Selecting genetic lesions with essential function for patients' leukaemia in vivo as targets for precision medicine

Información del proyecto

LeukaemiaTargeted

Identificador del acuerdo de subvención: 681524

DOI

10.3030/681524

Proyecto cerrado

Fecha de la firma de la CE 25 Julio 2016

Fecha de inicio 1 Agosto 2016

Fecha de finalización 31 Julio 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 945 818,00

Aportación de la UE

€ 1 945 818,00

Coordinado por

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (35)

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Autores: Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Publicado en: Biomarker Research, Edición 8/1, 2020, ISSN 2050-7771
Editor: BioMed Central, Springer Nature
DOI: 10.1186/s40364-020-00226-z

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC specific T-cell bispecific antibody

Autores: Christian Augsberger, Gerulf Hänel, Wei Xu, Vesna Pulko, Lydia Jasmin Hanisch, Angelique Augustin, John Challier, Katharina Hunt, Binje Vick, Pier Edoardo Rovatti, Christina Krupka, Maurine Rothe, Anne Schönle, Johannes Sam, Emmanuelle Lezan, Axel Ducret, Daniela Ortiz-Franyuti, Antje-Christine Walz, Jörg Benz, Alexander Bujotzek, Felix S Lichtenegger, Christian Gassner, Alejandro Carpy, Victor
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020010477

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Autores: Basit Salik, Hangyu Yi, Nunki Hassan, Nancy Santiappillai, Binje Vick, Patrick Connerty, Alastair Duly, Toby Trahair, Andrew J. Woo, Dominik Beck, Tao Liu, Karsten Spiekermann, Irmela Jeremias, Jianlong Wang, Maria Kavallaris, Michelle Haber, Murray D. Norris, Dan A. Liebermann, Richard J. D'Andrea, Christopher Murriel, Jenny Y. Wang
Publicado en: Cancer Cell, Edición 38/2, 2020, Página(s) 263-278.e6, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2020.05.014

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Autores: Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S. Pilka, Demetrios Aspris, Dan Leggate, Alan G. Hendrick, Natalie A. Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao M. L. Dias, Andrew J. Bannister, Binje Vick, Irmela Jeremias, George S. Vassiliou, Oliver Rausch, Kon
Publicado en: Nature, Edición 593/7860, 2021, Página(s) 597-601, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03536-w

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Autores: Ali Khateb, Anagha Deshpande, Yongmei Feng, Darren Finlay, Joo Sang Lee, Ikrame Lazar, Bertrand Fabre, Yan Li, Yu Fujita, Tongwu Zhang, Jun Yin, Ian Pass, Ido Livneh, Irmela Jeremias, Carol Burian, James R. Mason, Ronit Almog, Nurit Horesh, Yishai Ofran, Kevin Brown, Kristiina Vuori, Michael Jackson, Eytan Ruppin, Aniruddha J. Deshpande, Ze’ev A. Ronai
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25664-7

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

Autores: Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Paola Romecin, Meritxell Vinyoles, Marta Palomo, Néstor Tirado, Samanta Romina Zanetti, Manel Juan, Michela Carlet, Irmela Jeremias, Pablo Menéndez
Publicado en: Clinical and Translational Medicine, Edición 11/2, 2021, ISSN 2001-1326
Editor: Wiley Online Library
DOI: 10.1002/ctm2.280

The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis

Autores: Volker C. Kirsch, Christina Orgler, Simone Braig, Irmela Jeremias, David Auerbach, Rolf Müller, Angelika M. Vollmar, Stephan A. Sieber
Publicado en: Angewandte Chemie International Edition, Edición 59/4, 2020, Página(s) 1595-1600, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911158

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Autores: Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, Sébastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Müller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries, Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier, Josée Hébert, Guy Sauvageau, Judith B. Zaugg, Frédéric Barabé, Car
Publicado en: Blood, Edición 134/3, 2019, Página(s) 263-276, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2018862383

SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells

Autores: Siret Tahk, Binje Vick, Björn Hiller, Saskia Schmitt, Anetta Marcinek, Enrico D. Perini, Alexandra Leutbecher, Christian Augsberger, Anna Reischer, Benjamin Tast, Andreas Humpe, Irmela Jeremias, Marion Subklewe, Nadja C. Fenn, Karl-Peter Hopfner
Publicado en: Journal of Hematology & Oncology, Edición 14/1, 2021, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/s13045-021-01163-6

TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition

Autores: Shiva Bamezai, Deniz Demir, Alex Jose Pulikkottil, Fabio Ciccarone, Elena Fischbein, Amit Sinha, Chiara Borga, Geertruy te Kronnie, Lüder-Hinrich Meyer, Fabian Mohr, Maria Götze, Paola Caiafa, Klaus-Michael Debatin, Konstanze Döhner, Hartmut Döhner, Irene González-Menéndez, Leticia Quintanilla-Fend, Tobias Herold, Irmela Jeremias, Michaela Feuring-Buske, Christian Buske, Vijay P. S. Rawat
Publicado en: Leukemia, Edición 35/2, 2021, Página(s) 389-403, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-020-0864-3

Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice

Autores: Sarah Ebinger, Christina Zeller, Michela Carlet, Daniela Senft, Johannes W. Bagnoli, Wen-Hsin Liu, Maja Rothenberg-Thurley, Wolfgang Enard, Klaus H. Metzeler, Tobias Herold, Karsten Spiekermann, Binje Vick, Irmela Jeremias
Publicado en: Haematologica, Edición 105/12, 2020, Página(s) 2855-2860, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.226282

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

Autores: Sarah Ebinger, Erbey Ziya Özdemir, Christoph Ziegenhain, Sebastian Tiedt, Catarina Castro Alves, Michaela Grunert, Michael Dworzak, Christoph Lutz, Virginia A. Turati, Tariq Enver, Hans-Peter Horny, Karl Sotlar, Swati Parekh, Karsten Spiekermann, Wolfgang Hiddemann, Aloys Schepers, Bernhard Polzer, Stefan Kirsch, Martin Hoffmann, Bettina Knapp, Jan Hasenauer, Heike Pfeifer, Renate Panzer-Grümaye
Publicado en: Cancer Cell, Edición 30/6, 2016, Página(s) 849-862, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2016.11.002

The target landscape of clinical kinase drugs

Autores: Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne
Publicado en: Science, Edición 358/6367, 2017, Página(s) eaan4368, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aan4368

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Autores: Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. B
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07620-0

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

Autores: K Reiter, H Polzer, C Krupka, A Maiser, B Vick, M Rothenberg-Thurley, K H Metzeler, D Dörfel, H R Salih, G Jung, E Nößner, I Jeremias, W Hiddemann, H Leonhardt, K Spiekermann, M Subklewe, P A Greif
Publicado en: Leukemia, Edición 32/2, 2017, Página(s) 313-322, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.257

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

Autores: Stefanie Göllner, Thomas Oellerich, Shuchi Agrawal-Singh, Tino Schenk, Hans-Ulrich Klein, Christian Rohde, Caroline Pabst, Tim Sauer, Mads Lerdrup, Sigal Tavor, Friedrich Stölzel, Sylvia Herold, Gerhard Ehninger, Gabriele Köhler, Kuan-Ting Pan, Henning Urlaub, Hubert Serve, Martin Dugas, Karsten Spiekermann, Binje Vick, Irmela Jeremias, Wolfgang E Berdel, Klaus Hansen, Arthur Zelent, Claudia Wi
Publicado en: Nature Medicine, Edición 23/1, 2017, Página(s) 69-78, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.4247

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC

Autores: I Tirado-Gonzalez, E Czlonka, A Nevmerzhitskaya, D Soetopo, E Bergonzani, A Mahmoud, A Contreras, I Jeremias, U Platzbecker, J P Bourquin, U Kloz, F Van der Hoeven, H Medyouf
Publicado en: Leukemia, Edición 32/4, 2017, Página(s) 1049-1052, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.346

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice

Autores: Birgitta Christine Heckl, Michela Carlet, Binje Vick, Catrin Roolf, Ameera Alsadeq, Michaela Grunert, Wen-Hsin Liu, Andrea Liebl, Wolfgang Hiddemann, Rolf Marschalek, Denis Martin Schewe, Karsten Spiekermann, Christian Junghanss, Irmela Jeremias
Publicado en: Leukemia & Lymphoma, 2018, Página(s) 1-4, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.1080/10428194.2018.1509314

