Molecular dissection of the mechanisms of cell-cell fusion in the fission yeast

Project Information

CELLFUSION

Grant agreement ID: 681505

DOI 10.3030/681505

Project closed

EC signature date 2 May 2016

Start date 1 October 2016

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 955,99

EU contribution € 1 999 955,99

Coordinated by

UNIVERSITE DE LAUSANNE
Switzerland

Publications

Peer reviewed articles (16)

Molecular mechanisms of chemotropism and cell fusion in unicellular fungi

Author(s): Sophie G Martin
Published in: Journal of Cell Science, 2019, ISSN 1477-9137
Publisher: The Company of Biologists
DOI: 10.1242/jcs.230706

Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion

Author(s): Olivia Muriel, Laetitia Michon, Wanda Kukulski, Sophie G Martin
Published in: Journal of Cell Biology, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202103142

Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition

Author(s): Magdalena Marek, Vincent Vincenzetti, Sophie G. Martin
Published in: Journal of Cell Biology, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202001147

Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast

Author(s): Iker Lamas, Nathalie Weber, Sophie G Martin
Published in: Cells, 2020, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9092089

Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance

Author(s): Aleksandar Vještica, Melvin Bérard, Gaowen Liu, Laura Merlini, Pedro Junior Nkosi, Sophie G Martin
Published in: PLoS Biology, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001067

A focus on yeast mating: From pheromone signaling to cell-cell fusion

Author(s): Boris Sieber, Julia María Coronas-Serna, Sophie G Martin
Published in: Seminars in Cell and Developmental Biology, 2022, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2022.02.003

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Author(s): Iker Lamas , Laura Merlini , Aleksandar Vještica , Vincent Vincenzetti , Sophie G Martin
Published in: PLoS Biology, 2020, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3000600

Cell patterning by secretion-induced plasma membrane flows

Author(s): Veneta Gerganova, Iker Lamas, David M Rutkowski, Aleksandar Vještica, Daniela Gallo Castro, Vincent Vincenzetti, Dimitrios Vavylonis, Sophie G Martin
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abg6718

A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion

Author(s): Omaya Dudin, Laura Merlini, Felipe O. Bendezú, Raphaël Groux, Vincent Vincenzetti, Sophie G. Martin
Published in: PLOS Genetics, Issue 13/4, 2017, Page(s) e1006721, ISSN 1553-7404
Publisher: PLoS Genetics
DOI: 10.1371/journal.pgen.1006721

Inhibition of Ras activity coordinates cell fusion with cell–cell contact during yeast mating

Author(s): Laura Merlini, Bita Khalili, Omaya Dudin, Laetitia Michon, Vincent Vincenzetti, Sophie G. Martin
Published in: The Journal of Cell Biology, Issue 217/4, 2018, Page(s) 1467-1483, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201708195

Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization

Author(s): Aleksandar Vještica, Laura Merlini, Pedro Junior Nkosi, Sophie G. Martin
Published in: Nature, Issue 560/7718, 2018, Page(s) 397-400, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0407-5

Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks

Author(s): Bita Khalili, Laura Merlini, Vincent Vincenzetti, Sophie G. Martin, Dimitrios Vavylonis
Published in: PLOS Computational Biology, Issue 14/7, 2018, Page(s) e1006317, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1006317

Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction

Author(s): Daniela Gallo Castro, Sophie G. Martin
Published in: The Journal of Cell Biology, Issue 217/12, 2018, Page(s) 4215-4229, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201806016

Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins

Author(s): Ingrid Billault-Chaumartin, Sophie G. Martin
Published in: Current Biology, Issue 29/19, 2019, Page(s) 3165-3176.e6, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.07.088

A toolbox of stable integration vectors in the fission yeast Schizosaccharomyces pombe

Author(s): Aleksandar Vještica, Magdalena Marek, Pedro Junior Nkosi, Laura Merlini, Gaowen Liu, Melvin Bérard, Ingrid Billault-Chaumartin, Sophie G Martin
Published in: Journal of Cell Science, 2020, ISSN 1477-9137
Publisher: The Company of Biologists
DOI: 10.1242/jcs.240754

Going with the membrane flow: the impact of polarized secretion on bulk plasma membrane flows

Author(s): Veneta Gerganova, Sophie G Martin
Published in: FEBS Journal, 2021, ISSN 1742-4658
Publisher: John Wiley & Sons
DOI: 10.1111/febs.16287

Other (2)

The actin assembly requirements of the formin Fus1 to build the fusion focus

Author(s): Ingrid Billault-Chaumartin, Laetitia Michon, Caitlin A Anderson, Sarah E Yde, Cristian Suarez, Justyna Iwaszkiewicz, Vincent Zoete, David R Kovar, Sophie G Martin
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2022.03.24.485616

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

Author(s): Ingrid Billault-Chaumartin, Olivia Muriel, Laetitia Michon, Sophie G Martin
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2022.05.05.490810