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Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome

Publications

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

Author(s): Anna Lopatina Nitzan Tal, Rotem Sorek
Published in: Annual Review of Virology, 2020, ISSN 2327-056X
Publisher: Annual Reviews
DOI: 10.1146/annurev-virology-011620-040628

Prokaryotic viperins produce diverse antiviral molecules

Author(s): Aude Bernheim , Adi Millman, Gal Ofir , Gilad Meitav , Carmel Avraham , Helena Shomar , Masha M Rosenberg , Nir Tal , Sarah Melamed , Gil Amitai , Rotem Sorek
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2762-2

DISARM is a widespread bacterial defence system with broad anti-phage activities

Author(s): Gal Ofir, Sarah Melamed, Hila Sberro, Zohar Mukamel, Shahar Silverman, Gilad Yaakov, Shany Doron, Rotem Sorek
Published in: Nature Microbiology, 3/1, 2018, Page(s) 90-98, ISSN 2058-5276
Publisher: Macmillan Publishers Limited, part of Springer Nature
DOI: 10.1038/s41564-017-0051-0

Communication between viruses guides lysis–lysogeny decisions

Author(s): Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai, Rotem Sorek
Published in: Nature, 541/7638, 2017, Page(s) 488-493, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature21049

Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array

Author(s): Moran G. Goren, Shany Doron, Rea Globus, Gil Amitai, Rotem Sorek, Udi Qimron
Published in: Cell Reports, 16/11, 2016, Page(s) 2811-2818, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.08.043

High-resolution RNA 3′-ends mapping of bacterial Rho-dependent transcripts

Author(s): Dar, Daniel; Sorek, Rotem
Published in: Nucleic Acids Research, 1, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky274

HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance

Author(s): Mélodie Duval, Daniel Dar, Filipe Carvalho, Eduardo P. C. Rocha, Rotem Sorek, Pascale Cossart
Published in: Proceedings of the National Academy of Sciences, 115/52, 2018, Page(s) 13359-13364, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1810555115

Extensive reshaping of bacterial operons by programmed mRNA decay

Author(s): Daniel Dar, Rotem Sorek
Published in: PLOS Genetics, 14/4, 2018, Page(s) e1007354, ISSN 1553-7404
Publisher: PLoS
DOI: 10.1371/journal.pgen.1007354

Systematic discovery of antiphage defense systems in the microbial pangenome

Author(s): Shany Doron, Sarah Melamed, Gal Ofir, Azita Leavitt, Anna Lopatina, Mai Keren, Gil Amitai, Rotem Sorek
Published in: Science, 359/6379, 2018, Page(s) eaar4120, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar4120

Bacterial Retrons Function In Anti-Phage Defense

Author(s): Adi Millman , Aude Bernheim , Avigail Stokar-Avihail , Taya Fedorenko , Maya Voichek , Azita Leavitt, Yaara Oppenheimer-Shaanan, Rotem Sorek
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.065

Widespread utilization of peptide communication in phages infecting soil and pathogenic bacteria

Author(s): Avigail Stokar-Avihail, Nitzan Tal, Zohar Erez, Anna Lopatina, Rotem Sorek
Published in: Cell Host and Microbe, 2019, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.03.017

Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts

Author(s): Daniel Dar, Rotem Sorek
Published in: mbio, 2018, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01730-18

STING cyclic dinucleotide sensing originated in bacteria

Author(s): Benjamin R Morehouse , Apurva A Govande , Adi Millman , Alexander F A Keszei , Brianna Lowey , Gal Ofir , Sichen Shao , Rotem Sorek , Philip J Kranzusch
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2719-5

Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

Author(s): Adi Millman, Sarah Melamed, Gil Amitai, Rotem Sorek
Published in: Nature Microbiology, 2020, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-020-0777-y

Cyclic GMP–AMP signalling protects bacteria against viral infection

Author(s): Daniel Cohen, Sarah Melamed, Adi Millman, Gabriela Shulman, Yaara Oppenheimer-Shaanan, Assaf Kacen, Shany Doron, Gil Amitai, Rotem Sorek
Published in: Nature, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1605-5

The pan-immune system of bacteria: antiviral defence as a community resource

Author(s): Aude Bernheim, Rotem Sorek
Published in: Nature Reviews Microbiology, 2020, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-019-0278-2