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Autores: Jennifer R. Lynch, Basit Salik, Patrick Connerty, Binje Vick, Halina Leung, Aster Pijning, Irmela Jeremias, Karsten Spiekermann, Toby Trahair, Tao Liu, Michelle Haber, Murray D. Norris, Andrew J. Woo, Philip Hogg, Jianlong Wang, Jenny Y. Wang
Publicado en: Leukemia, 2019, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-018-0354-z

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in <i>FLT3</i>-ITD AML with concurrent epigenetic mutations

Autores: Anne-Kathrin Garz, Saskia Wolf, Sonja Grath, Verena Gaidzik, Stefan Habringer, Binje Vick, Martina Rudelius, Christoph Ziegenhain, Sylvia Herold, Marie-Theresa Weickert, Martha Smets, Christian Peschel, Robert A.J. Oostendorp, Sebastian Bultmann, Irmela Jeremias, Christian Thiede, Konstanze Döhner, Ulrich Keller, Katharina S. Götze
Publicado en: Oncotarget, Edición 8/65, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.21877

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics

Autores: Stefan Habringer, Constantin Lapa, Peter Herhaus, Margret Schottelius, Rouzanna Istvanffy, Katja Steiger, Julia Slotta-Huspenina, Andreas Schirbel, Heribert Hänscheid, Stefan Kircher, Andreas K. Buck, Katharina Götze, Binje Vick, Irmela Jeremias, Markus Schwaiger, Christian Peschel, Robert Oostendorp, Hans-Jürgen Wester, Götz-Ulrich Grigoleit, Ulrich Keller
Publicado en: Theranostics, Edición 8/2, 2018, Página(s) 369-383, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.21397

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

Autores: Ina-Katrin Siekmann, Kevin Dierck, Sebastian Prall, Marianne Klokow, Julia Strauss, Sophia Buhs, Antonina Wrzeszcz, Michael Bockmayr, Florian Beck, Magdalena Trochimiuk, Kristina Gottschling, Victoria Martens, Melissa Khosh-Naucke, Helwe Gerull, Jürgen Müller, Lena Behrmann, Martin Blohm, René P. Zahedi, Irmela Jeremias, Albert Sickmann, Peter Nollau, Martin A. Horstmann
Publicado en: Blood Advances, Edición 2/19, 2018, Página(s) 2554-2567, ISSN 2473-9529
Editor: Blood Journal
DOI: 10.1182/bloodadvances.2018020693

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

Autores: Sannia Sarrach, Yuanchi Huang, Sebastian Niedermeyer, Matthias Hachmeister, Laura Fischer, Sebastian Gille, Min Pan, Brigitte Mack, Gisela Kranz, Darko Libl, Juliane Merl-Pham, Stefanie M. Hauck, Elisa Paoluzzi Tomada, Matthias Kieslinger, Irmela Jeremias, Antonio Scialdone, Olivier Gires
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-20131-8

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia

Autores: Daniela Senft, Irmela Jeremias
Publicado en: Experimental Hematology, Edición 69, 2019, Página(s) 1-10, ISSN 0301-472X
Editor: Elsevier BV
DOI: 10.1016/j.exphem.2018.09.006

Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics

Autores: Fabian Koczian, Olga Nagło, Jan Vomacka, Binje Vick, Phil Servatius, Themistoklis Zisis, Britta Hettich, Uli Kazmaier, Stephan A. Sieber, Irmela Jeremias, Stefan Zahler, Simone Braig
Publicado en: Haematologica, Edición 104/3, 2019, Página(s) 546-555, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.197368

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Autores: Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25963-z

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Autores: Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq & Denis M. Schewe
Publicado en: communications biology, 2021, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-020-01591-z

