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Pathways to Alzheimer's disease

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Publications

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Author(s): Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas Norgren, Yelverton Tegner, Niklas Mattsson, Niels Andreasen, Martin Öst, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow
Published in: Scientific Reports, 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep36791

Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports

Author(s): Pashtun Shahim, Henrik Zetterberg, Yelverton Tegner, Kaj Blennow
Published in: Neurology, 88/19, 2017, Page(s) 1788-1794, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000003912

Apolipoprotein E genotypes and longevity across dementia disorders

Author(s): Tobias Skillbäck, Ronald Lautner, Niklas Mattsson, Jonathan M. Schott, Katarina Nägga, Lena Kilander, Anders Wimo, Bengt Winblad, Maria Eriksdotter, Kaj Blennow, Henrik Zetterberg
Published in: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.02.003

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Author(s): Ronald Lautner, Philip S. Insel, Tobias Skillbäck, Bob Olsson, Mikael Landén, Giovanni B. Frisoni, Sanna-Kaisa Herukka, Harald Hampel, Anders Wallin, Lennart Minthon, Oskar Hansson, Kaj Blennow, Niklas Mattsson, Henrik Zetterberg
Published in: Alzheimer's Research & Therapy, 9/1, 2017, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-017-0313-3

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Author(s): Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan M. Landau, Victor L. Villemagne, Sebastiaan Engelborghs, Mark M. Mintun, Alberto Lleo, José Luis Molinuevo, William J. Jagust, Giovanni B. Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M. Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P. Aal
Published in: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.02.009

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Author(s): Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Luc
Published in: JAMA Psychiatry, 75/1, 2018, Page(s) 84, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2017.3391

Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment

Author(s): Shorena Janelidze, Josef Pannee, Alvydas Mikulskis, Ping Chiao, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Published in: JAMA Neurology, 74/12, 2017, Page(s) 1492, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2017.2814

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Author(s): Sebastian Palmqvist, Michael Schöll, Olof Strandberg, Niklas Mattsson, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Susan Landau, William Jagust, Oskar Hansson
Published in: Nature Communications, 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01150-x

A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease

Author(s): Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, Wiesje van der Flier, Philip Scheltens, Floor Duits, Oskar Hansson, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-13831-0

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

Author(s): Tobias Skillbäck, Louise Delsing, Jane Synnergren, Niklas Mattsson, Shorena Janelidze, Katarina Nägga, Lena Kilander, Ryan Hicks, Anders Wimo, Bengt Winblad, Oskar Hansson, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg
Published in: Neurobiology of Aging, 59, 2017, Page(s) 1-9, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.06.028

Mass Spectrometric Analysis of Cerebrospinal Fluid Ubiquitin in Alzheimer's Disease and Parkinsonian Disorders

Author(s): Simon Sjödin, Oskar Hansson, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow
Published in: PROTEOMICS - Clinical Applications, 11/11-12, 2017, Page(s) 1700100, ISSN 1862-8346
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/prca.201700100

18 F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimer's disease

Author(s): Niklas Mattsson, Michael Schöll, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Philip S Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Jonas Jögi, Kaj Blennow, Oskar Hansson
Published in: EMBO Molecular Medicine, 9/9, 2017, Page(s) 1212-1223, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201707809

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype

Author(s): Shorena Janelidze, Joakim Hertze, Katarina Nägga, Karin Nilsson, Christer Nilsson, Malin Wennström, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Oskar Hansson
Published in: Neurobiology of Aging, 51, 2017, Page(s) 104-112, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2016.11.017

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease

Author(s): Annika Öhrfelt, Ann Brinkmalm, Julien Dumurgier, Gunnar Brinkmalm, Oskar Hansson, Henrik Zetterberg, Elodie Bouaziz-Amar, Jacques Hugon, Claire Paquet, Kaj Blennow
Published in: Alzheimer's Research & Therapy, 8/1, 2016, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-016-0208-8

