Objective
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines under clinical development that will be used as benchmark, and e) the liaison to a number of African leading scientists/programs which will foster the testing of future EHVA vaccines through EDCTP
Fields of science
- natural sciencesbiological scienceszoologymammalogyprimatology
- medical and health sciencesbasic medicineimmunologyimmunisation
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesmolecular biologystructural biology
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
75654 Paris
France
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Participants (46)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
67081 Strasbourg
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
33000 Bordeaux
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
33404 Talence
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1011 Lausanne
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69007 Lyon
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Participation ended
08036 Barcelona
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
08036 Barcelona
20251 Hamburg
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SW7 2AZ London
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00161 Roma
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93053 Regensburg
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17177 Stockholm
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8006 Zurich
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6500 Bellinzona
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20251 Hamburg
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OX1 2JD Oxford
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38058 Grenoble
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1105AZ Amsterdam
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
1105 BP Amsterdam
2288 GJ Rijswijk Zh
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80539 Muenchen
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6020 Innsbruck
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28006 Madrid
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1015 Lausanne
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3015 GD Rotterdam
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1013 NH Amsterdam
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33520 Tampere
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1003 Lausanne
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98109 Seattle Wa
75015 Paris 15
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3012 Bern
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2333 CN Leiden
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465 Entebbe
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255 Dar Es Salaam
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Maputo
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Abidjan
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WC1E 6BT London
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L69 7ZX Liverpool
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Participation ended
02114 Boston Ma
1050 Brussel
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00149 Roma
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40237 Dusseldorf
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75013 Paris
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10004 New York
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SW10 9NH London
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1228 Plan Les Ouates
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