European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates

Deliverables

Websites, patent fillings, videos etc. (3)

Draft EHVA dissemination and exploitation plan

The Exploitation Plan will outline how EHVA results will be further exploited beyond project lifespan for the use by the field, and to accelerate the development of promising vaccine candidates through engaging with the EDCTP and/or IMI and other donors and partners .

First EHVA newsletter and fact sheet developed and published

Public newsletter and a multilingual fact sheet on the consortium and the project

EHVA website and branding launched

Public website online. EHVA Graphic identity and tools

Documents, reports (1)

Posting EHVA-T-1 results in the study registry

Posting EHVA-T-1 trial results on the study registry

Publications

Peer reviewed articles (24)

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA

Author(s): Cynthia Lungu, Riddhima Banga, Rob A. Gruters, Francesco A. Procopio
Published in: Frontiers in Microbiology, Issue 12, 2021, ISSN 1664-302X
DOI: 10.3389/fmicb.2021.686690

Comparison of Safety and Vector-Specific Immune Responses in Healthy and HIV-Infected Populations Vaccinated with MVA-B

Author(s): Elvira Couto, Vicenç Diaz-Brito, Beatriz Mothe, Alberto C. Guardo, Irene Fernandez, Ainoa Ugarte, Flor Etcheverry, Carmen E. Gómez, Mariano Esteban, Judit Pich, Joan Albert Arnaiz, Juan Carlos López Bernaldo de Quirós, Christian Brander, Montserrat Plana, Felipe García, Lorna Leal
Published in: Vaccines, Issue 7/4, 2019, Page(s) 178, ISSN 2076-393X
DOI: 10.3390/vaccines7040178

Multi-arm, multi-stage randomised controlled trials for evaluating therapeutic HIV cure interventions

Author(s): Cecilia L Moore, Wolfgang Stöhr, Angela M Crook, Laura Richert, Jean-Daniel Leliévre, Giuseppe Pantaleo, Felipe García, Stefano Vella, Yves Lévy, Rodolphe Thiébaut, Sheena McCormack
Published in: The Lancet HIV, Issue 6/5, 2019, Page(s) e334-e340, ISSN 2352-3018
DOI: 10.1016/s2352-3018(19)30082-7

Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

Author(s): David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf Wagner
Published in: Vaccines, Issue 9/6, 2021, Page(s) 642, ISSN 2076-393X
DOI: 10.3390/vaccines9060642

Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

Author(s): Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
DOI: 10.1038/s41467-021-22608-z

Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost

Author(s): Agricola Joachim, Mohamed I. M. Ahmed, Georgios Pollakis, Lisa Rogers, Verena S. Hoffmann, Patricia Munseri, Said Aboud, Eligius F. Lyamuya, Muhammad Bakari, Merlin L. Robb, Britta Wahren, Eric Sandstrom, Charlotta Nilsson, Gunnel Biberfeld, Christof Geldmacher, Kathrin Held
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00719

Non-Neutralizing Antibodies Directed against HIV and Their Functions

Author(s): Luzia M. Mayr, Bin Su, Christiane Moog
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.01590

NK cell immune responses differ after prime and boost vaccination

Author(s): Jean‐Louis Palgen, Nicolas Tchitchek, Nicolas Huot, Jamila Elhmouzi‐Younes, Cécile Lefebvre, Pierre Rosenbaum, Nathalie Dereuddre‐Bosquet, Frédéric Martinon, Hakim Hocini, Antonio Cosma, Michaela Müller‐Trutwin, Yves Lévy, Roger Grand, Anne‐Sophie Beignon
Published in: Journal of Leukocyte Biology, Issue 105/5, 2019, Page(s) 1055-1073, ISSN 0741-5400
DOI: 10.1002/jlb.4a1018-391rr

Effective HIV vaccine

Author(s): Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 191-194, ISSN 1746-630X
DOI: 10.1097/coh.0000000000000371

Dürfen wir noch auf eine HIV-Impfung hoffen?

Author(s): Ralf Wagner, Benedikt Asbach
Published in: MMW - Fortschritte der Medizin, Issue 160/S2, 2018, Page(s) 24-27, ISSN 1438-3276
DOI: 10.1007/s15006-018-0649-z

Particle-based delivery of the HIV envelope protein

Author(s): Benedikt Asbach, Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 265-271, ISSN 1746-630X
DOI: 10.1097/coh.0000000000000366

Guiding the long way to broad HIV neutralization

Author(s): David Peterhoff, Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 257-264, ISSN 1746-630X
DOI: 10.1097/coh.0000000000000356

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

Author(s): Max Medina-Ramírez, Rogier W. Sanders, Quentin J. Sattentau
Published in: Current Opinion in HIV and AIDS, 2017, Page(s) 1, ISSN 1746-630X
DOI: 10.1097/COH.0000000000000363

Guiding the long way to neutralization

Author(s): Peterhoff D, Wagner R
Published in: Current Oppinion in HIV and AIDS, 2017, ISSN 1746-630X

Particle-based delivery of the HIV envelope protein

Author(s): Asbach B, Wagner R
Published in: Current Oppinion in HIV and AIDS, 2017, ISSN 1746-630X

Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis

Author(s): Melanie Wittner, Veronika Schlicker, Jana Libera, Jan-Hendrik Bockmann, Thomas Horvatits, Oliver Seiz, Silke Kummer, Carolin F. Manthey, Anja Hüfner, Marcus Kantowski, Thomas Rösch, Olaf Degen, Samuel Huber, Johanna M. Eberhard, Julian Schulze zur Wiesch
Published in: PLOS ONE, Issue 14/7, 2019, Page(s) e0220008, ISSN 1932-6203
DOI: 10.1371/journal.pone.0220008