Reference measurement procedure for CSF amyloid beta (Aβ) 1-42 and the CSF Aβ 1-42 /Aβ 1-40 ratio - a cross-validation study against amyloid PET

Author(s): Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow
Published in: Journal of Neurochemistry, 139/4, 2016, Page(s) 651-658, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.13838

Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ

Author(s): Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg
Published in: Molecular and Cellular Neuroscience, 85, 2017, Page(s) 211-219, ISSN 1044-7431
Publisher: Academic Press
DOI: 10.1016/j.mcn.2017.10.009

Cerebrospinal fluid β-amyloid 42 and neurofilament light relate to white matter hyperintensities

Author(s): Katie E. Osborn, Dandan Liu, Lauren R. Samuels, Elizabeth E. Moore, Francis E. Cambronero, Lealani Mae Y. Acosta, Susan P. Bell, Michelle A. Babicz, Elizabeth A. Gordon, Kimberly R. Pechman, L. Taylor Davis, Katherine A. Gifford, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson
Published in: Neurobiology of Aging, 68, 2018, Page(s) 18-25, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.03.028

Molecular biomarkers of Alzheimer's disease: progress and prospects

Author(s): Tammaryn Lashley, Jonathan M. Schott, Philip Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg
Published in: Disease Models & Mechanisms, 11/5, 2018, Page(s) dmm031781, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.031781

Inhibiting the Ca 2+ Influx Induced by Human CSF

Author(s): Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Published in: Cell Reports, 21/11, 2017, Page(s) 3310-3316, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.11.057

The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics

Author(s): Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Philip Scheltens, Sebastiaan Engelborghs, Giovanni Frisoni, José Luis Molinuevo, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Alison Baird, Richard Dobson, Cristina Legido-Quigley, Kristel Sleegers, Christine Van Broeckhoven, Lars Bertram, Mara ten Kate, Frederik Barkhof, Henrik Zetterberg, Simon Lovestone, Johannes Streffer, Piete
Published in: Alzheimer's Research & Therapy, 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0396-5

Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism

Author(s): Wojciech Michno, Ibrahim Kaya, Sofie Nyström, Laurent Guerard, K. Peter R. Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder
Published in: Analytical Chemistry, 90/13, 2018, Page(s) 8130-8138, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.8b01361

Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry

Author(s): Ibrahim Kaya, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Published in: ACS Chemical Neuroscience, 2018, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.8b00121

Novel Trimodal MALDI Imaging Mass Spectrometry (IMS3) at 10 μm Reveals Spatial Lipid and Peptide Correlates Implicated in Aβ Plaque Pathology in Alzheimer’s Disease

Author(s): Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Mehmet Başkurt, Henrik Zetterberg, Kaj Blenow, Jörg Hanrieder
Published in: ACS Chemical Neuroscience, 8/12, 2017, Page(s) 2778-2790, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.7b00314

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Author(s): Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Published in: ACS Chemical Neuroscience, 8/2, 2016, Page(s) 347-355, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.6b00391

Histology-Compatible MALDI Mass Spectrometry Based Imaging of Neuronal Lipids for Subsequent Immunofluorescent Staining

Author(s): Ibrahim Kaya, Wojciech Michno, Dimitri Brinet, Yasmine Iacone, Giulia Zanni, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder
Published in: Analytical Chemistry, 89/8, 2017, Page(s) 4685-4694, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.7b00313

Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease

Author(s): Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg
Published in: Sleep, 41/5, 2018, ISSN 0161-8105
Publisher: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsy025

Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer’s disease

Author(s): Flora H. Duits, Gunnar Brinkmalm, Charlotte E. Teunissen, Ann Brinkmalm, Philip Scheltens, Wiesje M. Van der Flier, Henrik Zetterberg, Kaj Blennow
Published in: Alzheimer's Research & Therapy, 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-017-0335-x

