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European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates

Objective

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines under clinical development that will be used as benchmark, and e) the liaison to a number of African leading scientists/programs which will foster the testing of future EHVA vaccines through EDCTP

Field of science

  • /natural sciences/biological sciences/molecular biology/structural biology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-PHC-2015-single-stage_RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 2 123 534,48

Participants (40)

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 0
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SANOFI PASTEUR SA
France
EU contribution
€ 85 000
Address
Avenue Pont Pasteur, 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 915 038,65
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE
Germany
EU contribution
€ 992 500
Address
Martinistrasse 52
20251 Hamburg
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 916 600
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 643 625
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 915 000
Address
Universitatsstrasse 31
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 508 246
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 0
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
EU contribution
€ 0
Address
Via Vincenzo Vela 6
6500 Bellinzona
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 616 500
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 564 977,50
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITE GRENOBLE ALPES
France
EU contribution
€ 567 637,50
Address
621 Avenue Centrale
38058 Grenoble
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 414 937,50
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Netherlands
EU contribution
€ 1 000 017,50
Address
Lange Kleiweg 161
2288 GJ Rijswijk Zh
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 365 000
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 515 000
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 414 973,75
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 310 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
STICHTING INTERNATIONAL AIDS VACCINE INITIATIVE THE NETHERLANDS
Netherlands
EU contribution
€ 90 601,98
Address
Van Diemenstraat 20, 200 Unit 48
1013 NH Amsterdam
Activity type
Other
FIT BIOTECH OY

Participation ended

Finland
EU contribution
€ 965 183,51
Address
Biokatu 8
33520 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROVACC FOUNDATION
Switzerland
EU contribution
€ 0
Address
Place Saint-francois 1 Etude Kellerhals Carrard
1003 Lausanne
Activity type
Other
FRED HUTCHINSON CANCER RESEARCH CENTER NON PROFIT CORPORATION
United States
EU contribution
€ 350 000
Address
Fairview Avenue 1100
98109 Seattle Wa
Activity type
Research Organisations
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 707 842
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
UNIVERSITAET BERN
Switzerland
EU contribution
€ 0
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
JANSSEN VACCINES & PREVENTION BV
Netherlands
EU contribution
€ 84 845
Address
Archimedesweg 4
2333 CN Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UGANDA NATIONAL HEALTH RESEARCH ORGANISATION
Uganda
EU contribution
€ 24 985
Address
Berkeley Lane Plot 2
465 Entebbe
Activity type
Research Organisations
NATIONAL INSTITUTE FOR MEDICAL RESEARCH
Tanzania
EU contribution
€ 15 000
Address
Sokoine Luthuli Drive Ocean Road
255 Dar Es Salaam
Activity type
Research Organisations
Instituto Nacional de Saúde
Mozambique
EU contribution
€ 15 000
Address
Avenida Eduardo Mondlane 1008
Maputo
Activity type
Research Organisations
ASSOCIATION PAC-CI
Côte d’Ivoire
EU contribution
€ 15 000
Address
Chu De Trechville 18 Usac Extension 18
Abidjan
Activity type
Research Organisations
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 2 514 226
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 299 999
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
THE GENERAL HOSPITAL CORPORATION
United States
EU contribution
€ 100 000
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 149 950
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 249 963,75
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
EUROPEAN AIDS TREATMENT GROUP EV
Germany
EU contribution
€ 50 000
Address
Mettmanner Strasse 24-26
40233 Dusseldorf
Activity type
Other
INSERM TRANSFERT SA
France
EU contribution
€ 452 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTERNATIONAL AIDS VACCINE INITIATIVE INC
United States
EU contribution
€ 3 718 436,63
Address
125 Broad Street, 9Th Floor
10004 New York
Activity type
Research Organisations
CHELSEA AND WESTMINSTER HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 516 901
Address
369 Fulham Road
SW10 9NH London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)