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

Autores: Chenchen Pan, Oliver Schoppe, Arnaldo Parra-Damas, Ruiyao Cai, Mihail Ivilinov Todorov, Gabor Gondi, Bettina von Neubeck, Nuray Böğürcü-Seidel, Sascha Seidel, Katia Sleiman, Christian Veltkamp, Benjamin Förstera, Hongcheng Mai, Zhouyi Rong, Omelyan Trompak, Alireza Ghasemigharagoz, Madita Alice Reimer, Angel M. Cuesta, Javier Coronel, Irmela Jeremias, Dieter Saur, Amparo Acker-Palmer, Till Ac
Publicado en: Cell, Edición 179/7, 2019, Página(s) 1661-1676.e19, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.11.013

CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries

Autores: Martin Becker, Heidi Noll-Puchta, Diana Amend, Florian Nolte, Christiane Fuchs, Irmela Jeremias, Christian J Braun
Publicado en: Nucleic Acids Research, 2020, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa459

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Autores: A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Fröhlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Do
Publicado en: Nature Medicine, Edición 26/2, 2020, Página(s) 207-214, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0738-2

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Autores: Matteo Libero Baroni, Diego Sanchez Martinez, Francisco Gutierrez Aguera, Heleia Roca Ho, Maria Castella, Samanta Zanetti, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Pedro Marin, Alex Bataller, Jordi Esteve, Binje Vick, Irmela Jeremias, Angel Lopez, Marc S
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 8/1, 2019, Página(s) e000845, ISSN 2051-1426
Editor: BMJ Journals
DOI: 10.1136/jitc-2020-000845

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Autores: Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sánchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bagchi, Soheil Meshinchi, Connie Eaves, Irmela Jeremias, Torsten Haferlach, David A. Frank, Ze’ev Ronai, Sumit Chanda, Scott A. Armstrong, Peter D. Adams, Ross L. Levine, Aniruddha J. Deshpande
Publicado en: Blood, Edición 137/24, 2021, Página(s) 3403-3415, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020009023

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Autores: Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-91760-9

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR

Autores: Dana Stenger, Tanja A. Stief, Theresa Kaeuferle, Semjon Willier, Felicitas Rataj, Kilian Schober, Binje Vick, Ramin Lotfi, Beate Wagner, Thomas G. P. Grünewald, Sebastian Kobold, Dirk H. Busch, Irmela Jeremias, Franziska Blaeschke, Tobias Feuchtinger
Publicado en: Blood, Edición 136/12, 2020, Página(s) 1407-1418, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020005185

Requirement for LIM kinases in acute myeloid leukemia

Autores: Patrizia Jensen, Michela Carlet, Richard F. Schlenk, Andrea Weber, Jana Kress, Ines Brunner, Mikołaj Słabicki, Gregor Grill, Simon Weisemann, Ya-Yun Cheng, Irmela Jeremias, Claudia Scholl, Stefan Fröhling
Publicado en: Leukemia, Edición 34/12, 2020, Página(s) 3173-3185, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-020-0943-5

Other (3)

X-Linked inhibitor of apoptosis protein (XIAP) exhibits an essential role of patients' acute lymphoblastic leukemia cells growing in vivo

Autores: J. Vergalli, M. Carlet, T. Hoffmann, M. Roth, J. Zuber, I. Jeremias
Publicado en: European Journal of Cancer, Edición 69, 2016, Página(s) S58-S59, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/s0959-8049(16)32762-9

Single Cell Clones Derived from a Patient's AML Xenograft Display Genetic and Functional Heterogeneity

Autores: Christina Maria Zeller, Daniel Richter, Binje Vick, Tobias Herold, Johannes Bagnoli, Maja Rothenberg-Thurley, Klaus H. Metzeler, Karsten Spiekermann, Wolfgang Enard, Irmela Jeremias
Publicado en: Blood, Edición 134/Supplement_1, 2019, Página(s) 1450-1450, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2019-127867

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Autores: Ehsan Bahrami, Martin Becker, Anna-Katharina Wirth, Jan Phillip Schmid, Tobias Herold, Rupert Öllinger, Roland Rad, Irmela Jeremias
Publicado en: Blood, Edición 134/Supplement_1, 2019, Página(s) 3945-3945, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2019-124288

Book chapters (1)

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

Autores: Irmela Jeremias, Denis M. Schewe
Publicado en: Biological Mechanisms of Minimal Residual Disease and Systemic Cancer, Edición 1100, 2018, Página(s) 127-139, ISBN 978-3-319-97745-4
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-97746-1_8