Epithelial cell sheets as engineering materials: mechanics, resilience and malleability

Project Information

EpiMech

Grant agreement ID: 681434

DOI

10.3030/681434

Project closed

EC signature date 27 May 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 989 875,00

EU contribution

€ 1 989 875,00

Coordinated by

UNIVERSITAT POLITECNICA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Measuring mechanical stress in living tissues

Author(s): Manuel Gómez-González, Ernest Latorre, Marino Arroyo, Xavier Trepat
Published in: Nature Reviews Physics, Issue 2, 2020, Page(s) 300–317, ISSN 2522-5820
Publisher: Nature Portfolio
DOI: 10.1038/s42254-020-0184-6

The 2019 motile active matter roadmap

Author(s): Gompper, G; Winkler, RG; Speck, T; Solon, A; Nardini, C; Peruani, F; Loewen, H; Golestanian, R; Kaupp, UB; Alvarez, L; Kioerboe, T; Lauga, E; Poon, W; de Simone, A; Cichos, F; Fischer, A; Landin, SM; Soeker, N; Kapral, R; Gaspard, P; Ripoll, M; Sagues, F; Yeomans, Julia; Doostmohammadi, A; Aronson, I; Bechinger, C; Stark, H; Hemelrijk, C; Nedelec, F; Sarkar, T; Aryaksama, T; Lacroix, M; Duclos, G;
Published in: Journal of Physics: Condensed Matter, Issue 09538984, 2020, Page(s) 193001, ISSN 0953-8984
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-648x/ab6348

Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking

Author(s): Dimitri Kaurin; Pradeep K. Bal; Marino Arroyo
Published in: Journal of the Royal Society Interface, Issue 17425689, 2022, Page(s) 20220183, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2022.0183

A physical mechanism of TANGO1-mediated bulky cargo export

Author(s): Ishier Raote, Morgan Chabanon, Nikhil Walani, Marino Arroyo, Maria F Garcia-Parajo, Vivek Malhotra, Felix Campelo
Published in: eLife, Issue 2050084X, 2020, Page(s) e59426, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59426

Morphable structures from unicellular organisms with active, shape-shifting envelopes: Variations on a theme by Gauss

Author(s): Giancarlo Cicconofri, Marino Arroyo, Giovanni Noselli, Antonio DeSimone
Published in: International Journal of Non-Linear Mechanics, Issue 00207462, 2020, Page(s) 103278, ISSN 0020-7462
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ijnonlinmec.2019.103278

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds.

Author(s): Dimitri Kaurin; Marino Arroyo
Published in: Physical Review Letters, Issue 00319007, 2019, Page(s) 228102, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.123.228102

A theory for the flow of chemically responsive polymer solutions: Equilibrium and shear-induced phase separation

Author(s): Marco de Corato; Marino Arroyo
Published in: Journal of Rheology, Issue 01486055, 2022, Page(s) 813, ISSN 0148-6055
Publisher: Society of Rheology
DOI: 10.1122/8.0000475

Spontaneous polarization and locomotion of an active particle with surface-mobile enzymes

Author(s): Marco De Corato; Ignacio Pagonabarraga; Loai K. E. A. Abdelmohsen; Samuel Sanchez; Marino Arroyo
Published in: Physical Review Fluids, Issue 2469990X, 2020, Page(s) 122001(R), ISSN 2469-990X
Publisher: American Physical Society
DOI: 10.1103/physrevfluids.5.122001

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Author(s): Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs
Published in: Nature Communications, Issue 20411723, 2021, Page(s) 6550, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Author(s): Hiroshi Noguchi; Caterina Tozzi; Marino Arroyo
Published in: Soft Matter, Issue 1744683X, 2022, Page(s) 3384-3394, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm00274d

Approximation of tensor fields on surfaces of arbitrary topology based on local Monge parametrizations

Author(s): Alejandro Torres-Sánchez; Daniel Santos-Oliván; Marino Arroyo
Published in: Journal of Computational Physics, Issue 405, 2020, Page(s) 109168, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2019.109168

Hydraulic fracturing in cells and tissues: fracking meets cell biology

Author(s): Marino Arroyo, Xavier Trepat
Published in: Current Opinion in Cell Biology, Issue 44, 2017, Page(s) 1-6, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2016.11.001

Active superelasticity in three-dimensional epithelia of controlled shape

Author(s): Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gómez-González, Marina Uroz, Léo Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Aránzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Published in: Nature, Issue 563/7730, 2018, Page(s) 203-208, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0671-4

Smart helical structures inspired by the pellicle of euglenids

Author(s): Giovanni Noselli, Marino Arroyo, Antonio DeSimone
Published in: Journal of the Mechanics and Physics of Solids, Issue 123, 2019, Page(s) 234-246, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2018.09.036