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS

Author(s): Lenka Novakova, Avadhesh Kumar Singh, Markus Axelsson, Marcus Ståhlman, Martin Adiels, Clas Malmeström, Henrik Zetterberg, Jan Borén, Jan Lycke, Susanna L. Cardell, Maria Blomqvist
Published in: Journal of Neurochemistry, 2018, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14452

Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease

Author(s): Marthe Gurine Førland, Annika Öhrfelt, Ingvild Dalen, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Kenn Freddy Pedersen, Guido Alves, Johannes Lange
Published in: Parkinsonism & Related Disorders, 49, 2018, Page(s) 4-8, ISSN 1353-8020
Publisher: Elsevier BV
DOI: 10.1016/j.parkreldis.2018.01.018

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

Author(s): Andre Strydom, Amanda Heslegrave, Carla M. Startin, Kin Y. Mok, John Hardy, Jurgen Groet, Dean Nizetic, Henrik Zetterberg
Published in: Alzheimer's Research & Therapy, 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0367-x

Serum neurofilament light chain in progressive supranuclear palsy

Author(s): Laura Donker Kaat, Lieke H. Meeter, Wan Zheng Chiu, Shami Melhem, Agnita J.W. Boon, Kaj Blennow, Henrik Zetterberg, John C. van Swieten
Published in: Parkinsonism & Related Disorders, 2018, ISSN 1353-8020
Publisher: Elsevier BV
DOI: 10.1016/j.parkreldis.2018.06.018

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Author(s): Andreas Bjorefeldt, Sebastian Illes, Henrik Zetterberg, Eric Hanse
Published in: Frontiers in Neural Circuits, 12, 2018, ISSN 1662-5110
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncir.2018.00005

Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease

Author(s): Lena L. Law, Rachael N. Rol, Stephanie A. Schultz, Ryan J. Dougherty, Dorothy F. Edwards, Rebecca L. Koscik, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Henrik Zetterberg, Kaj Blennow, Sanjay Asthana, Mark A. Sager, Bruce P. Hermann, Sterling C. Johnson, Dane B. Cook, Ozioma C. Okonkwo
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 2018, Page(s) 188-195, ISSN 2352-8729
Publisher: Alzheimer's Association
DOI: 10.1016/j.dadm.2018.01.001

Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort

Author(s): G. G. Kovacs, U. Andreasson, V. Liman, G. Regelsberger, M. I. Lutz, K. Danics, E. Keller, H. Zetterberg, K. Blennow
Published in: European Journal of Neurology, 24/11, 2017, Page(s) 1326-e77, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.13389

Association of Changes in Plasma Neurofilament Light and Tau Levels With Anesthesia and Surgery

Author(s): Lisbeth Evered, Brendan Silbert, David A. Scott, Henrik Zetterberg, Kaj Blennow
Published in: JAMA Neurology, 75/5, 2018, Page(s) 542, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2017.4913

The use of cerebrospinal fluid biomarkers to measure change in neurodegeneration in Alzheimer’s disease clinical trials

Author(s): Bob Olsson, Jonathan M. Schott, Kaj Blennow, Henrik Zetterberg
Published in: Expert Review of Neurotherapeutics, 17/8, 2017, Page(s) 767-775, ISSN 1473-7175
Publisher: Future Drugs Ltd.
DOI: 10.1080/14737175.2017.1341311

Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia - A nested case control study

Author(s): Lina Bergman, Henrik Zetterberg, Helena Kaihola, Henrik Hagberg, Kaj Blennow, Helena Åkerud
Published in: PLOS ONE, 13/5, 2018, Page(s) e0196025, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0196025

Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series Study

Author(s): Johan Ljungqvist, Henrik Zetterberg, Marios Mitsis, Kaj Blennow, Thomas Skoglund
Published in: Journal of Neurotrauma, 34/5, 2017, Page(s) 1124-1127, ISSN 0897-7151
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/neu.2016.4496