A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses

Author(s): Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Gómez
Published in: Viruses, Issue 11/2, 2019, Page(s) 160, ISSN 1999-4915
DOI: 10.3390/v11020160

The Envelope-Based Fusion Antigen GP120C14K Forming Hexamer-Like Structures Triggers T Cell and Neutralizing Antibody Responses Against HIV-1

Author(s): Suresh C. Raman, Ernesto Mejías-Pérez, Carmen E. Gomez, Juan García-Arriaza, Beatriz Perdiguero, Aneesh Vijayan, Mar Pérez-Ruiz, Ana Cuervo, César Santiago, Carlos Oscar S. Sorzano, Cristina Sánchez-Corzo, Christiane Moog, Judith A. Burger, Anna Schorcht, Rogier W. Sanders, José L. Carrascosa, Mariano Esteban
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02793

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

Author(s): Beatriz Perdiguero, Carmen Elena Gómez, Juan García-Arriaza, Cristina Sánchez-Corzo, Carlos Óscar S. Sorzano, Sarah Wilmschen, Dorothee von Laer, Benedikt Asbach, Christina Schmalzl, David Peterhoff, Song Ding, Ralf Wagner, Janine Kimpel, Yves Levy, Giuseppe Pantaleo, Mariano Esteban
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02941

An MVA Vector Expressing HIV-1 Envelope under the Control of a Potent Vaccinia Virus Promoter as a Promising Strategy in HIV/AIDS Vaccine Design

Author(s): Patricia Pérez, María Q. Marín, Adrián Lázaro-Frías, Carlos Óscar S. Sorzano, Mauro Di Pilato, Carmen E. Gómez, Mariano Esteban, Juan García-Arriaza
Published in: Vaccines, Issue 7/4, 2019, Page(s) 208, ISSN 2076-393X
DOI: 10.3390/vaccines7040208

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Author(s): Yuka Nadai, Kathrin Held, Sarah Joseph, Mohamed I. M. Ahmed, Verena S. Hoffmann, David Peterhoff, Marco Missanga, Asli Bauer, Agricola Joachim, Ulf Reimer, Johannes Zerweck, Sheena McCormack, Alethea V. Cope, Roger Tatoud, Robin J. Shattock, Merlin Lee Robb, Eric G. Sandstroem, Michael Hoelscher, Leonard Maboko, Muhammad Bakari, Arne Kroidl, Ralf Wagner, Jonathan Weber, Georgios Pollakis, Christof
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.00717

Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector

Author(s): C. Bresk, Tamara Hofer, Sarah Wilmschen, Marina Krismer, Anja Beierfuß, Grégory Effantin, Winfried Weissenhorn, Michael Hogan, Andrea Jordan, Rebecca Gelman, David Montefiori, Hua-Xin Liao, Joern Schmitz, Barton Haynes, Dorothee von Laer, Janine Kimpel
Published in: Viruses, Issue 11/2, 2019, Page(s) 159, ISSN 1999-4915
DOI: 10.3390/v11020159

Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV

Author(s): Sarah Wilmschen, Joern E. Schmitz, Janine Kimpel
Published in: Vaccines, Issue 7/3, 2019, Page(s) 119, ISSN 2076-393X
DOI: 10.3390/vaccines7030119

Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA

Author(s): Cynthia Lungu, Francesco A. Procopio, Ronald J. Overmars, Rob J. J. Beerkens, Jolanda J. C. Voermans, Shringar Rao, Henrieke A. B. Prins, Casper Rokx, Giuseppe Pantaleo, David A. M. C. van de Vijver, Tokameh Mahmoudi, Charles A. B. Boucher, Rob A. Gruters, Jeroen J. A. van Kampen
Published in: Viruses, Issue 12/9, 2020, Page(s) 973, ISSN 1999-4915
DOI: 10.3390/v12090973

Other (2)

Induction of MPER responses by immunization with Virus-Like Particles (VLPs) carrying a Broadly Neutralizing Antibody-selected HIV-1 Envelope

Author(s): Carolina Beltrán Pavez , Amanda Fabra García , Alberto Merino , Christian Brander, Josep M. Gatell, Felipe García Eloísa Yuste and Víctor Sánchez-Merino
Published in: 2016

Effective HIV vaccine – Narrow path to broadly neutralizing antibodies (editorial)

Author(s): Ralf Wagner
Published in: 2017

Conference proceedings (4)

Identification of novel HIV-1 vaccine candidates using mammalian cell-surface display and FACS panning

Author(s): Benjamin Zimmer, Veronika Grassmann, Tim-Henrik Bruun, Thomas Schubert, Anna Gabele, Alexander Kliche and Ralf Wagner
Published in: 2016

Generation of HIV-1 new envelope immunogens with optimized antigenicity profiles

Author(s): Glögl M., Schmid V.,  Kliche A., Peterhoff D. and Wagner R
Published in: 2016

Structure guided molecular engineering of stable C-clade Env trimer scaffolds for vaccine design

Author(s): David Peterhoff, Alexandra Hauser, Iris Ganser, Ralf Wagner
Published in: 2017

Identification and characterization of trimer stabilized HIV envelope protein

Author(s): Kliche A., Koop J., Ziegler C., Peterhoff D., Asbach B., Schütz A., Schmid V. and Wagner R
Published in: 2016