecke, Justus Duyster, Petya Apostolova, Martin J. Blaser, Burkhard Becher, Gerald B. Pier, Georg Häcker, Robert Zeiser
Published in: Proceedings of the National Academy of Sciences, Issue 116/41, 2019, Page(s) 20700-20706, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1908549116

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Author(s): Nimitha R. Mathew, Janaki M. Vinnakota, Petya Apostolova, Daniel Erny, Shaimaa Hamarsheh, Geoffroy Andrieux, Jung-Seok Kim, Kathrin Hanke, Tobias Goldmann, Louise Chappell-Maor, Nadia El-Khawanky, Gabriele Ihorst, Dominik Schmidt, Justus Duyster, Jürgen Finke, Thomas Blank, Melanie Boerries, Bruce R. Blazar, Steffen Jung, Marco Prinz, Robert Zeiser
Published in: Journal of Clinical Investigation, Issue 130/3, 2020, Page(s) 1315-1329, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci130272

Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans

Author(s): Johana Norona, Petya Apostolova, Dominik Schmidt, Rebekka Ihlemann, Nadine Reischmann, Gregory Taylor, Natalie Köhler, Jocelyn de Heer, Steffen Heeg, Geoffroy Andrieux, Benjamin A. Siranosian, Annette Schmitt-Graeff, Dietmar Pfeifer, Antonella Catalano, Ian Frew, Michele Proietti, Bodo Grimbacher, Alla Bulashevska, Ami S Bhatt, Tilman Brummer, Till Sebastian Clauditz, Tatjana Zabelina, Nicolaus K
Published in: Blood, 2020, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020005957

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author(s): Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut
Published in: Nature Medicine, Issue 24/3, 2018, Page(s) 282-291, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4484

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Author(s): Jan Hülsdünker, Katja J. Ottmüller, Hannes P. Neeff, Motoko Koyama, Zhan Gao, Oliver S. Thomas, Marie Follo, Ali Al-Ahmad, Gabriele Prinz, Sandra Duquesne, Heide Dierbach, Susanne Kirschnek, Tim Lämmermann, Martin J. Blaser, Brian T. Fife, Bruce R. Blazar, Andreas Beilhack, Geoffrey R. Hill, Georg Häcker, Robert Zeiser
Published in: Blood, Issue 131/16, 2018, Page(s) 1858-1869, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2017-10-812891

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

Author(s): N Stickel, K Hanke, D Marschner, G Prinz, M Köhler, W Melchinger, D Pfeifer, A Schmitt-Graeff, T Brummer, A Heine, P Brossart, D Wolf, N von Bubnoff, J Finke, J Duyster, J Ferrara, U Salzer, R Zeiser
Published in: Leukemia, Issue 31/12, 2017, Page(s) 2732-2741, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2017.137

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Author(s): Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O’Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark Bartholomä, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dier
Published in: Science Translational Medicine, Issue 10/429, 2018, Page(s) eaam7729, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam7729

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Author(s): A. Schonle, F. A. Hartl, J. Mentzel, T. Noltner, K. S. Rauch, A. Prestipino, S. A. Wohlfeil, P. Apostolova, A.-K. Hechinger, W. Melchinger, K. Fehrenbach, M. C. Guadamillas, M. Follo, G. Prinz, A.-K. Ruess, D. Pfeifer, M. Angel del Pozo, A. Schmitt-Graeff, J. Duyster, K. I. Hippen, B. R. Blazar, K. Schachtrup, S. Minguet, R. Zeiser
Published in: Blood, Issue 127/15, 2016, Page(s) 1930-1939, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2015-09-672428

"Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression"

Author(s): Hana Andrlová, Justin Mastroianni, Josef Madl, Johannes S. Kern, Wolfgang Melchinger, Heide Dierbach, Florian Wernet, Marie Follo, Kristin Technau-Hafsi, Cristina Has, Venugopal Rao Mittapalli, Marco Idzko, Ricarda Herr, Tilman Brummer, Hendrik Ungefroren, Hauke Busch, Melanie Boerries, Andreas Narr, Gabriele Ihorst, Claire Vennin, Annette Schmitt-Graeff, Susana Minguet, Paul Timpson, Justus Duys
Published in: Oncotarget, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.17160