Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome

Project Information

PhageResist

Grant agreement ID: 681203

DOI

10.3030/681203

Project closed

EC signature date 27 March 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

Author(s): Anna Lopatina Nitzan Tal, Rotem Sorek
Published in: Annual Review of Virology, 2020, ISSN 2327-056X
Publisher: Annual Reviews
DOI: 10.1146/annurev-virology-011620-040628

Prokaryotic viperins produce diverse antiviral molecules

Author(s): Aude Bernheim , Adi Millman, Gal Ofir , Gilad Meitav , Carmel Avraham , Helena Shomar , Masha M Rosenberg , Nir Tal , Sarah Melamed , Gil Amitai , Rotem Sorek
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2762-2

DISARM is a widespread bacterial defence system with broad anti-phage activities

Author(s): Gal Ofir, Sarah Melamed, Hila Sberro, Zohar Mukamel, Shahar Silverman, Gilad Yaakov, Shany Doron, Rotem Sorek
Published in: Nature Microbiology, Issue 3/1, 2018, Page(s) 90-98, ISSN 2058-5276
Publisher: Macmillan Publishers Limited, part of Springer Nature
DOI: 10.1038/s41564-017-0051-0

Communication between viruses guides lysis–lysogeny decisions

Author(s): Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai, Rotem Sorek
Published in: Nature, Issue 541/7638, 2017, Page(s) 488-493, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature21049

Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array

Author(s): Moran G. Goren, Shany Doron, Rea Globus, Gil Amitai, Rotem Sorek, Udi Qimron
Published in: Cell Reports, Issue 16/11, 2016, Page(s) 2811-2818, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.08.043

High-resolution RNA 3′-ends mapping of bacterial Rho-dependent transcripts

Author(s): Dar, Daniel; Sorek, Rotem
Published in: Nucleic Acids Research, Issue 1, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky274

HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance

Author(s): Mélodie Duval, Daniel Dar, Filipe Carvalho, Eduardo P. C. Rocha, Rotem Sorek, Pascale Cossart
Published in: Proceedings of the National Academy of Sciences, Issue 115/52, 2018, Page(s) 13359-13364, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1810555115

Extensive reshaping of bacterial operons by programmed mRNA decay

Author(s): Daniel Dar, Rotem Sorek
Published in: PLOS Genetics, Issue 14/4, 2018, Page(s) e1007354, ISSN 1553-7404
Publisher: PLoS
DOI: 10.1371/journal.pgen.1007354

Systematic discovery of antiphage defense systems in the microbial pangenome

Author(s): Shany Doron, Sarah Melamed, Gal Ofir, Azita Leavitt, Anna Lopatina, Mai Keren, Gil Amitai, Rotem Sorek
Published in: Science, Issue 359/6379, 2018, Page(s) eaar4120, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar4120

Bacterial Retrons Function In Anti-Phage Defense

Author(s): Adi Millman , Aude Bernheim , Avigail Stokar-Avihail , Taya Fedorenko , Maya Voichek , Azita Leavitt, Yaara Oppenheimer-Shaanan, Rotem Sorek
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.065

Widespread utilization of peptide communication in phages infecting soil and pathogenic bacteria

Author(s): Avigail Stokar-Avihail, Nitzan Tal, Zohar Erez, Anna Lopatina, Rotem Sorek
Published in: Cell Host and Microbe, 2019, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.03.017

Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts

Author(s): Daniel Dar, Rotem Sorek
Published in: mbio, 2018, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01730-18

STING cyclic dinucleotide sensing originated in bacteria

Author(s): Benjamin R Morehouse , Apurva A Govande , Adi Millman , Alexander F A Keszei , Brianna Lowey , Gal Ofir , Sichen Shao , Rotem Sorek , Philip J Kranzusch
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2719-5

Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

Author(s): Adi Millman, Sarah Melamed, Gil Amitai, Rotem Sorek
Published in: Nature Microbiology, 2020, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-020-0777-y

Cyclic GMP–AMP signalling protects bacteria against viral infection

Author(s): Daniel Cohen, Sarah Melamed, Adi Millman, Gabriela Shulman, Yaara Oppenheimer-Shaanan, Assaf Kacen, Shany Doron, Gil Amitai, Rotem Sorek
Published in: Nature, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1605-5

The pan-immune system of bacteria: antiviral defence as a community resource

Author(s): Aude Bernheim, Rotem Sorek
Published in: Nature Reviews Microbiology, 2020, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-019-0278-2