Fluid biomarkers for mild traumatic brain injury and related conditions

Author(s): Henrik Zetterberg, Kaj Blennow
Published in: Nature Reviews Neurology, 12/10, 2016, Page(s) 563-574, ISSN 1759-4758
Publisher: Nature Publishing Group
DOI: 10.1038/nrneurol.2016.127

Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study

Author(s): M. Axelsson, M. Sjögren, O. Andersen, K. Blennow, H. Zetterberg, J. Lycke
Published in: Acta Neurologica Scandinavica, 138/2, 2018, Page(s) 143-150, ISSN 0001-6314
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ane.12927

Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer’s disease: an update

Author(s): Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm, Johan Gobom
Published in: Expert Review of Proteomics, 14/11, 2017, Page(s) 1007-1020, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1384697

Applying fluid biomarkers to Alzheimer's disease

Author(s): Henrik Zetterberg
Published in: American Journal of Physiology-Cell Physiology, 313/1, 2017, Page(s) C3-C10, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00007.2017

High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

Author(s): Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke, Susanna L. Cardell
Published in: Frontiers in Immunology, 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.00260

Review: Tau in biofluids - relation to pathology, imaging and clinical features

Author(s): H. Zetterberg
Published in: Neuropathology and Applied Neurobiology, 43/3, 2017, Page(s) 194-199, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12378

Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals

Author(s): Albert M. Anderson, Jeffrey L. Lennox, Mark M. Mulligan, David W. Loring, Henrik Zetterberg, Kaj Blennow, Cari Kessing, Rajeth Koneru, Kirk Easley, William R. Tyor
Published in: Journal of NeuroVirology, 23/1, 2017, Page(s) 106-112, ISSN 1355-0284
Publisher: Springer Verlag
DOI: 10.1007/s13365-016-0466-z

Neurofilament light protein in blood predicts regional atrophy in Huntington disease

Author(s): Eileanoir B. Johnson, Lauren M. Byrne, Sarah Gregory, Filipe B. Rodrigues, Kaj Blennow, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Henrik Zetterberg, Sarah J. Tabrizi, Rachael I. Scahill, Edward J. Wild
Published in: Neurology, 90/8, 2018, Page(s) e717-e723, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000005005

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

Author(s): Lauren M Byrne, Filipe B Rodrigues, Kaj Blennow, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Rachael I Scahill, Sarah J Tabrizi, Henrik Zetterberg, Douglas Langbehn, Edward J Wild
Published in: The Lancet Neurology, 16/8, 2017, Page(s) 601-609, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/S1474-4422(17)30124-2

Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington’s Disease

Author(s): Filipe Brogueira Rodrigues, Lauren M. Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Henrik Zetterberg, Edward J. Wild
Published in: PLOS ONE, 11/9, 2016, Page(s) e0163479, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0163479

Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease

Author(s): Filipe Brogueira Rodrigues, Lauren Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Blair R. Leavitt, Henrik Zetterberg, Edward J. Wild
Published in: Journal of Neurochemistry, 139/1, 2016, Page(s) 22-25, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.13719

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Author(s): Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, Jamie Toombs, Henrietta Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, Tilo Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, Selina Wray, Henrik Zetterberg
Published in: Scientific Reports, 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep29200

Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy

Author(s): Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Published in: Cerebral Cortex, 2017, Page(s) 1-11, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhx157

Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study

Author(s): Andreas Pikwer, Markus Castegren, Sijal Namdar, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson
Published in: Journal of Neuroinflammation, 14/1, 2017, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-017-0950-2

Alzheimer's disease markers in the aged sheep ( Ovis aries )

Author(s): Suzanne J. Reid, Natasha E. Mckean, Kristen Henty, Erik Portelius, Kaj Blennow, Skye R. Rudiger, C. Simon Bawden, Renee R. Handley, Paul J. Verma, Richard L.M. Faull, Henry J. Waldvogel, Henrik Zetterberg, Russell G. Snell
Published in: Neurobiology of Aging, 58, 2017, Page(s) 112-119, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.06.020

Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus

Author(s): A. Jeppsson, Mikko Höltta, H. Zetterberg, K. Blennow, C. Wikkelsø, Mats Tullberg
Published in: Fluids and Barriers of the CNS, 13/1, 2016, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-016-0037-y

Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

Author(s): Ulf Andreasson, Kaj Blennow, Henrik Zetterberg
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 3, 2016, Page(s) 98-102, ISSN 2352-8729
Publisher: Alzheimer´s Association
DOI: 10.1016/j.dadm.2016.05.005

Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS

Author(s): Joakim Bergman, Ann Dring, Henrik Zetterberg, Kaj Blennow, Niklas Norgren, Jonathan Gilthorpe, Tommy Bergenheim, Anders Svenningsson
Published in: Neurology - Neuroimmunology Neuroinflammation, 3/5, 2016, Page(s) e271, ISSN 2332-7812
Publisher: American Academy of Neurology
DOI: 10.1212/NXI.0000000000000271

Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics

Author(s): N.K. Magdalinou, A.J. Noyce, R. Pinto, E. Lindstrom, J. Holmén-Larsson, M. Holtta, K. Blennow, H.R. Morris, T. Skillbäck, T.T. Warner, A.J. Lees, I. Pike, M. Ward, H. Zetterberg, J. Gobom
Published in: Parkinsonism & Related Disorders, 37, 2017, Page(s) 65-71, ISSN 1353-8020
Publisher: Elsevier BV
DOI: 10.1016/j.parkreldis.2017.01.016

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

Author(s): Bob Olsson, Ronald Lautner, Ulf Andreasson, Annika Öhrfelt, Erik Portelius, Maria Bjerke, Mikko Hölttä, Christoffer Rosén, Caroline Olsson, Gabrielle Strobel, Elizabeth Wu, Kelly Dakin, Max Petzold, Kaj Blennow, Henrik Zetterberg
Published in: The Lancet Neurology, 15/7, 2016, Page(s) 673-684, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/S1474-4422(16)00070-3

Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment

Author(s): Per Johansson, Erik G. Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Published in: PLOS ONE, 12/5, 2017, Page(s) e0176760, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0176760

Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster

Author(s): Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann-Christin Brorsson, Katarina Kågedal
Published in: The FEBS Journal, 283/19, 2016, Page(s) 3508-3522, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.13830

Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease

Author(s): Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
Published in: Scientific Reports, 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep38737

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

Author(s): Charles Arber, Jamie Toombs, Christopher Lovejoy, Natalie S. Ryan, Ross W. Paterson, Nanet Willumsen, Eleni Gkanatsiou, Erik Portelius, Kaj Blennow, Amanda Heslegrave, Jonathan M. Schott, John Hardy, Tammaryn Lashley, Nick C. Fox, Henrik Zetterberg, Selina Wray
Published in: Molecular Psychiatry, 2019, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-019-0410-8

Neurofilament light and tau as blood biomarkers for sports-related concussion

Author(s): Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kaj Blennow, Henrik Zetterberg
Published in: Neurology, 90/20, 2018, Page(s) e1780-e1788, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000005518

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

Author(s): Antoine Leuzy, Konstantinos Chiotis, Steen G. Hasselbalch, Juha O. Rinne, Alexandre de Mendonça, Markus Otto, Alberto Lleó, Miguel Castelo-Branco, Isabel Santana, Jarkko Johansson, Sarah Anderl-Straub, Christine A. F. von Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Sanna-Kaisa Herukka, Erik Portelius, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg
Published in: Brain, 139/9, 2016, Page(s) 2540-2553, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/aww160

Plasma neurofilament light chain concentration in the inherited peripheral neuropathies