A variational model of fracture for tearing brittle thin sheets

Author(s): Bin Li, Daniel Millán, Alejandro Torres-Sánchez, Benoît Roman, Marino Arroyo
Published in: Journal of the Mechanics and Physics of Solids, Issue 119, 2018, Page(s) 334-348, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2018.06.022

Swimming Euglena respond to confinement with a behavioural change enabling effective crawling

Author(s): Giovanni Noselli, Alfred Beran, Marino Arroyo, Antonio DeSimone
Published in: Nature Physics, Issue 15, 2019, Page(s) 496–502, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-019-0425-8

Modelling fluid deformable surfaces with an emphasis on biological interfaces

Author(s): Alejandro Torres-Sánchez, Daniel Millán, Marino Arroyo
Published in: Journal of Fluid Mechanics, Issue 872, 2019, Page(s) 218-271, ISSN 0022-1120
Publisher: Cambridge University Press
DOI: 10.1017/jfm.2019.341

The plasma membrane as a mechanochemical transducer

Author(s): Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1779, 2019, Page(s) 20180221, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0221

Combined molecular/continuum modeling reveals the role of friction during fast unfolding of coiled-coil proteins

Author(s): Alejandro Torres-Sánchez, Juan M. Vanegas, Prashant K. Purohit, Marino Arroyo
Published in: Soft Matter, Issue 15/24, 2019, Page(s) 4961-4975, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sm00117d

Embryonic self-fracking

Author(s): Marino Arroyo, Xavier Trepat
Published in: Science, Issue 365/6452, 2019, Page(s) 442-443, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay2860

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins

Author(s): Caterina Tozzi, Nikhil Walani, Marino Arroyo
Published in: New Journal of Physics, Issue 21/9, 2019, Page(s) 093004, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3ad6

Self-Propulsion of Active Colloids via Ion Release: Theory and Experiments

Author(s): Marco De Corato, Xavier Arqué, Tania Patiño, Marino Arroyo, Samuel Sánchez, and Ignacio Pagonabarraga
Published in: Physical Review Letters, Issue 124, 2020, Page(s) 108001, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.124.108001

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature.

Author(s): Caterina Tozzi; Nikhil Walani; Anabel-Lise Le Roux; Pere Roca-Cusachs; Marino Arroyo
Published in: Soft Matter, Issue 1744683X, 2021, Page(s) 3367-3379, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm01733g

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Author(s): Carlos Pérez-González, Gerardo Ceada, Francesco Greco, Marija Matejčić, Manuel Gómez-González, Natalia Castro, Anghara Menendez, Sohan Kale, Denis Krndija, Andrew G. Clark, Venkata Ram Gannavarapu, Adrián Álvarez-Varela, Pere Roca-Cusachs, Eduard Batlle, Danijela Matic Vignjevic, Marino Arroyo, Xavier Trepat
Published in: Nature Cell Biology, Issue 23, 2021, Page(s) 745–757, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

Mechanics of axisymmetric sheets of interlocking and slidable rods

Author(s): Davide Riccobelli; Giovanni Noselli; Marino Arroyo; Antonio DeSimone; Antonio DeSimone
Published in: Journal of the Mechanics and Physics of Solids, Issue 00225096, 2020, Page(s) 103969, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2020.103969

Thesis and dissertations (4)

Active superelasticity in three-dimensional epithelia of controlled shape

Author(s): Ernest Latorre
Published in: 2021
Publisher: UPC

A THEORETICAL AND COMPUTATIONAL STUDY OF THE MECHANICS OF BIOMEMBRANES AT MULTIPLE SCALES

Author(s): Alejandro Torres-Sanchez
Published in: 2017
Publisher: UPC

A theoretical and computational study of soft adhesion mediated by mobile binders

Author(s): Dimitri Kaurin
Published in: 2018
Publisher: Universitat Politècnica de Catalunya

A theoretical and computational study of the interaction between biomembranes and curved proteins

Author(s): Caterina Tozzi
Published in: 2021
Publisher: UPC

Book chapters (1)

Onsager’s Variational Principle in Soft Matter: Introduction and Application to the Dynamics of Adsorption of Proteins onto Fluid Membranes

Author(s): Marino Arroyo, Nikhil Walani, Alejandro Torres-Sánchez, Dimitri Kaurin
Published in: Mechanics and Physics of Lipid Bilayers, 2018, Page(s) 287-332, ISBN 978-3-319-56348-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-56348-0_6

Intellectual Property Rights

Patent (1)

MORPHABLE SHEET STRUCTURE

Application/Publication number: 20 19081739
Date: 2019-11-19
Applicant(s): UNIVERSITAT POLITECNICA DE CATALUNYA