Author(s): Åsa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M. Reilly, Alexander M. Rossor
Published in: Neurology, 90/6, 2018, Page(s) e518-e524, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000004932

Blood-based NfL

Author(s): Oskar Hansson, Shorena Janelidze, Sara Hall, Nadia Magdalinou, Andrew J. Lees, Ulf Andreasson, Niklas Norgren, Jan Linder, Lars Forsgren, Radu Constantinescu, Henrik Zetterberg, Kaj Blennow
Published in: Neurology, 88/10, 2017, Page(s) 930-937, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000003680

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

Author(s): Christopher G. Taylor, Georg Meisl, Mathew H. Horrocks, Henrik Zetterberg, Tuomas P. J. Knowles, David Klenerman
Published in: Analytical Chemistry, 90/17, 2018, Page(s) 10385-10393, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.8b02226

Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study

Author(s): Ram A. Sharma, Andrew W. Varga, Omonigho M. Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D. Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L. Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S. Babb, Kaj Blennow, Henrik Zetterberg, Shou E. Lu, Sandra G. Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gossel
Published in: American Journal of Respiratory and Critical Care Medicine, 197/7, 2018, Page(s) 933-943, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.201704-0704oc

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Author(s): Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin, Federico E. Rey
Published in: Alzheimer's Research & Therapy, 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0451-2

Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease

Author(s): Niklas Mattsson, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Michael Schöll, Philip S. Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Kaj Blennow, Jonas Jögi, Oskar Hansson
Published in: Neurology, 90/5, 2018, Page(s) e388-e395, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000004887

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

Author(s): Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson
Published in: Neurology, 90/1, 2017, Page(s) e73-e81, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000004749

Serum neurofilament light in familial Alzheimer disease

Author(s): Philip S.J. Weston, Teresa Poole, Natalie S. Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B. Malone, R. Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N. Rossor, Jonathan M. Schott, Henrik Zetterberg, Nick C. Fox
Published in: Neurology, 89/21, 2017, Page(s) 2167-2175, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000004667

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease

Author(s): Brownjohn, Philip W.; Smith, James; Portelius, Erik; Serneels, Lutgarde; Kvartsberg, Hlin; De Strooper, Bart; Blennow, Kaj; Zetterberg, Henrik; Livesey, Frederick J.
Published in: Stem Cell Reports, 4, 2017, Page(s) 870-882, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.17863/CAM.9285

The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease

Author(s): Mony J. de Leon, Elizabeth Pirraglia, Ricardo S. Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siegel, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blennow
Published in: PLOS ONE, 13/2, 2018, Page(s) e0191240, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0191240

Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia

Author(s): Andrew P. Merluzzi, Cynthia M. Carlsson, Sterling C. Johnson, Suzanne E. Schindler, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin
Published in: Neurology, 91/5, 2018, Page(s) e436-e443, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000005901

Astroglial activation and altered amyloid metabolism in human repetitive concussion

Author(s): Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L. Brody, Kaj Blennow, Henrik Zetterberg
Published in: Neurology, 88/15, 2017, Page(s) 1400-1407, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000003816

Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein

Author(s): Anna Zettergren, Kina Höglund, Silke Kern, Valgeir Thorvaldsson, Msc Johan Skoog, Oskar Hansson, Niels Andreasen, Nenad Bogdanovic, Kaj Blennow, Ingmar Skoog, Henrik Zetterberg
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-36650-3

Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer’s Disease

Author(s): Per Johansson, Erik G. Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Published in: Journal of Alzheimer's Disease, 59/3, 2017, Page(s) 1017-1026, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-170226

Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected patients: a retrospective cross-sectional study

Author(s): Sofie Jespersen, Karin Kæreby Pedersen, Birgitta Anesten, Henrik Zetterberg, Dietmar Fuchs, Magnus Gisslén, Lars Hagberg, Marius Trøseid, Susanne Dam Nielsen
Published in: BMC Infectious Diseases, 16/1, 2016, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-016-1510-6